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Author Wolfram Scheurlen

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Social inequalities in the participation and activity of children and adolescents with leukemia, brain tumors, and sarcomas (SUPATEEN): a protocol for a multicenter longitudinal prospective observational study.

Julia Roick, Reinhard Berner, Toralf Bernig, Bernhard Erdlenbruch, Gabriele Escherich, Jörg Faber, Christoph Klein, Konrad Bochennek, Christian Kratz, Joachim Kühr, Alfred Längler, Holger N Lode, Markus Metzler, Hermann Müller, Dirk Reinhardt, Axel Sauerbrey, Florian Schepper, Wolfram Scheurlen, Dominik Schneider, Georg Christof Schwabe, Matthias Richter,

<h4>Background</h4>About 2000 children and adolescents under the age of 18 are diagnosed with cancer each year in Germany. Because of current medical treatment methods, a high survival rate can be reached for many types of the disease. Nevertheless, patients face a number of long-term effects related to the treatment. As ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):48]

Cited: 0 times

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Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma.

Ann-Kathrin Desch, Kristin Hartung, Ante Botzen, Alexander Brobeil, Mathias Rummel, Lars Kurch, Thomas Georgi, Theresa Jox, Stefan Bielack, Stefan Burdach, Carl Friedrich Classen, Alexander Claviez, Klaus-Michael Debatin, Martin Ebinger, Angelika Eggert, Jörg Faber, Christian Flotho, Michael Frühwald, Norbert Graf, Norbert Jorch, Udo Kontny, Christof Kramm, Andreas Kulozik, Joachim Kühr, Karl-Walter Sykora, Markus Metzler, Hermann L Müller, Michaela Nathrath, Thomas Nüßlein, Michael Paulussen, Arnulf Pekrun, Dirk Reinhardt, Harald Reinhard, Claudia Rössig, Axel Sauerbrey, Paul-Gerhardt Schlegel, Dominik T Schneider, Wolfram Scheurlen, Lothar Schweigerer, Thorsten Simon, Meinolf Suttorp, Peter Vorwerk, Roland Schmitz, Regine Kluge, Christine Mauz-Körholz, Dieter Körholz, Stefan Gattenlöhner, Andreas Bräuninger,

We used hybrid capture-targeted next-generation sequencing of circulating cell-free DNA (ccfDNA) of pediatric Hodgkin lymphoma (PHL) patients to determine pathogenic mechanisms and assess the clinical utility of this method. Hodgkin-Reed/Sternberg (HRS) cell-derived single nucleotide variants, insertions/deletions, translocations and VH-DH-JH rearrangements were detected in pretherapy ccfDNA of 72 of 96 patients. ... Read more >>

Leukemia (Leukemia)
[2020, 34(1):151-166]

Cited: 11 times

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Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Sebastian M Waszak, Paul A Northcott, Ivo Buchhalter, Giles W Robinson, Christian Sutter, Susanne Groebner, Kerstin B Grund, Laurence Brugières, David T W Jones, Kristian W Pajtler, A Sorana Morrissy, Marcel Kool, Dominik Sturm, Lukas Chavez, Aurelie Ernst, Sebastian Brabetz, Michael Hain, Thomas Zichner, Maia Segura-Wang, Joachim Weischenfeldt, Tobias Rausch, Balca R Mardin, Xin Zhou, Cristina Baciu, Christian Lawerenz, Jennifer A Chan, Pascale Varlet, Lea Guerrini-Rousseau, Daniel W Fults, Wiesława Grajkowska, Peter Hauser, Nada Jabado, Young-Shin Ra, Karel Zitterbart, Suyash S Shringarpure, Francisco M De La Vega, Carlos D Bustamante, Ho-Keung Ng, Arie Perry, Tobey J MacDonald, Pablo Hernáiz Driever, Anne E Bendel, Daniel C Bowers, Geoffrey McCowage, Murali M Chintagumpala, Richard Cohn, Timothy Hassall, Gudrun Fleischhack, Tone Eggen, Finn Wesenberg, Maria Feychting, Birgitta Lannering, Joachim Schüz, Christoffer Johansen, Tina V Andersen, Martin Röösli, Claudia E Kuehni, Michael Grotzer, Kristina Kjaerheim, Camelia M Monoranu, Tenley C Archer, Elizabeth Duke, Scott L Pomeroy, Redmond Shelagh, Stephan Frank, David Sumerauer, Wolfram Scheurlen, Marina V Ryzhova, Till Milde, Christian P Kratz, David Samuel, Jinghui Zhang, David A Solomon, Marco Marra, Roland Eils, Claus R Bartram, Katja von Hoff, Stefan Rutkowski, Vijay Ramaswamy, Richard J Gilbertson, Andrey Korshunov, Michael D Taylor, Peter Lichter, David Malkin, Amar Gajjar, Jan O Korbel, Stefan M Pfister,

<h4>Background</h4>Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma predisposition genes have not been defined and screening guidelines for genetic counselling and testing for paediatric patients are not available. We aimed to assess and define these genes to provide evidence for future screening guidelines.<h4>Methods</h4>In this international, multicentre ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2018, 19(6):785-798]

Cited: 89 times

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Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy.

