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Anti-inflammatory and NF-κB inhibitory activity of aerial parts of Cestrum diurnum

Amina Khatun, Mahmudur Rahman, Lutfun Nesa, Chung Yeng Looi, Won Fen Wong, Hazrina Hazni, Mohamad Azrul bin Mahdzir, Shaikh Jamal Uddin, Khalijah Awang, Jamil Ahmad Shilpi,

Abstract Background Cestrum diurnum L. (Solanaceae) is used in various traditional medicine for pain and related disorders. The Malayali tribe of Tamil Nadu in India use the leaf in joint pain. In the Chinese traditional medicine it is used for the treatment of burns and swellings. Present study ... Read more >>

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Chronic Inflammatory Diseases at Secondary Sites Ensuing Urogenital or Pulmonary Chlamydia Infections.

Yi Ying Cheok, Chalystha Yie Qin Lee, Heng Choon Cheong, Chung Yeng Looi, Won Fen Wong,

Chlamydia trachomatis and C. pneumoniae are members of the Chlamydiaceae family of obligate intracellular bacteria. The former causes diseases predominantly at the mucosal epithelial layer of the urogenital or eye, leading to pelvic inflammatory diseases or blindness; while the latter is a major causative agent for pulmonary infection. On top ... Read more >>

Microorganisms (Microorganisms)
[2020, 8(1):]

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Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia.

Heng Choon Cheong, Polly Soo Xi Yap, Chun Wie Chong, Yi Ying Cheok, Chalystha Yie Qin Lee, Grace Min Yi Tan, Sofiah Sulaiman, Jamiyah Hassan, Negar Shafiei Sabet, Chung Yeng Looi, Rishein Gupta, Bernard Arulanandam, Sazaly AbuBakar, Cindy Shuan Ju Teh, Li Yen Chang, Won Fen Wong,

The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. In ... Read more >>

PLoS ONE (PloS one)
[2019, 14(11):e0224658]

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Emerging frontiers of deep eutectic solvents in drug discovery and drug delivery systems.

Mohamad Hamdi Zainal-Abidin, Maan Hayyan, Gek Cheng Ngoh, Won Fen Wong, Chung Yeng Looi,

The applications of eutectic systems, including deep eutectic solvents (DESs), in diverse sectors have drawn significant interest from researchers, academicians, engineers, medical scientists, and pharmacists. Eutecticity increases drug dissolution, improves drug penetration, and acts as a synthesis route for drug carriers. To date, DESs have been extensively explored as potential ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2019, 316:168-195]

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The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges.

Chin-Yap Loh, Jian Yi Chai, Ting Fang Tang, Won Fen Wong, Gautam Sethi, Muthu Kumaraswamy Shanmugam, Pei Pei Chong, Chung Yeng Looi,

Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metastasis and chemoresistance in cancer patients. The hallmark of ... Read more >>

Cells (Cells)
[2019, 8(10):]

Cited: 1 time

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Chlamydia and Its Many Ways of Escaping the Host Immune System.

Won Fen Wong, James P Chambers, Rishein Gupta, Bernard P Arulanandam,

The increasing number of new cases of Chlamydia infection worldwide may be attributed to the pathogen's ability to evade various host immune responses. Summarized here are means of evasion utilized by Chlamydia enabling survival in a hostile host environment. The pathogen's persistence involves a myriad of molecular interactions manifested in ... Read more >>

J Pathog (Journal of pathogens)
[2019, 2019:8604958]

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Corrigendum: The Microbiome and Irritable Bowel Syndrome - A Review on the Pathophysiology, Current Research and Future Therapy.

Pei Pei Chong, Voon Kin Chin, Chung Yeng Looi, Won Fen Wong, Priya Madhavan, Voon Chen Yong,

[This corrects the article DOI: 10.3389/fmicb.2019.01136.]. ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:1870]

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The Microbiome and Irritable Bowel Syndrome - A Review on the Pathophysiology, Current Research and Future Therapy.

Pei Pei Chong, Voon Kin Chin, Chung Yeng Looi, Won Fen Wong, Priya Madhavan, Voon Chen Yong,

Irritable bowel syndrome (IBS) is a functional disorder which affects a large proportion of the population globally. The precise etiology of IBS is still unknown, although consensus understanding proposes IBS to be of multifactorial origin with yet undefined subtypes. Genetic and epigenetic factors, stress-related nervous and endocrine systems, immune dysregulation ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:1136]

Cited: 3 times

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Lung-infiltrating T helper 17 cells as the major source of interleukin-17A production during pulmonary Cryptococcus neoformans infection.

