Full Text Journal Articles by
Author William Carroll

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FLT3 inhibitor lestaurtinib plus chemotherapy for newly diagnosed KMT2A-rearranged infant acute lymphoblastic leukemia: Children's Oncology Group trial AALL0631.

Patrick A Brown, John A Kairalla, Joanne M Hilden, ZoAnn E Dreyer, Andrew J Carroll, Nyla A Heerema, Cindy Wang, Meenakshi Devidas, Lia Gore, Wanda L Salzer, Naomi J Winick, William L Carroll, Elizabeth A Raetz, Michael J Borowitz, Donald Small, Mignon L Loh, Stephen P Hunger,

Infants with KMT2A-rearranged acute lymphoblastic leukemia (KMT2A-r ALL) have a poor prognosis. KMT2A-r ALL overexpresses FLT3, and the FLT3 inhibitor (FLT3i) lestaurtinib potentiates chemotherapy-induced cytotoxicity in preclinical models. Children's Oncology Group (COG) AALL0631 tested whether adding lestaurtinib to post-induction chemotherapy improved event-free survival (EFS). After chemotherapy induction, KMT2A-r infants received ... Read more >>

Leukemia (Leukemia)
[2021, :]

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A WHO resolution on epilepsy and other neurological disorders.

Andrea Sylvia Winkler, Matilde Leonardi, Benedict Daniel Michael, Foad Abd-Allah, William Carroll, Alla Guekht, ,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):171-172]

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Late isolated central nervous system relapse in childhood B-cell acute lymphoblastic leukemia treated with intensified systemic therapy and delayed reduced-dose cranial radiation: A report from the Children’s Oncology Group study AALL02P2

Caroline Hastings, Yichen Chen, Meenakshi Devidas, Ritchey, Naomi Winick, William Carroll, Stephen Hunger, Brent Wood, Robert Marcus, Julio Barredo,

<h4>Background: </h4> Patients with late, occurring ≥18 months post-diagnosis, isolated central nervous relapse (iCNS-R) of B-acute lymphoblastic leukemia (ALL) have excellent outcomes with chemotherapy plus cranial radiotherapy, with 5-yr overall survival (OS) approaching 80% in POG 9412. Subsequent relapse and radiation-related morbidity remain the causes of treatment failure and long-term ... Read more >>

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Adolescent Presentation of Nasal Chondromesenchymal Hamartoma: A Case Report and Literature Review.

Sydney L Moseley, Yekaterina Eichel, Mary S Richardson, William W Carroll, David R White,

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2021, :]

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Reply to A. K. Agrawal et al.

Kimberly P Dunsmore, Stuart S Winter, Meenakshi Devidas, Naomi J Winick, William L Carroll, Stephen P Hunger,

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, 39(6):695-696]

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Excellent Outcomes With Reduced Frequency of Vincristine and Dexamethasone Pulses in Standard-Risk B-Lymphoblastic Leukemia: Results From Children's Oncology Group AALL0932.

Anne L Angiolillo, Reuven J Schore, John A Kairalla, Meenakshi Devidas, Karen R Rabin, Patrick Zweidler-McKay, Michael J Borowitz, Brent Wood, Andrew J Carroll, Nyla A Heerema, Mary V Relling, Johann Hitzler, Ashley R Lane, Kelly W Maloney, Cindy Wang, Mylène Bassal, William L Carroll, Naomi J Winick, Elizabeth A Raetz, Mignon L Loh, Stephen P Hunger,

<h4>Purpose</h4>AALL0932 evaluated two randomized maintenance interventions to optimize disease-free survival (DFS) while reducing the burden of therapy in children with newly diagnosed NCI standard-risk (SR) B-acute lymphoblastic leukemia (B-ALL).<h4>Methods</h4>AALL0932 enrolled 9,229 patients with B-ALL; 2,364 average-risk (AR) patients were randomly assigned (2 × 2 factorial design) at the start of ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, :JCO2000494]

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Outcomes after late bone marrow and very early central nervous system relapse of childhood B-acute lymphoblastic leukemia: a report from the Children's Oncology Group phase III study AALL0433.

