Full Text Journal Articles by
Author William A Ricke

Advertisement

Find full text journal articles






Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.

Jordan E Vellky, Emily A Ricke, Wei Huang, William A Ricke,

Differentiating between indolent and aggressive prostate cancers (CaP) is important to decrease over-treatment and increase survival for men with aggressive disease. Nucleolar prominence is a histologic hallmark of CaP; however, the expression, localization, and functional significance of specific nucleolar proteins has not been thoroughly investigated. Nucleolar protein BOP1 has been ... Read more >>

Am J Pathol (The American journal of pathology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Co-Occurrence of Lower Urinary Tract Symptoms and Frailty among Community-Dwelling Older Men.

Scott R Bauer, Rebecca Scherzer, Anne M Suskind, Peggy Cawthon, Kristine E Ensrud, William A Ricke, Kenneth Covinsky, Lynn M Marshall, ,

BACKGROUND/OBJECTIVES:To estimate associations between lower urinary tract symptoms (LUTS) and phenotypic frailty in older men. DESIGN:Cross-sectional study. SETTING:Community-dwelling men recruited from 2000 to 2002 from six U.S. academic centers for the Osteoporotic Fractures in Men Study. PARTICIPANTS:A total of 5,979 men aged 65 and older. MEASUREMENTS:The independent variable was LUTS severity ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Development and prevalence of castration-resistant prostate cancer subtypes.

Jordan E Vellky, William A Ricke,

BACKGROUND:Castration-resistant prostate cancer (CRPC) occurs when prostate cancer (CaP) progresses under therapy-induced castrate conditions. Several mechanisms have been proposed to explain this acquired resistance, many of which are driven by androgen receptor (AR). Recent findings, however, sub-classified CRPC by downregulation/absence of AR in certain subtypes that consequently do not respond ... Read more >>

Neoplasia (Neoplasia (New York, N.Y.))
[2020, 22(11):566-575]

Cited: 0 times

View full text PDF listing >>



Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia.

Petra Popovics, Wisam N Awadallah, Sarah E Kohrt, Thomas C Case, Nicole L Miller, Emily A Ricke, Wei Huang, Marisol Ramirez-Solano, Qi Liu, Chad M Vezina, Robert J Matusik, William A Ricke, Magdalena M Grabowska,

BACKGROUND:Male lower urinary tract symptoms (LUTS) occur in more than half of men above 50 years of age. LUTS were traditionally attributed to benign prostatic hyperplasia (BPH) and therefore the clinical terminology often uses LUTS and BPH interchangeably. More recently, LUTS were also linked to fibrogenic and inflammatory processes. We ... Read more >>

Prostate (The Prostate)
[2020, 80(10):731-741]

Cited: 0 times

View full text PDF listing >>



Interactive Effects of Perinatal BPA or DES and Adult Testosterone and Estradiol Exposure on Adult Urethral Obstruction and Bladder, Kidney, and Prostate Pathology in Male Mice.

Julia A Taylor, Maren Bell Jones, Cynthia L Besch-Williford, Ashley F Berendzen, William A Ricke, Frederick S Vom Saal,

Obstructive voiding disorder (OVD) occurs during aging in men and is often, but not always, associated with increased prostate size, due to benign prostatic hyperplasia (BPH), prostatitis, or prostate cancer. Estrogens are known to impact the development of both OVD and prostate diseases, either during early urogenital tract development in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(11):]

Cited: 0 times

View full text PDF listing >>



Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: urethral histology.

Hannah Ruetten, Kyle A Wegner, Conner L Kennedy, Anne Turco, Helen L Zhang, Peiqing Wang, Jaskiran Sandhu, Simran Sandhu, Jacquelyn Morkrid, Zunyi Wang, Jill Macoska, Richard E Peterson, Dale E Bjorling, William A Ricke, Paul C Marker, Chad M Vezina,

The National Institutes of Health leveled new focus on sex as a biological variable with the goal of understanding sex-specific differences in health and physiology. We previously published a functional assessment of the impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology (Ruetten H, Wegner KA, Zhang ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2020, 318(3):F617-F627]

Cited: 0 times

View full text PDF listing >>



AGING ALTERS STEROID HORMONE METABOLISM AND EXACERBATES LOWER URINARY TRACT DYSFUNCTION IN MICE.