Elaheh Movahed, Yi Ying Cheok, Grace Min Yi Tan, Chalystha Yie Qin Lee, Heng Choon Cheong, Rukumani Devi Velayuthan, Sun Tee Tay, Pei Pei Chong, Won Fen Wong, Chung Yeng Looi,

BACKGROUND:IL-17A has emerged as a key player in the pathologies of inflammation, autoimmune disease, and immunity to microbes since its discovery two decades ago. In this study, we aim to elucidate the activity of IL-17A in the protection against Cryptococcus neoformans, an opportunistic fungus that causes fatal meningoencephalitis among AIDS ... Read more >>

BMC Immunol. (BMC immunology)
[2018, 19(1):32]

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Metabolomics and 16S rRNA sequencing of human colorectal cancers and adjacent mucosa.

Mun Fai Loke, Eng Guan Chua, Han Ming Gan, Kumar Thulasi, Jane W Wanyiri, Iyadorai Thevambiga, Khean Lee Goh, Won Fen Wong, Jamuna Vadivelu,

Colorectal cancer (CRC) is ranked the third most common cancer in human worldwide. However, the exact mechanisms of CRC are not well established. Furthermore, there may be differences between mechanisms of CRC in the Asian and in the Western populations. In the present study, we utilized a liquid chromatography-mass spectrometry ... Read more >>

PLoS ONE (PloS one)
[2018, 13(12):e0208584]

Cited: 1 time

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CPAF, HSP60 and MOMP antigens elicit pro-inflammatory cytokines production in the peripheral blood mononuclear cells from genital Chlamydia trachomatis-infected patients.

Heng Choon Cheong, Chalystha Yie Qin Lee, Yi Ying Cheok, Esaki M Shankar, Negar S Sabet, Grace Min Yi Tan, Elaheh Movahed, Tee Cian Yeow, Sofiah Sulaiman, Won Fen Wong, Chung Yeng Looi, Rishein Gupta, Jamiyah Hassan, Bernard Arulanandam, Sazaly AbuBakar,

BACKGROUND:Persistent inflammation caused by Chlamydia trachomatis in the female genital compartment represents one of the major causes of pelvic inflammatory disease (PID), ectopic pregnancy and infertility in females. Here, we examined the pro-inflammatory cytokine response following stimulation with three different types of C. trachomatis antigens, viz. chlamydial protease-like factor (CPAF), ... Read more >>

Immunobiology (Immunobiology)
[2019, 224(1):34-41]

Cited: 4 times

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Transcriptomic and Genomic Approaches for Unravelling Candida albicans Biofilm Formation and Drug Resistance-An Update.

Pei Pei Chong, Voon Kin Chin, Won Fen Wong, Priya Madhavan, Voon Chen Yong, Chung Yeng Looi,

Candida albicans is an opportunistic fungal pathogen, which causes a plethora of superficial, as well as invasive, infections in humans. The ability of this fungus in switching from commensalism to active infection is attributed to its many virulence traits. Biofilm formation is a key process, which allows the fungus to ... Read more >>

Genes (Basel) (Genes)
[2018, 9(11):]

Cited: 2 times

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Nipah Virus Infection of Immature Dendritic Cells Increases Its Transendothelial Migration Across Human Brain Microvascular Endothelial Cells.

Vunjia Tiong, Meng-Hooi Shu, Won Fen Wong, Sazaly AbuBakar, Li-Yen Chang,

Nipah virus (NiV) can infect multiple organs in humans with the central nervous system (CNS) being the most severely affected. Currently, it is not fully understood how NiV spreads throughout the body. NiV has been shown to infect certain leukocyte populations and we hypothesized that these infected cells could cross ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2018, 9:2747]

Cited: 1 time

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Chronic restraint stress impairs sociability but not social recognition and spatial memoryin C57BL/6J mice.

Mohd Aizat Zain, Vijayapandi Pandy, Abu Bakar Abdul Majeed, Won Fen Wong, Zahurin Mohamed,

Chronic stress has been associated with impairment of memory, learning, and social cognition. In animal studies, chronic stress has been shown to impair rodent sociability behaviour which mimics social withdrawal as observed in depression patients. The effect of chronic stress on social recognition, however, is uncertain. Moreover, with reference to ... Read more >>

Exp. Anim. (Experimental animals)
[2019, 68(1):113-124]

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Phencyclidine dose optimisation for induction of spatial learning and memory deficits related to schizophrenia in C57BL/6 mice.