Glen Lew, Yichen Chen, Xiaomin Lu, Susan R Rheingold, James A Whitlock, Meenakshi Devidas, Caroline A Hastings, Naomi J Winick, William L Carroll, Brent L Wood, Michael J Borowitz, Michael A Pulsipher, Stephen P Hunger,

Outcomes after relapse of childhood B-acute lymphoblastic leukemia (B-ALL) are poor, and optimal therapy is unclear. Children's Oncology Group study AALL0433 evaluated a new platform for relapsed ALL. Between March 2007 and October 2013 AALL0433 enrolled 275 participants with late bone marrow or very early isolated central nervous system (iCNS) ... Read more >>

Haematologica (Haematologica)
[2021, 106(1):46-55]

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Comparison of CALGB 10403 (Alliance) and COG AALL0232 toxicity results in young adults with acute lymphoblastic leukemia.

Anjali S Advani, Eric Larsen, Kristina Laumann, Selina M Luger, Michaela Liedtke, Meenakshi Devidas, Zhiguo Chen, Jun Yin, Matthew C Foster, David Claxton, Kristin Coffan, Martin S Tallman, Frederick R Appelbaum, Harry Erba, Richard M Stone, Stephen P Hunger, Jennifer L McNeer, Mignon L Loh, Elizabeth Raetz, Naomi Winick, William Carroll, Richard A Larson, Wendy Stock,

Adolescents and young adults (AYAs) with acute lymphoblastic leukemia have improved outcomes when treated with pediatric-inspired regimens. CALGB 10403 was the largest prospective study to evaluate the feasibility of using a pediatric regimen in AYAs with acute lymphoblastic leukemia up to 40 years of age. This article presents the toxicity ... Read more >>

Blood Adv (Blood advances)
[2021, 5(2):504-512]

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Improving Head and Neck Microvascular Reconstructive Care with a Novel Perioperative Checklist.

Joshua J Kain, James D Johns, David Alexander, William R Carroll, Jessica W Grayson, Erin J Buczek,

<h4>Objective/hypothesis</h4>To appraise the utility of a novel EMR-based checklist for complex head and neck microvascular free-tissue reconstruction.<h4>Study design</h4>A prospectively collected retrospective matched cohort study from a single tertiary care academic institution.<h4>Methods</h4>A retrospective matched cohort study from an academic tertiary care center with 76 total patients analyzed for disease-specific and quality ... Read more >>

Laryngoscope (The Laryngoscope)
[2021, :]

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Characterization of COVID-19 disease in pediatric oncology patients: The New York-New Jersey regional experience.

P Pallavi Madhusoodhan, Joanna Pierro, Jordan Musante, Prachi Kothari, Bradley Gampel, Burton Appel, Adam Levy, Adit Tal, Laura Hogan, Archana Sharma, Shari Feinberg, Alissa Kahn, Ashley Pinchinat, Teena Bhatla, Chana L Glasser, Prakash Satwani, Elizabeth A Raetz, Kenan Onel, William L Carroll,

<h4>Purpose</h4>Pediatric oncology patients undergoing active chemotherapy are suspected to be at a high risk for severe disease secondary to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection; however, data to support this are lacking. We aim to describe the characteristics of coronavirus disease 2019 (COVID-19) in this population and also its ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, 68(3):e28843]

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Cost comparison between surgical and conservative management for pediatric sinogenic subperiosteal abscesses.

