Full Text Journal Articles by
Author Wolfgang Weidner


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The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics.

Francesco Lotti, Francesca Frizza, Giancarlo Balercia, Arcangelo Barbonetti, Hermann M Behre, Aldo E Calogero, Jann-Frederik Cremers, Felice Francavilla, Andrea M Isidori, Sabine Kliesch, Sandro La Vignera, Andrea Lenzi, Marios Marcou, Adrian Pilatz, Olev Poolamets, Margus Punab, Maria Fernanda Peraza Godoy, Osvaldo Rajmil, Gianmaria Salvio, Osama Shaeer, Wolfgang Weidner, Elisa Maseroli, Sarah Cipriani, Elisabetta Baldi, Selene Degl'Innocenti, Giovanna Danza, Anna Lucia Caldini, Alessandro Terreni, Luca Boni, Csilla Krausz, Mario Maggi,

<h4>Background</h4>Infertility affects 7%-12% of men, and its etiology is unknown in half of cases. To fill this gap, use of the male genital tract color-Doppler ultrasound (MGT-CDUS) has progressively expanded. However, MGT-CDUS still suffers from lack of standardization. Hence, the European Academy of Andrology (EAA) has promoted a multicenter study ... Read more >>

Andrology (Andrology)
[2020, 8(5):1005-1020]

Cited: 1 time

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Sperm recovery and ICSI outcomes in men with non-obstructive azoospermia: a systematic review and meta-analysis.

Giovanni Corona, Suks Minhas, Aleksander Giwercman, Carlo Bettocchi, Marij Dinkelman-Smit, Gert Dohle, Ferdinando Fusco, Ates Kadioglou, Sabine Kliesch, Zsolt Kopa, Csilla Krausz, Fiore Pelliccione, Alessandro Pizzocaro, Jens Rassweiler, Paolo Verze, Linda Vignozzi, Wolfgang Weidner, Mario Maggi, Nikolaos Sofikitis,

BACKGROUND:Factor affecting sperm retrieval rate (SRR) or pregnancy rates (PR) after testicular sperm extraction (TESE) in patients with non-obstructive azoospermia (NOA) have not been systematically evaluated. In addition, although micro-TESE (mTESE) has been advocated as the gold standard for sperm retrieval in men with NOA, its superiority over conventional TESE ... Read more >>

Hum Reprod Update (Human reproduction update)
[2019, 25(6):733-757]

Cited: 19 times

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High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval.

Adrian Pilatz, Jill Kilb, Huelya Kaplan, Daniela Fietz, Hamid Hossain, Christian G Schüttler, Thorsten Diemer, Martin Bergmann, Eugen Domann, Wolfgang Weidner, Florian Wagenlehner, Hans-Christian Schuppe,

Considering infection/inflammation to be an important risk factor in male infertility, the aim of this study was to make a comprehensive evaluation of the prevalence of urogenital tract infection/inflammation and its potential impact on sperm retrieval in azoospermic patients. In this prospective study, 71 patients with azoospermia were subjected to ... Read more >>

Andrologia (Andrologia)
[2019, 51(10):e13401]

Cited: 2 times

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Elevated seminal plasma estradiol and epigenetic inactivation of ESR1 and ESR2 is associated with CP/CPPS.

Nils Nesheim, Stuart Ellem, Temuujin Dansranjavin, Christina Hagenkötter, Elena Berg, Rupert Schambeck, Hans-Christian Schuppe, Adrian Pilatz, Gail Risbridger, Wolfgang Weidner, Florian Wagenlehner, Undraga Schagdarsurengin,

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is associated with urinary tract symptoms and hormonal imbalances amongst others. The heterogeneous clinical presentation, unexplored molecular background and lack of prostate biopsies complicate therapy. Here, using liquid biopsies, we performed a comprehensive translational study on men diagnosed with CP/CPPS type III (<i>n</i><b><i>=</i></b> 50; ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(28):19623-19639]

Cited: 1 time

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Low testosterone in ApoE/LDL receptor double-knockout mice is associated with rarefied testicular capillaries together with fewer and smaller Leydig cells.

