Full Text Journal Articles by
Author William R Clarke

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A Rare Complication in a Child Undergoing Resection of a Huge Thoracic Lipoma.

Barbara J Meinecke, William R Clarke, Paul S Pagel,

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2021, :]

Cited: 0 times

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Phase 3 trial of human islet-after-kidney transplantation in type 1 diabetes.

James F Markmann, Michael R Rickels, Thomas L Eggerman, Nancy D Bridges, David E Lafontant, Julie Qidwai, Eric Foster, William R Clarke, Malek Kamoun, Rodolfo Alejandro, Melena D Bellin, Kathryn Chaloner, Christine W Czarniecki, Julia S Goldstein, Bernhard J Hering, Lawrence G Hunsicker, Dixon B Kaufman, Olle Korsgren, Christian P Larsen, Xunrong Luo, Ali Naji, José Oberholzer, Andrew M Posselt, Camillo Ricordi, Peter A Senior, A M James Shapiro, Peter G Stock, Nicole A Turgeon,

Allogeneic islet transplant offers a minimally invasive option for β cell replacement in the treatment of type 1 diabetes (T1D). The CIT consortium trial of purified human pancreatic islets (PHPI) in patients with T1D after kidney transplant (CIT06), a National Institutes of Health-sponsored phase 3, prospective, open-label, single-arm pivotal trial ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, 21(4):1477-1492]

Cited: 2 times

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Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial.

Karen C Johnston, Askiel Bruno, Qi Pauls, Christiana E Hall, Kevin M Barrett, William Barsan, Amy Fansler, Katrina Van de Bruinhorst, Scott Janis, Valerie L Durkalski-Mauldin, ,

<h4>Importance</h4>Hyperglycemia during acute ischemic stroke is common and is associated with worse outcomes. The efficacy of intensive treatment of hyperglycemia in this setting remains unknown.<h4>Objectives</h4>To determine the efficacy of intensive treatment of hyperglycemia during acute ischemic stroke.<h4>Design, setting, and participants</h4>The Stroke Hyperglycemia Insulin Network Effort (SHINE) randomized clinical trial included ... Read more >>

JAMA (JAMA)
[2019, 322(4):326-335]

Cited: 32 times

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CLPTM1L/CRR9 ectodomain interaction with GRP78 at the cell surface signals for survival and chemoresistance upon ER stress in pancreatic adenocarcinoma cells.

William R Clarke, Laufey Amundadottir, Michael A James,

Altered regulation of endoplasmic reticulum (ER) homeostasis has been implicated in many cancers and has recently become a therapeutic and chemosensitization target of interest. We have identified Cleft Lip and Palate Transmembrane 1-Like (CLPTM1L)/Cisplatin Resistance Related Protein 9 (CRR9) as an ER stress related mediator of cytoprotection in pancreatic cancer. ... Read more >>

Int J Cancer (International journal of cancer)
[2019, 144(6):1367-1378]

Cited: 8 times

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Improved Health-Related Quality of Life in a Phase 3 Islet Transplantation Trial in Type 1 Diabetes Complicated by Severe Hypoglycemia.

Eric D Foster, Nancy D Bridges, Irene D Feurer, Thomas L Eggerman, Lawrence G Hunsicker, Rodolfo Alejandro, ,

OBJECTIVE:Attaining glycemic targets without severe hypoglycemic events (SHEs) is a challenging treatment goal for patients with type 1 diabetes complicated by impaired awareness of hypoglycemia (IAH). The CIT Consortium Protocol 07 (CIT-07) trial showed islet transplantation to be an effective treatment for subjects with IAH and intractable SHEs. We evaluated ... Read more >>

Diabetes Care (Diabetes care)
[2018, 41(5):1001-1008]

Cited: 21 times

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Erratum. National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65:3418-3428.

Camillo Ricordi, Julia S Goldstein, A N Balamurugan, Gregory L Szot, Tatsuya Kin, Chengyang Liu, Christine W Czarniecki, Barbara Barbaro, Nancy D Bridges, Jose Cano, William R Clarke, Thomas L Eggerman, Lawrence G Hunsicker, Dixon B Kaufman, Aisha Khan, David-Erick Lafontant, Elina Linetsky, Xunrong Luo, James F Markmann, Ali Naji, Olle Korsgren, Jose Oberholzer, Nicole A Turgeon, Daniel Brandhorst, Andrew S Friberg, Ji Lei, Ling-Jia Wang, Joshua J Wilhelm, Jamie Willits, Xiaomin Zhang, Bernhard J Hering, Andrew M Posselt, Peter G Stock, A M James Shapiro,

Diabetes (Diabetes)
[2017, 66(9):2531]

Cited: 3 times

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Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia.