Kathinka Krull, Marina Kunstreich, Annika Bronsema, Kirsten Bleckmann, Carl-Friedrich Classen, Bernhard Erdlenbruch, Norbert Jorch, Reinhard Kolb, Alfred Leipold, Olga Moser, Aram Prokop, Wolfram Scheurlen, Daniel Steinbach, Janina Klasen-Sansone, Dirk Klee, Gabriele Escherich, Anja Moericke, Martin Schrappe, Arndt Borkhardt, Michaela Kuhlen,

Osteonecrosis (ON) is a common and debilitating side effect of anti-leukemic treatment in children with acute lymphoblastic leukemia (ALL). However, the impact of leukemia itself on ON development remains elusive. We analyzed 76 children enrolled in the ongoing OPAL trial, who had magnetic resonance imaging (MRI) studies at diagnosis. MRI ... Read more >>

Leuk Lymphoma (Leukemia & lymphoma)
[2019, 60(1):78-84]

Cited: 4 times

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DNA methylation-based classification of central nervous system tumours.

David Capper, David T W Jones, Martin Sill, Volker Hovestadt, Daniel Schrimpf, Dominik Sturm, Christian Koelsche, Felix Sahm, Lukas Chavez, David E Reuss, Annekathrin Kratz, Annika K Wefers, Kristin Huang, Kristian W Pajtler, Leonille Schweizer, Damian Stichel, Adriana Olar, Nils W Engel, Kerstin Lindenberg, Patrick N Harter, Anne K Braczynski, Karl H Plate, Hildegard Dohmen, Boyan K Garvalov, Roland Coras, Annett Hölsken, Ekkehard Hewer, Melanie Bewerunge-Hudler, Matthias Schick, Roger Fischer, Rudi Beschorner, Jens Schittenhelm, Ori Staszewski, Khalida Wani, Pascale Varlet, Melanie Pages, Petra Temming, Dietmar Lohmann, Florian Selt, Hendrik Witt, Till Milde, Olaf Witt, Eleonora Aronica, Felice Giangaspero, Elisabeth Rushing, Wolfram Scheurlen, Christoph Geisenberger, Fausto J Rodriguez, Albert Becker, Matthias Preusser, Christine Haberler, Rolf Bjerkvig, Jane Cryan, Michael Farrell, Martina Deckert, Jürgen Hench, Stephan Frank, Jonathan Serrano, Kasthuri Kannan, Aristotelis Tsirigos, Wolfgang Brück, Silvia Hofer, Stefanie Brehmer, Marcel Seiz-Rosenhagen, Daniel Hänggi, Volkmar Hans, Stephanie Rozsnoki, Jordan R Hansford, Patricia Kohlhof, Bjarne W Kristensen, Matt Lechner, Beatriz Lopes, Christian Mawrin, Ralf Ketter, Andreas Kulozik, Ziad Khatib, Frank Heppner, Arend Koch, Anne Jouvet, Catherine Keohane, Helmut Mühleisen, Wolf Mueller, Ute Pohl, Marco Prinz, Axel Benner, Marc Zapatka, Nicholas G Gottardo, Pablo Hernáiz Driever, Christof M Kramm, Hermann L Müller, Stefan Rutkowski, Katja von Hoff, Michael C Frühwald, Astrid Gnekow, Gudrun Fleischhack, Stephan Tippelt, Gabriele Calaminus, Camelia-Maria Monoranu, Arie Perry, Chris Jones, Thomas S Jacques, Bernhard Radlwimmer, Marco Gessi, Torsten Pietsch, Johannes Schramm, Gabriele Schackert, Manfred Westphal, Guido Reifenberger, Pieter Wesseling, Michael Weller, Vincent Peter Collins, Ingmar Blümcke, Martin Bendszus, Jürgen Debus, Annie Huang, Nada Jabado, Paul A Northcott, Werner Paulus, Amar Gajjar, Giles W Robinson, Michael D Taylor, Zane Jaunmuktane, Marina Ryzhova, Michael Platten, Andreas Unterberg, Wolfgang Wick, Matthias A Karajannis, Michel Mittelbronn, Till Acker, Christian Hartmann, Kenneth Aldape, Ulrich Schüller, Rolf Buslei, Peter Lichter, Marcel Kool, Christel Herold-Mende, David W Ellison, Martin Hasselblatt, Matija Snuderl, Sebastian Brandner, Andrey Korshunov, Andreas von Deimling, Stefan M Pfister,

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present ... Read more >>

Nature (Nature)
[2018, 555(7697):469-474]

Cited: 505 times

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Corrigendum to "A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma - A final report" [Eur J of Canc (2017) 206-225].

