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Author William S Harmsen

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Editorial: understanding IBS pathophysiology through "converging channels" of research-authors' reply.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1215-1216]

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Phase II evaluation of Stereotactic Ablative Radiotherapy (SABR) and immunity in 11C-Choline-PET/CT-identified oligometastatic castration-resistant prostate cancer.

Henan Zhang, Jacob J Orme, Feven Abraha, B J Stish, Val J Lowe, Fabrice Lucien, Erik J Tryggestad, Michael S Bold, Lance C Pagliaro, C Richard Choo, Debra H Brinkmann, Matthew J Iott, Brian J Davis, J Fernando Quevedo, William S Harmsen, Brian A Costello, Geoffrey B Johnson, Mark A Nathan, Kenneth R Olivier, Thomas M Pisansky, Eugene D Kwon, Haidong Dong, Sean S Park,

<h4>Purpose</h4>Outcomes for resistant metastatic castration-resistant prostate cancer (CRPC) are poor. Stereotactic ablative radiotherapy (SABR) induces anti-tumor immunity in clinical and preclinical studies, but immunological biomarkers are lacking.<h4>Experimental design</h4>89 patients with oligometastatic CRPC were identified by <sup>11</sup>C-Choline-PET (Choline-PET) from August 2016-December 2019 and treated with SABR. Pre-specified co-primary endpoints were 2-year ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, :]

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Changes in National Google Trends and Local Healthcare Utilization After High-Impact Gastroenterology Publications.

Amrit K Kamboj, Siddharth Agarwal, Victor G Chedid, Prasad G Iyer, Kent R Bailey, William S Harmsen, David A Katzka,

<h4>Introduction</h4>We examined national Google Trends and local healthcare utilization after 3 high-impact gastroenterology publications.<h4>Methods</h4>Changes in US Google Trends and Olmsted County health utilization were studied.<h4>Results</h4>Publication views within 30 days were 51,458 (Imperiale), 49,759 (Pimentel), and 18,750 (Gomm). Colonoscopy searches (P = 0.04) and Cologuard tests performed (P < 0.01) increased ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, :]

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Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

<h4>Background</h4>Irritable bowel syndrome (IBS) patients often experience meal-associated symptoms. However, the underlying mechanisms are unclear.<h4>Aim</h4>To determine small intestinal mechanisms of lipid-induced symptoms and rectal hypersensitivity in IBS METHODS: We recruited 26 IBS patients (12 IBS-C, 14 IBS-D) and 15 healthy volunteers (HV). In vivo permeability was assessed using saccharide excretion ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1179-1192]

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Development and validation of a prediction score for safe outpatient colorectal resections.

Fabian Grass, Martin Hübner, Kevin T Behm, Kellie L Mathis, Dieter Hahnloser, Courtney N Day, William S Harmsen, Nicolas Demartines, David W Larson,

<h4>Background</h4>Avoiding unnecessary inpatient stay may decrease hospital-acquired complications and costs while increasing patient satisfaction. This study aimed to develop and validate a score to identify patients eligible for safe same-day discharge after colorectal resections.<h4>Methods</h4>This bi-institutional retrospective cohort study included consecutive patients undergoing elective colon and rectal resections (2011-2018) for benign ... Read more >>

Surgery (Surgery)
[2021, :]

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Perianal magnetic resonance imaging findings and their potential impact on outcome in children with perianal fistulizing Crohn disease.

Muhammad Rehan Khan, Jessica A Ulrich, Nathan C Hull, Akitoshi Inoue, William S Harmsen, William A Faubion, Joel G Fletcher, Imad Absah,

<h4>Background</h4>Children with perianal fistulizing Crohn disease require intensive medical management but also have a higher risk for subsequent surgical interventions.<h4>Objective</h4>We performed a retrospective study to identify patient factors and perianal anatomical features by pelvic MR that are associated with surgical interventions in these children.<h4>Materials and methods</h4>We included children with Crohn ... Read more >>

Pediatr Radiol (Pediatric radiology)
[2021, :]

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A Population-Based Study of the Incidence and Natural History of Degenerative Thoracic Aortic Aneurysms.

