Full Text Journal Articles by
Author William A Cliby

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Rectosigmoid resection by gynecologic oncologists versus colorectal surgeons: as long as it catches the mouse, does the color of the cat matter?

Suk Joon Chang, Christina Fotopoulou, Robert E Bristow, Dennis S Chi, William A Cliby,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e51]

Cited: 0 times

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Association of a novel endometrial cancer biomarker panel with prognostic risk, platinum insensitivity, and targetable therapeutic options.

Jesus Gonzalez Bosquet, Qing Zhang, William A Cliby, Jamie N Bakkum-Gamez, Ling Cen, Sean C Dowdy, Mark E Sherman, S John Weroha, Amy C Clayton, Benjamin R Kipp, Kevin C Halling, Fergus J Couch, Karl C Podratz,

During the past decade, the age-adjusted mortality rate for endometrial cancer (EC) increased 1.9% annually with TP53 mutant (TP53-mu) EC disproportionally represented in advanced disease and deaths. Therefore, we aimed to assess pivotal molecular parameters that differentiate clinical outcomes in high- and low-risk EC. Using the Cancer Genome Atlas, we ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0245664]

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Appropriate triage allows aggressive primary debulking surgery with rates of morbidity and mortality comparable to interval surgery after chemotherapy.

Deepa M Narasimhulu, Aneesa Thannickal, Amanika Kumar, Amy L Weaver, Michaela E McGree, Carrie L Langstraat, William A Cliby,

<h4>Objective</h4>Morbidity and mortality (M/M) after primary debulking surgery (PDS) is often cited as a rationale for neoadjuvant chemotherapy and interval debulking surgery (IDS). We tested if using an evidence-based algorithm to identify patients fit for surgery would reduce M/M after PDS to that seen after IDS.<h4>Methods</h4>We included women who underwent ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 160(3):681-687]

Cited: 0 times

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Invasive vulvar extramammary Paget's disease in the United States.

Toni P Kilts, Beverly Long, Amy E Glasgow, Jamie N Bakkum-Gamez, Elizabeth B Habermann, William A Cliby,

<h4>Objective</h4>To assess the incidence, treatment, and outcomes in patients with invasive vulvar extramammary Paget's disease (EMPD) in a national cohort of patients.<h4>Methods</h4>Patients from the Surveillance, Epidemiology and End Results (SEER) database with diagnoses of vulvar EMPD from 1992 to 2016 were included. Demographic, treatment, and outcome data were analyzed.<h4>Results</h4>A total ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 157(3):649-655]

Cited: 2 times

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Less guessing, more evidence in identifying patients least fit for cytoreductive surgery in advanced ovarian cancer: A triage algorithm to individualize surgical management.

Deepa Maheswari Narasimhulu, Amanika Kumar, Amy L Weaver, Carrie L Langstraat, William A Cliby,

<h4>Objective</h4>We previously reported an algorithm that identifies women at high risk of postoperative morbidity & mortality (M/M) as a tool to triage between neoadjuvant chemotherapy and primary surgery for epithelial ovarian cancer (EOC). We sought to independently validate its performance using multicenter data.<h4>Methods</h4>Women who underwent surgery for stage IIIC/IV EOC ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 157(3):572-577]

Cited: 3 times

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Advanced Ovarian Cancer: Weighing the Risks and Benefits of Surgery.

Amanika Kumar, William A Cliby,

Treatment for patients with advanced ovarian cancer includes a combination of platinum-based chemotherapy and maximally cytoreductive surgery. The 2 options for initial treatment include upfront surgery followed by adjuvant chemotherapy or neoadjuvant chemotherapy followed by interval surgery. Deciding between which approach is a on the basis of several factors: (1) ... Read more >>

Clin Obstet Gynecol (Clinical obstetrics and gynecology)
[2020, 63(1):74-79]

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Implementing robotic surgery for uterine cancer in the United States: Better outcomes without increased costs.

Jvan Casarin, Chao Song, Francesco Multinu, Serena Cappuccio, Emelline Liu, Kristina A Butler, Gretchen E Glaser, William A Cliby, Carrie L Langstraat, Fabio Ghezzi, Alex Z Fu, Andrea Mariani,

OBJECTIVE:To examine the effect of robotic-assisted surgery implementation for treatment of endometrial cancer in the United States on 30-day clinical outcomes and costs. METHODS:We retrospectively reviewed data of adult patients who underwent total hysterectomy for endometrial cancer in the US hospitals in Premier Healthcare Database between January 1, 2008 and ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 156(2):451-458]

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Multicenter study comparing oncologic outcomes after lymph node assessment via a sentinel lymph node algorithm versus comprehensive pelvic and paraaortic lymphadenectomy in patients with serous and clear cell endometrial carcinoma.