Astrid K Gnekow, David A Walker, Daniela Kandels, Susan Picton, Giorgio Perilongo, Jacques Grill, Tore Stokland, Per Eric Sandstrom, Monika Warmuth-Metz, Torsten Pietsch, Felice Giangaspero, René Schmidt, Andreas Faldum, Denise Kilmartin, Angela De Paoli, Gian Luca De Salvo, ,

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2018, 90:156-157]

Cited: 0 times

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Haematological malignancies following temozolomide treatment for paediatric high-grade glioma.

Michael Karremann, Nadja Krämer, Marion Hoffmann, Maria Wiese, Andreas Beilken, Selim Corbacioglu, Dagmar Dilloo, Pablo Hernáiz Driever, Wolfram Scheurlen, Andreas Kulozik, Gerrit H Gielen, André O von Bueren, Matthias Dürken, Christof M Kramm,

<h4>Background</h4>Temozolomide (TMZ) is widely used in high-grade glioma (HGG). There is a major concern of treatment-induced secondary haematological malignancies (SHMs). Due to the poor overall survival of HGG patients, the true incidence is yet elusive. Thus, the aim of this study was to determine the risk of SHMs following TMZ ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2017, 81:1-8]

Cited: 2 times

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A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma - A final report.

Astrid K Gnekow, David A Walker, Daniela Kandels, Susan Picton, Giorgio Perilongo, Jacques Grill, Tore Stokland, Per Eric Sandstrom, Monika Warmuth-Metz, Torsten Pietsch, Felice Giangaspero, René Schmidt, Andreas Faldum, Denise Kilmartin, Angela De Paoli, Gian Luca De Salvo, ,

<h4>Background</h4>The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration of 12 months of treatment after resection.<h4>Methods</h4>Within the European comprehensive treatment strategy for childhood LGG, the International Society of Paediatric Oncology-Low ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2017, 81:206-225]

Cited: 25 times

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New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Dominik Sturm, Brent A Orr, Umut H Toprak, Volker Hovestadt, David T W Jones, David Capper, Martin Sill, Ivo Buchhalter, Paul A Northcott, Irina Leis, Marina Ryzhova, Christian Koelsche, Elke Pfaff, Sariah J Allen, Gnanaprakash Balasubramanian, Barbara C Worst, Kristian W Pajtler, Sebastian Brabetz, Pascal D Johann, Felix Sahm, Jüri Reimand, Alan Mackay, Diana M Carvalho, Marc Remke, Joanna J Phillips, Arie Perry, Cynthia Cowdrey, Rachid Drissi, Maryam Fouladi, Felice Giangaspero, Maria Łastowska, Wiesława Grajkowska, Wolfram Scheurlen, Torsten Pietsch, Christian Hagel, Johannes Gojo, Daniela Lötsch, Walter Berger, Irene Slavc, Christine Haberler, Anne Jouvet, Stefan Holm, Silvia Hofer, Marco Prinz, Catherine Keohane, Iris Fried, Christian Mawrin, David Scheie, Bret C Mobley, Matthew J Schniederjan, Mariarita Santi, Anna M Buccoliero, Sonika Dahiya, Christof M Kramm, André O von Bueren, Katja von Hoff, Stefan Rutkowski, Christel Herold-Mende, Michael C Frühwald, Till Milde, Martin Hasselblatt, Pieter Wesseling, Jochen Rößler, Ulrich Schüller, Martin Ebinger, Jens Schittenhelm, Stephan Frank, Rainer Grobholz, Istvan Vajtai, Volkmar Hans, Reinhard Schneppenheim, Karel Zitterbart, V Peter Collins, Eleonora Aronica, Pascale Varlet, Stephanie Puget, Christelle Dufour, Jacques Grill, Dominique Figarella-Branger, Marietta Wolter, Martin U Schuhmann, Tarek Shalaby, Michael Grotzer, Timothy van Meter, Camelia-Maria Monoranu, Jörg Felsberg, Guido Reifenberger, Matija Snuderl, Lynn Ann Forrester, Jan Koster, Rogier Versteeg, Richard Volckmann, Peter van Sluis, Stephan Wolf, Tom Mikkelsen, Amar Gajjar, Kenneth Aldape, Andrew S Moore, Michael D Taylor, Chris Jones, Nada Jabado, Matthias A Karajannis, Roland Eils, Matthias Schlesner, Peter Lichter, Andreas von Deimling, Stefan M Pfister, David W Ellison, Andrey Korshunov, Marcel Kool,

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor ... Read more >>

Cell (Cell)
[2016, 164(5):1060-1072]

Cited: 281 times

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Omission of doxorubicin from the treatment of stage II-III, intermediate-risk Wilms' tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial.

