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Author Wenqiang Zhang

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Late-onset Hearing Loss From Congenital Cytomegalovirus Infection After Newborn Period in a Highly Immune Population in China.

Chengbin Wang, Xiaolin Liu, Shiwen Wang, Wenqiang Zhang, Haiyan Wang, Wei Ma, Xiangxin Meng, Xingqu Xu, Zhan Li, Qiang Pan, Shuxia Zhang, Ping Wang, Qian Lin, Xiaofang Wang, Minal Amin, Sheila Dollard, Aiqiang Xu, Winnie Chung,

After following 141 children with likely asymptomatic congenital cytomegalovirus infection in a highly immune population in China, four children (2.8%) were found to have late-onset hearing loss. No maternal or childhood factors, except higher saliva cytomegalovirus viral load at birth (P = 0.03), were associated with increased risk of developing ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):70-73]

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Synergy between vinorelbine and afatinib in the inhibition of non-small cell lung cancer progression by EGFR and p53 signaling pathways.

Zhen Liu, Qingshan Fu, Yu Wang, Li Cui, Wenqiang Zhang, Yuou Teng, Peng Yu,

Currently, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) were approved for the treatment of non-small cell lung cancer (NSCLC) patients harboring EGFR mutation. However, some lung cancer patients fail to respond and eventually develop drug resistance. Therefore, new therapeutic strategies are needed to improve the outcomes for substantial ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 134:111144]

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Highly Stable Zr(IV)-Based Metal-Organic Frameworks for Chiral Separation in Reversed-Phase Liquid Chromatography.

Hong Jiang, Kuiwei Yang, Xiangxiang Zhao, Wenqiang Zhang, Yan Liu, Jianwen Jiang, Yong Cui,

Separation of racemic mixtures is of great importance and interest in chemistry and pharmacology. Porous materials including metal-organic frameworks (MOFs) have been widely explored as chiral stationary phases (CSPs) in chiral resolution. However, it remains a challenge to develop new CSPs for reversed-phase high-performance liquid chromatography (RP-HPLC), which is the ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, 143(1):390-398]

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Ti3C2 MXene as a new nanofiller for robust and conductive elastomer composites.

Qunyang Li, Bangchao Zhong, Wenqiang Zhang, Zhixin Jia, Demin Jia, Si Qin, Jing Wang, Joselito M Razal, Xungai Wang,

Ti3C2 MXene with a layered 2D structure was applied as a novel functional filler in rubber for the first time. A facile and green method was proposed to fabricate rubber/Ti3C2 nanocomposites via a freeze-drying & mechanical mixing process. It was found that Ti3C2 with ∼1 nm thickness fabricated by etching ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(31):14712-14719]

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Liquid Metal-Polymer Microlattice Metamaterials with High Fracture Toughness and Damage Recoverability.

Wenqiang Zhang, Juzheng Chen, Xiang Li, Yang Lu,

Biological materials exhibit excellent fracture toughness due to their ability to dissipate energy during crack propagating through the combination of various constituents with different stiffnesses. Replicating this mechanism in engineering materials is important in mechanical systems and emerging applications such as flexible electronics and soft robotics. Here a novel liquid ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(46):e2004190]

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Constructing conductive titanium carbide nanosheet (MXene) network on polyurethane/polyacrylonitrile fibre framework for flexible strain sensor.

Zhixin Jia, Zhangjie Li, Shufei Ma, Wenqiang Zhang, Yongjun Chen, Yuanfang Luo, Demin Jia, Bangchao Zhong, Joselito M Razal, Xungai Wang, Lingxue Kong,

<h4>Hypothesis</h4>MXenes (two-dimensional early transition metal carbides and carbonitrides) possess both excellent conductivity and surface hydrophilicity, enabling more diverse potential applications. However, in flexible strain sensors, the flexible substrates are usually composed of hydrophobic elastomers such as thermoplastic polyurethane (TPU). To enhance the interactions between MXenes and hydrophobic. substrates, it is ... Read more >>

J Colloid Interface Sci (Journal of colloid and interface science)
[2021, 584:1-10]

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Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein in the Ocular Tissues of a Patient Previously Infected With Coronavirus Disease 2019.

