Full Text Journal Articles by
Author Wojciech Szczeklik

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Myocardial injury after noncardiac surgery - an update.

Wojciech Szczeklik, Jakub Fronczek,

<h4>Purpose of review</h4>After successfully reducing mortality in the operating room, the time has come for anesthesiologists to conquer postoperative complications. This review aims to raise awareness about myocardial injury after noncardiac surgery (MINS), its definition, diagnosis, clinical importance, and treatment.<h4>Recent findings</h4>MINS, defined as an elevated postoperative troponin judged to be ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):381-386]

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The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study.

Christian Jung, Hans Flaatten, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan W De Lange, Bertrand Guidet, ,

<h4>Background</h4>The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):149]

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New-onset atrial fibrillation in the intensive care unit: Protocol for an international inception cohort study (AFIB-ICU).

Mik Wetterslev, Morten Hylander Møller, Anders Granholm, Nicolai Haase, Christian Hassager, Theis Lange, Johanna Hästbacka, Erika Wilkman, Sheila Nainan Myatra, Jiawei Shen, Youzhong An, Martin Siegemund, Paul J Young, Tayyba N Aslam, Wojciech Szczeklik, Anders Aneman, Yaseen M Arabi, Maria Cronhjort, Frederik Keus, Anders Perner,

<h4>Introduction</h4>New-onset atrial fibrillation (NOAF) is frequently observed in critically ill patients and may be associated with prolonged hospital stay and increased mortality. Considerable variation exists in the reported frequencies of NOAF due to the lack of a standardised definition and detection method. Importantly, there are limited data on NOAF in ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, :]

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Perioperative lung ultrasound pattern changes in patients undergoing gynecological procedures - a prospective observational study.

Pawel Krawczyk, Agnieszka Jastrzebska, Wojciech Szczeklik, Janusz Andres,

<h4>Objectives</h4>General anesthesia and positive pressure ventilation are associated with perioperative pulmonary complications. Lung ultrasound (LUS) is a method used to evaluate lung parenchyma. The purpose of this study was to evaluate LUS patterns in a cohort of women undergoing gynecological surgery with uncomplicated general anesthesia.<h4>Material and methods</h4>Patients were assessed according ... Read more >>

Ginekol Pol (Ginekologia polska)
[2021, :]

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Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs.

Lenneke E M Haas, Ariane Boumendil, Hans Flaatten, Bertrand Guidet, Mercedes Ibarz, Christian Jung, Rui Moreno, Alessandro Morandi, Finn H Andersen, Tilemachos Zafeiridis, Sten Walther, Sandra Oeyen, Susannah Leaver, Ximena Watson, Carole Boulanger, Wojciech Szczeklik, Joerg C Schefold, Maurizio Cecconi, Brian Marsh, Michael Joannidis, Yuriy Nalapko, Muhammed Elhadi, Jesper Fjølner, Antonio Artigas, Dylan W de Lange, ,

<h4>Background</h4>Sepsis is one of the most frequent reasons for acute intensive care unit (ICU) admission of very old patients and mortality rates are high. However, the impact of pre-existing physical and cognitive function on long-term outcome of ICU patients ≥ 80 years old (very old intensive care patients (VIPs)) with sepsis is unclear.<h4>Objective</h4>To ... Read more >>

Age Ageing (Age and ageing)
[2021, :]

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Predicting myocardial injury and other cardiac complications after elective noncardiac surgery with the Revised Cardiac Risk Index: the VISION study.

