Full Text Journal Articles by
Author William M Switzer

Advertisement

Find full text journal articles






Complete Genome Sequence of a Baboon Simian Foamy Virus Isolated from an Infected Human.

Anupama Shankar, Vedapuri Shanmugam, William M Switzer,

We obtained the full-length genome of a simian foamy virus (SFV) from an infected human. This virus originated from a baboon (Papio species, strain SFVpxx_hu9406). The genome is 13,113 nucleotides long with the canonical SFV genome structure. Phylogenetically, SFVpxx_hu9406 clustered closely with SFVpan_V909/03F from a captive baboon and other Cercopithecidae ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2020, 9(27):]

Cited: 0 times

View full text PDF listing >>



Molecular Epidemiology of the HIV-1 Subtype B Sub-Epidemic in Bulgaria.

Ivailo Alexiev, Ellsworth M Campbell, Sergey Knyazev, Yi Pan, Lyubomira Grigorova, Reneta Dimitrova, Aleksandra Partsuneva, Anna Gancheva, Asya Kostadinova, Carole Seguin-Devaux, William M Switzer,

HIV-1 subtype B is the predominant strain in Bulgaria, yet little is known about the molecular epidemiology of these infections, including its origin and transmissibility. We used a phylodynamics approach by combining and analyzing 663 HIV-1 polymerase (pol) sequences collected from persons diagnosed with HIV/AIDS between 1988-2018 and associated epidemiologic ... Read more >>

Viruses (Viruses)
[2020, 12(4):]

Cited: 0 times

View full text PDF listing >>



Advertisement

Using an Established Outbreak Response Plan and Molecular Epidemiology Methods in an HIV Transmission Cluster Investigation, Tennessee, January-June 2017.

Lindsey Sizemore, Mary-Margaret Fill, Samantha A Mathieson, Jennifer Black, Meredith Brantley, Kelly Cooper, Joy Garrett, William M Switzer, Philip J Peters, Carolyn Wester,

INTRODUCTION:In April 2017, the Tennessee Department of Health (TDH) was notified of an increase in the number of persons newly diagnosed with HIV in eastern Tennessee in the same month. Two were identified as persons with a history of injection drug use (IDU) and named each other as syringe-sharing partners, ... Read more >>

Public Health Rep (Public health reports (Washington, D.C. : 1974))
[2020, 135(3):329-333]

Cited: 0 times

View full text PDF listing >>



Investigation of Presumptive HIV Transmission Associated with Hospitalization Using Nucleotide Sequence Analysis - New York, 2017.

Bridget J Anderson, Ernest Clement, Randall Collura, Abigail Gallucci, Emily Westheimer, Sarah Braunstein, Karen Southwick, Eleanor Adams, Emily Lutterloh, Charles Gonzalez, Robert McDonald, Hongwei Jia, William M Switzer, Priti R Patel, M Patricia Joyce, Alexandra M Oster,

Since implementation of Standard Precautions* for the prevention of bloodborne pathogen transmission in 1985, health care-associated transmission of human immunodeficiency virus (HIV) in the United States has been rare (1). In October 2017, the New York City Department of Health and Mental Hygiene (NYCDOHMH) and the New York State Department ... Read more >>

MMWR Morb. Mortal. Wkly. Rep. (MMWR. Morbidity and mortality weekly report)
[2020, 69(10):260-264]

Cited: 0 times

View full text PDF listing >>



Phylodynamic Analysis Complements Partner Services by Identifying Acute and Unreported HIV Transmission.

Ellsworth M Campbell, Anne Patala, Anupama Shankar, Jin-Fen Li, Jeffrey A Johnson, Emily Westheimer, Cynthia L Gay, Stephanie E Cohen, William M Switzer, Philip J Peters,

Tailoring public health responses to growing HIV transmission clusters depends on accurately mapping the risk network through which it spreads and identifying acute infections that represent the leading edge of cluster growth. HIV transmission links, especially those involving persons with acute HIV infection (AHI), can be difficult to uncover, or ... Read more >>

Viruses (Viruses)
[2020, 12(2):]

Cited: 0 times

View full text PDF listing >>



Trends in HIV-2 Diagnoses and Use of the HIV-1/HIV-2 Differentiation Test - United States, 2010-2017.