Ying Huang, Hartzell V Schaff, Joseph A Dearani, Gustavo S Oderich, Thomas C Bower, Manju Kalra, Kevin L Greason, Alberto Pochettino, Jason K Viehman, William S Harmsen, Peter Gloviczki, Randall R DeMartino,

<h4>Objective</h4>To investigate the incidence and natural history of degenerative thoracic aortic aneurysms (TAAs) and compare results between ascending (aTAAs) and descending TAAs (dTAAs).<h4>Patients and methods</h4>This population-based cohort study used the Rochester Epidemiology Project database from January 1, 1995, through December 31, 2015. Patients were classified as the aTAA or dTAA ... Read more >>

Mayo Clin Proc (Mayo Clinic proceedings)
[2021, 96(10):2628-2638]

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Determining age and sex-specific distribution of pancreatic whole-gland CT attenuation using artificial intelligence aided image segmentation: Associations with body composition and pancreatic cancer risk.

Laurens P Janssens, Alexander D Weston, Dhruv Singh, Grant Spears, William S Harmsen, Naoki Takahashi, Kenneth A Philbrick, Bradley J Erickson, Barham K Abu Dayyeh, Suresh T Chari, Vinay Chandrasekhara, Ferga C Gleeson, Michael J Levy, Randall K Pearson, Bret T Petersen, Santhi Swaroop Vege, Shounak Majumder,

<h4>Background & aims</h4>Increased intrapancreatic fat is associated with pancreatic diseases; however, there are no established objective diagnostic criteria for fatty pancreas. On non-contrast computed tomography (CT), adipose tissue shows negative Hounsfield Unit (HU) attenuations (-150 to -30 HU). Using whole organ segmentation on non-contrast CT, we aimed to describe whole gland ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2021, :]

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The Outcomes of Laparoscopic Biliopancreatic Diversion with Duodenal Switch on Gastro-esophageal Reflux Disease: the Mayo Clinic Experience.

Joseph N Badaoui, Todd A Kellogg, Barham K Abu Dayyeh, Justin W Maroun, Travis J McKenzie, William S Harmsen, Michael L Kendrick, Omar M Ghanem,

<h4>Purpose</h4>The outcomes of laparoscopic biliopancreatic diversion with duodenal switch (BPD-DS) on gastro-esophageal reflux disease (GERD) are not well elucidated.<h4>Material/methods</h4>This retrospective review included patients undergoing laparoscopic primary BPD-DS at Mayo Clinic from 2009 to 2019. GERD parameters analyzed included subjective symptom report/anti-reflux medication intake and/or endoscopic findings. GERD-HRQL questionnaire was also ... Read more >>

Obes Surg (Obesity surgery)
[2021, 31(10):4363-4370]

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The Epidemiology of Microscopic Colitis in Olmsted County, Minnesota: Population-Based Study From 2011 to 2019.

June Tome, Kanika Sehgal, Amrit K Kamboj, William S Harmsen, Patricia P Kammer, Edward V Loftus, William J Tremaine, Sahil Khanna, Darrell S Pardi,

<h4>Background & aims</h4>Epidemiologic studies from Europe and North America have reported an increasing incidence of microscopic colitis (MC) in the late 20th century, followed by a plateau. This population-based study assessed recent incidence trends and the overall prevalence of MC over the past decade.<h4>Methods</h4>Residents of Olmsted County, MN, diagnosed with ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

Cited: 1 time

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Autologous blood patch pleurodesis for prolonged postoperative air leaks.

