Full Text Journal Articles by
Author William A Mattingly

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Socioeconomic Position and the Incidence, Severity, and Clinical Outcomes of Hospitalized Patients With Community-Acquired Pneumonia.

Timothy L Wiemken, Ruth M Carrico, Stephen P Furmanek, Brian E Guinn, William A Mattingly, Paula Peyrani, Julio A Ramirez,

OBJECTIVES:The influence of socioeconomic disparities on adults with pneumonia is not well understood. The objective of our study was to evaluate the relationship between community-level socioeconomic position, as measured by an area deprivation index, and the incidence, severity, and outcomes among adults with community-acquired pneumonia (CAP). METHODS:This was an ancillary ... Read more >>

Public Health Rep (Public health reports (Washington, D.C. : 1974))
[2020, 135(3):364-371]

Cited: 0 times

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Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine Against Hospitalization for Community-Acquired Pneumonia in Older US Adults: A Test-Negative Design.

John M McLaughlin, Qin Jiang, Raul E Isturiz, Heather L Sings, David L Swerdlow, Bradford D Gessner, Ruth M Carrico, Paula Peyrani, Timothy L Wiemken, William A Mattingly, Julio A Ramirez, Luis Jodar,

Background:Following universal recommendation for use of 13-valent pneumococcal conjugate vaccine (PCV13) in US adults aged ≥65 years in September 2014, we conducted the first real-world evaluation of PCV13 vaccine effectiveness (VE) against hospitalized vaccine-type community-acquired pneumonia (CAP) in this population. Methods:Using a test-negative design, we identified cases and controls from ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 67(10):1498-1506]

Cited: 10 times

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Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia.

Forest W Arnold, Gustavo Lopardo, Timothy L Wiemken, Robert Kelley, Paula Peyrani, William A Mattingly, Charles Feldman, Martin Gnoni, Rosemeri Maurici, Julio A Ramirez, ,

BACKGROUND:Community-acquired pneumonia (CAP) has a potential complication of bacteremia. The objective of this study was to define the clinical outcomes of patients with CAP and bacteremia treated with and without a macrolide. MATERIALS AND METHODS:Secondary analysis of the Community-Acquired Pneumonia Organization database of hospitalized patients with CAP. Patients with a ... Read more >>

Respir Med (Respiratory medicine)
[2018, 140:115-121]

Cited: 2 times

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Googling your hand hygiene data: Using Google Forms, Google Sheets, and R to collect and automate analysis of hand hygiene compliance monitoring.

Timothy L Wiemken, Stephen P Furmanek, William A Mattingly, Janet Haas, Julio A Ramirez, Ruth M Carrico,

BACKGROUND:Hand hygiene is one of the most important interventions in the quest to eliminate healthcare-associated infections, and rates in healthcare facilities are markedly low. Since hand hygiene observation and feedback are critical to improve adherence, we created an easy-to-use, platform-independent hand hygiene data collection process and an automated, on-demand reporting ... Read more >>

Am J Infect Control (American journal of infection control)
[2018, 46(6):617-619]

Cited: 0 times

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Adults Hospitalized With Pneumonia in the United States: Incidence, Epidemiology, and Mortality.

Julio A Ramirez, Timothy L Wiemken, Paula Peyrani, Forest W Arnold, Robert Kelley, William A Mattingly, Raul Nakamatsu, Senen Pena, Brian E Guinn, Stephen P Furmanek, Annuradha K Persaud, Anupama Raghuram, Francisco Fernandez, Leslie Beavin, Rahel Bosson, Rafael Fernandez-Botran, Rodrigo Cavallazzi, Jose Bordon, Claudia Valdivieso, Joann Schulte, Ruth M Carrico, ,

Understanding the burden of community-acquired pneumonia (CAP) is critical to allocate resources for prevention, management, and research. The objectives of this study were to define incidence, epidemiology, and mortality of adult patients hospitalized with CAP in the city of Louisville, and to estimate burden of CAP in the US adult ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 65(11):1806-1812]

Cited: 32 times

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The Effects of Kentucky's Comprehensive Opioid Legislation on Patients Presenting with Prescription Opioid or Heroin Abuse to One Urban Emergency Department.