Ying Yan, Bo Diao, Yueping Liu, Wenqiang Zhang, Gang Wang, Xiao Chen,

<h4>Importance</h4>Coronavirus disease 2019 (COVID-19) has been recognized as a pandemic by the World Health Organization. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also infect tissues besides the respiratory system, such as the ocular tissues, remains unclear.<h4>Objective</h4>To determine whether SARS-CoV-2 exists intracellularly in the ocular tissues of a patient ... Read more >>

JAMA Ophthalmol (JAMA ophthalmology)
[2020, :]

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Application of enhanced recovery after surgery in total knee arthroplasty in patients with haemophilia A: A pilot study.

Yan Wu, Haipeng Xue, Wenqiang Zhang, Yuhong Wu, Yanwei Yang, Hong Ji,

<h4>Aim</h4>To identify the effect of enhanced recovery after surgery (ERAS) and rapid rehabilitation concepts on the outcomes of patients with haemophilia A undergoing total knee arthroplasty.<h4>Design</h4>Randomized controlled trial.<h4>Methods</h4>The primary endpoint was postoperative hospital stay. The secondary endpoints were pain scores, joint function scores, haemoglobin levels at 3 and 7 days after surgery and satisfaction ... Read more >>

Nurs Open (Nursing open)
[2021, 8(1):80-86]

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Engineered High-Loaded Mixed-Monoclonal Antibodies (Adalimumab, Rituximab and Trastuzumab) Polymeric Nanoparticle for Rheumatoid Arthritis Treatment: A Proof of Concept.

Yeteng He, Yuxuan Xin, Elaine Cruz Rosas, Luciana Magalhães Rebelo Alencar, Ralph Santos-Oliveira, Xianbo Peng, Hongjian Yu, Jinhao Fu, Wenqiang Zhang,

Rheumatoid arthritis, a chronic disease, affects from 0.5% to 1% of the world population. The main consequences include loss of joint functionality and severe pain, with lost in life quality and increased risk of morbidity and mortality. The main strategy for RA treatment relies in early diagnosis as targeted therapy. ... Read more >>

J Biomed Nanotechnol (Journal of biomedical nanotechnology)
[2020, 16(8):1254-1266]

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A meta-analysis of the rate and related factors of glaucomatous optic nerve damage in patients with Glaucomatocyclitic Crisis.

Huafang Guo, Wenqiang Zhang, Qian Ye,

<h4>Purpose</h4>To systematic analysis of domestic and foreign literature on the incidence and related factors of glaucomatous optic nerve damage (GOND) in patients with Glaucomatocyclitic Crisis (PSS).<h4>Methods</h4>A computerized literature search was carried out in PubMed database, Wanfang Medical Database, China National Knowledge Infrastructure to collected domestic and foreign research studies on ... Read more >>

Int Ophthalmol (International ophthalmology)
[2020, 40(11):3145-3153]

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In situ high-resolution measurement of phosphorus, iron and sulfur by diffusive gradients in thin films in sediments of black-odorous rivers in the Pearl River Delta region, South China.

Nan Rong, Wenzhou Lu, Chaoyu Zhang, Yishu Wang, Jialiang Zhu, Wenqiang Zhang, Pei Lei,

The cycling of phosphorus (P), iron (Fe) and sulfur (S) in sediments has been previously investigated, but its impacts on the formation of black-odorous waterbodies remains unclear. Here, high-resolution (i.e., 2 mm for P and Fe, and 0.042 mm for S of 2D presentation) simultaneous measurements of P, Fe, and S profiles ... Read more >>

Environ Res (Environmental research)
[2020, 189:109918]

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Application of rapid rehabilitation surgical concept in perioperative nursing of patients undergoing single-port thoracoscopic lobectomy.

Qian Ding, Wenqiang Zhang, Li Wei, Shuang He, Fengjuan Yang, Yanyan Ning, Qingfeng Liu, Yi He,

Minerva Med (Minerva medica)
[2020, :]

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Power-efficient neural network with artificial dendrites.

