Full Text Journal Articles by
Author William A Banks

Advertisement

Find full text journal articles






Effects of apolipoprotein E isoform, sex, and diet on insulin BBB pharmacokinetics in mice.

Elizabeth M Rhea, Kim Hansen, Sarah Pemberton, Eileen Ruth S Torres, Sarah Holden, Jacob Raber, William A Banks,

Age, apolipoprotein E (apoE) isoform, sex, and diet can independently affect the risk for the development of Alzheimer's disease (AD). Additionally, synergy between some of these risk factors have been observed. However, the relation between the latter three risk factors has not been investigated. Central nervous system (CNS) insulin resistance ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):18636]

Cited: 0 times

View full text PDF listing >>



Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain.

Aric F Logsdon, Kendra L Francis, Nicole E Richardson, Shannon J Hu, Chelsea L Faber, Bao Anh Phan, Vy Nguyen, Naly Setthavongsack, William A Banks, Randy L Woltjer, C Dirk Keene, Caitlin S Latimer, Michael W Schwartz, Jarrad M Scarlett, Kimberly M Alonge,

The extracellular matrix (ECM) of the brain comprises unique glycan "sulfation codes" that influence neurological function. Perineuronal nets (PNNs) are chondroitin sulfate-glycosaminoglycan (CS-GAG) containing matrices that enmesh neural networks involved in memory and cognition, and loss of PNN matrices is reported in patients with neurocognitive and neuropsychiatric disorders including Alzheimer's ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Editorial: Application for Nanotechnology for the Treatment of Brain Diseases and Disorders.

Jia Li, Meng Zheng, Yan Zou, Pu Chun Ke, Miqin Zhang, William A Banks, Bingyang Shi,

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2021, 9:743160]

Cited: 0 times

View full text PDF listing >>



Interactions of Lipids, Lipoproteins, and Apolipoproteins with the Blood-Brain Barrier.

Elizabeth M Rhea, William A Banks,

Lipids and lipoproteins are a diverse group of substances and their interactions with the blood-brain barrier (BBB) is similarly diverse. Some lipoproteins such as high density lipoprotein (HDL), apolipoprotein (apo) A-I, apoJ, some free fatty acids, and triglycerides cross the BBB whereas others such as apoE do not. Some forms ... Read more >>

Pharm Res (Pharmaceutical research)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice.

Subhashis Banerjee, Sarbani Ghoshal, Clemence Girardet, Kelly M DeMars, Changjun Yang, Michael L Niehoff, Andrew D Nguyen, Prerana Jayanth, Brittany A Hoelscher, Fenglian Xu, William A Banks, Kim M Hansen, Jinsong Zhang, Eduardo Candelario-Jalil, Susan A Farr, Andrew A Butler,

The neural functions of adropin, a secreted peptide highly expressed in the brain, have not been investigated. In humans, adropin is highly expressed in astrocytes and peaks during critical postnatal periods of brain development. Gene enrichment analysis of transcripts correlating with adropin expression suggests processes relevant to aging-related neurodegenerative diseases ... Read more >>

NPJ Aging Mech Dis (NPJ aging and mechanisms of disease)
[2021, 7(1):23]

Cited: 0 times

View full text PDF listing >>



Effects of Rapamycin on Insulin Brain Endothelial Cell Binding and Blood-Brain Barrier Transport.

Steven Nguyen, William A Banks, Elizabeth M Rhea,

Rapamycin is an exogenous compound that has been shown to improve cognition in Alzheimer's disease mouse models and can regulate pathways downstream of the insulin receptor signaling pathway. Insulin is also known to improve cognition in rodent models of Alzheimer's disease. Central nervous system (CNS) insulin must first cross the ... Read more >>

Med Sci (Basel) (Medical sciences (Basel, Switzerland))
[2021, 9(3):]

Cited: 0 times

View full text PDF listing >>



Pitavastatin Ameliorates Lipopolysaccharide-Induced Blood-Brain Barrier Dysfunction.