Mohd Aizat Zain, Elham Rouhollahi, Vijayapandi Pandy, Vasudevan Mani, Abu Bakar Abdul Majeed, Won Fen Wong, Zahurin Mohamed,

Phencyclidine (PCP) has been used to model cognitive deficits related to schizophrenia in rats and mice. However, the model in mice is not consistent in terms of the PCP effective dose reported. Furthermore, most of the previous studies in mice excluded the presence of drug washout period in the regime. ... Read more >>

Exp. Anim. (Experimental animals)
[2018, 67(4):421-429]

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Interleukin-17A Secreted from the Lung–infiltrating T Helper 17 Cells Renders Protective Immunity to Pulmonary Cryptococcus neoformans Infection

Elaheh Movahed, Grace Min Yi Tan, Heng Choon Cheong, Chalystha Yie Qin Lee, Yi Ying Cheok, Sun Tee Tay, Pei Pei Chong, Won Fen Wong, Chung Yeng Looi,

ABSTRACT IL-17A has emerged as a key player in the pathologies of inflammation, autoimmune disease, and immunity to microbes since its discovery two decades ago. In this study, we aim to elucidate the activity of IL-17A in the protection against Cryptococcus neoformans , an opportunistic fungus that causes fatal meningoencephalitis ... Read more >>

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Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents.

Ampornphan Siriviriyanun, Ya-Ju Tsai, Siew Hui Voon, Siaw Fui Kiew, Toyoko Imae, Lik Voon Kiew, Chung Yeng Looi, Won Fen Wong, Hong Boon Lee, Lip Yong Chung,

In this study, nanohybrid materials consisting of graphene oxide (GO), β‑cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) were successfully prepared by covalent bonding. GO-CD and GO-CD-DEN were found to be potential nanocarriers for anticancer drugs including chemotherapeutics (doxorubicin (DOX), camptothecin (CPT)) and photosensitizer (protoporphyrin IX (PpIX)). GO-CD possessed 1.2 times ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2018, 89:307-315]

Cited: 2 times

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Phenylpropanoids isolated from Piper sarmentosum Roxb. induce apoptosis in breast cancer cells through reactive oxygen species and mitochondrial-dependent pathways.

Arshia Hematpoor, Mohammadjavad Paydar, Sook Yee Liew, Yasodha Sivasothy, Nooshin Mohebali, Chung Yeng Looi, Won Fen Wong, Mohd Sofian Azirun, Khalijah Awang,

The aim of the present study is to isolate bioactive compounds from the roots of Piper sarmentosum and examine the mechanism of action using human breast cancer cell line (MDA-MB-231). Bioassay guided-fractionation of methanolic extract led to the isolation of asaricin (1) and isoasarone (2). Asaricin (1) and isoasarone (2) ... Read more >>

Chem. Biol. Interact. (Chemico-biological interactions)
[2018, 279:210-218]

Cited: 2 times

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Unraveling the cytotoxicity and metabolic pathways of binary natural deep eutectic solvent systems.

Yves Paul Mbous, Maan Hayyan, Won Fen Wong, Chung Yeng Looi, Mohd Ali Hashim,

In this study, the anticancer potential and cytotoxicity of natural deep eutectic solvents (NADESs) were assessed using HelaS3, PC3, A375, AGS, MCF-7, and WRL-68 hepatic cell lines. NADESs were prepared from choline chloride, fructose, or glucose and compared with an N,N-diethyl ethanolammonium chloride:triethylene glycol DES. The NADESs (98 ≤ EC50 ≥ 516 mM) were less ... Read more >>

Sci Rep (Scientific reports)
[2017, 7:41257]

Cited: 10 times

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Phytometabolites Targeting the Warburg Effect in Cancer Cells: A Mechanistic Review.