Sarah M Sussman, Daniel D Sharbel, Arsh Momin, John D Prosser, William W Carroll,

<h4>Background</h4>There remains variation in management of orbital complications of acute bacterial rhinosinusitis (ABRS); specifically, those subperiosteal abscesses that present without immediate surgical indication. Recent systematic reviews on management and proposed treatment algorithms are helpful but do not consider the financial implications for healthcare systems and patients.<h4>Methods</h4>A retrospective chart review of ... Read more >>

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2021, 140:110542]

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Nasal dorsum reconstruction after pediatric nasal dermoid excision.

William W Carroll, Zachary Farhood, David R White, Krishna G Patel,

<h4>Background</h4>To review our experience with pediatric nasal dermoids, and discuss reconstructive options for the nasal dorsum after pediatric nasal dermoid removal.<h4>Methods</h4>Retrospective review of pediatric nasal dermoid cases from January 1 2005 through October 1 2016.<h4>Results</h4>Twenty-five cases (12 males, 13 females) were identified. Median age at time of surgery was 24 ... Read more >>

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2021, 140:110502]

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The effects of sample handling on proteomics assessed by reverse phase protein arrays (RPPA): Functional proteomic profiling in leukemia.

Terzah M Horton, Fieke W Hoff, Anneke van Dijk, Gaye N Jenkins, Debra Morrison, Teena Bhatla, Laura Hogan, Eleny Romanos-Sirakis, Julia Meyer, William L Carroll, Yihua Qiu, Tao Wang, Qianxing Mo, Steven M Kornblau,

Reverse phase protein arrays (RPPA) can assess protein expression and activation states in large numbers of samples (n > 1000) and evidence suggests feasibility in the setting of multi-institution clinical trials. Despite evidence in solid tumors, little is known about protein stability in leukemia. Proteins collected from leukemia cells in blood and ... Read more >>

J Proteomics (Journal of proteomics)
[2021, 233:104046]

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Evolution of the Epigenetic Landscape in Childhood B Acute Lymphoblastic Leukemia and Its Role in Drug Resistance.

Shella Saint Fleur-Lominy, Nikki A Evensen, Teena Bhatla, Gunjan Sethia, Sonali Narang, Jun H Choi, Xiaotu Ma, Jun J Yang, Stephen Kelly, Elizabeth Raetz, Richard C Harvey, Cheryl Willman, Mignon L Loh, Stephen P Hunger, Patrick A Brown, Kylie M Getz, Cem Meydan, Christopher E Mason, Aristotelis Tsirigos, William L Carroll,

Although B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children and while highly curable, it remains a leading cause of cancer-related mortality. The outgrowth of tumor subclones carrying mutations in genes responsible for resistance to therapy has led to a Darwinian model of clonal selection. Previous work ... Read more >>

Cancer Res (Cancer research)
[2020, 80(23):5189-5202]

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Genetics of osteonecrosis in pediatric acute lymphoblastic leukemia and general populations.

Wenjian Yang, Meenakshi Devidas, Yiwei Liu, Colton Smith, Yunfeng Dai, Naomi Winick, Stephen P Hunger, Mignon L Loh, Elizabeth A Raetz, Eric Larsen, William L Carroll, Stuart S Winter, Kimberly Panter Dunsmore, Leonard A Mattano, Mary V Relling, Seth E Karol,

Blood (Blood)
[2020, :]

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Immunotherapy in Pediatric B-Cell Acute Lymphoblastic Leukemia: Advances and Ongoing Challenges.

Sylwia Jasinski, Francis Andrew De Los Reyes, Gloria Contreras Yametti, Joanna Pierro, Elizabeth Raetz, William L Carroll,

Leukemia, most commonly B-cell acute lymphoblastic leukemia (B-ALL), accounts for about 30% of childhood cancer diagnoses. While there have been dramatic improvements in childhood ALL outcomes, certain subgroups-particularly those who relapse-fare poorly. In addition, cure is associated with significant short- and long-term side effects. Given these challenges, there is great ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2020, 22(5):485-499]

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INDOLENT, NONPROGRESSIVE, MULTIFOCAL CHOROIDAL LESIONS: A Presumed Benign Choroidal Lymphoid Disease.