Anne H Peruski, Laura G Wesolowski, Kevin P Delaney, Pollyanna R Chavez, S Michele Owen, Timothy C Granade, Vickie Sullivan, William M Switzer, Xueyuan Dong, John T Brooks, M Patricia Joyce,

Since 2014, the recommended laboratory testing algorithm for diagnosing human immunodeficiency virus (HIV) infection has included a supplemental HIV-1/HIV-2 differentiation test to confirm infection type on the basis of the presence of type-specific antibodies (1). Correctly identifying HIV-1 and HIV-2 infections is vital because their epidemiology and clinical management differ. ... Read more >>

MMWR Morb. Mortal. Wkly. Rep. (MMWR. Morbidity and mortality weekly report)
[2020, 69(3):63-66]

Cited: 0 times

View full text PDF listing >>



Natural selection favoring more transmissible HIV detected in United States molecular transmission network.

Joel O Wertheim, Alexandra M Oster, William M Switzer, Chenhua Zhang, Nivedha Panneer, Ellsworth Campbell, Neeraja Saduvala, Jeffrey A Johnson, Walid Heneine,

HIV molecular epidemiology can identify clusters of individuals with elevated rates of HIV transmission. These variable transmission rates are primarily driven by host risk behavior; however, the effect of viral traits on variable transmission rates is poorly understood. Viral load, the concentration of HIV in blood, is a heritable viral ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):5788]

Cited: 1 time

View full text PDF listing >>



Seroreactivity against Marburg or related filoviruses in West and Central Africa.

Imke Steffen, Kai Lu, Nicole A Hoff, Prime Mulembakani, Emile Okitolonda Wemakoy, Jean-Jacques Muyembe-Tamfum, Nicaise Ndembi, Catherine A Brennan, John Hackett, William M Switzer, Sentob Saragosti, Guy O Mbensa, Syria Laperche, Anne W Rimoin, Graham Simmons,

A serological survey of 2,430 archived serum samples collected between 1997 and 2012 was conducted to retrospectively determine the prevalence of Marburg virus in five African countries. Serum samples were screened for neutralizing antibodies in a pseudotype micro-neutralization assay and confirmed by enzyme-linked immunosorbent assay (ELISA). Surprisingly, a seroprevalence for ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):124-128]

Cited: 0 times

View full text PDF listing >>



Opioid Use Fueling HIV Transmission in an Urban Setting: An Outbreak of HIV Infection Among People Who Inject Drugs-Massachusetts, 2015-2018.

Charles Alpren, Erica L Dawson, Betsey John, Kevin Cranston, Nivedha Panneer, H Dawn Fukuda, Kathleen Roosevelt, R Monina Klevens, Janice Bryant, Philip J Peters, Sheryl B Lyss, William M Switzer, Amanda Burrage, Ashley Murray, Christine Agnew-Brune, Tracy Stiles, Paul McClung, Ellsworth M Campbell, Courtney Breen, Liisa M Randall, Sharoda Dasgupta, Shauna Onofrey, Danae Bixler, Kischa Hampton, Jenifer Leaf Jaeger, Katherine K Hsu, William Adih, Barry Callis, Linda R Goldman, Susie P Danner, Hongwei Jia, Matthew Tumpney, Amy Board, Catherine Brown, Alfred DeMaria, Kate Buchacz,

Objectives. To describe and control an outbreak of HIV infection among people who inject drugs (PWID).Methods. The investigation included people diagnosed with HIV infection during 2015 to 2018 linked to 2 cities in northeastern Massachusetts epidemiologically or through molecular analysis. Field activities included qualitative interviews regarding service availability and HIV ... Read more >>

Am J Public Health (American journal of public health)
[2020, 110(1):37-44]

Cited: 1 time

View full text PDF listing >>



Evaluation of the performance of the Cepheid Xpert HIV-1 Viral Load Assay for quantitative and diagnostic uses.