Kathy Pritchard-Jones, Christophe Bergeron, Beatriz de Camargo, Marry M van den Heuvel-Eibrink, Tomas Acha, Jan Godzinski, Foppe Oldenburger, Liliane Boccon-Gibod, Ivo Leuschner, Gordan Vujanic, Bengt Sandstedt, Jan de Kraker, Harm van Tinteren, Norbert Graf, ,

<h4>Background</h4>Before this study started, the standard postoperative chemotherapy regimen for stage II-III Wilms' tumour pretreated with chemotherapy was to include doxorubicin. However, avoidance of doxorubicin-related cardiotoxicity effects is important to improve long-term outcomes for childhood cancers that have excellent prognosis. We aimed to assess whether doxorubicin can be omitted safely ... Read more >>

Lancet (Lancet (London, England))
[2015, 386(9999):1156-1164]

Cited: 54 times

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Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

David T W Jones, Barbara Hutter, Natalie Jäger, Andrey Korshunov, Marcel Kool, Hans-Jörg Warnatz, Thomas Zichner, Sally R Lambert, Marina Ryzhova, Dong Anh Khuong Quang, Adam M Fontebasso, Adrian M Stütz, Sonja Hutter, Marc Zuckermann, Dominik Sturm, Jan Gronych, Bärbel Lasitschka, Sabine Schmidt, Huriye Seker-Cin, Hendrik Witt, Marc Sultan, Meryem Ralser, Paul A Northcott, Volker Hovestadt, Sebastian Bender, Elke Pfaff, Sebastian Stark, Damien Faury, Jeremy Schwartzentruber, Jacek Majewski, Ursula D Weber, Marc Zapatka, Benjamin Raeder, Matthias Schlesner, Catherine L Worth, Cynthia C Bartholomae, Christof von Kalle, Charles D Imbusch, Sylwester Radomski, Chris Lawerenz, Peter van Sluis, Jan Koster, Richard Volckmann, Rogier Versteeg, Hans Lehrach, Camelia Monoranu, Beate Winkler, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E Kulozik, Martin Ebinger, Martin U Schuhmann, Yoon-Jae Cho, Scott L Pomeroy, Andreas von Deimling, Olaf Witt, Michael D Taylor, Stephan Wolf, Matthias A Karajannis, Charles G Eberhart, Wolfram Scheurlen, Martin Hasselblatt, Keith L Ligon, Mark W Kieran, Jan O Korbel, Marie-Laure Yaspo, Benedikt Brors, Jörg Felsberg, Guido Reifenberger, V Peter Collins, Nada Jabado, Roland Eils, Peter Lichter, Stefan M Pfister, ,

Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with mitogen-activated protein kinase (MAPK) pathway alterations. Surgically inaccessible midline tumors are therapeutically challenging, showing sustained tendency for progression and often becoming a chronic disease with substantial morbidities. Here we describe whole-genome sequencing of 96 pilocytic astrocytomas, with matched ... Read more >>

Nat Genet (Nature genetics)
[2013, 45(8):927-932]

Cited: 357 times

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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Paul A Northcott, Catherine Lee, Thomas Zichner, Adrian M Stütz, Serap Erkek, Daisuke Kawauchi, David J H Shih, Volker Hovestadt, Marc Zapatka, Dominik Sturm, David T W Jones, Marcel Kool, Marc Remke, Florence M G Cavalli, Scott Zuyderduyn, Gary D Bader, Scott VandenBerg, Lourdes Adriana Esparza, Marina Ryzhova, Wei Wang, Andrea Wittmann, Sebastian Stark, Laura Sieber, Huriye Seker-Cin, Linda Linke, Fabian Kratochwil, Natalie Jäger, Ivo Buchhalter, Charles D Imbusch, Gideon Zipprich, Benjamin Raeder, Sabine Schmidt, Nicolle Diessl, Stephan Wolf, Stefan Wiemann, Benedikt Brors, Chris Lawerenz, Jürgen Eils, Hans-Jörg Warnatz, Thomas Risch, Marie-Laure Yaspo, Ursula D Weber, Cynthia C Bartholomae, Christof von Kalle, Eszter Turányi, Peter Hauser, Emma Sanden, Anna Darabi, Peter Siesjö, Jaroslav Sterba, Karel Zitterbart, David Sumerauer, Peter van Sluis, Rogier Versteeg, Richard Volckmann, Jan Koster, Martin U Schuhmann, Martin Ebinger, H Leighton Grimes, Giles W Robinson, Amar Gajjar, Martin Mynarek, Katja von Hoff, Stefan Rutkowski, Torsten Pietsch, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Andreas E Kulozik, Andreas von Deimling, Olaf Witt, Roland Eils, Richard J Gilbertson, Andrey Korshunov, Michael D Taylor, Peter Lichter, Jan O Korbel, Robert J Wechsler-Reya, Stefan M Pfister,

Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoral heterogeneity of medulloblastoma, identifying four distinct molecular subgroups. Group 3 and group 4 subgroup medulloblastomas account ... Read more >>

Nature (Nature)
[2014, 511(7510):428-434]

Cited: 245 times

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Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.