William J Carroll, Gabor Deak, Mark J Daily, Eduardo Cunha de Souza, Heather N Shelsta, Antonio Marcelo Barbante Casella, Lee M Jampol,

<h4>Purpose</h4>In 2012, four patients with multiple asymptomatic, indolent, unilateral, choroidal lesions were described. We suspected benign-behaving lymphocytes infiltrating the choroid. This article expands the number of patients and duration of follow-up and speculates further on the etiology. Although histopathologic confirmation of these lesions is still unknown, the natural course of ... Read more >>

Retina (Retina (Philadelphia, Pa.))
[2020, 40(10):1980-1987]

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In an era of uncertainty: Impact of COVID-19 on dental education.

Man Hung, Frank W Licari, Eric S Hon, Evelyn Lauren, Sharon Su, Wendy C Birmingham, Lori L Wadsworth, Jane H Lassetter, Tyler C Graff, William Harman, William B Carroll, Martin S Lipsky,

<h4>Purpose/objectives</h4>The coronavirus disease 2019 (COVID-19) pandemic arguably represents the worst public health crisis of the 21<sup>st</sup> century. However, no empirical study currently exists in the literature that examines the impact of the COVID-19 pandemic on dental education. This study evaluated the impact of COVID-19 on dental education and dental students' ... Read more >>

J Dent Educ (Journal of dental education)
[2021, 85(2):148-156]

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Association of GATA3 polymorphisms with minimal residual disease and relapse risk in childhood acute lymphoblastic leukemia.

Hui Zhang, Anthony Pak-Yin Liu, Meenakshi Devidas, Shawn H R Lee, Xueyuan Cao, Deqing Pei, Michael Borowitz, Brent Wood, Julie M Gastier-Foster, Yunfeng Dai, Elizabeth Raetz, Eric Larsen, Naomi Winick, W Paul Bowman, Seth Karol, Wenjian Yang, Paul L Martin, William L Carroll, Ching-Hon Pui, Charles G Mullighan, William E Evans, Cheng Cheng, Stephen P Hunger, Mary V Relling, Mignon L Loh, Jun J Yang,

<h4>Background</h4>Minimal residual disease (MRD) after induction therapy is one of the strongest prognostic factors in childhood acute lymphoblastic leukemia (ALL), and MRD-directed treatment intensification improves survival. Little is known about the effects of inherited genetic variants on inter-patient variability in MRD.<h4>Methods</h4>A genome-wide association study (GWAS) was performed on 2,597 children ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2020, :]

Cited: 1 time

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Children's Oncology Group AALL0434: A Phase III Randomized Clinical Trial Testing Nelarabine in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia.

Kimberly P Dunsmore, Stuart S Winter, Meenakshi Devidas, Brent L Wood, Natia Esiashvili, Zhiguo Chen, Nancy Eisenberg, Nikki Briegel, Robert J Hayashi, Julie M Gastier-Foster, Andrew J Carroll, Nyla A Heerema, Barbara L Asselin, Karen R Rabin, Patrick A Zweidler-Mckay, Elizabeth A Raetz, Mignon L Loh, Kirk R Schultz, Naomi J Winick, William L Carroll, Stephen P Hunger,

<h4>Purpose</h4>Nelarabine is effective in inducing remission in patients with relapsed and refractory T-cell acute lymphoblastic leukemia (T-ALL) but has not been fully evaluated in those with newly diagnosed disease.<h4>Patients and methods</h4>From 2007 to 2014, Children's Oncology Group trial AALL0434 (ClinicalTrials.gov identifier: NCT00408005) enrolled 1,562 evaluable patients with T-ALL age 1-31 ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(28):3282-3293]

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Dental care and personal protective measures for dentists and non-dental health care workers.