Brooke A Schlappe, Amy L Weaver, Michaela E McGree, Jennifer Ducie, Ane Gerda Zahl Eriksson, Sean C Dowdy, William A Cliby, Gretchen E Glaser, Nadeem R Abu-Rustum, Andrea Mariani, Mario M Leitao,

<h4>Objectives</h4>To compare survival after nodal assessment using a sentinel lymph node (SLN) algorithm versus comprehensive pelvic and paraaortic lymphadenectomy (LND) in serous or clear cell endometrial carcinoma, and to compare survival in node-negative cases.<h4>Methods</h4>Three-year recurrence-free survival (RFS) and overall survival were compared between one institution that used comprehensive LND to ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 156(1):62-69]

Cited: 5 times

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Using evidence to direct quality improvement efforts: Defining the highest impact complications after complex cytoreductive surgery for ovarian cancer.

Deepa Maheswari Narasimhulu, Katherine A Bews, Kristine T Hanson, Yu-Hui H Chang, Sean C Dowdy, William A Cliby,

<h4>Objective</h4>We sought to identify postoperative complications with the greatest impact on patient-centric outcomes to serve as high yield QI targets in ovarian cancer (OC) surgery.<h4>Methods</h4>Women undergoing complex CRS (defined as cytoreductive surgery with colon resection) for OC between January 1, 2012 and 12/31/2016 were identified from the National Surgical Quality ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 156(2):278-283]

Cited: 1 time

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Role of lymphadenectomy in endometrial cancer with nonbulky lymph node metastasis: Comparison of comprehensive surgical staging and sentinel lymph node algorithm.

Francesco Multinu, Jennifer A Ducie, Ane Gerda Zahl Eriksson, Brooke A Schlappe, William A Cliby, Gretchen E Glaser, Tommaso Grassi, Gary L Keeney, Amy L Weaver, Nadeem R Abu-Rustum, Mario M Leitao, Andrea Mariani,

<h4>Objectives</h4>To compare survival and progression outcomes between 2 nodal assessment approaches in patients with nonbulky stage IIIC endometrial cancer (EC).<h4>Methods</h4>Patients with stage IIIC EC treated at 2 institutions were retrospectively identified. At 1 institution, a historical series (2004-2008) was treated with systematic pelvic and para-aortic lymphadenectomy (LND cohort). At the ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 155(2):177-185]

Cited: 3 times

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Using an evidence-based triage algorithm to reduce 90-day mortality after primary debulking surgery for advanced epithelial ovarian cancer.

Deepa M Narasimhulu, Amanika Kumar, Amy L Weaver, Michaela E McGree, Carrie L Langstraat, William A Cliby,

<h4>Objective</h4>To evaluate the impact of an evidence-based triage algorithm to decide between primary debulking surgery (PDS) and neoadjuvant chemotherapy followed by interval debulking surgery (NACT/IDS) for advanced epithelial ovarian cancer (EOC).<h4>Methods</h4>Surgical morbidity and mortality (M/M) after PDS for stage IIIC-IV EOC at Mayo Clinic after implementation of the triage algorithm ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 155(1):58-62]

Cited: 5 times

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Comparing risk stratification criteria for predicting lymphatic dissemination in endometrial cancer.

Toni P Kilts, Gretchen E Glaser, Carrie L Langstraat, Amanika Kumar, Amy L Weaver, Michaela E Mc Gree, Bobbie S Gostout, Karl C Podratz, Sean C Dowdy, William A Cliby, Andrea Mariani, Jamie N Bakkum-Gamez,

<h4>Objective</h4>To compare two published risk stratification models (Milwaukee Model vs. Mayo Criteria) to predict lymphatic dissemination (LD) in endometrioid endometrial cancer (EC).<h4>Methods</h4>Patients with stage I-III EC undergoing surgery from 1/1/2004-9/30/2013 were retrospectively reviewed and classified as low-risk vs at-risk for LD using two independent risk models. LD was defined as ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 155(1):21-26]

Cited: 0 times

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Genes associated with bowel metastases in ovarian cancer.