Kiran A Faryar, Clifford L Freeman, Annuradha K Persaud, Stephen P Furmanek, Brian E Guinn, William A Mattingly, Timothy L Wiemken, Kimberley A Buckner, Martin R Huecker,

Prescription opioid abuse has increased to epidemic proportions in the United States. Kentucky, along with other states, passed comprehensive legislation to monitor and curb opioid prescribing.This paper characterizes patients who presented to the emergency department (ED) after abusing prescription opioids and heroin prior to and after the passage of House ... Read more >>

J Emerg Med (The Journal of emergency medicine)
[2017, 53(6):805-814]

Cited: 2 times

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Methods for computational disease surveillance in infection prevention and control: Statistical process control versus Twitter's anomaly and breakout detection algorithms.

Timothy L Wiemken, Stephen P Furmanek, William A Mattingly, Marc-Oliver Wright, Annuradha K Persaud, Brian E Guinn, Ruth M Carrico, Forest W Arnold, Julio A Ramirez,

BACKGROUND:Although not all health care-associated infections (HAIs) are preventable, reducing HAIs through targeted intervention is key to a successful infection prevention program. To identify areas in need of targeted intervention, robust statistical methods must be used when analyzing surveillance data. The objective of this study was to compare and contrast ... Read more >>

Am J Infect Control (American journal of infection control)
[2018, 46(2):124-132]

Cited: 0 times

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The order of administration of macrolides and beta-lactams may impact the outcomes of hospitalized patients with community-acquired pneumonia: results from the community-acquired pneumonia organization.

Paula Peyrani, Timothy L Wiemken, Mark L Metersky, Forest W Arnold, William A Mattingly, Charles Feldman, Rodrigo Cavallazzi, Rafael Fernandez-Botran, Jose Bordon, Julio A Ramirez,

The beneficial effect of macrolides for the treatment of community-acquired pneumonia (CAP) in combination with beta-lactams may be due to their anti-inflammatory activity. In patients with pneumococcal meningitis, the use of steroids improves outcomes only if they are administered before beta-lactams. The objective of this study was to compare outcomes ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2018, 50(1):13-20]

Cited: 6 times

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Infection prevention and control and the refugee population: Experiences from the University of Louisville Global Health Center.

Ruth M Carrico, Linda Goss, Timothy L Wiemken, Rahel S Bosson, Paula Peyrani, William A Mattingly, Allison Pauly, Rebecca A Ford, Stanley Kotey, Julio A Ramirez,

During 2016, approximately 140,000 individuals entered the United States as part of the federal government refugee resettlement program and established themselves in communities in virtually every state. No national database regarding refugee health currently exists; therefore, little is known about existing infectious diseases, conditions, and cultural practices that impact successful ... Read more >>

Am J Infect Control (American journal of infection control)
[2017, 45(6):673-676]

Cited: 2 times

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Process control charts in infection prevention: Make it simple to make it happen.

Timothy L Wiemken, Stephen P Furmanek, Ruth M Carrico, William A Mattingly, Annuradha K Persaud, Brian E Guinn, Robert R Kelley, Julio A Ramirez,

Quality improvement is central to Infection Prevention and Control (IPC) programs. Challenges may occur when applying quality improvement methodologies like process control charts, often due to the limited exposure of typical IPs. Because of this, our team created an open-source database with a process control chart generator for IPC programs. ... Read more >>

Am J Infect Control (American journal of infection control)
[2017, 45(3):216-221]

Cited: 0 times

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Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia: a pilot study.

Timothy L Wiemken, Robert R Kelley, Rafael Fernandez-Botran, William A Mattingly, Forest W Arnold, Stephen P Furmanek, Marcos I Restrepo, James D Chalmers, Paula Peyrani, Rodrigo Cavallazzi, Jose Bordon, Stefano Aliberti, Julio A Ramirez,

Patients with severe community-acquired pneumonia (CAP) are believed to have an exaggerated inflammatory response to bacterial infection. Therapies aiming to modulate the inflammatory response have been largely unsuccessful, perhaps reflecting that CAP is a heterogeneous disorder that cannot be modulated by a single anti-inflammatory approach. We hypothesize that the host ... Read more >>

Univ Louisville J Respir Infect (The University of Louisville journal of respiratory infections)
[2017, 1(1):3-11]

Cited: 1 time

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Disinfectant sprays versus wipes: Applications in behavioral health.