Shankargouda Patil, Ibtisam Hussain Moafa, Shilpa Bhandi, Mohammed Abdurabu Jafer, Samar Saeed Khan, Shahrukh Khan, William B Carroll, Kamran Habib Awan,

As a pathogen spread primarily by the respiratory route COVID-19 infection not only poses significant risks to health care workers, but to dentists and dental health care workers, owing to the potential prolonged exposure and proximity to patients. This holds true for non-dentist health care workers who often in the ... Read more >>

Dis Mon (Disease-a-month : DM)
[2020, 66(9):101056]

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World Brain Day 2020: move together to end Parkinson's disease.

Tissa Wijeratne, Wolfgang Grisold, Claudia Trenkwalder, William Carroll,

Lancet Neurol (The Lancet. Neurology)
[2020, 19(8):643]

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Serum neurofilament light as a biomarker in progressive multiple sclerosis.

Raju Kapoor, Kathryn E Smith, Mark Allegretta, Douglas L Arnold, William Carroll, Manuel Comabella, Roberto Furlan, Christopher Harp, Jens Kuhle, David Leppert, Tatiana Plavina, Finn Sellebjerg, Caroline Sincock, Charlotte E Teunissen, Ilir Topalli, Florian von Raison, Elizabeth Walker, Robert J Fox,

There is an unmet need in multiple sclerosis (MS) therapy for treatments to stop progressive disability. The development of treatments may be accelerated if novel biomarkers are developed to overcome the limitations of traditional imaging outcomes revealed in early phase trials. In January 2019, the International Progressive MS Alliance convened ... Read more >>

Neurology (Neurology)
[2020, 95(10):436-444]

Cited: 3 times

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Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia.

Eun Ji Gang, Hye Na Kim, Yao-Te Hsieh, Yongsheng Ruan, Heather A Ogana, Solomon Lee, Jennifer Pham, Huimin Geng, Eugene Park, Lars Klemm, Cheryl L Willman, William L Carroll, Steven D Mittelman, Etan Orgel, Matthew J Oberley, Chintan Parekh, Hisham Abdel-Azim, Deepa Bhojwani, Alan S Wayne, Adèle De Arcangelis, Elisabeth Georges-Labouesse, Elizabeth Wayner, Halvard Bonig, Aspram Minasyan, Johanna Ten Hoeve, Thomas G Graeber, Markus Müschen, Nora Heisterkamp, Yong-Mi Kim,

Resistance to multimodal chemotherapy continues to limit the prognosis of acute lymphoblastic leukemia (ALL). This occurs in part through a process called adhesion-mediated drug resistance, which depends on ALL cell adhesion to the stroma through adhesion molecules, including integrins. Integrin α6 has been implicated in minimal residual disease in ALL ... Read more >>

Blood (Blood)
[2020, 136(2):210-223]

Cited: 2 times

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Successful Outcomes of Newly Diagnosed T Lymphoblastic Lymphoma: Results From Children's Oncology Group AALL0434.

Robert J Hayashi, Stuart S Winter, Kimberly P Dunsmore, Meenakshi Devidas, Zhiguo Chen, Brent L Wood, Michelle L Hermiston, David T Teachey, Sherrie L Perkins, Rodney R Miles, Elizabeth A Raetz, Mignon L Loh, Naomi J Winick, William L Carroll, Stephen P Hunger, Megan S Lim, Thomas G Gross, Catherine M Bollard,

<h4>Purpose</h4>The Children's Oncology Group (COG) protocol AALL0434 evaluated the safety and efficacy of multi-agent chemotherapy with Capizzi-based methotrexate/pegaspargase (C-MTX) in patients with newly diagnosed pediatric T-cell lymphoblastic lymphoma (T-LL) and gained preliminary data using nelarabine in high-risk patients.<h4>Patients and methods</h4>The trial enrolled 299 patients, age 1-31 years. High-risk (HR) patients ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(26):3062-3070]

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