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Which Septic Shock Patients With Non-Overt DIC Progress to DIC After Admission? Point-of-Care Thromboelastography Testing.

Sang-Min Kim, Sang-Il Kim, Gina Yu, Youn-Jung Kim, Won Young Kim,

<h4>Background</h4>Disseminated intravascular coagulation (DIC) is a life-threatening complication of septic shock; however, risk factors for its development after admission are unknown. Thromboelastography (TEG) can reflect coagulation disturbances in early non-overt DIC that are not detected by standard coagulation tests. This study investigated the risk factors including TEG findings as early ... Read more >>

Shock (Shock (Augusta, Ga.))
[2022, 57(2):168-174]

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Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis.

Yu Kyung Jun, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Yong Jin Jung, Won Kim, Hyun Sun Park, Dong Hyeon Lee, Seong-Joon Koh,

Despite the importance of Helicobacter pylori infection and portal hypertension (PH)-associated gastrointestinal (GI) diseases, such as esophageal varices and portal hypertensive gastropathy (PHG), the impact of H. pylori infection on PH-related GI complications has not yet been elucidated. This meta-analysis investigated the association between H. pylori infection and the risk ... Read more >>

PLoS One (PloS one)
[2022, 17(1):e0261448]

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Immunostimulation of tumor microenvironment by targeting tumor-associated macrophage with hypoxia-responsive nanocomplex for enhanced anti-tumor therapy.

Yeoul Kang, Junha Lim, Gurusamy Saravanakumar, Jinseong Kim, Mihyeon Park, Sooseok Im, Won Jong Kim,

Tumor-associated macrophages (TAMs), which dampen the therapeutic efficacy of cancer immunotherapy, are the key players in the immunosuppressive tumor microenvironment (TME). Therefore, reprogramming TAMs into tumoricidal M1 macrophages possesses considerable potential as a novel immunotherapy. However, the low bioavailability of polarization agents and limited accumulation of TAMs restrict their anti-tumor ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2022, :]

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A randomized controlled trial of stem cell injection for tendon tear.

Se-Woong Chun, Won Kim, Sang Yoon Lee, Chai-Young Lim, Keewon Kim, Jeong-Gil Kim, Chul-Hyun Park, Sung Hwan Hong, Hye Jin Yoo, Sun G Chung,

Tendons have limited reparative ability and perform a relatively simple mechanical function via the extracellular matrix. Thus, the injured tendon might be treated successfully by stem cell transplantation. We performed a randomized, controlled study to investigate the effects of mesenchymal stem cell injection for treating partial tears in the supraspinatus tendon. ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):818]

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The association between the type of anesthesia and hemodynamic instability during pheochromocytoma surgery: a retrospective cohort study.

Won Woong Kim, Doo-Hwan Kim, Jae Won Cho, Cheong-Sil Rah, Yu-Mi Lee, Ki-Wook Chung, Jung-Min Koh, Seung Hun Lee, Suck Joon Hong, Yeon Ju Kim, Tae-Yon Sung,

<h4>Background</h4>Pheochromocytoma often carries a risk for perioperative hemodynamic instability (HDI). The aim of this study is to evaluate the risk factors of intraoperative HDI during minimally invasive posterior retroperitoneal adrenalectomy (PRA) for pheochromocytoma.<h4>Materials and methods</h4>This retrospective study analyzed the prospectively collected data of 172 patients who underwent laparoscopic PRA or ... Read more >>

Surg Endosc (Surgical endoscopy)
[2022, :]

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A sequential approach using the age-adjusted fibrosis-4 index and vibration-controlled transient elastography to detect advanced fibrosis in Korean patients with non-alcoholic fatty liver disease.

Dong Hyeon Lee, Se Un Sung, Yun Kyu Lee, Ik Hyeon Lim, Heejoon Jang, Sae Kyoung Joo, Jeong Hwan Park, Mee Soo Chang, Young Ho So, Won Kim, ,

<h4>Background and aims</h4>Vibration-controlled transient elastography (VCTE) has shown good diagnostic performance in predicting fibrosis stages in patients with non-alcoholic fatty liver disease (NAFLD). However, an optimal diagnostic approach to detect advanced fibrosis in patients with NAFLD has not been established.<h4>Approach and results</h4>We prospectively collected data from 539 subjects who underwent ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2022, :]

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Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.