Xinyi Li, Jianshi Tang, Qingtian Zhang, Bin Gao, J Joshua Yang, Sen Song, Wei Wu, Wenqiang Zhang, Peng Yao, Ning Deng, Lei Deng, Yuan Xie, He Qian, Huaqiang Wu,

In the nervous system, dendrites, branches of neurons that transmit signals between synapses and soma, play a critical role in processing functions, such as nonlinear integration of postsynaptic signals. The lack of these critical functions in artificial neural networks compromises their performance, for example in terms of flexibility, energy efficiency ... Read more >>

Nat Nanotechnol (Nature nanotechnology)
[2020, 15(9):776-782]

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iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin-angiotensin system-mediated congenital ureteropelvic junction obstruction.

Ruiyu Liu, Wenqiang Zhang, Mayao Luo, Xia Qin, Fang Yang, Qiang Wei,

<h4>Objective</h4>Ureteropelvic junction obstruction (UPJO) is a common renal obstructive disorder, but its pathogenic mechanisms remain largely unclear. We aimed to investigate the potential involvement of the renin-angiotensin system in congenital UPJO pathogenesis.<h4>Methods</h4>Differentially expressed proteins in exosomes isolated from amniotic fluid of patients with congenital UPJO were characterized using iTRAQ (isobaric ... Read more >>

Exp Cell Res (Experimental cell research)
[2020, 393(1):112086]

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Anti-tubulin agent vinorelbine inhibits metastasis of cancer cells by regulating epithelial-mesenchymal transition.

Hongyu Liu, Qingshan Fu, Yao Lu, Wenqiang Zhang, Peng Yu, Zhen Liu, Xiaosheng Sun,

Cancer invasion and metastasis are the leading causes of death. The process of metastasis or tumor cell dissemination is still much of a mystery. Emerging evidence has shown that epithelial-mesenchymal transition (EMT) plays a vital role in the progression of malignant tumor including the inducing cell invasion and metastasis as ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 200:112332]

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Topology-Based Functionalization of Robust Chiral Zr-Based Metal-Organic Frameworks for Catalytic Enantioselective Hydrogenation.

Hong Jiang, Wenqiang Zhang, Xing Kang, Ziping Cao, Xu Chen, Yan Liu, Yong Cui,

The design and development of robust and porous supported catalysts with high activity and selectivity is extremely significant but very challenging for eco-friendly synthesis of fine chemicals and pharmaceuticals. We report here the design and synthesis of highly stable chiral Zr(IV)-based MOFs with different topologies to support Ir complexes and demonstrate ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(21):9642-9652]

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Kellerin alleviates cognitive impairment in mice after ischemic stroke by multiple mechanisms.

Wenqiang Zhang, Yan Mi, Kun Jiao, Jikai Xu, Tingting Guo, Di Zhou, Xueni Zhang, Hui Ni, Yu Sun, Kun Wei, Ning Li, Yue Hou,

Ischemic stroke is a global disease with high disability and mortality rates. Cognitive impairment is one of the major clinical features of ischemic stroke, and microglia-mediated inflammation has been shown to be an important contributor to the pathogenesis of ischemic stroke. Kellerin, extracted from Ferula sinkiangensis, was previously shown to ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, 34(9):2258-2274]

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Identification, in vitro evaluation and modeling studies of the constituents from the roots of Arnebia euchroma for antitumor activity and STAT3 inhibition.

Huihui Cao, Wenqiang Zhang, Dongyi Liu, Manting Hou, Shiyu Liu, Wenkai He, Jiawei Lin, Meng Shao,

Phytochemical investigation of the roots of Arnebia euchroma led to the isolation of a new dimeric naphthoquinone, shikometabolin H (1), a new meroterpeniod, epoxyarnebinol (5) and a new ring A-seco hopane triterpenoid, 2, 3-secodiplopterol dioic acid (7), together with 18 known compounds. The structures of the new compounds were elucidated ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 96:103655]

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Fully hardware-implemented memristor convolutional neural network.

Peng Yao, Huaqiang Wu, Bin Gao, Jianshi Tang, Qingtian Zhang, Wenqiang Zhang, J Joshua Yang, He Qian,

Memristor-enabled neuromorphic computing systems provide a fast and energy-efficient approach to training neural networks<sup>1-4</sup>. However, convolutional neural networks (CNNs)-one of the most important models for image recognition<sup>5</sup>-have not yet been fully hardware-implemented using memristor crossbars, which are cross-point arrays with a memristor device at each intersection. Moreover, achieving software-comparable results ... Read more >>

Nature (Nature)
[2020, 577(7792):641-646]

Cited: 9 times

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[Prevalence and associated factors of underweight among the elderly in Qionglai City].