Teresa T Liu, William A Ricke,

AbstractBenign prostatic hyperplasia (BPH) is a disease of aging that impacts 50% of men in their 50s and 90% of men in their 80s. While rodent models have been invaluable in the study of lower urinary tract dysfunction (LUTD) associated with human disease, many studies recapitulate aspects of aging, steroid ... Read more >>

(Innovation in aging)
[2019, 3(Suppl 1):S887-S888]

Cited: 0 times

View full text PDF listing >>



Fetal bisphenol A and ethinylestradiol exposure alters male rat urogenital tract morphology at birth: Confirmation of prior low-dose findings in CLARITY-BPA.

Kristen S Uchtmann, Julia A Taylor, Barry G Timms, Richard W Stahlhut, Emily A Ricke, Mark R Ellersieck, Frederick S Vom Saal, William A Ricke,

Bisphenol A (BPA) is a contaminant in virtually all Americans. To examine BPA's adverse effects, the FDA-NCTR, NIEHS, and 14 groups of academic scientists formed a consortium: CLARITY-BPA. The purpose of our study was to investigate the effects of a wide range of doses of BPA on fetal development of ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 91:131-141]

Cited: 2 times

View full text PDF listing >>



Synthesis and biological evaluation of FICZ analogues as agonists of aryl hydrocarbon receptor.

Hao Wu, Binkai Liu, Ka Yang, Gabrielle N Winston-McPherson, Eric D Leisten, Chad M Vezina, William A Ricke, Richard E Peterson, Weiping Tang,

The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor involved in multiple biological processes including immune cell differentiation, intestinal function and inflammation. Based on the scaffold of naturally occurring AhR ligand 6-formylindolo (3,2-b) carbazole (FICZ, 2), a series of analogues has been designed, synthesized and evaluated by cell-based ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & medicinal chemistry letters)
[2020, 30(5):126959]

Cited: 0 times

View full text PDF listing >>



Insight and Resources From a Study of the "Impact of Sex, Androgens, and Prostate Size on C57BL/6J Mouse Urinary Physiology.

Hannah Ruetten, Kyle A Wegner, Helen L Zhang, Peiqing Wang, Jaskiran Sandhu, Simran Sandhu, Jacquelyn Morkrid, Brett Mueller, Zunyi Wang, Jill Macoska, Richard E Peterson, Dale E Bjorling, William A Ricke, Paul C Marker, Chad M Vezina,

The purpose of this symposium report is to summarize information from a session 3 oral presentation at the Society of Toxicologic Pathology Annual Symposium in Raleigh, North Carolina. Mice are genetically tractable and are likely to play an important role in elucidating environmental, genetic, and aging-related mechanisms of urinary dysfunction ... Read more >>

Toxicol Pathol (Toxicologic pathology)
[2019, 47(8):1038-1042]

Cited: 0 times

View full text PDF listing >>



Incidence of androgen receptor and androgen receptor variant 7 coexpression in prostate cancer.

Jordan E Vellky, Tyler M Bauman, Emily A Ricke, Wei Huang, William A Ricke,

BACKGROUND:Prostate cancer (PRCA) is an androgen-driven disease, where androgens act through the androgen receptor (AR) to induce proliferation and survival of tumor cells. Recently, AR splice variant 7 (ARv7) has been implicated in advanced stages of PRCA and clinical recurrence. With the widespread use of AR-targeted therapies, there has been ... Read more >>

Prostate (The Prostate)
[2019, 79(16):1811-1822]

Cited: 0 times

View full text PDF listing >>



Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms: What Is the Role and Significance of Inflammation?

Granville L Lloyd, Jeffrey M Marks, William A Ricke,

PURPOSE OF REVIEW:The purpose of this review is to summarize the role and significance of inflammation as a putative additional factor contributing to lower urinary tract symptoms and the progression of benign prostatic hyperplasia. We review (1) the histologic definition of prostatic inflammation and its prevalence, (2) the effects inflammation ... Read more >>

Curr Urol Rep (Current urology reports)
[2019, 20(9):54]

Cited: 2 times

View full text PDF listing >>



Modeling human prostate cancer progression in vitro.