Pavel S Roshanov, Daniel I Sessler, Clara K Chow, Amit X Garg, Michael W Walsh, Ngan N Lam, Ainslie M Hildebrand, Bruce M Biccard, Rey R Acedillo, S Danielle MacNeil, Vincent W Lee, Wojciech Szczeklik, Marko Mrkobrada, Lehana Thabane, P J Devereaux,

<h4>Background</h4>The Revised Cardiac Risk Index (RCRI) is widely used to estimate risk of cardiac complications after noncardiac surgery; its estimates do not capture myocardial injury after noncardiac surgery (MINS). We evaluated the incidence of cardiac complications including MINS across RCRI risk classes and the RCRI's ability to discriminate, before surgery, ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2021, :]

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Differences in Mortality in Critically Ill Elderly Patients During the Second COVID-19 Surge in Europe

Christian Jung, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Finn Andersen, Rui Moreno, Susannah Leaver, Ariane Boumendil, Dylan De Lange, Bertrand Guidet, Hans Flaatten, COVIP Study Group,

Purpose: The primary aim of this study was to assess the outcome of elderly ICU patients treated during the spring and autumn COVID-19 surges in Europe. Methods: A prospective European observation study (The COVIP study) in ICU patients aged 70 years and older admitted with COVID-19 disease from March to ... Read more >>

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The Impact of Frailty on Survival in Elderly Intensive Care Patients with COVID-19 – the COVIP Study

Christian Jung, Hans Flaatten, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan De Lange, Bertrand Guidet,

<h4>Background: </h4> The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the ... Read more >>

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Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Waleed Alhazzani, Laura Evans, Fayez Alshamsi, Morten Hylander Møller, Marlies Ostermann, Hallie C Prescott, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Flavia Machado, Hannah Wunsch, Mark Crowther, Maurizio Cecconi, Younsuck Koh, Lisa Burry, Daniel S Chertow, Wojciech Szczeklik, Emilie Belley-Cote, Massimiliano Greco, Malgorzata Bala, Ryan Zarychanski, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Sheila Nainan Myatra, Amy Arrington, Ruth Kleinpell, Giuseppe Citerio, Kimberley Lewis, Elizabeth Bridges, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Muhammed Alshahrani, Zainab Al Duhailib, Greg S Martin, Lewis J Kaplan, Craig M Coopersmith, Massimo Antonelli, Andrew Rhodes,

<h4>Background</h4>The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients with severe or critical coronavirus disease 2019 in the ICU.<h4>Methods</h4>The Surviving Sepsis Campaign Coronavirus Disease 2019 panel has expanded to ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e219-e234]

Cited: 3 times

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Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study.

Hans Flaatten, Bertrand Guidet, Finn H Andersen, Antonio Artigas, Maurizio Cecconi, Ariane Boumendil, Muhammed Elhadi, Jesper Fjølner, Michael Joannidis, Christian Jung, Susannah Leaver, Brian Marsh, Rui Moreno, Sandra Oeyen, Yuriy Nalapko, Joerg C Schefold, Wojciech Szczeklik, Sten Walther, Ximena Watson, Tilemachos Zafeiridis, Dylan W de Lange, ,

<h4>Purpose</h4>Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments developed to assess frailty, but few of them can be used in emergency situations. In this setting ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):22]

Cited: 2 times

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Preoperative levels of natriuretic peptides and the incidence of postoperative atrial fibrillation after noncardiac surgery: a prospective cohort study.

Wojciech Szczeklik, Yannick LeManach, Jakub Fronczek, Kamil Polok, David Conen, Finlay A McAlister, Sadeesh Srinathan, Pablo Alonso-Coello, Bruce Biccard, Emmanuelle Duceppe, Diane Heels-Ansdell, Jacek Górka, Shirley Pettit, Pavel S Roshanov, P J Devereaux,

<h4>Background</h4>Postoperative atrial fibrillation (POAF) is associated with clinically significant short- and long-term complications after noncardiac surgery. Our aim was to describe the incidence of clinically important POAF after noncardiac surgery and establish the prognostic value of N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in this context.<h4>Methods</h4>The Vascular events In noncardiac Surgery patIents ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(49):E1715-E1722]

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Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis.