Wenqiang Zhang, Shizhong Kong, Xinya Ma, Chuan Dai, Siyi Li, Zonglei Zhou, Rongsheng Luan,

OBJECTIVE:To examine the prevalence and associated factors of underweight among the elderly in Qionglai City. METHODS:A total of 14 929 residents aged ≥60 years recruited through multistage stratified cluster random sampling in 24 towns or streets of Qionglai City were surveyed from August to October 2018, including 7581 males and ... Read more >>

Wei Sheng Yan Jiu (Wei sheng yan jiu = Journal of hygiene research)
[2020, 49(1):51-55]

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Early-life exposure to the Chinese famine of 1959-61 and risk of Hyperuricemia: results from the China health and retirement longitudinal study.

Wenqiang Zhang, Rongsheng Luan,

BACKGROUND:Short-term starvation has been related to hyperuricemia. However, little is known about the long-term effect of early-life exposure to famine on hyperuricemia risk in adulthood. METHODS:The analysis included 2383 participants from the China Health and Retirement Longitudinal Study in 2015. Hyperuricemia was diagnosed as serum uric acid ≥7 mg/dL in men ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):15]

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Distribution of nitrogen and phosphorus and estimation of nutrient fluxes in the water and sediments of Liangzi Lake, China.

Xin Meng, Wenqiang Zhang, Baoqing Shan,

Water samples and sediments from Liangzi Lake were taken and used to study the vertical distribution characteristics of nitrogen (N) and phosphorus (P) in both the overlying and pore water. Fluxes of ammonia (NH4+-N) and phosphate (PO43--P) were calculated using a one-dimensional transport-reaction model based on Fick's First Law. The ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, 27(7):7096-7104]

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The effects of urbanization and rainfall on the distribution of, and risks from, phenolic environmental estrogens in river sediment.

Zhenhan Li, Wenqiang Zhang, Baoqing Shan,

There is increasing concern about phenolic environmental estrogens (PEEs) in river systems, especially in economically developed regions, because of their potential to impact ecological systems. We studied the distribution of, ecological risks from, and factors that influenced PEEs in the sediments from the Duliujian River in the Beijing-Tianjin-Hebei Urban Agglomeration ... Read more >>

Environ Pollut (Environmental pollution (Barking, Essex : 1987))
[2019, 250:1010-1018]

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Novel astrovirus types circulating in Shandong Province (Eastern China) during 2016: A clinical and environmental surveillance.

Zexin Tao, Haiyan Wang, Wenqiang Zhang, Aiqiang Xu,

<h4>Background</h4>In recent years, several novel astroviruses have been discovered by molecular assays. Their prevalence in many parts of the world remains unclear.<h4>Objectives</h4>To investigate the existence and genetic diversity of novel astroviruses in China.<h4>Study design</h4>Stool specimens were collected from patients suffering gastroenteritis from two hospitals in Jinan city in 2016, and ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2019, 116:69-73]

Cited: 1 time

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ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells.

Wenbin Zhong, Mengyang Xu, Chanjuan Li, Biying Zhu, Xiuye Cao, Dan Li, Huanzhao Chen, Chunxiu Hu, Rong Li, Chengwei Luo, Guoping Pan, Wenqiang Zhang, Chaofeng Lai, Tong Wang, Xin Du, Hong Chen, Guowang Xu, Vesa M Olkkonen, Pingsheng Lei, Jun Xu, Daoguang Yan,

Leukemia stem cells (LSCs) are a rare subpopulation of abnormal hematopoietic stem cells (HSCs) that propagates leukemia and are responsible for the high frequency of relapse in therapies. Detailed insights into LSCs' survival will facilitate the identification of targets for therapeutic approaches. Here, we develop an inhibitor, LYZ-81, which targets ... Read more >>

Cell Rep (Cell reports)
[2019, 26(8):2166-2177.e9]

Cited: 2 times

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