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Author Wenjuan Xing

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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.

Yinlong Zhao, Shukuan Ling, Jianwei Li, Guohui Zhong, Ruikai Du, Youyou Li, Yanqing Wang, Caizhi Liu, Xiaoyan Jin, Wei Liu, Tong Liu, Yuheng Li, Dingsheng Zhao, Weijia Sun, Zizhong Liu, Zifan Liu, Junjie Pan, Xinxin Yuan, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li,

<h4>Aims</h4>3' untranslated region (3' UTR) of mRNA is more conserved than other non-coding sequences in vertebrate genomes, and its sequence space has substantially expanded during the evolution of higher organisms, which substantiates their significance in biological regulation. However, the independent role of 3' UTR in cardiovascular disease was largely unknown.<h4>Methods ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(36):3786-3799]

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WWP1 deficiency protects from cardiac remodeling induced by simulated microgravity

Guohui Zhong, Dingsheng Zhao, Jianwei Li, Zifan Liu, Junjie Pan, Xinxin Yuan, Wenjuan Xing, Yinglong Zhao, Shukuan Ling, Yingxian Li,

Cardiac muscle is extremely sensitive to changes in loading conditions, the microgravity during space flight can cause cardiac remodeling and function decline. At present, the mechanism of microgravity-induced cardiac remodeling remains to be revealed. WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is an important activator of pressure-overload induced cardiac ... Read more >>

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C1q/TNF-related protein-9 ameliorates hypoxia-induced pulmonary hypertension by regulating secretion of endothelin-1 and nitric oxide mediated by AMPK in rats.

Qiaoyan Jin, Hui Su, Rui Yang, Yanzhen Tan, Buying Li, Wei Yi, Qianqian Dong, Haifeng Zhang, Wenjuan Xing, Xin Sun,

Injury/dysfunction of the endothelium of pulmonary arteries contributes to hypoxia-induced pulmonary hypertension (HPH). We investigated whether C1q/tumor necrosis factor-related protein-9 (CTRP9), a newly identified cardiovascular agent, has protective roles in the development of HPH. HPH was induced in adult male rats by chronic hypobaric hypoxia. CTRP9 overexpression by adeno-associated virus ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):11372]

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Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push-Pull Effect in Humans.

Changyang Xing, Yuan Gao, Xinpei Wang, Wenjuan Xing, Yunnan Liu, Yujia Lei, Xing Zhang, Shu Zhang, Lijun Yuan, Feng Gao,

Exposure to acute transition from negative (-Gz) to positive (+ Gz) gravity significantly impairs cerebral perfusion in pilots of high-performance aircraft during push-pull maneuver. This push-pull effect may raise the risk for loss of vision or consciousness. The aim of the present study was to explore effective countermeasures against cerebral ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:672351]

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

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Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: The role of omentin-1.

Qianqian Dong, Wenjuan Xing, Kaifeng Li, Xuanxuan Zhou, Siwang Wang, Haifeng Zhang,

<h4>Rationale</h4>Hypertension in obesity has become a major threat for public health. Omentin-1, a novel adipokine, is down-regulated in obesity. Tetrahydroxystilbene glycoside (TSG) is the main ingredient extracted from Polygonum multiflorum Thunb (PMT), a traditional Chinese medicinal herb safely used for protecting cardiovascular systems over bimillennium. This study aims to examine ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 186:114489]

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Tribbles Homolog 3-Mediated Vascular Insulin Resistance Contributes to Hypoxic Pulmonary Hypertension in Intermittent Hypoxia Rat Model.

Fang Fan, Jinxiao He, Hui Su, Haifeng Zhang, Hao Wang, Qianqian Dong, Minghua Zeng, Wenjuan Xing, Xin Sun,

This study aimed to investigate the role of vascular insulin resistance (VIR) and Tribbles homolog 3 (TRIB3) in the pathogenesis of hypoxia-induced pulmonary hypertension (HPH). Rats were subjected to low air pressure and low oxygen intermittently for 4 weeks to induce HPH. The mean right ventricular pressure (mRVP), mean pulmonary ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:542146]

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Upregulated hepatokine fetuin B aggravates myocardial ischemia/reperfusion injury through inhibiting insulin signaling in diabetic mice.