Takashi Fujimoto, Yoichi Morofuji, Andrej Kovac, Michelle A Erickson, Mária A Deli, Masami Niwa, William A Banks,

Statins have neuroprotective effects on neurological diseases, including a pleiotropic effect possibly related to blood-brain barrier (BBB) function. In this study, we investigated the effects of pitavastatin (PTV) on lipopolysaccharide (LPS)-induced BBB dysfunction in an in vitro BBB model comprising cocultured primary mouse brain endothelial cells, pericytes, and astrocytes. LPS ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(7):]

Cited: 0 times

View full text PDF listing >>



Corrigendum to "Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity" [Journal of Controlled Release 191 (2014) 34-46].

Xiang Yi, Dongfen Yuan, Susan A Farr, William A Banks, Chi-Duen Poon, Alexander V Kabanov,

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Characterization of systemic immunosuppression by IDH mutant glioma small extracellular vesicles.

Nils Ludwig, Aparna Rao, Poorva Sandlesh, Saigopalakrishna S Yerneni, Alexander D Swain, Kristin M Bullock, Kim M Hansen, Xiaoran Zhang, Emade Jaman, Jordan Allen, Katharine Krueger, Chang-Sook Hong, William A Banks, Theresa L Whiteside, Nduka M Amankulor,

<h4>Background</h4>Gliomas are the most common primary brain tumors and are universally fatal. Mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2) define a distinct glioma subtype associated with an immunosuppressive tumor microenvironment. Mechanisms underlying systemic immunosuppression in IDH mutant (mutIDH) gliomas are largely unknown. Here, we define genotype-specific local and ... Read more >>

Neuro Oncol (Neuro-oncology)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Deficient Leptin Cellular Signaling Plays a Key Role in Brain Ultrastructural Remodeling in Obesity and Type 2 Diabetes Mellitus.

Melvin R Hayden, William A Banks,

The triad of obesity, metabolic syndrome (MetS), Type 2 diabetes mellitus (T2DM) and advancing age are currently global societal problems that are expected to grow over the coming decades. This triad is associated with multiple end-organ complications of diabetic vasculopathy (maco-microvessel disease), neuropathy, retinopathy, nephropathy, cardiomyopathy, cognopathy encephalopathy and/or late-onset ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(11):]

Cited: 0 times

View full text PDF listing >>



Traumatic Brain Injury Broadly Affects GABAergic Signaling in Dentate Gyrus Granule Cells.

Alejandro Parga Becerra, Aric F Logsdon, William A Banks, Christopher B Ransom,

Traumatic brain injury (TBI) causes cellular and molecular alterations that contribute to neuropsychiatric disease and epilepsy. GABAergic dysfunction figures prominently in the pathophysiology of TBI, yet the effects of TBI on tonic inhibition in hippocampus remain uncertain. We used a mouse model of severe TBI [controlled cortical impact (CCI)] to ... Read more >>

eNeuro (eNeuro)
[2021, 8(3):]

Cited: 0 times

View full text PDF listing >>



Healthy aging and the blood-brain barrier.

William A Banks, May J Reed, Aric F Logsdon, Elizabeth M Rhea, Michelle A Erickson,

The blood-brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourishment of the CNS, its homeostatic regulation and communication between the CNS and peripheral tissues. The cells ... Read more >>

Nat Aging (Nature aging)
[2021, 1(3):243-254]

Cited: 1 time

View full text PDF listing >>



A historical perspective on the interactions of insulin at the blood-brain barrier.

Elizabeth M Rhea, William A Banks,

Subsequent to the discovery of insulin in 1921, the role of insulin in the brain has been investigated throughly. The ability of insulin to act within the brain to regulate peripheral glucose levels helped evolve the research surrounding the ability of insulin to be transported into the brain. Investigations aiming ... Read more >>

J Neuroendocrinol (Journal of neuroendocrinology)
[2021, 33(4):e12929]

Cited: 0 times

View full text PDF listing >>



The neurovascular extracellular matrix in health and disease.