Mohadeseh Hasanpourghadi, Chung Yeng Looi, Ashok Kumar Pandurangan, Gautam Sethi, Won Fen Wong, Mohd Rais Mustafa,

Phytometabolites are functional elements derived from plants and most of them exhibit therapeutic characteristics such as anti-cancer, anti-inflammatory and anti-oxidant effects. Phytometabolites exert their anti-cancer effect by targeting multiple signaling pathways. One of the remarkable phenomena targeted by phytometabolites is the Warburg effect. The Warburg effect describes the observation that ... Read more >>

Curr Drug Targets (Current drug targets)
[2017, 18(9):1086-1094]

Cited: 15 times

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Renal targeting potential of a polymeric drug carrier, poly-l-glutamic acid, in normal and diabetic rats.

Hann-Juang Chai, Lik-Voon Kiew, Yunni Chin, Anwar Norazit, Suzita Mohd Noor, Yoke-Lin Lo, Chung-Yeng Looi, Yeh-Siang Lau, Tuck-Meng Lim, Won-Fen Wong, Nor Azizan Abdullah, Munavvar Zubaid Abdul Sattar, Edward J Johns, Zamri Chik, Lip-Yong Chung,

Poly-l-glutamic acid (PG) has been used widely as a carrier to deliver anticancer chemotherapeutics. This study evaluates PG as a selective renal drug carrier.3H-deoxycytidine-labeled PGs (17 or 41 kDa) and 3H-deoxycytidine were administered intravenously to normal rats and streptozotocin-induced diabetic rats. The biodistribution of these compounds was determined over 24 ... Read more >>

Int J Nanomedicine (International journal of nanomedicine)
[2017, 12:577-591]

Cited: 2 times

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Applications of deep eutectic solvents in biotechnology and bioengineering-Promises and challenges.

Yves Paul Mbous, Maan Hayyan, Adeeb Hayyan, Won Fen Wong, Mohd Ali Hashim, Chung Yeng Looi,

Deep eutectic solvents (DESs) have been touted recently as potential alternatives to ionic liquids (ILs). Although they possess core characteristics that are similar to those of ILs (e.g., low volatility, non-flammability, low melting points, low vapor pressure, dipolar nature, chemical and thermal stability, high solubility, and tuneability), DESs are superior ... Read more >>

Biotechnol. Adv. (Biotechnology advances)
[2017, 35(2):105-134]

Cited: 17 times

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Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells.

Yuan Seng Wu, Ivy Chung, Won Fen Wong, Atsushi Masamune, Maw Shin Sim, Chung Yeng Looi,

We previously showed that pancreatic stellate cells (PSC) secreted interleukin (IL)-6 and promoted pancreatic ductal adenocarcinoma (PDAC) cell proliferation via nuclear factor erythroid 2 (Nrf2)-mediated metabolic reprogramming. Epithelial-mesenchymal transition (EMT) is a key process for the metastatic cascade. To study the mechanism of PDAC progression to metastasis, we investigated the ... Read more >>

Biochim Biophys Acta Gen Subj (Biochimica et biophysica acta. General subjects)
[2017, 1861(2):296-306]

Cited: 24 times

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Insertion of single-chain variable fragment (scFv) peptide linker improves surface display of influenza hemagglutinin (HA1) on non-recombinant Lactococcus lactis.

Pui-Fong Jee, Fez-Shin Chen, Meng-Hooi Shu, Won Fen Wong, Raha Abdul Rahim, Sazaly AbuBakar, Li-Yen Chang,

Heterologous protein displayed on the surface of Lactococcus lactis using the binding domain of N-acetylmuramidase (AcmA) has a potential application in vaccine delivery. In this study, we developed a non-recombinant L. lactis surface displaying the influenza A (H1N1) 2009 hemagglutinin (HA1). Three recombinant proteins, HA1/L/AcmA, HA1/AcmA, and HA1 were overexpressed ... Read more >>

Biotechnol. Prog. (Biotechnology progress)
[2017, 33(1):154-162]

Cited: 1 time

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Natural deep eutectic solvents: cytotoxic profile.

Maan Hayyan, Yves Paul Mbous, Chung Yeng Looi, Won Fen Wong, Adeeb Hayyan, Zulhaziman Salleh, Ozair Mohd-Ali,

The purpose of this study was to investigate the cytotoxic profiles of different ternary natural deep eutectic solvents (NADESs) containing water. For this purpose, five different NADESs were prepared using choline chloride as a salt, alongside five hydrogen bond donors (HBD) namely glucose, fructose, sucrose, glycerol, and malonic acid. Water ... Read more >>

Springerplus (SpringerPlus)
[2016, 5(1):913]

Cited: 11 times

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