Bernhard J Hering, William R Clarke, Nancy D Bridges, Thomas L Eggerman, Rodolfo Alejandro, Melena D Bellin, Kathryn Chaloner, Christine W Czarniecki, Julia S Goldstein, Lawrence G Hunsicker, Dixon B Kaufman, Olle Korsgren, Christian P Larsen, Xunrong Luo, James F Markmann, Ali Naji, Jose Oberholzer, Andrew M Posselt, Michael R Rickels, Camillo Ricordi, Mark A Robien, Peter A Senior, A M James Shapiro, Peter G Stock, Nicole A Turgeon, ,

<h4>Objective</h4>Impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events (SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes (T1D). Current therapies are effective in preventing SHEs in 50-80% of patients with IAH and SHEs, leaving a substantial number of patients at risk. We evaluated the effectiveness and ... Read more >>

Diabetes Care (Diabetes care)
[2016, 39(7):1230-1240]

Cited: 187 times

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Consistency of quantitative scores of hypoglycemia severity and glycemic lability and comparison with continuous glucose monitoring system measures in long-standing type 1 diabetes.

Peter A Senior, Melena D Bellin, Rodolfo Alejandro, Jon W Yankey, William R Clarke, Julie C Qidwai, Traci R Schwieger, Thomas L Eggerman, Mark A Robien, Michael R Rickels, ,

<h4>Background</h4>In long-standing type 1 diabetes (T1D), loss of endogenous insulin secretion and glucose dysregulation can lead to severe hypoglycemia and associated complications. Here, we report the serial consistency and the correlation between different scores that characterize glucose dysregulation using self-monitoring of blood glucose (SMBG), in a cohort of T1D individuals ... Read more >>

Diabetes Technol Ther (Diabetes technology & therapeutics)
[2015, 17(4):235-242]

Cited: 12 times

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Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON) trial: main results.

Randolph S Marshall, Joanne R Festa, Ying-Kuen Cheung, Marykay A Pavol, Colin P Derdeyn, William R Clarke, Tom O Videen, Robert L Grubb, Kevin Slane, William J Powers, Ronald M Lazar, ,

<h4>Objective</h4>To determine whether extracranial-intracranial (EC-IC) bypass can improve cognition over 2 years compared to best medical therapy alone in patients with symptomatic internal carotid artery (ICA) occlusion and increased oxygen extraction fraction (OEF) on PET.<h4>Methods</h4>Patients underwent (15)O PET and were randomized if OEF ratio was >1.13 on the occluded side. ... Read more >>

Neurology (Neurology)
[2014, 82(9):744-751]

Cited: 28 times

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Lower stroke risk with lower blood pressure in hemodynamic cerebral ischemia.

William J Powers, William R Clarke, Robert L Grubb, Tom O Videen, Harold P Adams, Colin P Derdeyn, ,

<h4>Objective</h4>To determine whether strict blood pressure (BP) control is the best medical management for patients with symptomatic carotid artery occlusion and hemodynamic cerebral ischemia.<h4>Methods</h4>In this prospective observational cohort study, we analyzed data from 91 participants in the nonsurgical group of the Carotid Occlusion Surgery Study (COSS) who had recent symptomatic ... Read more >>

Neurology (Neurology)
[2014, 82(12):1027-1032]

Cited: 16 times

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Investigating the mechanisms of perioperative ischemic stroke in the Carotid Occlusion Surgery Study.

Matthew R Reynolds, Robert L Grubb, William R Clarke, William J Powers, Gregory J Zipfel, Harold P Adams, Colin P Derdeyn, ,

<h4>Object</h4>The Carotid Occlusion Surgery Study (COSS) was a large, prospective clinical trial that examined whether superficial temporal artery-middle cerebral artery (STA-MCA) bypass, in addition to best medical therapy, reduced the risk of ipsilateral ischemic stroke in patients with carotid artery occlusion and hemodynamic cerebral ischemia. Despite improved cerebral hemodynamics and ... Read more >>

J Neurosurg (Journal of neurosurgery)
[2013, 119(4):988-995]

Cited: 15 times

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Surgical results of the Carotid Occlusion Surgery Study.