Volker Hovestadt, David T W Jones, Simone Picelli, Wei Wang, Marcel Kool, Paul A Northcott, Marc Sultan, Katharina Stachurski, Marina Ryzhova, Hans-Jörg Warnatz, Meryem Ralser, Sonja Brun, Jens Bunt, Natalie Jäger, Kortine Kleinheinz, Serap Erkek, Ursula D Weber, Cynthia C Bartholomae, Christof von Kalle, Chris Lawerenz, Jürgen Eils, Jan Koster, Rogier Versteeg, Till Milde, Olaf Witt, Sabine Schmidt, Stephan Wolf, Torsten Pietsch, Stefan Rutkowski, Wolfram Scheurlen, Michael D Taylor, Benedikt Brors, Jörg Felsberg, Guido Reifenberger, Arndt Borkhardt, Hans Lehrach, Robert J Wechsler-Reya, Roland Eils, Marie-Laure Yaspo, Pablo Landgraf, Andrey Korshunov, Marc Zapatka, Bernhard Radlwimmer, Stefan M Pfister, Peter Lichter,

Epigenetic alterations, that is, disruption of DNA methylation and chromatin architecture, are now acknowledged as a universal feature of tumorigenesis. Medulloblastoma, a clinically challenging, malignant childhood brain tumour, is no exception. Despite much progress from recent genomics studies, with recurrent changes identified in each of the four distinct tumour subgroups ... Read more >>

Nature (Nature)
[2014, 510(7506):537-541]

Cited: 211 times

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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Marcel Kool, David T W Jones, Natalie Jäger, Paul A Northcott, Trevor J Pugh, Volker Hovestadt, Rosario M Piro, L Adriana Esparza, Shirley L Markant, Marc Remke, Till Milde, Franck Bourdeaut, Marina Ryzhova, Dominik Sturm, Elke Pfaff, Sebastian Stark, Sonja Hutter, Huriye Seker-Cin, Pascal Johann, Sebastian Bender, Christin Schmidt, Tobias Rausch, David Shih, Jüri Reimand, Laura Sieber, Andrea Wittmann, Linda Linke, Hendrik Witt, Ursula D Weber, Marc Zapatka, Rainer König, Rameen Beroukhim, Guillaume Bergthold, Peter van Sluis, Richard Volckmann, Jan Koster, Rogier Versteeg, Sabine Schmidt, Stephan Wolf, Chris Lawerenz, Cynthia C Bartholomae, Christof von Kalle, Andreas Unterberg, Christel Herold-Mende, Silvia Hofer, Andreas E Kulozik, Andreas von Deimling, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Martin Hasselblatt, John R Crawford, Gerald A Grant, Nada Jabado, Arie Perry, Cynthia Cowdrey, Sydney Croul, Gelareh Zadeh, Jan O Korbel, Francois Doz, Olivier Delattre, Gary D Bader, Martin G McCabe, V Peter Collins, Mark W Kieran, Yoon-Jae Cho, Scott L Pomeroy, Olaf Witt, Benedikt Brors, Michael D Taylor, Ulrich Schüller, Andrey Korshunov, Roland Eils, Robert J Wechsler-Reya, Peter Lichter, Stefan M Pfister, ,

Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(s) of primary resistance and identify pathways cooperating with aberrant SHH signaling, we sequenced and profiled a large cohort of SHH-MBs (n = 133). SHH pathway mutations involved PTCH1 (across all age ... Read more >>

Cancer Cell (Cancer cell)
[2014, 25(3):393-405]

Cited: 322 times

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Treatment of the bone marrow failure in Fanconi anemia patients with danazol.

Kathrin Scheckenbach, Mary Morgan, Judith Filger-Brillinger, Matthias Sandmann, Bruce Strimling, Wolfram Scheurlen, Detlev Schindler, Ulrich Göbel, Helmut Hanenberg,

More than 90% of Fanconi anemia (FA) patients experience progressive bone marrow failure during life with a median onset at 8 years of age. As matched sibling donor transplantation as preferred treatment is not available for the majority of patients, several synthetic androgens have been used as short-term treatment options ... Read more >>

Blood Cells Mol Dis (Blood cells, molecules & diseases)
[2012, 48(2):128-131]

Cited: 23 times

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Dissecting the genomic complexity underlying medulloblastoma.