Laura Wesolowski, William Fowler, Wei Luo, Vickie Sullivan, Silvina Masciotra, Tara Smith, Rebecca Rossetti, Kevin Delaney, Emeka Oraka, Pollyanna Chavez, Steven Ethridge, William M Switzer, S Michele Owen,

BACKGROUND:Cepheid's Xpert HIV-1 Viral Load (Xpert VL), a simplified, automated, single-use quantitative assay used with the GeneXpert System, is not FDA approved. OBJECTIVES:Using stored plasma, we conducted a study to assess the ability of Xpert VL to quantify viral load relative to the Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 (Cobas VL) ... Read more >>

J. Clin. Virol. (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2020, 122:104214]

Cited: 0 times

View full text PDF listing >>



Simian Foamy Viruses in Central and South America: A New World of Discovery.

André F Santos, Liliane T F Cavalcante, Cláudia P Muniz, William M Switzer, Marcelo A Soares,

Foamy viruses (FVs) are the only exogenous retrovirus to date known to infect neotropical primates (NPs). In the last decade, an increasing number of strains have been completely or partially sequenced, and molecular evolution analyses have identified an ancient co-speciation with their hosts. In this review, the improvement of diagnostic ... Read more >>

Viruses (Viruses)
[2019, 11(10):]

Cited: 0 times

View full text PDF listing >>



Serologic Prevalence of Ebola Virus in Equatorial Africa.

Imke Steffen, Kai Lu, Lauren K Yamamoto, Nicole A Hoff, Prime Mulembakani, Emile O Wemakoy, Jean-Jacques Muyembe-Tamfum, Nicaise Ndembi, Catherine A Brennan, John Hackett, Susan L Stramer, William M Switzer, Sentob Saragosti, Guy O Mbensa, Syria Laperche, Anne W Rimoin, Graham Simmons,

We conducted a serologic survey of 2,430 serum samples collected during 1997-2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization assay and a newly developed luciferase immunoprecipitation system ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2019, 25(5):911-918]

Cited: 3 times

View full text PDF listing >>



Genome-Wide Patterns of Gene Expression in a Wild Primate Indicate Species-Specific Mechanisms Associated with Tolerance to Natural Simian Immunodeficiency Virus Infection.

Noah D Simons, Geeta N Eick, Maria J Ruiz-Lopez, David Hyeroba, Patrick A Omeja, Geoffrey Weny, HaoQiang Zheng, Anupama Shankar, Simon D W Frost, James H Jones, Colin A Chapman, William M Switzer, Tony L Goldberg, Kirstin N Sterner, Nelson Ting,

Over 40 species of nonhuman primates host simian immunodeficiency viruses (SIVs). In natural hosts, infection is generally assumed to be nonpathogenic due to a long coevolutionary history between host and virus, although pathogenicity is difficult to study in wild nonhuman primates. We used whole-blood RNA-seq and SIV prevalence from 29 ... Read more >>

Genome Biol Evol (Genome biology and evolution)
[2019, 11(6):1630-1643]

Cited: 1 time

View full text PDF listing >>



A Multiplex HIV Incidence Assay for Inferring Recent HIV-1 Transmission and Time of Infection.

Kelly A Curtis, Ellsworth M Campbell, Debra L Hanson, Donna L Rudolph, Joan Duwve, Sara J Blosser, Jessica Gentry, Judith Lovchik, Philip J Peters, Sherry Michele Owen, William M Switzer,

BACKGROUND:Laboratory assays for determining recent HIV-1 infection are an important public health tool for aiding in the estimation of HIV incidence. Some incidence assay analytes are remarkably predictive of time since seroconversion and may be useful for additional applications, such as predicting recent transmission events during HIV outbreaks and informing ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2019, 80(4):454-460]

Cited: 0 times

View full text PDF listing >>



Undisclosed HIV infection among MSM in a behavioral surveillance study.