Irsa S Hasan, Mark S Allen, Stephen D Cassivi, William S Harmsen, Nandita Mahajan, Francis C Nichols, Janani Reisenauer, Robert K Shen, Dennis A Wigle, Shanda H Blackmon,

<h4>Background</h4>A prolonged air leak (PAL) is the most frequent complication after pulmonary resection. This study aimed to assess the safety and efficacy of autologous blood patch pleurodesis (ABPP) to treat PAL.<h4>Methods</h4>A prospectively maintained database identified patients with a PAL after pulmonary resection for lung cancer between 2015-2019. In this observational ... Read more >>

J Thorac Dis (Journal of thoracic disease)
[2021, 13(6):3347-3358]

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The prognostic value, sensitivity, and specificity of multiparametric magnetic resonance imaging before salvage radiotherapy for prostate cancer.

William G Breen, Bradley J Stish, William S Harmsen, Adam T Froemming, Lance A Mynderse, C Richard Choo, Brian J Davis, Thomas M Pisansky,

<h4>Aim</h4>To determine the operational characteristics of pelvic magnetic resonance imaging (MRI) prior to salvage radiation therapy (SRT) for biochemically recurrent prostate cancer following radical prostatectomy.<h4>Methods and materials</h4>We reviewed the medical records of 386 patients who underwent MRI prior to SRT. We assessed associations of pre-SRT MRI findings with biochemical recurrence ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 161:9-15]

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Liver Stiffness Measured by Either Magnetic Resonance or Transient Elastography Is Associated With Liver Fibrosis and Is an Independent Predictor of Outcomes Among Patients With Primary Biliary Cholangitis.

Karim T Osman, Daniel B Maselli, Ilkay S Idilman, Daniel J Rowan, Jason K Viehman, William S Harmsen, Denise M Harnois, Elizabeth J Carey, Andrea A Gossard, Nicholas F LaRusso, Keith D Lindor, Sudhakar K Venkatesh, John E Eaton,

<h4>Goals</h4>We aimed to describe the diagnostic and prognostic performance of transient elastography (TE) and magnetic resonance elastography (MRE) in patients with primary biliary cholangitis (PBC).<h4>Background</h4>The diagnostic performance of TE and MRE in detecting advanced fibrosis in PBC and in predicting outcomes independent of existing serologic prognostic markers is incompletely understood.<h4>Materials ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, 55(5):449-457]

Cited: 3 times

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Predicting Adverse Pathologic Features and Clinical Outcomes of Resectable Pancreas Cancer With Preoperative CA 19-9.

Roman O Kowalchuk, Scott C Lester, Rondell P Graham, William S Harmsen, Lizhi Zhang, Thorvardur R Halfdanarson, Rory L Smoot, Hunter C Gits, Wen Wee Ma, Dawn Owen, Amit Mahipal, Robert C Miller, Michelle A Neben Wittich, Sean P Cleary, Robert R McWilliams, Michael G Haddock, Christopher L Hallemeier, Mark J Truty, Kenneth W Merrell,

<h4>Background</h4>We evaluated preoperative CA 19-9 levels in patients with resected pancreatic cancer to analyze whether they were predictive of clinical outcomes and could help select patients for additional therapy. We hypothesized that elevated CA 19-9 would be associated with worse pathologic findings and oncologic outcomes.<h4>Methods</h4>This study assessed 509 patients with ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:651119]

Cited: 1 time

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Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults.

Katayoun Khoshbin, Lehar Khanna, Daniel Maselli, Jessica Atieh, Margaret Breen-Lyles, Kayla Arndt, Deborah Rhoten, Roy B Dyer, Ravinder J Singh, Sunita Nayar, Sandra Bjerkness, William S Harmsen, Irene Busciglio, Michael Camilleri,

<h4>Background</h4>Oral monosaccharides and disaccharides are used to measure in vivo human gut permeability through urinary excretion.<h4>Aims</h4>The aims were as follows: (1) to obtain normative data on small intestinal and colonic permeability; (2) to assess variance on standard 16 g fiber diet performed twice; (3) to determine whether dietary fiber influences gut ... Read more >>

Gastroenterology (Gastroenterology)
[2021, 161(2):463-475.e13]

Cited: 1 time

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Surgical Approach to Transverse Colon Cancer: Analysis of Current Practice and Oncological Outcomes Using the National Cancer Database.