David T W Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J Pugh, Volker Hovestadt, Adrian M Stütz, Tobias Rausch, Hans-Jörg Warnatz, Marina Ryzhova, Sebastian Bender, Dominik Sturm, Sabrina Pleier, Huriye Cin, Elke Pfaff, Laura Sieber, Andrea Wittmann, Marc Remke, Hendrik Witt, Sonja Hutter, Theophilos Tzaridis, Joachim Weischenfeldt, Benjamin Raeder, Meryem Avci, Vyacheslav Amstislavskiy, Marc Zapatka, Ursula D Weber, Qi Wang, Bärbel Lasitschka, Cynthia C Bartholomae, Manfred Schmidt, Christof von Kalle, Volker Ast, Chris Lawerenz, Jürgen Eils, Rolf Kabbe, Vladimir Benes, Peter van Sluis, Jan Koster, Richard Volckmann, David Shih, Matthew J Betts, Robert B Russell, Robert B Russell, Simona Coco, Gian Paolo Tonini, Ulrich Schüller, Volkmar Hans, Norbert Graf, Yoo-Jin Kim, Camelia Monoranu, Wolfgang Roggendorf, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E Kulozik, Andreas von Deimling, Olaf Witt, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U Schuhmann, Michael C Frühwald, Martin Hasselblatt, Nada Jabado, Stefan Rutkowski, André O von Bueren, Dan Williamson, Steven C Clifford, Martin G McCabe, V Peter Collins, Stephan Wolf, Stefan Wiemann, Hans Lehrach, Benedikt Brors, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Paul A Northcott, Michael D Taylor, Matthew Meyerson, Scott L Pomeroy, Marie-Laure Yaspo, Jan O Korbel, Andrey Korshunov, Roland Eils, Stefan M Pfister, Peter Lichter,

Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children, and shows tremendous biological and clinical heterogeneity. Despite recent treatment advances, approximately 40% of children experience tumour recurrence, and 30% will die from their disease. Those who ... Read more >>

Nature (Nature)
[2012, 488(7409):100-105]

Cited: 491 times

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Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

Dominik Sturm, Hendrik Witt, Volker Hovestadt, Dong-Anh Khuong-Quang, David T W Jones, Carolin Konermann, Elke Pfaff, Martje Tönjes, Martin Sill, Sebastian Bender, Marcel Kool, Marc Zapatka, Natalia Becker, Manuela Zucknick, Thomas Hielscher, Xiao-Yang Liu, Adam M Fontebasso, Marina Ryzhova, Steffen Albrecht, Karine Jacob, Marietta Wolter, Martin Ebinger, Martin U Schuhmann, Timothy van Meter, Michael C Frühwald, Holger Hauch, Arnulf Pekrun, Bernhard Radlwimmer, Tim Niehues, Gregor von Komorowski, Matthias Dürken, Andreas E Kulozik, Jenny Madden, Andrew Donson, Nicholas K Foreman, Rachid Drissi, Maryam Fouladi, Wolfram Scheurlen, Andreas von Deimling, Camelia Monoranu, Wolfgang Roggendorf, Christel Herold-Mende, Andreas Unterberg, Christof M Kramm, Jörg Felsberg, Christian Hartmann, Benedikt Wiestler, Wolfgang Wick, Till Milde, Olaf Witt, Anders M Lindroth, Jeremy Schwartzentruber, Damien Faury, Adam Fleming, Magdalena Zakrzewska, Pawel P Liberski, Krzysztof Zakrzewski, Peter Hauser, Miklos Garami, Almos Klekner, Laszlo Bognar, Sorana Morrissy, Florence Cavalli, Michael D Taylor, Peter van Sluis, Jan Koster, Rogier Versteeg, Richard Volckmann, Tom Mikkelsen, Kenneth Aldape, Guido Reifenberger, V Peter Collins, Jacek Majewski, Andrey Korshunov, Peter Lichter, Christoph Plass, Nada Jabado, Stefan M Pfister,

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical amino acids (K27 and G34) of histone H3.3 in one-third of pediatric GBM. Here, we show that each H3F3A mutation defines an epigenetic subgroup of ... Read more >>

Cancer Cell (Cancer cell)
[2012, 22(4):425-437]