Andrea Mariani, Chen Wang, Ann L Oberg, Shaun M Riska, Michelle Torres, Joseph Kumka, Francesco Multinu, Gunisha Sagar, Debarshi Roy, Deok-Beom Jung, Qing Zhang, Tommaso Grassi, Daniel W Visscher, Vatsal P Patel, Ling Jin, Julie K Staub, William A Cliby, Saravut J Weroha, Kimberly R Kalli, Lynn C Hartmann, Scott H Kaufmann, Ellen L Goode, Viji Shridhar,

<h4>Objective</h4>This study is designed to identify genes and pathways that could promote metastasis to the bowel in high-grade serous ovarian cancer (OC) and evaluate their associations with clinical outcomes.<h4>Methods</h4>We performed RNA sequencing of OC primary tumors (PTs) and their corresponding bowel metastases (n = 21 discovery set; n = 18 replication set). Differentially expressed ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 154(3):495-504]

Cited: 6 times

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Ultrastaging of negative pelvic lymph nodes to decrease the true prevalence of isolated paraaortic dissemination in endometrial cancer.

Francesco Multinu, Jvan Casarin, Serena Cappuccio, Gary L Keeney, Gretchen E Glaser, William A Cliby, Amy L Weaver, Michaela E McGree, Stefano Angioni, Gavino Faa, Mario M Leitao, Nadeem R Abu-Rustum, Andrea Mariani,

<h4>Objective</h4>This study aimed to determine the prevalence of occult pelvic lymph node metastasis in patients with endometrial cancer (EC) with isolated paraaortic dissemination who underwent pelvic and paraaortic lymphadenectomy.<h4>Methods</h4>From 2004 to 2008, patients undergoing surgery for EC at our institution were prospectively treated according to a validated surgical algorithm relying ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 154(1):60-64]

Cited: 1 time

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Models to predict outcomes after primary debulking surgery: Independent validation of models to predict suboptimal cytoreduction and gross residual disease.

Amanika Kumar, Shannon Sheedy, Bohyun Kim, Rudy Suidan, Debra M Sarasohn, Ines Nikolovski, Yulia Lakhman, Michaela E McGree, Amy L Weaver, Dennis Chi, William A Cliby,

<h4>Objective</h4>Treatment planning requires accurate estimation of surgical complexity (SC) and residual disease (RD) at primary debulking surgery (PDS) for advanced ovarian cancer (OC). We sought to independently validate two published computed tomography (CT) prediction models.<h4>Methods</h4>We included stage IIIC/IV OC patients who underwent PDS from 2003 to 2011. Two prediction models ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 154(1):72-76]

Cited: 2 times

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Should mucosal bowel invasion in ovarian cancer be assigned to FIGO stage IV disease?

Ismail Mert, Amanika Kumar, Diogo Torres, Yajue Huang, Michaela E McGree, Amy L Weaver, William A Cliby,

OBJECTIVES:The FIGO staging consensus agreement from 2012 indicates that bowel mucosal invasion for epithelial ovarian cancer (EOC) should be assigned to stage IV disease. Finding no evidence justifying this recommendation, we examined the impact of recto-sigmoid colonic invasion on survival based on depth of invasion. METHODS:Patients having recto-sigmoid resection to ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 153(2):238-241]

Cited: 3 times

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Frailty in ovarian cancer identified the need for increased postoperative care requirements following cytoreductive surgery.

TingTing Yao, Stephanie R DeJong, Michaela E McGree, Amy L Weaver, William A Cliby, Amanika Kumar,

<h4>Objectives</h4>We sought to examine the relationship between frailty and complicated postoperative courses, including intensive care unit (ICU) admission and non-home discharge, in patients with advanced ovarian cancer (OC) undergoing primary debulking surgery (PDS) for curative intent.<h4>Methods</h4>Patients were identified from a retrospectively collected database at a single institution between 1/1/2003-12/31/2011. A ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 153(1):68-73]

Cited: 0 times

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Factors influencing the adoption of the sentinel lymph node technique for endometrial cancer staging: an international survey of gynecologic oncologists.

Jvan Casarin, Francesco Multinu, Nadeem Abu-Rustum, David Cibula, William A Cliby, Fabio Ghezzi, Mario Leitao, Ikuo Konishi, Joo-Hyun Nam, Denis Querleu, Pamela T Soliman, Kathleen J Yost, Amy L Weaver, Andrea Mariani, Gretchen E Glaser,

<h4>Objective</h4>To explore the factors influencing adoption of the sentinel lymph node (SLN) technique for endometrial cancer staging among gynecologic oncologists.<h4>Methods</h4>A self-administered, web-based survey was sent via email (April 20 through May 21, 2017) to all members of European Society of Gynecologic Oncologists, International Gynecologic Cancer Society, and Society of Gynecologic ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2019, 29(1):60-67]

Cited: 4 times

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Beyond prophylaxis: Extended risk of venous thromboembolism following primary debulking surgery for ovarian cancer.