Aric F Logsdon, Elizabeth M Rhea, May Reed, William A Banks, Michelle A Erickson,

The blood-brain barrier (BBB) is a vital interface that supports normal brain functions. Endothelial cells (ECs) are the main component of the BBB and are highly specialized to govern the transfer of substances into brain. The EC lumen is enmeshed with an extracellular matrix (ECM), known as the endothelial glycocalyx ... Read more >>

Exp Biol Med (Maywood) (Experimental biology and medicine (Maywood, N.J.))
[2021, 246(7):835-844]

Cited: 0 times

View full text PDF listing >>



The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.

Elizabeth M Rhea, Aric F Logsdon, Kim M Hansen, Lindsey M Williams, May J Reed, Kristen K Baumann, Sarah J Holden, Jacob Raber, William A Banks, Michelle A Erickson,

It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood-brain barrier in ... Read more >>

Nat Neurosci (Nature neuroscience)
[2021, 24(3):368-378]

Cited: 43 times

View full text PDF listing >>



Intranasal Delivery: Effects on the Neuroimmune Axes and Treatment of Neuroinflammation.

Elizabeth M Rhea, Aric F Logsdon, William A Banks, Michelle E Erickson,

This review highlights the pre-clinical and clinical work performed to use intranasal delivery of various compounds from growth factors to stem cells to reduce neuroimmune interactions. We introduce the concept of intranasal (IN) delivery and the variations of this delivery method based on the model used (i.e., rodents, non-human primates, ... Read more >>

Pharmaceutics (Pharmaceutics)
[2020, 12(11):]

Cited: 4 times

View full text PDF listing >>



The microvascular extracellular matrix in brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA).

Mamatha Damodarasamy, Robert B Vernon, Jasmine L Pathan, C Dirk Keene, Anthony J Day, William A Banks, May J Reed,

<h4>Background</h4>The microvasculature (MV) of brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA), in the absence of concurrent pathologies (e.g., infarctions, Lewy bodies), is incompletely understood.<h4>Objective</h4>To analyze microvascular density, diameter and extracellular matrix (ECM) content in association with ADNC and CAA.<h4>Methods</h4>We examined samples of cerebral cortex and ... Read more >>

Fluids Barriers CNS (Fluids and barriers of the CNS)
[2020, 17(1):60]

Cited: 0 times

View full text PDF listing >>



Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats.

Kimberly M Alonge, Zaman Mirzadeh, Jarrad M Scarlett, Aric F Logsdon, Jenny M Brown, Elaine Cabrales, Christina K Chan, Karl J Kaiyala, Marie A Bentsen, William A Banks, Miklos Guttman, Thomas N Wight, Gregory J Morton, Michael W Schwartz,

We recently showed that perineuronal nets (PNNs) enmesh glucoregulatory neurons in the arcuate nucleus (Arc) of the mediobasal hypothalamus (MBH)<sup>1</sup>, but whether these PNNs play a role in either the pathogenesis of type 2 diabetes (T2D) or its treatment remains unclear. Here we show that PNN abundance within the Arc ... Read more >>

Nat Metab (Nature metabolism)
[2020, 2(10):1025-1033]

Cited: 6 times

View full text PDF listing >>



Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics.

Therese S Salameh, Elizabeth M Rhea, Konrad Talbot, William A Banks,

Among the more promising treatments proposed for Alzheimer's disease (AD) and Parkinson's disease (PD) are those reducing brain insulin resistance. The antidiabetics in the class of incretin receptor agonists (IRAs) reduce symptoms and brain pathology in animal models of AD and PD, as well as glucose utilization in AD cases ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2020, 180:114187]

Cited: 9 times

View full text PDF listing >>



Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure.