Kai Steinfeld, Daniela Beyer, Christian Mühlfeld, Andrea Mietens, Gerrit Eichner, Bora Altinkilic, Marian Kampschulte, Qingkui Jiang, Gabriele A Krombach, Thomas Linn, Wolfgang Weidner, Ralf Middendorff,

The testis as a site for atherosclerotic changes has so far attracted little attention. We used the apolipoprotein E (ApoE)/low density lipoprotein (LDL) receptor deficient mouse model (KO) for atherosclerosis (20, 40, 60 and 87-week-old) to investigate whether Leydig cells or the capillary network are responsible for reduced serum testosterone ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):5424]

Cited: 4 times

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Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback.

Klaus Deckmann, Amir Rafiq, Christian Erdmann, Christian Illig, Melanie Durschnabel, Jürgen Wess, Wolfgang Weidner, Thomas Bschleipfer, Wolfgang Kummer,

We have recently identified a cholinergic chemosensory cell in the urethral epithelium, urethral brush cell (UBC), that, upon stimulation with bitter or bacterial substances, initiates a reflex detrusor activation. Here, we elucidated cholinergic mechanisms that modulate UBC responsiveness. We analyzed muscarinic acetylcholine receptor (M1-5 mAChR) expression by using RT-PCR in ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2018, 32(6):2903-2910]

Cited: 3 times

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The polymorphism L204F affects transport and membrane expression of the sodium-dependent organic anion transporter SOAT (SLC10A6).

Katharina Bakhaus, Daniela Fietz, Sabine Kliesch, Wolfgang Weidner, Martin Bergmann, Joachim Geyer,

Sodium-dependent organic anion transporter (SOAT) represents a membrane transporter specific for sulfated steroid hormones, which are supposed to participate in the regulation of reproductive processes. In man, SOAT shows predominant mRNA expression in the testis and here was localized to primary spermatocytes. SOAT mRNA expression is significantly downregulated in different ... Read more >>

J Steroid Biochem Mol Biol (The Journal of steroid biochemistry and molecular biology)
[2018, 179:36-44]

Cited: 2 times

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Expression of ciliated bronchial epithelium 1 during human spermatogenesis.

Christiane Pleuger, Daniela Fietz, Katja Hartmann, Hans-Christian Schuppe, Wolfgang Weidner, Sabine Kliesch, Mark Baker, Moira K O'Bryan, Martin Bergmann,

<h4>Objective</h4>To define the precise cellular localization of ciliated bronchial epithelium 1 (CBE1) in the human testis and test its relationship to impaired spermatogenesis.<h4>Design</h4>Gene expression analysis, and histologic and immunohistochemical evaluation.<h4>Setting</h4>University research laboratories and andrologic outpatient clinic.<h4>Patient(s)</h4>Forty-three human testicular biopsies: 12 biopsies showing normal spermatogenesis (NSP), 8 with maturation arrest at ... Read more >>

Fertil Steril (Fertility and sterility)
[2017, 108(1):47-54]

Cited: 2 times

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Urogenital Infection as a Risk Factor for Male Infertility.

Hans-Christian Schuppe, Adrian Pilatz, Hamid Hossain, Thorsten Diemer, Florian Wagenlehner, Wolfgang Weidner,

<h4>Background</h4>Infections of the genital tract are considered common causes of male fertility disorders, with a prevalence of 6-10%. Most of the affected men are asymptomatic. The diagnostic evaluation is based mainly on laboratory testing. Inconsistent diagnostic criteria have been applied to date, and this may explain the controversial debate about ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2017, 114(19):339-346]

Cited: 36 times

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Effect of Hospital and Surgeon Case Volume on Perioperative Quality of Care and Short-term Outcomes After Radical Cystectomy for Muscle-invasive Bladder Cancer: Results From a European Tertiary Care Center Cohort.