Wenjuan Xing, Yanzhen Tan, Kaifeng Li, Pei Tian, Fei Tian, Haifeng Zhang,

Patients with type 2 diabetes mellitus (T2DM) are more susceptible to acute myocardial ischemia/reperfusion (MI/R) injury. However, the mechanism remains largely elusive. Clinical observation showed that high levels of hepatokine fetuin-B (FetB) in plasma are significantly associated with both diabetes and coronary artery diseases. This study was aimed to determine ... Read more >>

J Mol Cell Cardiol (Journal of molecular and cellular cardiology)
[2021, 151:163-172]

Cited: 5 times

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A novel methodology for rat aortic pulse wave velocity assessment by Doppler ultrasound: validation against invasive measurements.

Zhen Wang, Zihao Fu, Yong Yang, Wenjuan Xing, Xing Zhang, Jiaping Wang, Yongzhi Li, Lijun Yuan, Feng Gao,

There is still lack of a simple, accurate, and noninvasive method for rat aortic pulse wave velocity (PWV) measurement, especially the transit distance cannot be accurately measured. Thus, we aimed to derive an equation for aortic transit distance as a function of the nose-to-rump length (L) and to test the ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2019, 317(6):H1376-H1387]

Cited: 3 times

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Antifibrotic cardioprotection of berberine via downregulating myocardial IGF-1 receptor-regulated MMP-2/MMP-9 expression in diabetic rats.

Guohua Li, Wenjuan Xing, Min Zhang, Fenghao Geng, Hongyan Yang, Haifeng Zhang, Xing Zhang, Jia Li, Ling Dong, Feng Gao,

Diabetic cardiac fibrosis increases ventricular stiffness and facilitates the occurrence of diastolic dysfunction. Our previous studies have shown that berberine, a natural alkaloid, attenuates cardiac ischemia-reperfusion injury in diabetic rats. The aim of present study was to investigate the effects of long-term berberine treatment on cardiac remodeling in diabetic rats ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2018, 315(4):H802-H813]

Cited: 13 times

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Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing optic atrophy 1 processing in the failing heart.

Yongzheng Guo, Zhen Wang, Xinghua Qin, Jie Xu, Zuoxu Hou, Hongyan Yang, Xuechao Mao, Wenjuan Xing, Xiaoliang Li, Xing Zhang, Feng Gao,

Aims:Heart failure (HF) is characterized by reduced fatty acid (FA) utilization associated with mitochondrial dysfunction. Recent evidence has shown that enhancing FA utilization may provide cardioprotection against HF. Our aim was to investigate the effects and the underlying mechanisms of cardiac FA utilization on cardiac function in response to pressure ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2018, 114(7):979-991]

Cited: 12 times

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Tetrahydroxystilbene Glycoside Improves Microvascular Endothelial Dysfunction and Ameliorates Obesity-Associated Hypertension in Obese ZDF Rats Via Inhibition of Endothelial Autophagy.

Qianqian Dong, Wenjuan Xing, Feifei Su, Xiangyan Liang, Fei Tian, Feng Gao, Siwang Wang, Haifeng Zhang,

<h4>Aims</h4>Obesity is a major risk for hypertension. Endothelial dysfunction contributes to increased peripheral vascular resistance and subsequent hypertension. Autophagy regulates endothelial function, however, whether autophagy is related to hypertension in obesity remains largely unclear. We wished to ascertain: (i) the role of autophagy in obesity-induced hypertension and the underlying mechanisms; ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2017, 43(1):293-307]

Cited: 9 times

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Tetrahydroxystilbene Glucoside Inhibits Excessive Autophagy and Improves Microvascular Endothelial Dysfunction in Prehypertensive Spontaneously Hypertensive Rats.