Bernhard Wernly, Raphael Romano Bruno, Malte Kelm, Ariane Boumendil, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Stefano Finazzi, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Michael Lichtenauer, Johanna M Muessig, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agvald Öhman, Bernado Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, David Niederseer, Andreas Valentin, Ximena Watson, Susannah Leaver, Carole Boulanger, Sten Walther, Joerg C Schefold, Michael Joannidis, Yuriy Nalapko, Muhammed Elhadi, Jesper Fjølner, Tilemachos Zafeiridis, Dylan W De Lange, Bertrand Guidet, Hans Flaatten, Christian Jung, ,

Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and predictors of mortality. In total, 7555 patients were included in this analysis, 3973 (53%) male and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18671]

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On predictions in critical care: The individual prognostication fallacy in elderly patients.

Michael Beil, Sigal Sviri, Hans Flaatten, Dylan W De Lange, Christian Jung, Wojciech Szczeklik, Susannah Leaver, Andrew Rhodes, Bertrand Guidet, P Vernon van Heerden,

Predicting the future course of critical conditions involves personal experience, heuristics and statistical models. Although these methods may perform well for some cases and population averages, they suffer from substantial shortcomings when applied to individual patients. The reasons include methodological problems of statistical modeling as well as limitations of cross-sectional ... Read more >>

J Crit Care (Journal of critical care)
[2021, 61:34-38]

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Anti-cytokine targeted therapies for ANCA-associated vasculitis.

Malgorzata M Bala, Teresa J Malecka-Massalska, Magdalena Koperny, Joanna F Zajac, Jarosław D Jarczewski, Wojciech Szczeklik,

<h4>Background</h4>Anti-neutrophilic cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) are a group of rare auto-inflammatory diseases that affects mainly small vessels. AAV includes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Anti-cytokine targeted therapy uses biological agents capable of specifically targeting and neutralising cytokine mediators of the inflammatory ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 9:CD008333]

Cited: 1 time

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The wave of very old people in the intensive care unit-A challenge in decision-making.

Peter Vernon van Heerden, Sigal Sviri, Michael Beil, Wojciech Szczeklik, Dylan de Lange, Christian Jung, Bertrand Guidet, Susannah Leaver, Andrew Rhodes, Ariane Boumendil, Hans Flaatten,

In this paper the authors express the opinion that there is much to be learned about the 80+ year old age group as it relates to critical care and end-of-life matters. We need to learn how to better predict outcome, we need to learn our limitations and deal with uncertainties, ... Read more >>

J Crit Care (Journal of critical care)
[2020, 60:290-293]

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Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS): an international prospective cohort study establishing diagnostic criteria and prognostic importance.

Pavel S Roshanov, John W Eikelboom, Daniel I Sessler, Clive Kearon, Gordon H Guyatt, Mark Crowther, Vikas Tandon, Flavia Kessler Borges, Andre Lamy, Richard Whitlock, Bruce M Biccard, Wojciech Szczeklik, Mohamed Panju, Jessica Spence, Amit X Garg, Michael McGillion, Tomas VanHelder, Peter A Kavsak, Justin de Beer, Mitchell Winemaker, Yannick Le Manach, Tej Sheth, Jehonathan H Pinthus, Deborah Siegal, Lehana Thabane, Marko R I Simunovic, Ryszard Mizera, Sebastian Ribas, Philip J Devereaux,

<h4>Background</h4>We aimed to establish diagnostic criteria for bleeding independently associated with mortality after noncardiac surgery (BIMS) defined as bleeding during or within 30 days after noncardiac surgery that is independently associated with mortality within 30 days of surgery, and to estimate the proportion of 30-day postoperative mortality potentially attributable to ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(1):163-171]

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Perioperative Lung Ultrasound Pattern Changes: A Prospective Observational Study

Paweł Krawczyk, Agnieszka Jastrzębska, Wojciech Szczeklik, Janusz Andres,

<h4>Background: </h4> General anesthesia and positive pressure ventilation are associated with perioperative pulmonary complications. Lung ultrasound (LUS) is a method used to evaluate lung parenchyma. The purpose of this study was to evaluate LUS patterns in a cohort of women undergoing gynecological surgery with uncomplicated general anesthesia. Methods Patients ... Read more >>

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Preoperative prediction of Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS): an international prospective cohort study.