Malte W Vetterlein, Christian P Meyer, Sami-Ramzi Leyh-Bannurah, Roman Mayr, Michael Gierth, Hans-Martin Fritsche, Maximilian Burger, Bastian Keck, Bernd Wullich, Thomas Martini, Christian Bolenz, Armin Pycha, Julian Hanske, Florian Roghmann, Joachim Noldus, Patrick J Bastian, Christian Gilfrich, Matthias May, Michael Rink, Felix K-H Chun, Roland Dahlem, Margit Fisch, Atiqullah Aziz, ,

<h4>Background</h4>Case volume has been suggested to affect surgical outcomes in different arrays of procedures. We aimed to delineate the relationship between case volume and surgical outcomes and quality of care criteria of radical cystectomy (RC) in a prospectively collected multicenter cohort.<h4>Patients and methods</h4>This was a retrospective analysis of a prospectively ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2017, 15(5):e809-e817]

Cited: 6 times

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Prospective evaluation of scrotal ultrasound and intratesticular perfusion by color-coded duplex sonography (CCDS) in TESE patients with azoospermia.

Bora Altinkilic, Adrian Pilatz, Thorsten Diemer, Julia Wolf, Martin Bergmann, Sarah Schönbrunn, Uwe Ligges, Hans-Christian Schuppe, Wolfgang Weidner,

<h4>Purpose</h4>The objective of this study was to assess whether CCDS might improve the outcome of testicular sperm retrieval in patients with azoospermia. Furthermore, we evaluated potential sonographic alterations of the testis before and after trifocal and Micro-TESE.<h4>Methods</h4>78 patients were enrolled prospectively: 24 with obstructive azoospermia (OA) and 54 with non-obstructive ... Read more >>

World J Urol (World journal of urology)
[2018, 36(1):125-133]

Cited: 6 times

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Chronic Prostatitis Affects Male Reproductive Health and Is Associated with Systemic and Local Epigenetic Inactivation of C-X-C Motif Chemokine 12 Receptor C-X-C Chemokine Receptor Type 4.

Undraga Schagdarsurengin, Lisa M Teuchert, Christina Hagenkötter, Nils Nesheim, Temuujin Dansranjavin, Hans-Christian Schuppe, Sabrina Gies, Adrian Pilatz, Wolfgang Weidner, Florian M E Wagenlehner,

Background/Aims/Objectives: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has detrimental effects on the quality of life including the aspect of sexual dysfunction. The aim of the study was to identify if there was an adverse effect on the male genital compartment and if there are systemic or compartment-specific local signals for ... Read more >>

Urol Int (Urologia internationalis)
[2017, 98(1):89-101]

Cited: 2 times

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Expression of katanin p80 in human spermatogenesis.

Christiane Pleuger, Daniela Fietz, Katja Hartmann, Wolfgang Weidner, Sabine Kliesch, Moira K O'Bryan, Adriaan Dorresteijn, Martin Bergmann,

<h4>Objective</h4>To define the stage-by-stage expression of KATNB1 during human spermatogenesis.<h4>Design</h4>Gene expression analysis, histologic and immunohistochemical evaluation.<h4>Setting</h4>University research laboratories and andrological clinic.<h4>Patient(s)</h4>Eighty human testicular biopsy samples: 43 showing normal spermatogenesis, 9 with maturation arrest at level of spermatocytes, 8 with maturation arrest at level of spermatogonia, and 20 with a Sertoli ... Read more >>

Fertil Steril (Fertility and sterility)
[2016, 106(7):1683-1690.e1]

Cited: 10 times

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Highly Conserved Testicular Localization of Claudin-11 in Normal and Impaired Spermatogenesis.

Angelika Stammler, Benjamin Udo Lüftner, Sabine Kliesch, Wolfgang Weidner, Martin Bergmann, Ralf Middendorff, Lutz Konrad,

In this study we tested expression of tight junction proteins in human, mouse and rat and analyzed the localization of claudin-11 in testis of patients with normal and impaired spermatogenesis. Recent concepts generated in mice suggest that the stage-specifically expressed claudin-3 acts as a basal barrier, sealing the seminiferous epithelium ... Read more >>

PLoS One (PloS one)
[2016, 11(8):e0160349]

Cited: 13 times

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Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia.