Robert L Grubb, William J Powers, William R Clarke, Tom O Videen, Harold P Adams, Colin P Derdeyn, ,

<h4>Object</h4>The Carotid Occlusion Surgery Study (COSS) was conducted to determine if superficial temporal artery-middle cerebral artery (STA-MCA) bypass, when added to the best medical therapy, would reduce subsequent ipsilateral stroke in patients with complete internal carotid artery (ICA) occlusion and an elevated oxygen extraction fraction (OEF) in the cerebral hemisphere ... Read more >>

J Neurosurg (Journal of neurosurgery)
[2013, 118(1):25-33]

Cited: 42 times

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Case report: giant cardiac malignancy in a nine-year-old female.

John P Scott, Todd J Troshynski, William R Clarke, Ronald K Woods, David R Lal, Richard J Berens, Richard L Tower,

<h4>Purpose</h4>To describe the management of a giant cardiac malignancy initially diagnosed as an anterior mediastinal mass.<h4>Clinical features</h4>A nine-year-old female with right facial swelling and chronic cough was diagnosed with a large right mediastinal mass. Intermittent ventricular and supraventricular arrhythmias were noted on admission electrocardiograms. Empiric corticosteroid and radiation therapy did ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2012, 59(11):1048-1051]

Cited: 0 times

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Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial.

Margaret Rosenfeld, Felix Ratjen, Lyndia Brumback, Stephen Daniel, Ron Rowbotham, Sharon McNamara, Robin Johnson, Richard Kronmal, Stephanie D Davis, ,

<h4>Context</h4>Inhaled hypertonic saline is recommended as therapy for patients 6 years or older with cystic fibrosis (CF), but its efficacy has never been evaluated in patients younger than 6 years with CF.<h4>Objective</h4>To determine if hypertonic saline reduces the rate of protocol-defined pulmonary exacerbations in patients younger than 6 years with ... Read more >>

JAMA (JAMA)
[2012, 307(21):2269-2277]

Cited: 80 times

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Commentary: Extracranial-intracranial bypass for stroke in 2012: response to the critique of the carotid occlusion surgery study "It was déjà vu all over again".

William J Powers, William R Clarke, Harold P Adams, Colin P Derdeyn, Robert L Grubb,

Neurosurgery (Neurosurgery)
[2012, 71(3):E772-6]

Cited: 6 times

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Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial.

William J Powers, William R Clarke, Robert L Grubb, Tom O Videen, Harold P Adams, Colin P Derdeyn, ,

<h4>Context</h4>Patients with symptomatic atherosclerotic internal carotid artery occlusion (AICAO) and hemodynamic cerebral ischemia are at high risk for subsequent stroke when treated medically.<h4>Objective</h4>To test the hypothesis that extracranial-intracranial (EC-IC) bypass surgery, added to best medical therapy, reduces subsequent ipsilateral ischemic stroke in patients with recently symptomatic AICAO and hemodynamic cerebral ... Read more >>

JAMA (JAMA)
[2011, 306(18):1983-1992]

Cited: 243 times

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Initial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosis.

Nicole Mayer-Hamblett, Richard A Kronmal, Ronald L Gibson, Margaret Rosenfeld, George Retsch-Bogart, Miriam M Treggiari, Jane L Burns, Umer Khan, Bonnie W Ramsey, ,

<h4>Rationale</h4>The risk of pulmonary exacerbation following Pseudomonas aeruginosa (Pa) acquisition in children with cystic fibrosis (CF) is unknown.<h4>Objectives</h4>To determine if failure of antibiotic therapy to eradicate Pa and frequency of Pa recurrence are associated with increased exacerbation risk.<h4>Methods</h4>The cohort included 282 children with CF who participated in the EPIC trial ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2012, 47(2):125-134]

Cited: 47 times

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Quantification of CLR1401, a novel alkylphosphocholine anticancer agent, in rat plasma by hydrophilic interaction liquid chromatography-tandem mass spectrometric detection.

Hongliang Jiang, Michelle J Cannon, Maria Banach, Anatoly N Pinchuk, Giangthy N Ton, Christie Scheuerell, Marc A Longino, Jamey P Weichert, Richard Tollefson, William R Clarke, Qin C Ji, Xiangyu Jiang,

A rapid and specific LC-MS/MS based bioanalytical method was developed and validated for the determination of 18-(p-iodophenyl)octadecyl phosphocholine (CLR1401), a novel phosphocholine drug candidate, in rat plasma. The optimal chromatographic behavior of CLR1401 was achieved on a Kromasil silica column (50 mm x 3 mm, 5 microm) under hydrophilic interaction ... Read more >>

J Chromatogr B Analyt Technol Biomed Life Sci (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences)
[2010, 878(19):1513-1518]

Cited: 4 times

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A flexible futility monitoring method with time-varying conditional power boundary.