Teresa T Liu, Jonathan A Ewald, Emily A Ricke, Robert Bell, Colin Collins, William A Ricke,

Detailed mechanisms involved in prostate cancer (CaP) development and progression are not well understood. Current experimental models used to study CaP are not well suited to address this issue. Previously, we have described the hormonal progression of non-tumorigenic human prostate epithelial cells (BPH1) into malignant cells via tissue recombination. Here, ... Read more >>

Carcinogenesis (Carcinogenesis)
[2019, 40(7):893-902]

Cited: 1 time

View full text PDF listing >>



Expression and distribution of PIEZO1 in the mouse urinary tract.

Marianela G Dalghi, Dennis R Clayton, Wily G Ruiz, Mohammad M Al-Bataineh, Lisa M Satlin, Thomas R Kleyman, William A Ricke, Marcelo D Carattino, Gerard Apodaca,

The proper function of the organs that make up the urinary tract (kidneys, ureters, bladder, and urethra) depends on their ability to sense and respond to mechanical forces, including shear stress and wall tension. However, we have limited understanding of the mechanosensors that function in these organs and the tissue ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2019, 317(2):F303-F321]

Cited: 1 time

View full text PDF listing >>



MRI-based method for lower urinary tract dysfunction in adult male mice.

Dalton T McLean, David R Rutkowski, Teresa Liu, Diego Hernando, William A Ricke, Alejandro Roldán-Alzate,

Benign prostatic hyperplasia (BPH) develops in the majority of men as they age. As a result, lower urinary tract symptoms (LUTS) often develop, which significantly decrease quality of life. One model of studying BPH/LUTS in mice is to use a hormone-induced model of lower urinary tract dysfunction (LUTD), but current ... Read more >>

(American journal of clinical and experimental urology)
[2019, 7(3):153-158]

Cited: 0 times

View full text PDF listing >>



Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: functional assessment.

Hannah Ruetten, Kyle A Wegner, Helen L Zhang, Peiqing Wang, Jaskiran Sandhu, Simran Sandhu, Brett Mueller, Zunyi Wang, Jill Macoska, Richard E Peterson, Dale E Bjorling, William A Ricke, Paul C Marker, Chad M Vezina,

Laboratory mice are used to identify causes of urinary dysfunction including prostate-related mechanisms of lower urinary tract symptoms. Effective use of mice for this purpose requires a clear understanding of molecular, cellular, anatomic, and endocrine contributions to voiding function. Whether the prostate influences baseline voiding function has not been specifically ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2019, 317(4):F996-F1009]

Cited: 0 times

View full text PDF listing >>



Estrogen receptor 1 expression and methylation of Esr1 promoter in mouse fetal prostate mesenchymal cells induced by gestational exposure to bisphenol A or ethinylestradiol.

Ramji K Bhandari, Julia A Taylor, Jennifer Sommerfeld-Sager, Donald E Tillitt, William A Ricke, Frederick S Vom Saal,

Fetal/neonatal environmental estrogen exposures alter developmental programing of the prostate gland causing onset of diseases later in life. We have previously shown in vitro that exposures to 17β-estradiol (E2) and the endocrine disrupting chemical bisphenol A, at concentrations relevant to human exposure, cause an elevation of estrogen receptor α (Esr1) ... Read more >>

(Environmental epigenetics)
[2019, 5(3):dvz012]

Cited: 1 time

View full text PDF listing >>



Tissue-specific quantification and localization of androgen and estrogen receptors in prostate cancer.

Priyanka D Sehgal, Tyler M Bauman, Tristan M Nicholson, Jordan E Vellky, Emily A Ricke, Weiping Tang, Wei Xu, Wei Huang, William A Ricke,

Androgens and estrogens, working together, promote prostate cancer (PRCA) initiation and progression, with androgens acting via androgen receptor (AR) and estrogens acting primarily through estrogen receptor α (ERα). While the interplay between these steroid hormones has been established, the interaction between steroid hormone receptors in prostatic disease remains unstudied. The ... Read more >>

Hum. Pathol. (Human pathology)
[2019, 89:99-108]

Cited: 3 times

View full text PDF listing >>



Void sorcerer: an open source, open access framework for mouse uroflowmetry.