Britta Klein, Thomas Haggeney, Daniela Fietz, Sivanjah Indumathy, Kate L Loveland, Mark Hedger, Sabine Kliesch, Wolfgang Weidner, Martin Bergmann, Hans-Christian Schuppe,

<h4>Study question</h4>Which immune cells and cytokine profiles are characteristic for testicular germ cell neoplasia and what consequences does this have for the understanding of the related testicular immunopathology?<h4>Summary answer</h4>The unique immune environment of testicular germ cell neoplasia comprises B cells and dendritic cells as well as high transcript levels of ... Read more >>

Hum Reprod (Human reproduction (Oxford, England))
[2016, 31(10):2192-2202]

Cited: 23 times

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Sexually Transmitted Disease and Male Infertility: A Systematic Review.

Mikkel Fode, Ferdinando Fusco, Larry Lipshultz, Wolfgang Weidner,

<h4>Context</h4>Theoretically, sexually transmitted diseases (STDs) have the potential to disrupt male fertility; however, the topic remains controversial.<h4>Objective</h4>To describe the possible association between STDs and male infertility and to explore possible pathophysiologic mechanisms.<h4>Evidence acquisition</h4>We performed a systematic literature review in accordance with the PRISMA guidelines. PubMed, Embase, and the Cochrane Library ... Read more >>

Eur Urol Focus (European urology focus)
[2016, 2(4):383-393]

Cited: 12 times

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Mapping the testicular interstitial fluid proteome from normal rats.

Peter G Stanton, Caroline F H Foo, Adam Rainczuk, Andrew N Stephens, Mark Condina, Liza O'Donnell, Wolfgang Weidner, Tomomoto Ishikawa, Lyndsey Cruickshanks, Lee B Smith, Robert I McLachlan,

Communication between the testicular somatic (Sertoli, Leydig, peritubular myoid, macrophage) and germ cell types is essential for sperm production (spermatogenesis), but the communicating factors are poorly understood. We reasoned that identification of proteins in the testicular interstitial fluid (TIF) that bathes these cells could provide a new means to explore ... Read more >>

Proteomics (Proteomics)
[2016, 16(17):2391-2402]

Cited: 4 times

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Complications After Systematic, Random, and Image-guided Prostate Biopsy.

Marco Borghesi, Hashim Ahmed, Robert Nam, Edward Schaeffer, Riccardo Schiavina, Samir Taneja, Wolfgang Weidner, Stacy Loeb,

<h4>Context</h4>Prostate biopsy (PB) represents the gold standard method to confirm the presence of cancer. In addition to traditional random or systematic approaches, a magnetic resonance imaging (MRI)-guided technique has been introduced recently.<h4>Objective</h4>To perform a systematic review of complications after transrectal ultrasound (TRUS)-guided, transperineal, and MRI-guided PB.<h4>Evidence acquisition</h4>We performed a systematic ... Read more >>

Eur Urol (European urology)
[2017, 71(3):353-365]

Cited: 94 times

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Flexible Vesiculovasoscopy Using a Microoptical System in a Human Cadaver Model: An Experimental Approach for Atraumatic Endoscopy of the Seminal Tract.

Daniel Schlager, Moritz Maas, Simon Hein, Fabian Adams, Martin Schoenthaler, Ulrich Wetterauer, Thorsten Diemer, Wolfgang Weidner, Arkadiusz Miernik,

<h4>Objectives</h4>The most common pathologies of the seminal tract are persistent hematospermia, seminal vesicle stones, and seminal duct obstruction. Endoscopic diagnostic work-up of the seminal tract is impeded by complex anatomy and lack of technical equipment. To date, there is no standardized endoscopic approach. The purpose of this study was to ... Read more >>

J Endourol (Journal of endourology)
[2016, 30(8):934-938]

Cited: 2 times

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TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility.