Jacopo Crippa, Fabian Grass, Pietro Achilli, Kevin T Behm, Kellie L Mathis, Courtney N Day, William S Harmsen, Giulio M Mari, David W Larson,

<h4>Background</h4>Surgical treatment for transverse colon cancer involves either extended colectomy or segmental resection, depending on the location of the tumor and surgeon perspective. However, the oncological safety of segmental resection has not yet been established in large cohort studies.<h4>Objective</h4>This study aims to compare segmental resection versus extended colectomy for transverse ... Read more >>

Dis Colon Rectum (Diseases of the colon and rectum)
[2021, 64(3):284-292]

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Intensity modulated radiotherapy for anal canal squamous cell carcinoma: A 16-year single institution experience.

Krishan R Jethwa, Courtney N Day, Harigopal Sandhyavenu, Karthik Gonuguntla, William S Harmsen, William G Breen, David M Routman, Allison E Garda, Joleen M Hubbard, Thorvardur R Halfdanarson, Michelle A Neben-Wittich, Kenneth W Merrell, Christopher L Hallemeier, Michael G Haddock,

<h4>Introduction</h4>To report long-term efficacy and adverse events (AEs) associated with intensity modulated radiotherapy (IMRT) for patients with anal canal squamous cell carcinoma (ASCC).<h4>Materials and methods</h4>This was a retrospective review of patients with ASCC who received curative-intent IMRT and concurrent chemotherapy (98%) between 2003 and 2019. Overall survival (OS), colostomy-free survival ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 28:17-23]

Cited: 1 time

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Ablative radiotherapy for ultracentral lung cancers: Dosimetric, geometric, and volumetric predictors of outcomes and toxicity.

William G Breen, Elizabeth B Jeans, Kimberly R Gergelis, Yolanda I Garces, Sean S Park, Kenneth W Merrell, Tobias D Peikert, Aaron S Mansfield, Dennis A Wigle, William S Harmsen, David C Ellerbusch, Kenneth R Olivier, J John Lucido, Dawn Owen,

<h4>Background</h4>Ultracentral lung cancers arise near the proximal bronchial tree (PBT), trachea, or esophagus, and have been associated with worse outcomes and increased toxicity after radiotherapy. We sought to associate dosimetric and anatomic factors with oncologic outcomes and toxicities.<h4>Methods</h4>One-hundred ten patients treated with ablative, curative-intent radiotherapy for ultracentral, node-negative, non-small cell ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 158:246-252]

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The Natural History of Chronic Unexplained Gastrointestinal Disorders and Gastroesophageal Reflux During 20 Years: A US Population-Based Study.

Rok Seon Choung, Yuri A Saito, Cathy D Schleck, William S Harmsen, Alan R Zinsmeister, Joseph A Murray, Nicholas J Talley,

<h4>Objective</h4>To explore the natural history of chronic unexplained gastrointestinal (GI) symptoms and to determine the longitudinal trends of prevalence during a 20-year period in a single US community.<h4>Methods</h4>Between January 1, 1990, and December 31, 2009, valid self-report questionnaires of GI symptoms were mailed to randomly selected cohorts of a community. ... Read more >>

Mayo Clin Proc (Mayo Clinic proceedings)
[2021, 96(3):563-576]

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Factors Predicting Response, Perioperative Outcomes, and Survival Following Total Neoadjuvant Therapy for Borderline/Locally Advanced Pancreatic Cancer.

Mark J Truty, Michael L Kendrick, David M Nagorney, Rory L Smoot, Sean P Cleary, Rondell P Graham, Ajit H Goenka, Christopher L Hallemeier, Michel G Haddock, William S Harmsen, Amit Mahipal, Robert R McWilliams, Thorvardur R Halfdanarson, Axel F Grothey,

<h4>Objective</h4>To identify predictive factors associated with operative morbidity, mortality, and survival outcomes in patients with borderline resectable (BR) or locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC) undergoing total neoadjuvant therapy (TNT).<h4>Background</h4>The optimal preoperative treatment sequencing for BR/LA PDA is unknown. TNT, or systemic chemotherapy followed by chemoradiation (CRT), addresses both ... Read more >>

Ann Surg (Annals of surgery)
[2021, 273(2):341-349]

Cited: 33 times

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Bias Against Complex Lung Cancer Surgery.