Ying Zhang, William R Clarke,

<h4>Background</h4>In an ongoing multi-center randomized control clinical trial, the Carotid Occlusion Surgery Study (COSS), the study protocol specifies multiple interim analyses whose results will be reviewed by an independent DSMB to determine if the trial needs to be stopped early due to either efficacy or futility. Conditional power is used ... Read more >>

Clin Trials (Clinical trials (London, England))
[2010, 7(3):209-218]

Cited: 3 times

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The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial.

Arthur M Pancioli, Joseph Broderick, Thomas Brott, Thomas Tomsick, Jane Khoury, Judy Bean, Gregory del Zoppo, Dawn Kleindorfer, Daniel Woo, Pooja Khatri, John Castaldo, James Frey, James Gebel, Scott Kasner, Chelsea Kidwell, Thomas Kwiatkowski, Richard Libman, Richard Mackenzie, Phillip Scott, Sidney Starkman, R Jason Thurman, ,

<h4>Background and purpose</h4>Multiple approaches are being studied to enhance the rate of thrombolysis for acute ischemic stroke. Treatment of myocardial infarction with a combination of a reduced-dose fibrinolytic agent and a glycoprotein (GP) IIb/IIIa receptor antagonist has been shown to improve the rate of recanalization versus fibrinolysis alone. The combined ... Read more >>

Stroke (Stroke)
[2008, 39(12):3268-3276]

Cited: 78 times

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Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage.

Michael M Todd, Bradley J Hindman, William R Clarke, James C Torner, Julie B Weeks, Emine O Bayman, Qian Shi, Christina M Spofford, ,

<h4>Objective</h4>We examined the incidence of perioperative fever and its relationship to outcome among patients enrolled in the Intraoperative Hypothermia for Aneurysm Surgery Trial.<h4>Methods</h4>One thousand patients with initial World Federation of Neurological Surgeons grades of I to III undergoing clipping of intracranial aneurysms after subarachnoid hemorrhage were randomized to intraoperative normothermia ... Read more >>

Neurosurgery (Neurosurgery)
[2009, 64(5):897-908; discussion 908]

Cited: 33 times

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Re: Who cares about paperwork?

William R Clarke,

J Occup Environ Med (Journal of occupational and environmental medicine)
[2008, 50(10):1093; author reply 1093-4]

Cited: 0 times

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Translating research into practice intervention improves management of acute pain in older hip fracture patients.

Marita G Titler, Keela Herr, John M Brooks, Xian-Jin Xie, Gail Ardery, Margo L Schilling, J Lawrence Marsh, Linda Q Everett, William R Clarke,

<h4>Objective</h4>To test an interdisciplinary, multifaceted, translating research into practice (TRIP) intervention to (a) promote adoption, by physicians and nurses, of evidence-based (EB) acute pain management practices in hospitalized older adults, (b) decrease barriers to use of EB acute pain management practices, and (c) decrease pain intensity of older hospitalized adults.<h4>Study ... Read more >>

Health Serv Res (Health services research)
[2009, 44(1):264-287]

Cited: 23 times

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Hyperglycemia in patients undergoing cerebral aneurysm surgery: its association with long-term gross neurologic and neuropsychological function.

Jeffrey J Pasternak, Diana G McGregor, Darrell R Schroeder, William L Lanier, Qian Shi, Bradley J Hindman, William R Clarke, James C Torner, Julie B Weeks, Michael M Todd, ,

<h4>Objective</h4>To evaluate whether elevated intraoperative blood glucose concentrations are associated with an increased risk of long-term neurologic dysfunction in patients at risk for ischemic brain injury.<h4>Patients and methods</h4>Data from 1000 patients were retrieved from the Intraoperative Hypothermia for Aneurysm Surgery Trial database. All patients were recruited between February 2000 and ... Read more >>

Mayo Clin Proc (Mayo Clinic proceedings)
[2008, 83(4):406-417]

Cited: 42 times

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Accounting for intraclass correlations and controlling for baseline differences in a cluster-randomised evidence-based practice intervention study.

Xian-Jin Xie, Marita G Titler, William R Clarke,

<h4>Background</h4>In health care and community-based intervention studies, cluster-randomised designs have been increasingly used because of administrative convenience, a desire to decrease treatment contamination, and the need to avoid ethical issues that might arise. While useful, cluster-randomised designs present challenges for data analysis. First, because of dependencies that exist among subjects ... Read more >>

Worldviews Evid Based Nurs (Worldviews on evidence-based nursing)
[2008, 5(2):95-101]

Cited: 3 times

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