Meritxell Ventura-Cots, Josepmaria Argemi, Patricia D Jones, Carolin Lackner, Mohamed El Hag, Juan G Abraldes, Edilmar Alvarado, Ana Clemente, Samitha Ravi, Antonio Alves, Mohamed Alboraie, Jose Altamirano, Sergio Barace, Francisco Bosques, Robert Brown, Juan Caballeria, Joaquin Cabezas, Sofia Carvalhana, Helena Cortez-Pinto, Adilia Costa, Delphine Degré, Carlos Fernandez-Carillo, Nathalie Ganne-Carrie, Guadalupe Garcia-Tsao, Joan Genesca, John Koskinas, Nicolas Lanthier, Alexandre Louvet, Juan José Lozano, Michael R Lucey, Steven Masson, Philippe Mathurin, Nahum Mendez-Sanchez, Rosa Miquel, Christophe Moreno, Taofic Mounajjed, Gemma Odena, Won Kim, Pau Sancho-Bru, R Warren Sands, Justyna Szafranska, Laurine Verset, Bern Schnabl, Christine Sempoux, Vijay Shah, Debbie Lindsay Shawcross, Rudolf E Stauber, Beate K Straub, Elizabeth Verna, Dina Tiniakos, Eric Trépo, Victor Vargas, Càndid Villanueva, John T Woosley, Marianne Ziol, Sebastian Mueller, Peter Stärkel, Ramon Bataller,

<h4>Objective</h4>Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking.<h4>Design</h4>Two large cohorts of patients were recruited in an international, observational multicentre study: a retrospective cohort of ... Read more >>

Gut (Gut)
[2022, :]

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Long-term effect of the eradication of Helicobacter pylori on the hemoglobin A1c in type 2 diabetes or prediabetes patients.

Won Seok Kim, Yonghoon Choi, Nayoung Kim, Seon Hee Lim, Gitark Noh, Ki Wook Kim, Jaehyung Park, Hyeongho Jo, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee,

<h4>Background/aims</h4>The long-term effect of Helicobacter pylori eradication on the metabolic syndrome or diabetes are unclear. The aim of this study was to evaluate the effect of H. pylori eradication on glycemic control in type 2 diabetes mellitus (T2DM) or prediabetes mellitus (preDM).<h4>Methods</h4>A total of 124 asymptomatic subjects with T2DM or ... Read more >>

Korean J Intern Med (The Korean journal of internal medicine)
[2022, :]

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Lymph-Directed Self-Immolative Nitric Oxide Prodrug for Inhibition of Intractable Metastatic Cancer.

Taejeong Kim, Jeeyeon Suh, Jihoon Kim, Won Jong Kim,

There has been a significant clinical demand for lymph-directed anti-metastatic therapy as tumor-draining lymph nodes play pivotal roles in cancer metastasis which accounts for more than 90% of tumor-related deaths. Despite the high potential of nitric oxide (NO) in anti-cancer therapy owing to its biocompatibility and tumor cell-specific cytotoxicity, the ... Read more >>

Adv Sci (Weinh) (Advanced science (Weinheim, Baden-Wurttemberg, Germany))
[2022, :e2101935]

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Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures.

Mitchell C Krawczyk, Jillian R Haney, Lin Pan, Christine Caneda, Rana R Khankan, Samuel D Reyes, Julia W Chang, Marco Morselli, Harry V Vinters, Anthony C Wang, Inma Cobos, Michael J Gandal, Marvin Bergsneider, Won Kim, Linda M Liau, William Yong, Ali Jalali, Benjamin Deneen, Gerald A Grant, Gary W Mathern, Aria Fallah, Ye Zhang,

Astrocytes are critical for the development and function of synapses. There are notable species differences between human astrocytes and commonly used animal models. Yet, it is unclear whether astrocytic genes involved in synaptic function are stable or exhibit dynamic changes associated with disease states and age in humans, which is ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2022, :]

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Performing Group Difference Testing on Graph Structured Data From GANs: Analysis and Applications in Neuroimaging.

Tuan Q Dinh, Yunyang Xiong, Zhichun Huang, Tien Vo, Akshay Mishra, Won Hwa Kim, Sathya N Ravi, Vikas Singh,

Generative adversarial networks (GANs) have emerged as a powerful generative model in computer vision. Given their impressive abilities in generating highly realistic images, they are also being used in novel ways in applications in the life sciences. This raises an interesting question when GANs are used in scientific or biomedical ... Read more >>

IEEE Trans Pattern Anal Mach Intell (IEEE transactions on pattern analysis and machine intelligence)
[2022, 44(2):877-889]

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Biomarker Analysis for Combination Therapy of Vitamin C and Thiamine in Septic Shock: A Post-Hoc Study of the ATESS Trial.