Brooke E Hoots, Cyprian Wejnert, Amy Martin, Richard Haaland, Silvina Masciotra, Catlainn Sionean, Amanda Smith, William M Switzer, Gabriela Paz-Bailey, ,

OBJECTIVE:As a proxy for undiagnosed HIV, the Centers for Disease Control and Prevention's National HIV Behavioral Surveillance (NHBS) monitors participants who report being unaware of their infection, defined as self-reporting an HIV-negative or unknown status during the interview but testing positive for HIV infection. We validated the NHBS measure of ... Read more >>

AIDS (AIDS (London, England))
[2019, 33(5):913-918]

Cited: 1 time

View full text PDF listing >>



Corrigendum to "Spumaretroviruses: Updated taxonomy and nomenclature" [Virology 516 (2018) 158-164].

Arifa S Khan, Jochen Bodem, Florence Buseyne, Antoine Gessain, Welkin Johnson, Jens H Kuhn, Jacek Kuzmak, Dirk Lindemann, Maxine L Linial, Martin Löchelt, Magdalena Materniak-Kornas, Marcelo A Soares, William M Switzer,

Virology (Lond) (Virology)
[2019, 528:]

Cited: 1 time

View full text PDF listing >>



Notes from the Field: HIV Diagnoses Among Persons Who Inject Drugs - Northeastern Massachusetts, 2015-2018.

Kevin Cranston, Charles Alpren, Betsey John, Erica Dawson, Kathleen Roosevelt, Amanda Burrage, Janice Bryant, William M Switzer, Courtney Breen, Philip J Peters, Tracy Stiles, Ashley Murray, H Dawn Fukuda, William Adih, Linda Goldman, Nivedha Panneer, Barry Callis, Ellsworth M Campbell, Liisa Randall, Anne Marie France, R Monina Klevens, Sheryl Lyss, Shauna Onofrey, Christine Agnew-Brune, Michael Goulart, Hongwei Jia, Matthew Tumpney, Paul McClung, Sharoda Dasgupta, Danae Bixler, Kischa Hampton, , Jenifer Leaf Jaeger, Kate Buchacz, Alfred DeMaria,

MMWR Morb. Mortal. Wkly. Rep. (MMWR. Morbidity and mortality weekly report)
[2019, 68(10):253-254]

Cited: 6 times

View full text PDF listing >>



Identifying Clusters of Recent and Rapid HIV Transmission Through Analysis of Molecular Surveillance Data.

Alexandra M Oster, Anne Marie France, Nivedha Panneer, M Cheryl Bañez Ocfemia, Ellsworth Campbell, Sharoda Dasgupta, William M Switzer, Joel O Wertheim, Angela L Hernandez,

BACKGROUND:Detecting recent and rapid spread of HIV can help prioritize prevention and early treatment for those at highest risk of transmission. HIV genetic sequence data can identify transmission clusters, but previous approaches have not distinguished clusters of recent, rapid transmission. We assessed an analytic approach to identify such clusters in ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2018, 79(5):543-550]

Cited: 13 times

View full text PDF listing >>



A large HCV transmission network enabled a fast-growing HIV outbreak in rural Indiana, 2015.

Sumathi Ramachandran, Hong Thai, Joseph C Forbi, Romeo Regi Galang, Zoya Dimitrova, Guo-Liang Xia, Yulin Lin, Lili T Punkova, Pamela R Pontones, Jessica Gentry, Sara J Blosser, Judith Lovchik, William M Switzer, Eyasu Teshale, Philip Peters, John Ward, Yury Khudyakov, ,

BACKGROUND:A high prevalence (92.3%) of hepatitis C virus (HCV) co-infection among HIV patients identified during a large HIV outbreak associated with injection of oxymorphone in Indiana prompted genetic analysis of HCV strains. METHODS:Molecular epidemiological analysis of HCV-positive samples included genotyping, sampling intra-host HVR1 variants by next-generation sequencing (NGS) and constructing ... Read more >>

EBioMedicine (EBioMedicine)
[2018, 37:374-381]

Cited: 3 times

View full text PDF listing >>



A Strategy for PrEP Clinicians to Manage Ambiguous HIV Test Results During Follow-up Visits.

Dawn K Smith, William M Switzer, Philip Peters, Kevin P Delaney, Timothy C Granade, Silvina Masciotra, Luke Shouse, John T Brooks,

Prompt determination of HIV infection status is critical during follow-up visits for patients taking pre-exposure prophylaxis (PrEP) medication. Those who are uninfected can then continue safely taking PrEP, and those few who have acquired HIV infection can initiate an effective treatment regimen. However, a few recent cases have been reported ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(8):ofy180]

Cited: 3 times

View full text PDF listing >>



Maintenance and reappearance of extremely divergent intra-host HIV-1 variants.