Timothy L Wiemken, Whitney Powell, Ruth M Carrico, William A Mattingly, Robert R Kelley, Stephen P Furmanek, Debra Johnson, Julio A Ramirez,

We evaluated the utility and usability of a spray and a wipe-based cleaner/disinfectant in a behavioral health setting where health care providers institute cleaning and disinfection procedures. The spray-based version resulted in significantly lower adenosine triphosphate readings after use compared with the wipe version. Staff surveys indicated that users preferred ... Read more >>

Am J Infect Control (American journal of infection control)
[2016, 44(12):1698-1699]

Cited: 0 times

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The upper respiratory tract microbiome of hospitalised patients with community-acquired pneumonia of unknown aetiology: a pilot study.

Timothy L Wiemken, Venkatakrishna Rao Jala, Robert R Kelley, Paula Peyrani, William A Mattingly, Forest W Arnold, Patricio W Cabral, Rodrigo Cavallazzi, Bodduluri Haribabu, Julio A Ramirez,

The composition of the upper respiratory tract microbiome may play an important role in the development of lower respiratory tract infections. Here, we characterised the microbiome of the nasopharynx and oropharynx of hospitalised patients with community-acquired pneumonia (CAP) with unknown aetiology in an attempt to obtain insight into the aetiology ... Read more >>

Pneumonia (Nathan) (Pneumonia (Nathan Qld.))
[2015, 6:83-89]

Cited: 0 times

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An iterative workflow for creating biomedical visualizations using Inkscape and D3.js.

William A Mattingly, Robert R Kelley, Julia H Chariker, Tim Weimken, Julio Ramirez,

BMC Bioinformatics (BMC bioinformatics)
[2015, 16(Suppl 15):P10-P10]

Cited: 0 times

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Real-Time Enrollment Dashboard For Multisite Clinical Trials.

William A Mattingly, Robert R Kelley, Timothy L Wiemken, Julia H Chariker, Paula Peyrani, Brian E Guinn, Laura E Binford, Kimberley Buckner, Julio Ramirez,

OBJECTIVE:Achieving patient recruitment goals are critical for the successful completion of a clinical trial. We designed and developed a web-based dashboard for assisting in the management of clinical trial screening and enrollment. MATERIALS AND METHODS:We use the dashboard to assist in the management of two observational studies of community-acquired pneumonia. ... Read more >>

Contemp Clin Trials Commun (Contemporary clinical trials communications)
[2015, 1:17-21]

Cited: 3 times

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Visual grids for managing data completeness in clinical research datasets.

Robert R Kelley, William A Mattingly, Timothy L Wiemken, Mohammad Khan, Daniel Coats, Daniel Curran, Julia H Chariker, Julio Ramirez,

Missing data arise in clinical research datasets for reasons ranging from incomplete electronic health records to incorrect trial data collection. This has an adverse effect on analysis performed with the data, but it can also affect the management of a clinical trial itself. We propose two graphical visualization schemes to ... Read more >>

J Biomed Inform (Journal of biomedical informatics)
[2015, 54:337-344]

Cited: 1 time

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Efficacy of a novel skin antiseptic against carbapenem-resistant Enterobacteriaceae.

Timothy L Wiemken, Robert R Kelley, Ruth M Carrico, Laura E Binford, Brian E Guinn, William A Mattingly, Paula Peyrani, Julio A Ramirez,

Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are increasing on a global scale. Because of the need for CRE transmission prevention and control, we sought to evaluate the efficacy of a silver-based skin antiseptic against these organisms. Using a human skin analog, a third party laboratory conducted efficacy testing. The results ... Read more >>

Am J Infect Control (American journal of infection control)
[2015, 43(4):380-382]

Cited: 2 times

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