Jong Eun Park, You Hwan Jo, Sung Yeon Hwang, Won Young Kim, Seung Mok Ryoo, Dong-Hyun Jang, Taegyun Kim, Youn-Jung Kim, Seonwoo Kim, Hyun Cho, Gun Tak Lee, Sung Phil Chung, Sung-Hyuk Choi, Tae Gun Shin, Gil Joon Suh, ,

<h4>Introduction</h4>We evaluated the effects of vitamin C and thiamine administration on biomarkers in patients with septic shock.<h4>Methods</h4>This was a post-hoc analysis of the Ascorbic Acid and Thiamine Effect in Septic Shock (ATESS) trial, a multicenter, double-blind, randomized controlled trial. Patients were randomized to either a treatment group (intravenous vitamin C ... Read more >>

Shock (Shock (Augusta, Ga.))
[2022, 57(1):81-87]

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Impact of Visceral Fat on Survival and Metastasis of Stage III Colorectal Cancer.

Jung Won Park, Soo Yeon Chang, Joon Seok Lim, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Won Ho Kim, Tae Il Kim,

<h4>Background/aims</h4>Previous studies have investigated the relationship between visceral obesity and the risk of colorectal tumors. Visceral obesity may affect the outcome of colorectal cancer (CRC), including survival and metastasis. We investigated the associations between visceral adipose tissue and oncologic outcomes in stage III CRC.<h4>Methods</h4>Four hundred seventy-two patients with stage III ... Read more >>

Gut Liver (Gut and liver)
[2022, 16(1):53-61]

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Pegfilgrastim Prophylaxis is Effective in the Prevention of Febrile Neutropenia and Reduces Mortality in Patients Aged ≥75 Years with Diffuse Large B-Cell Lymphoma Treated with R-CHOP: A Prospective Cohort Study.

Seong Hyun Jeong, Seok Jin Kim, Dok Hyun Yoon, Yong Park, Hye Jin Kang, Youngil Koh, Gyeong-Won Lee, Won-Sik Lee, Deok-Hwan Yang, Young Rok Do, Min Kyoung Kim, Kwai Han Yoo, Yoon Seok Choi, Hwan Jung Yun, Jun Ho Yi, Jae-Cheol Jo, Hyeon-Seok Eom, Jae-Yong Kwak, Ho-Jin Shin, Byeong Bae Park, Shin Young Hyun, Seong Yoon Yi, Ji-Hyun Kwon, Sung Yong Oh, Hyo Jung Kim, Byeong Seok Sohn, Jong Ho Won, Se-Hyung Kim, Ho-Sup Lee, Cheolwon Suh, Won Seog Kim,

<h4>Purpose</h4>Febrile neutropenia (FN) can cause suboptimal treatment and treatment-related mortality (TRM) in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP).<h4>Materials and methods</h4>We conducted a prospective cohort study to evaluate the effectiveness of pegfilgrastim prophylaxis in DLBCL patients receiving R-CHOP, and we compared them ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2021, :]

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A Case Study of Quantizing Convolutional Neural Networks for Fast Disease Diagnosis on Portable Medical Devices.

Mukhammed Garifulla, Juncheol Shin, Chanho Kim, Won Hwa Kim, Hye Jung Kim, Jaeil Kim, Seokin Hong,

Recently, the amount of attention paid towards convolutional neural networks (CNN) in medical image analysis has rapidly increased since they can analyze and classify images faster and more accurately than human abilities. As a result, CNNs are becoming more popular and play a role as a supplementary assistant for healthcare ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2021, 22(1):]

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Adipsic Hypernatremia after Clipping of a Ruptured Aneurysm in the Anterior Communicating Artery: A Case Report.

Won Ki Kim, Taeho Lee, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Wookyung Chung, Ji Yong Jung,

Adipsia is a rare disorder that occurs due to damage to the osmoreceptor and not feeling thirst despite hyperosmolality. Adipsic hypernatremia can occur when there is damage to the anterior communicating artery that supplies blood to osmoreceptors, and the level of arginine vasopressin secretion varies widely. A 37-year-old woman, suffering ... Read more >>

Electrolyte Blood Press (Electrolyte & blood pressure : E & BP)
[2021, 19(2):56-60]

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Weakly-supervised deep learning for ultrasound diagnosis of breast cancer.

Jaeil Kim, Hye Jung Kim, Chanho Kim, Jin Hwa Lee, Keum Won Kim, Young Mi Park, Hye Won Kim, So Yeon Ki, You Me Kim, Won Hwa Kim,

Conventional deep learning (DL) algorithm requires full supervision of annotating the region of interest (ROI) that is laborious and often biased. We aimed to develop a weakly-supervised DL algorithm that diagnosis breast cancer at ultrasound without image annotation. Weakly-supervised DL algorithms were implemented with three networks (VGG16, ResNet34, and GoogLeNet) ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):24382]

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Risk of non-Hodgkin lymphoma in breast cancer survivors: a nationwide cohort study.