Zunyi Wang, Emmanuel Contreras Guzman, Amit Nimunkar, Kimberly P Keil, Chad M Vezina, William A Ricke, Jill Macoska, Dale E Bjorling,

Observational and experimental studies of rodent voiding behaviors have greatly contributed to our understanding of lower urinary tract function including the complex social, environmental, and internal stimuli that affect voiding in health and models of disease. Void spot assays (VSA), cystometry (awake or anesthetized), and uroflowmetry are techniques commonly used ... Read more >>

(American journal of clinical and experimental urology)
[2019, 7(3):170-177]

Cited: 1 time

View full text PDF listing >>



Prostate Transition Zone Fibrosis is Associated with Clinical Progression in the MTOPS Study.

Jill A Macoska, Kristen S Uchtmann, Glen E Leverson, Kevin T McVary, William A Ricke,

PURPOSE:Medications targeting androgen receptor activity (eg finasteride) or smooth muscle contractility (eg doxazosin) do not resolve lower urinary tract symptoms indicative of lower urinary tract dysfunction in an important subgroup of men. Recently fibrosis has been implicated as another pathobiology contributing to male lower urinary tract symptoms but to our ... Read more >>

J. Urol. (The Journal of urology)
[2019, 202(6):1240-1247]

Cited: 0 times

View full text PDF listing >>



Inflammation, Voiding and Benign Prostatic Hyperplasia Progression.

Granville L Lloyd, William A Ricke, Kevin T McVary,

J. Urol. (The Journal of urology)
[2019, 201(5):868-870]

Cited: 0 times

View full text PDF listing >>



Targeting a fibrotic bottleneck may provide an opening in the treatment of LUTS.

William A Ricke, Reginald C Bruskewitz, Teresa T Liu,

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2019, 316(6):F1091-F1093]

Cited: 1 time

View full text PDF listing >>



Expression and Localization of DDX3 in Prostate Cancer Progression and Metastasis.

Jordan E Vellky, Emily A Ricke, Wei Huang, William A Ricke,

Survival rates decrease significantly when localized prostate cancer (CaP) becomes metastatic, emphasizing the need for improved targeted therapies. DDX3, an RNA helicase, has widespread functions in RNA regulation, in both the nucleus and cytoplasm. Although DDX3 has been implicated as a prognostic marker for many cancers, including primary CaP, its ... Read more >>

Am. J. Pathol. (The American journal of pathology)
[2019, 189(6):1256-1267]

Cited: 1 time

View full text PDF listing >>



Development of the human prostate.

Gerald R Cunha, Chad M Vezina, Dylan Isaacson, William A Ricke, Barry G Timms, Mei Cao, Omar Franco, Laurence S Baskin,

This paper provides a detailed compilation of human prostatic development that includes human fetal prostatic gross anatomy, histology, and ontogeny of selected epithelial and mesenchymal differentiation markers and signaling molecules throughout the stages of human prostatic development: (a) pre-bud urogenital sinus (UGS), (b) emergence of solid prostatic epithelial buds from ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2018, 103:24-45]

Cited: 8 times

View full text PDF listing >>



Endocrine disruptor bisphenol A is implicated in urinary voiding dysfunction in male mice.

Tristan M Nicholson, Jalissa L Nguyen, Glen E Leverson, Julia A Taylor, Frederick S Vom Saal, Ronald W Wood, William A Ricke,

Estrogens, acting synergistically with androgens, are known from animal experiments to be important in lower urinary tract symptoms (LUTS) and benign prostate enlargement. Human exposure to environmental estrogens occurs throughout the life span, but the urologic health risks in men are largely unknown. Bisphenol A (BPA) is an endocrine disruptor ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 315(5):F1208-F1216]

Cited: 3 times

View full text PDF listing >>



Advertisement

Disclaimer
1.1212 s