Pavel S Roshanov, Gordon H Guyatt, Vikas Tandon, Flavia K Borges, Andre Lamy, Richard Whitlock, Bruce M Biccard, Wojciech Szczeklik, Mohamed Panju, Jessica Spence, Amit X Garg, Michael McGillion, John W Eikelboom, Daniel I Sessler, Clive Kearon, Mark Crowther, Tomas VanHelder, Peter A Kavsak, Justin de Beer, Mitchell Winemaker, Yannick Le Manach, Tej Sheth, Jehonathan H Pinthus, Deborah Siegal, Lehana Thabane, Marko R I Simunovic, Ryszard Mizera, Sebastian Ribas, Philip J Devereaux,

<h4>Background</h4>Diagnostic criteria for Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS) have been defined as bleeding that leads to a postoperative haemoglobin <70 g L<sup>-1</sup>, leads to blood transfusion, or is judged to be the direct cause of death. Preoperative prediction guides for BIMS can facilitate informed consent and ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(1):172-180]

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Perioperative cardiovascular complications rate and activity of coagulation and fibrinolysis among patients undergoing vascular surgery for peripheral artery disease and abdominal aortic aneurysm.

Kamil Polok, Jacek Górka, Jakub Fronczek, Teresa Iwaniec, Karolina Górka, Wojciech Szczeklik,

<h4>Objectives</h4>To compare preoperative coagulation and fibrinolysis activity and incidence of perioperative complications between patients undergoing vascular procedures for peripheral artery disease and abdominal aortic aneurysm.<h4>Methods</h4>This is a substudy of a prospective observational cohort study (VISION; NCT00512109) in which we recruited patients aged ≥45 years, undergoing surgery for peripheral artery disease and ... Read more >>

Vascular (Vascular)
[2021, 29(1):134-142]

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Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.

Bakhtawar K Mahmoodi, Vinicius Tragante, Marcus E Kleber, Michael V Holmes, Amand F Schmidt, Raymond O McCubrey, Laurence J Howe, Kenan Direk, Hooman Allayee, Ekaterina V Baranova, Peter S Braund, Graciela E Delgado, Niclas Eriksson, Crystel M Gijsberts, Yan Gong, Jaana Hartiala, Mahyar Heydarpour, Gerard Pasterkamp, Salma Kotti, Pekka Kuukasjärvi, Petra A Lenzini, Daniel Levin, Leo-Pekka Lyytikäinen, Jochen D Muehlschlegel, Christopher P Nelson, Kjell Nikus, Anna P Pilbrow, W H Wilson Tang, Sander W van der Laan, Jessica van Setten, Ragnar O Vilmundarson, John Deanfield, Panos Deloukas, Frank Dudbridge, Stefan James, Ify R Mordi, Andrej Teren, Thomas O Bergmeijer, Simon C Body, Michiel Bots, Ralph Burkhardt, Rhonda M Cooper-DeHoff, Sharon Cresci, Nicolas Danchin, Robert N Doughty, Diederick E Grobbee, Emil Hagström, Stanley L Hazen, Claes Held, Imo E Hoefer, G Kees Hovingh, Julie A Johnson, Marcin P Kaczor, Mika Kähönen, Olaf H Klungel, Jari O Laurikka, Terho Lehtimäki, Anke H Maitland-van der Zee, Ruth McPherson, Colin N Palmer, Adriaan O Kraaijeveld, Carl J Pepine, Marek Sanak, Naveed Sattar, Markus Scholz, Tabassome Simon, John A Spertus, Alexandre F R Stewart, Wojciech Szczeklik, Joachim Thiery, Frank L J Visseren, Johannes Waltenberger, A Mark Richards, Chim C Lang, Vicky A Cameron, Axel Åkerblom, Guillaume Pare, Winfried März, Nilesh J Samani, Aroon D Hingorani, Jurriën M Ten Berg, Lars Wallentin, Folkert W Asselbergs, Riyaz S Patel,