Danbee Kang, Sang Eun Yoon, Dongwook Shin, Jin Lee, Yun Soo Hong, Se Kyung Lee, Jeong Eon Lee, Yeon Hee Park, Jin Seok Ahn, Eliseo Guallar, Won Seog Kim, Jungho Lee, Seok Jin Kim, Juhee Cho,

Several studies have suggested that estrogens have a protective function against lymphomagenesis. The treatment of breast cancer is driven by subtype classification, and the assessment of hormone receptor status is important for treatment selection. Thus, we evaluated the association between breast cancer and the incidence of NHL. We conducted a ... Read more >>

Blood Cancer J (Blood cancer journal)
[2021, 11(12):200]

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Single-Agent Mosunetuzumab Shows Durable Complete Responses in Patients With Relapsed or Refractory B-Cell Lymphomas: Phase I Dose-Escalation Study.

Lihua E Budde, Sarit Assouline, Laurie H Sehn, Stephen J Schuster, Sung-Soo Yoon, Dok Hyun Yoon, Matthew J Matasar, Francesc Bosch, Won Seog Kim, Loretta J Nastoupil, Ian W Flinn, Mazyar Shadman, Catherine Diefenbach, Carol O'Hear, Huang Huang, Antonia Kwan, Chi-Chung Li, Emily C Piccione, Michael C Wei, Shen Yin, Nancy L Bartlett,

<h4>Purpose</h4>Mosunetuzumab is a bispecific antibody targeting CD20 and CD3 that redirects T cells to engage and eliminate malignant B cells and is being developed for relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs).<h4>Methods</h4>This first-in-human trial (ClinicalTrials.gov identifier: NCT02500407) evaluated the safety and tolerability and efficacy of mosunetuzumab in patients with ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, :JCO2100931]

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Application of Multigene Panel Testing In Patients With High Risk for Hereditary Colorectal Cancer: A Descriptive Report Focused On Genotype-Phenotype Correlation.

Ji Soo Park, Jung Won Park, Saeam Shin, Seung-Tae Lee, Sang Joon Shin, Byung Soh Min, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Won Ho Kim, Tae Il Kim,

Genetic test solely based on clinical feature of hereditary colorectal cancer has limitations in clinical practice. This study aimed to analyze the result of comprehensive multigene panel tests based on clinical findings. This was a cross-sectional study based on a prospectively complied database. The study was conducted at a tertiary ... Read more >>

Dis Colon Rectum (Diseases of the colon and rectum)
[2021, :]

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Reversible severe tricuspid regurgitation associated with Graves' disease: A case report.

Ja-Yeon Lee, Sun Hwa Lee, Won Ho Kim,

<h4>Rationale</h4>Graves' disease is the most common cause of thyrotoxicosis. Cardiovascular signs and symptoms are frequent in patients with thyrotoxicosis and right heart failure with severe tricuspid regurgitation (TR) is a rare manifestation of hyperthyroidism.<h4>Patient concerns</h4>A 41-year-old woman with a history of Graves' disease presented to the emergency department with worsening ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(51):e28432]

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Author Correction: Insulin smart drug delivery nanoparticles of aminophenylboronic acid-POSS molecule at neutral pH.

Won Jung Kim, Yong-Jin Kwon, Chung-Hyun Cho, Sang-Kyu Ye, Kyu Oh Kim,

Sci Rep (Scientific reports)
[2021, 11(1):23870]

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Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest.

Seok-In Hong, June-Sung Kim, Youn-Jung Kim, Won Young Kim,

We aimed to investigate the prognostic value of dynamic changes in arterial blood gas analysis (ABGA) measured after the start of cardiopulmonary resuscitation (CPR) for return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest (OHCA). This prospective observational study was conducted at the emergency department of a university ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):23165]

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Nonalcoholic fatty liver disease-based risk prediction of adverse pregnancy outcomes: Ready for prime time?

Seung Mi Lee, Won Kim,

Clin Mol Hepatol (Clinical and molecular hepatology)
[2022, 28(1):47-49]

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Does Transection of the Superficial MCL During HTO Result in Progressive Valgus Instability? [Formula: see text].

Joo-Hwan Kim, Dong Jin Ryu, Sung-Sahn Lee, Seung Pil Jang, Jae Sung Park, Won Jae Kim, Il-Su Kim, Joon Ho Wang,

<h4>Background</h4>During high tibial osteotomy (HTO), the superficial medial collateral ligament (sMCL) is cut or released at any degree to expose the osteotomy site and achieve the targeted alignment correction according to the surgeon's preference. However, it is still unclear whether transection of sMCL increases valgus laxity.<h4>Purpose</h4>We aimed to assess the ... Read more >>

Am J Sports Med (The American journal of sports medicine)
[2022, 50(1):142-151]

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