James S Meabon, David G Cook, Mayumi Yagi, Garth E Terry, Donna J Cross, Mark Muzi, Kathleen F Pagulayan, Aric F Logsdon, Abigail G Schindler, Vikas Ghai, Kai Wang, Shannon Fallen, Yong Zhou, Taek-Kyun Kim, Inyoul Lee, William A Banks, Erik S Carlson, Cynthia Mayer, Rebecca C Hendrickson, Murray A Raskind, Desiree A Marshall, Daniel P Perl, C Dirk Keene, Elaine R Peskind,

Mounting evidence points to the significance of neurovascular-related dysfunction in veterans with blast-related mTBI, which is also associated with reduced [<sup>18</sup>F]-fluorodeoxyglucose (FDG) uptake. The goal of this study was to determine whether plasma VEGF-A is altered in veterans with blast-related mTBI and address whether VEGF-A levels correlate with FDG uptake ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2020, 417:117049]

Cited: 0 times

View full text PDF listing >>



The impact of acute rosiglitazone on insulin pharmacokinetics at the blood-brain barrier.

Demi C Galindo, William A Banks, Elizabeth M Rhea,

<h4>Introduction</h4>CNS insulin levels are decreased and insulin receptor signalling is dampened in Alzheimer's disease (AD). Increasing CNS insulin levels through a variety of methods has been shown to improve memory. Indeed, medications routinely used to improve insulin resistance in type 2 diabetes are now being repurposed for memory enhancement. CNS ... Read more >>

Endocrinol Diabetes Metab (Endocrinology, diabetes & metabolism)
[2020, 3(3):e00149]

Cited: 1 time

View full text PDF listing >>



Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury.

Aric F Logsdon, Abigail G Schindler, James S Meabon, Mayumi Yagi, Melanie J Herbert, William A Banks, Murray A Raskind, Desiree A Marshall, C Dirk Keene, Daniel P Perl, Elaine R Peskind, David G Cook,

We investigated the role of nitric oxide synthase (NOS) in mediating blood-brain barrier (BBB) disruption and peripheral immune cell infiltration in the cerebellum following blast exposure. Repetitive, but not single blast exposure, induced delayed-onset BBB disruption (72 hours post-blast) in cerebellum. The NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) administered after blast ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9420]

Cited: 4 times

View full text PDF listing >>



Pituitary adenylate cyclase-activating polypeptide: Protective effects in stroke and dementia.

Naoko Nonaka, William A Banks, Seiji Shioda,

Evidence shows that pituitary adenylate cyclase-activating polypeptide (PACAP) improves stroke outcomes and dementia. The blood-brain barrier (BBB) controls the peptide and regulatory protein exchange between the central nervous system and the blood; the transport of these regulatory substances across the BBB has been altered in animal models of stroke and ... Read more >>

Peptides (Peptides)
[2020, 130:170332]

Cited: 3 times

View full text PDF listing >>



Comparison of the rate of dedifferentiation with increasing passages among cell sources for an in vitro model of the blood-brain barrier.

Takashi Fujimoto, Yoichi Morofuji, Shinsuke Nakagawa, Andrej Kovac, Nobutaka Horie, Tsuyoshi Izumo, Masami Niwa, Takayuki Matsuo, William A Banks,

Cell culture-based blood-brain barrier (BBB) models are useful experimental tools for developing central nervous system drugs. Several endothelial cell sources exist for BBB models, including primary cultured brain endothelial cells and immortalized cell lines. Among them, primary cell-based models are considered suitable for the functional analysis of the BBB; however, ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2020, 127(8):1117-1124]

Cited: 0 times

View full text PDF listing >>



Alterations in Plasma microRNA and Protein Levels in War Veterans with Chronic Mild Traumatic Brain Injury.

Vikas Ghai, Shannon Fallen, David Baxter, Kelsey Scherler, Taek-Kyun Kim, Yong Zhou, James S Meabon, Aric F Logsdon, William A Banks, Abigail G Schindler, David G Cook, Elaine R Peskind, Inyoul Lee, Kai Wang,

Blast-related mild traumatic brain injury (mTBI) is considered the "signature" injury of the wars in Iraq and Afghanistan. Identifying biomarkers that could aid in diagnosis and assessment of chronic mTBI are urgently needed, as little progress has been made toward identifying blood-based biomarkers of repetitive mTBI in the chronic state. ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(12):1418-1430]

Cited: 4 times

View full text PDF listing >>



Advertisement


Disclaimer

1.1531 s