Cited: 895 times

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Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Paul A Northcott, David J H Shih, John Peacock, Livia Garzia, A Sorana Morrissy, Thomas Zichner, Adrian M Stütz, Andrey Korshunov, Jüri Reimand, Steven E Schumacher, Rameen Beroukhim, David W Ellison, Christian R Marshall, Anath C Lionel, Stephen Mack, Adrian Dubuc, Yuan Yao, Vijay Ramaswamy, Betty Luu, Adi Rolider, Florence M G Cavalli, Xin Wang, Marc Remke, Xiaochong Wu, Readman Y B Chiu, Andy Chu, Eric Chuah, Richard D Corbett, Gemma R Hoad, Shaun D Jackman, Yisu Li, Allan Lo, Karen L Mungall, Ka Ming Nip, Jenny Q Qian, Anthony G J Raymond, Nina T Thiessen, Richard J Varhol, Inanc Birol, Richard A Moore, Andrew J Mungall, Robert Holt, Daisuke Kawauchi, Martine F Roussel, Marcel Kool, David T W Jones, Hendrick Witt, Africa Fernandez-L, Anna M Kenney, Robert J Wechsler-Reya, Peter Dirks, Tzvi Aviv, Wieslawa A Grajkowska, Marta Perek-Polnik, Christine C Haberler, Olivier Delattre, Stéphanie S Reynaud, François F Doz, Sarah S Pernet-Fattet, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Wolfram Scheurlen, Charles G Eberhart, Michelle Fèvre-Montange, Anne Jouvet, Ian F Pollack, Xing Fan, Karin M Muraszko, G Yancey Gillespie, Concezio Di Rocco, Luca Massimi, Erna M C Michiels, Nanne K Kloosterhof, Pim J French, Johan M Kros, James M Olson, Richard G Ellenbogen, Karel Zitterbart, Leos Kren, Reid C Thompson, Michael K Cooper, Boleslaw Lach, Roger E McLendon, Darell D Bigner, Adam Fontebasso, Steffen Albrecht, Nada Jabado, Janet C Lindsey, Simon Bailey, Nalin Gupta, William A Weiss, László Bognár, Almos Klekner, Timothy E Van Meter, Toshihiro Kumabe, Teiji Tominaga, Samer K Elbabaa, Jeffrey R Leonard, Joshua B Rubin, Linda M Liau, Erwin G Van Meir, Maryam Fouladi, Hideo Nakamura, Giuseppe Cinalli, Miklós Garami, Peter Hauser, Ali G Saad, Achille Iolascon, Shin Jung, Carlos G Carlotti, Rajeev Vibhakar, Young Shin Ra, Shenandoah Robinson, Massimo Zollo, Claudia C Faria, Jennifer A Chan, Michael L Levy, Poul H B Sorensen, Matthew Meyerson, Scott L Pomeroy, Yoon-Jae Cho, Gary D Bader, Uri Tabori, Cynthia E Hawkins, Eric Bouffet, Stephen W Scherer, James T Rutka, David Malkin, Steven C Clifford, Steven J M Jones, Jan O Korbel, Stefan M Pfister, Marco A Marra, Michael D Taylor,

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. ... Read more >>

Nature (Nature)
[2012, 488(7409):49-56]

Cited: 435 times

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Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.

Andrey Korshunov, Marc Remke, Marcel Kool, Thomas Hielscher, Paul A Northcott, Dan Williamson, Elke Pfaff, Hendrik Witt, David T W Jones, Marina Ryzhova, Yoon-Jae Cho, Andrea Wittmann, Axel Benner, William A Weiss, Andreas von Deimling, Wolfram Scheurlen, Andreas E Kulozik, Steven C Clifford, V Peter Collins, Frank Westermann, Michael D Taylor, Peter Lichter, Stefan M Pfister,

Focal high-level amplifications of MYC (or MYCC) define a subset of high-risk medulloblastoma patients. However, the prognostic role of MYCN oncogene amplification remains unresolved. We aimed to evaluate the prognostic value of this alteration alone and in combination with biological modifiers in 67 pediatric medulloblastomas with MYCN amplification (MYCN-MB). Twenty-one ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2012, 123(4):515-527]

Cited: 42 times

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Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.

Tobias Rausch, David T W Jones, Marc Zapatka, Adrian M Stütz, Thomas Zichner, Joachim Weischenfeldt, Natalie Jäger, Marc Remke, David Shih, Paul A Northcott, Elke Pfaff, Jelena Tica, Qi Wang, Luca Massimi, Hendrik Witt, Sebastian Bender, Sabrina Pleier, Huriye Cin, Cynthia Hawkins, Christian Beck, Andreas von Deimling, Volkmar Hans, Benedikt Brors, Roland Eils, Wolfram Scheurlen, Jonathon Blake, Vladimir Benes, Andreas E Kulozik, Olaf Witt, Dianna Martin, Cindy Zhang, Rinnat Porat, Diana M Merino, Jonathan Wasserman, Nada Jabado, Adam Fontebasso, Lars Bullinger, Frank G Rücker, Konstanze Döhner, Hartmut Döhner, Jan Koster, Jan J Molenaar, Rogier Versteeg, Marcel Kool, Uri Tabori, David Malkin, Andrey Korshunov, Michael D Taylor, Peter Lichter, Stefan M Pfister, Jan O Korbel,

Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering ... Read more >>

Cell (Cell)
[2012, 148(1-2):59-71]

Cited: 439 times

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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.