<h4>Background</h4>Studies examining the role of factor V Leiden among patients at higher risk of atherothrombotic events, such as those with established coronary heart disease (CHD), are lacking. Given that coagulation is involved in the thrombus formation stage on atherosclerotic plaque rupture, we hypothesized that factor V Leiden may be a ... Read more >>

Circulation (Circulation)
[2020, 142(6):546-555]

Cited: 1 time

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Remdesivir use in patients with coronavirus COVID-19 disease: a systematic review and meta-analysis of the Chinese Lancet trial with the NIH trial

Paul Elias Alexander, Joshua Piticaru, Kimberley Lewis, Komal Aryal, Priya Thomas, Wojciech Szczeklik, Jakub Fronczek, Kamil Polok, Waleed Alhazzani, Manoj Mammen,

<h4>Background</h4> Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus SARS-CoV-2, has led to significant global mortality and morbidity. Until now, no treatment has proven to be effective in COVID-19. To explore whether the use of remdesivir, initially an experimental broad-spectrum antiviral, is effective in the treatment of hospitalized patients ... Read more >>

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Time from admission to surgery in Polish patients with hip fractures: temporal trends in the last decade and association with duration of hospitalization and in-hospital mortality.

Kamil Polok, Zbigniew Pilecki, Halina Kutaj-Wąsikowska, Barbara Kutryba, Rosa Sunol, Grzegorz Pilecki, Jacek Górka, Jakub Fronczek, Wojciech Szczeklik,

<h4>Introduction</h4>Hip fracture is an important cause of morbidity and mortality among elderly patients worldwide. It poses a particular challenge for healthcare systems with limited financial and human resources.<h4>Objectives</h4>The aim of the study was to assess factors associated with the length of hospital stay and in‑hospital mortality, focusing on the time ... Read more >>

Pol Arch Intern Med (Polish archives of internal medicine)
[2020, 130(6):506-511]

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Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study.

Mercedes Ibarz, Ariane Boumendil, Lenneke E M Haas, Marian Irazabal, Hans Flaatten, Dylan W de Lange, Alessandro Morandi, Finn H Andersen, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zaferidis, Bertrand Guidet, Antonio Artigas, ,

BACKGROUND:The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determine ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):56]

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Myocardial injury after non-cardiac surgery: diagnosis and management.

P J Devereaux, Wojciech Szczeklik,

Myocardial injury after non-cardiac surgery (MINS) is due to myocardial ischaemia (i.e. supply-demand mismatch or thrombus) and is associated with an increased risk of mortality and major vascular complications at 30 days and up to 2 years after non-cardiac surgery. The diagnostic criteria for MINS includes an elevated post-operative troponin measurement ... Read more >>

Eur Heart J (European heart journal)
[2020, 41(32):3083-3091]

Cited: 7 times

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Changes in neoadjuvant chemotherapy utilization in muscle invasive bladder cancer treatment: a tertiary center retrospective study.

Katarzyna Gronostaj, Anna Katarzyna Czech, Jakub Fronczek, Tomasz Wiatr, Mikołaj Przydacz, Przemysław Dudek, Łukasz Curyło, Wojciech Szczeklik, Piotr Chłosta,

Introduction:The year 2015 brought a major shift in the national health care system in Poland - the diagnosis and treatment of patients with malignant diseases became a priority. Close multidisciplinary collaboration was facilitated to optimize patients' care. The aim of this study was to investigate temporal changes in neoadjuvant chemotherapy ... Read more >>

Cent European J Urol (Central European journal of urology)
[2020, 73(1):13-18]

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