Beth E Wagner, Carrie L Langstraat, Michaela E McGree, Amy L Weaver, Shikha Sarangi, Bahareh Mokri, Sean C Dowdy, William A Cliby, Amanika Kumar, Jamie N Bakkum-Gamez,

<h4>Objective</h4>To determine the incidence and risk factors for venous thromboembolism (VTE) within six months after primary debulking surgery (PDS) for epithelial ovarian cancer (EOC).<h4>Methods</h4>In a historical cohort, we estimated the cumulative incidence of clinically diagnosed VTE within 6 months among consecutive women who underwent PDS for EOC at a single institution ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 152(2):286-292]

Cited: 4 times

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Mesenchymal molecular subtype is an independent predictor of severe postoperative complications after primary debulking surgery for advanced ovarian cancer.

Diogo Torres, Amanika Kumar, Jamie N Bakkum-Gamez, Amy L Weaver, Michaela E McGree, Chen Wang, Carrie L Langstraat, William A Cliby,

<h4>Objective</h4>To evaluate the contribution of molecular subtype to 30-day postoperative complications and 90-day mortality after primary debulking surgery (PDS) in advanced stage high-grade serous ovarian cancer (HGSOC).<h4>Methods</h4>Patients with stages III-IV HGSOC undergoing PDS from 1994 to 2011 with available molecular subtyping were included. Residual disease (RD) status was categorized as ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 152(2):223-227]

Cited: 3 times

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Cancer-associated stroma significantly contributes to the mesenchymal subtype signature of serous ovarian cancer.

Qing Zhang, Chen Wang, William A Cliby,

<h4>Objective</h4>Mesenchymal (MES) subtype of high-grade serous ovarian cancer (HGSOC) is associated with worse outcomes including survival and resectability compared with other molecular subtypes. Molecular subtypes have historically been derived from 'tumor', consisting of both cancer and stromal cells. We sought to determine the origins of multiple MES subtype gene signatures ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 152(2):368-374]

Cited: 7 times

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Quality indicators in gynecologic oncology.

Sean C Dowdy, William A Cliby, Abimbola O Famuyide,

Gynecol Oncol (Gynecologic oncology)
[2018, 151(2):366-373]

Cited: 0 times

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Multicenter study comparing oncologic outcomes between two nodal assessment methods in patients with deeply invasive endometrioid endometrial carcinoma: A sentinel lymph node algorithm versus a comprehensive pelvic and paraaortic lymphadenectomy.

Brooke A Schlappe, Amy L Weaver, Jennifer A Ducie, Ane Gerda Zahl Eriksson, Sean C Dowdy, William A Cliby, Gretchen E Glaser, Robert A Soslow, Kaled M Alektiar, Vicky Makker, Nadeem R Abu-Rustum, Andrea Mariani, Mario M Leitao,

<h4>Objectives</h4>To compare oncologic outcomes in the staging of deeply invasive endometrioid endometrial carcinoma (EEC) using a sentinel lymph node algorithm (SLN) versus pelvic and paraaortic lymphadenectomy to the renal veins (LND); to compare outcomes in node-negative cases.<h4>Methods</h4>At two institutions, patients with deeply invasive (≥50% myometrial invasion) EEC were identified. One ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2018, 151(2):235-242]

Cited: 8 times

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Impact of Sentinel Node Approach in Gynecologic Cancer on Training Needs.

Amanika Kumar, Sumer A Wallace, William A Cliby, Gretchen E Glaser, Andrea Mariani, Mario M Leitao, Michael Frumovitz, Carrie L Langstraat,

STUDY OBJECTIVE:We sought to estimate the impact of sentinel nodes in gynecologic oncology on fellowship training and discuss potential solutions. DESIGN:Retrospective multi-institution cohort (Canadian Task Force classification II-2). SETTING:Three tertiary cancer referral cancer centers. PATIENTS:Patients with endometrial and vulvar cancer undergoing lymph node evaluation. INTERVENTIONS:Patient history and fellow case volumes ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2019, 26(4):727-732]

Cited: 1 time

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LY2157299 Monohydrate, a TGF-βR1 Inhibitor, Suppresses Tumor Growth and Ascites Development in Ovarian Cancer.

Qing Zhang, Xiaonan Hou, Bradley J Evans, Jamison L VanBlaricom, Saravut J Weroha, William A Cliby,

Transforming growth factor beta (TGF-β) signaling has pleiotropic functions regulating cancer initiation, development, and metastasis, and also plays important roles in the interaction between stromal and cancer cells, making the pathway a potential therapeutic target. LY2157299 monohydrate (LY), an inhibitor of TGF-β receptor I (TGFBRI), was examined for its ability ... Read more >>

Cancers (Basel) (Cancers)
[2018, 10(8):]

Cited: 8 times

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