Jeremy Schwartzentruber, Andrey Korshunov, Xiao-Yang Liu, David T W Jones, Elke Pfaff, Karine Jacob, Dominik Sturm, Adam M Fontebasso, Dong-Anh Khuong Quang, Martje Tönjes, Volker Hovestadt, Steffen Albrecht, Marcel Kool, Andre Nantel, Carolin Konermann, Anders Lindroth, Natalie Jäger, Tobias Rausch, Marina Ryzhova, Jan O Korbel, Thomas Hielscher, Peter Hauser, Miklos Garami, Almos Klekner, Laszlo Bognar, Martin Ebinger, Martin U Schuhmann, Wolfram Scheurlen, Arnulf Pekrun, Michael C Frühwald, Wolfgang Roggendorf, Christoph Kramm, Matthias Dürken, Jeffrey Atkinson, Pierre Lepage, Alexandre Montpetit, Magdalena Zakrzewska, Krzystof Zakrzewski, Pawel P Liberski, Zhifeng Dong, Peter Siegel, Andreas E Kulozik, Marc Zapatka, Abhijit Guha, David Malkin, Jörg Felsberg, Guido Reifenberger, Andreas von Deimling, Koichi Ichimura, V Peter Collins, Hendrik Witt, Till Milde, Olaf Witt, Cindy Zhang, Pedro Castelo-Branco, Peter Lichter, Damien Faury, Uri Tabori, Christoph Plass, Jacek Majewski, Stefan M Pfister, Nada Jabado,

Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult and paediatric cases. To explore the genetic events underlying this distinction, we sequenced the exomes of 48 paediatric GBM samples. Somatic mutations in the H3.3-ATRX-DAXX chromatin ... Read more >>

Nature (Nature)
[2012, 482(7384):226-231]

Cited: 1192 times

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Adult medulloblastoma comprises three major molecular variants.

Marc Remke, Thomas Hielscher, Paul A Northcott, Hendrik Witt, Marina Ryzhova, Andrea Wittmann, Axel Benner, Andreas von Deimling, Wolfram Scheurlen, Arie Perry, Sidney Croul, Andreas E Kulozik, Peter Lichter, Michael D Taylor, Stefan M Pfister, Andrey Korshunov,

<h4>Purpose</h4>Medulloblastoma is a rare primary brain tumor in adults, whereas it constitutes the most common malignant brain tumor in children. Integrated genomics approaches revealed at least four distinct disease variants in children. The aim of this study was to investigate molecular subtypes and their prognostic implication in a large cohort ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2011, 29(19):2717-2723]

Cited: 126 times

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Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma.

Jan Smida, Daniel Baumhoer, Michael Rosemann, Axel Walch, Stefan Bielack, Christopher Poremba, Klaus Remberger, Eberhard Korsching, Wolfram Scheurlen, Christian Dierkes, Stefan Burdach, Gernot Jundt, Michael J Atkinson, Michaela Nathrath,

<h4>Purpose</h4>Osteosarcoma, the most common primary malignant tumor of the bone, is characterized by complex karyotypes with numerous structural and numerical alterations. Despite attempts to establish molecular prognostic markers at the time of diagnosis, the most accepted predictive factor remains the histologic evaluation of necrosis after neoadjuvant chemotherapy. The present approach ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2010, 16(16):4256-4267]

Cited: 58 times

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Sorafenib and cisplatin/doxorubicin (PLADO) in pediatric hepatocellular carcinoma.

Irene Schmid, Beate Häberle, Michael H Albert, Selim Corbacioglu, Birgit Fröhlich, Norbert Graf, Birgit Kammer, Udo Kontny, Ivo Leuschner, Hans-Gerhard Scheel-Walter, Wolfram Scheurlen, Sebastian Werner, Thomas Wiesel, Dietrich von Schweinitz,

<h4>Purpose</h4>Overall survival is poor in children with primary unresectable hepatocellular carcinoma. Sorafenib has been shown to significantly improve progression-free survival in adult hepatocellular carcinoma (HCC) patients. We evaluated the experience of PLADO (cisplatin 80 mg/m(2) /day, doxorubicin 2 × 30 mg/m(2) /day) in combination with sorafenib in pediatric HCC patients.<h4>Patients and methods</h4>Clinical data of ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2012, 58(4):539-544]

Cited: 24 times

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FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma.

Marc Remke, Thomas Hielscher, Andrey Korshunov, Paul A Northcott, Sebastian Bender, Marcel Kool, Frank Westermann, Axel Benner, Huriye Cin, Marina Ryzhova, Dominik Sturm, Hendrik Witt, Daniel Haag, Grischa Toedt, Andrea Wittmann, Anna Schöttler, André O von Bueren, Andreas von Deimling, Stefan Rutkowski, Wolfram Scheurlen, Andreas E Kulozik, Michael D Taylor, Peter Lichter, Stefan M Pfister,

<h4>Purpose</h4>Integrated genomics approaches have revealed at least four distinct biologic variants of medulloblastoma: WNT (wingless), SHH (sonic hedgehog), group C, and group D. Because of the remarkable clinical heterogeneity of group D tumors and the dismal prognosis of group C patients, it is vital to identify molecular biomarkers that will ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2011, 29(29):3852-3861]

Cited: 100 times

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