Mark S Allen, William S Harmsen, Jay Mandrekar, Gaetano Rocco,

<h4>Background</h4>Lung cancer remains a major public health problem. There remain differences in mortality among socioeconomic and racial groups. Using The Society of Thoracic Surgeons General Thoracic Surgery database, we attempted to determine whether there were differences in treatment choices by thoracic surgeons based on patients' race or insurance.<h4>Methods</h4>Using data from ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, :]

Cited: 0 times

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Chemoradiotherapy for patients with locally advanced or unresectable extra-hepatic biliary cancer.

Krishan R Jethwa, Shilpa Sannapaneni, Trey C Mullikin, William S Harmsen, Molly M Petersen, Phanindra Antharam, Brady Laughlin, Amit Mahipal, Thorvardur R Halfdanarson, Kenneth W Merrell, Michelle Neben-Wittich, Terence T Sio, Michael G Haddock, Christopher L Hallemeier,

<h4>Background</h4>Although surgical resection is the preferred curative-intent treatment option for patients with non-metastatic, extra-hepatic biliary cancer (EBC), radiotherapy (RT) or chemoradiotherapy (CRT) may be utilized in select cases when surgical resection is not feasible. The purpose of this study is to report the efficacy and adverse events (AEs) associated with ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2020, 11(6):1408-1420]

Cited: 0 times

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Patient-reported functional outcomes in a cohort of hand and foot sarcoma survivors treated with limb sparing surgery and radiation therapy.

Safia K Ahmed, Suneetha Kaggal, William S Harmsen, Jessica W Sawyer, Matthew T Houdek, Peter S Rose, Ivy A Petersen,

<h4>Background and objectives</h4>Describe patient-reported functional outcomes for hand and foot sarcoma survivors treated with limb-sparing surgery and radiation therapy (LSS + RT).<h4>Methods</h4>Fifty-four patients with hand/wrist and foot/ankle sarcomas treated with LSS + RT from 1991 to 2015 were identified. Survivors ≥18 years old without subsequent amputation completed self-assessed functional surveys: Toronto upper extremity salvage score ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2021, 123(1):110-116]

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Long-Term Outcomes After Transcatheter and Surgical Aortic Valve Replacement in Patients With Cirrhosis: A Guide for the Hepatologist.

Thoetchai Bee Peeraphatdit, Vuyisile T Nkomo, Niyada Naksuk, Douglas A Simonetto, Nimish Thakral, Grant M Spears, William S Harmsen, Vijay H Shah, Kevin L Greason, Patrick S Kamath,

<h4>Background and aims</h4>Hepatologists often determine whether transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) is preferred for patients with cirrhosis and severe aortic stenosis. The goal of this cohort study is to compare outcomes following TAVR and SAVR in patients with cirrhosis to inform the preferred intervention.<h4>Approach ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, 72(5):1735-1746]

Cited: 2 times

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BALAD and BALAD-2 predict survival of hepatocellular carcinoma patients: a North American cohort study.

Nicha Wongjarupong, Gabriela M Negron-Ocasio, Kristin C Mara, Kritika Prasai, Mohamed A Abdallah, Keun Soo Ahn, Ju Dong Yang, Benyam D Addissie, Nasra H Giama, William S Harmsen, Terry M Therneau, Lewis R Roberts,

<h4>Background</h4>The BALAD score and BALAD-2 class derived from bilirubin, albumin, AFP, AFP-L3, and des-gamma-carboxyprothrombin (DCP) are effective in predicting mortality in HCC, but have not been validated in North America.<h4>Methods</h4>148 HCC patients from 2000 to 2015 who had all five biomarkers tested at diagnosis were included. Hazard ratios (HR) were ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2021, 23(5):762-769]

Cited: 1 time

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