Kai Ni, Temuujin Dansranjavin, Nina Rogenhofer, Nihan Oeztuerk, Johanna Deuker, Martin Bergmann, Hans-Christian Schuppe, Florian Wagenlehner, Wolfgang Weidner, Klaus Steger, Undraga Schagdarsurengin,

<h4>Study question</h4>Are ten-eleven-translocation (TET) 1-3 family enzymes involved in human spermatogenesis and do they impact male fertility?<h4>Summary answer</h4>TET1, TET2 and TET3 are successively expressed at different stages of human spermatogenesis, and their expression levels associate with male fertility.<h4>What is known already</h4>Spermatogenesis is a complex cell differentiation process accompanied by a ... Read more >>

Hum Reprod (Human reproduction (Oxford, England))
[2016, 31(7):1411-1424]

Cited: 14 times

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Murine and Human Spermatids Are Characterized by Numerous, Newly Synthesized and Differentially Expressed Transcription Factors and Bromodomain-Containing Proteins.

Elisabeth Sabine Klaus, Nicola Helena Gonzalez, Martin Bergmann, Marek Bartkuhn, Wolfgang Weidner, Sabine Kliesch, Christina Rathke,

Much of spermatid differentiation takes place in the absence of active transcription, but in the early phase, large amounts of mRNA are synthesized, translationally repressed, and stored. Most nucleosomal histones are then degraded, and chromatin is repackaged by protamines. For both transcription and the histone-to-protamine transition in differentiating spermatids, chromatin ... Read more >>

Biol Reprod (Biology of reproduction)
[2016, 95(1):4]

Cited: 2 times

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Urosepsis: Overview of the Diagnostic and Treatment Challenges.

Florian M E Wagenlehner, Adrian Pilatz, Wolfgang Weidner, Kurt G Naber,

Urosepsis is defined as sepsis caused by an infection in the urogenital tract. In approximately 30% of all septic patients the infectious focus is localized in the urogenital tract, mainly due to obstructions at various levels, such as ureteral stones. Urosepsis may also occur after operations in the urogenital tract. ... Read more >>

Microbiol Spectr (Microbiology spectrum)
[2015, 3(5):]

Cited: 9 times

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Contemporary Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome.

Giuseppe Magistro, Florian M E Wagenlehner, Magnus Grabe, Wolfgang Weidner, Christian G Stief, J Curtis Nickel,

<h4>Context</h4>Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common condition that causes severe symptoms, bother, and quality-of-life impact in the 8.2% of men who are believed to be affected. Research suggests a complex pathophysiology underlying this syndrome that is mirrored by its heterogeneous clinical presentation. Management of patients diagnosed with ... Read more >>

Eur Urol (European urology)
[2016, 69(2):286-297]

Cited: 54 times

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Microsurgical Spermatic Cord Denervation as a Treatment for Chronic Scrotal Content Pain: A Multicenter Open Label Trial.

Marcelo Marconi, Cristian Palma, Pablo Troncoso, Arturo Dell Oro, Thorsten Diemer, Wolfgang Weidner,

<h4>Purpose</h4>We prospectively evaluated the results of microsurgical spermatic cord denervation in a series of patients with chronic scrotal content pain in a multicenter study, including 1 center in Germany and 3 centers in Chile.<h4>Materials and methods</h4>A total of 50 patients with chronic scrotal content pain more than 3 months in duration were prospectively ... Read more >>

J Urol (The Journal of urology)
[2015, 194(5):1323-1327]

Cited: 12 times

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Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta.

Atiqullah Aziz, Michael Gierth, Michael Rink, Marianne Schmid, Felix K Chun, Roland Dahlem, Florian Roghmann, Rein-Jüri Palisaar, Joachim Noldus, Jörg Ellinger, Stefan C Müller, Armin Pycha, Thomas Martini, Christian Bolenz, Rudolf Moritz, Edwin Herrmann, Bastian Keck, Bernd Wullich, Roman Mayr, Hans-Martin Fritsche, Maximilian Burger, Patrick J Bastian, Christian Seitz, Sabine Brookman-May, Evanguelos Xylinas, Shahrokh F Shariat, Margit Fisch, Matthias May, ,

<h4>Unlabelled</h4>Radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB) is associated with heterogeneous functional and oncological outcomes. The aim of this study was to generate trifecta and pentafecta criteria to optimize outcome reporting after RC.<h4>Methods</h4>We interviewed 50 experts to consider a virtual group of patients (age ≤ 75 years, ... Read more >>

World J Urol (World journal of urology)
[2015, 33(12):1945-1950]

Cited: 4 times

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