Joel O Wertheim, Alexandra M Oster, Ben Murrell, Neeraja Saduvala, Walid Heneine, William M Switzer, Jeffrey A Johnson,

Understanding genetic variation in human immunodeficiency virus (HIV) is clinically and immunologically important for patient treatment and vaccine development. We investigated the longitudinal intra-host genetic variation of HIV in over 3,000 individuals in the US National HIV Surveillance System with at least four reported HIV-1 polymerase (pol) sequences. In this ... Read more >>

Virus Evol (Virus evolution)
[2018, 4(2):vey030]

Cited: 1 time

View full text PDF listing >>



Spumaretroviruses: Updated taxonomy and nomenclature.

Arifa S Khan, Jochen Bodem, Florence Buseyne, Antoine Gessain, Welkin Johnson, Jens H Kuhn, Jacek Kuzmak, Dirk Lindemann, Maxine L Linial, Martin Löchelt, Magdalena Materniak-Kornas, Marcelo A Soares, William M Switzer,

Spumaretroviruses, commonly referred to as foamy viruses, are complex retroviruses belonging to the subfamily Spumaretrovirinae, family Retroviridae, which naturally infect a variety of animals including nonhuman primates (NHPs). Additionally, cross-species transmissions of simian foamy viruses (SFVs) to humans have occurred following exposure to tissues of infected NHPs. Recent research has ... Read more >>

Virology (Lond) (Virology)
[2018, 516:158-164]

Cited: 16 times

View full text PDF listing >>



A multiplexed RT-LAMP assay for detection of group M HIV-1 in plasma or whole blood.

Kelly A Curtis, Daphne Morrison, Donna L Rudolph, Anupama Shankar, Laura S P Bloomfield, William M Switzer, S Michele Owen,

Isothermal nucleic acid amplification techniques, such as reverse-transcription loop-mediated isothermal amplification (RT-LAMP), exhibit characteristics that are suitable for the development of a rapid, low-cost NAT that can be used at the POC. For demonstration of utility for global use, studies are needed to validate the performance of RT-LAMP for the ... Read more >>

J. Virol. Methods (Journal of virological methods)
[2018, 255:91-97]

Cited: 2 times

View full text PDF listing >>



Detailed Transmission Network Analysis of a Large Opiate-Driven Outbreak of HIV Infection in the United States.

Ellsworth M Campbell, Hongwei Jia, Anupama Shankar, Debra Hanson, Wei Luo, Silvina Masciotra, S Michele Owen, Alexandra M Oster, Romeo R Galang, Michael W Spiller, Sara J Blosser, Erika Chapman, Jeremy C Roseberry, Jessica Gentry, Pamela Pontones, Joan Duwve, Paula Peyrani, Ron M Kagan, Jeannette M Whitcomb, Philip J Peters, Walid Heneine, John T Brooks, William M Switzer,

In January 2015, an outbreak of undiagnosed human immunodeficiency virus (HIV) infections among persons who inject drugs (PWID) was recognized in rural Indiana. By September 2016, 205 persons in this community of approximately 4400 had received a diagnosis of HIV infection. We report results of new approaches to analyzing epidemiologic ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2017, 216(9):1053-1062]

Cited: 20 times

View full text PDF listing >>



Characterization of New HIV Infections among Adults ≥45 Years—New York City, North Carolina, San Francisco, 2011–2013.

Mary Evans, Anne Patala, Ellsworth Campbell, Emily Westheimer, Cynthia L Gay, Stephanie E Cohen, William M Switzer, Philip J Peters,

AbstractBackgroundWhile HIV prevention activities are often focused on younger people, older people can also be at risk for HIV infection. We aimed to characterize HIV transmission in older adults.MethodsThe STOP study was a multi-site prospective study of persons with acute HIV infection (AHI) from 2011 to 2013. Older adults were ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S15-S15]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.3572 s