Qianqian Dong, Wenjuan Xing, Feng Fu, Zhenghua Liu, Jie Wang, Xiangyan Liang, Xuanxuan Zhou, Qian Yang, Wei Zhang, Feng Gao, Siwang Wang, Haifeng Zhang,

Autophagy exists in vascular endothelial cells, but the relationship between autophagy and blood vessel dysfunction in hypertension remains elusive. This study aimed to investigate role of autophagy in vascular endothelial dysfunction in prehypertension and hypertension and the underlying mechanisms involved. Furthermore, we sought to determine if and how tetrahydroxystilbene glucoside ... Read more >>

Am J Chin Med (The American journal of Chinese medicine)
[2016, 44(7):1393-1412]

Cited: 8 times

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SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.

Lu Yang, Julei Zhang, Wenjuan Xing, Xing Zhang, Jie Xu, Haifeng Zhang, Li Chen, Xiaona Ning, Gang Ji, Jia Li, Qingchuan Zhao, Feng Gao,

Recent evidence implicates the critical role of Sirtuin 3 (SIRT3) in the development of many metabolic diseases, but the contribution of SIRT3 to vascular homeostasis remains largely unknown. The aim of this study was to investigate the role of SIRT3 in endothelial insulin resistance and vascular dysfunction in obesity. We ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:23366]

Cited: 17 times

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Apocynum venetum leaf attenuates myocardial ischemia/reperfusion injury by inhibiting oxidative stress.

Wenqing Wang, Xiangyan Liang, Dong Fu, Ru Tie, Wenjuan Xing, Lele Ji, Fange Liu, Haifeng Zhang, Rong Li,

Apocynum venetum, a Chinese medicinal herb, is reported to be neuroprotective. However, whether Apocynum venetum leaf extract (AVLE) protects against ischemic myocardium remains elusive. Our present study was aimed to observe the effects of AVLE preconditioning on myocardial ischemia/reperfusion (MI/R) injury and to investigate the possible mechanisms. Rats were treated ... Read more >>

Am J Chin Med (The American journal of Chinese medicine)
[2015, 43(1):71-85]

Cited: 9 times

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Magnolol administration in normotensive young spontaneously hypertensive rats postpones the development of hypertension: role of increased PPAR gamma, reduced TRB3 and resultant alleviative vascular insulin resistance.

Xiangyan Liang, Wenjuan Xing, Jinxiao He, Feng Fu, Wei Zhang, Feifei Su, Fange Liu, Lele Ji, Feng Gao, Hui Su, Xin Sun, Haifeng Zhang,

Patients with prehypertension are more likely to progress to manifest hypertension than those with optimal or normal blood pressure. However, the mechanisms underlying the development from prehypertension to hypertension still remain largely elusive and the drugs for antihypertensive treatment in prehypertension are absent. Here we determined the effects of magnolol ... Read more >>

PLoS One (PloS one)
[2015, 10(3):e0120366]

Cited: 9 times

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Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms.

Zhenwei Shi, Feng Fu, Liming Yu, Wenjuan Xing, Feifei Su, Xiangyan Liang, Ru Tie, Lele Ji, Miaozhang Zhu, Jun Yu, Haifeng Zhang,

Diabetes mellitus increases morbidity/mortality of ischemic heart disease. Although atrial natriuretic peptide and C-type natriuretic peptide reduce the myocardial ischemia-reperfusion damage in nondiabetic rats, whether vasonatrin peptide (VNP), the artificial synthetic chimera of atrial natriuretic peptide and C-type natriuretic peptide, confers cardioprotective effects against ischemia-reperfusion injury, especially in diabetic patients, ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2015, 308(4):H281-90]

Cited: 24 times

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Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms.

Wei Zhang, Fang Fu, Ru Tie, Xiangyan Liang, Fei Tian, Wenjuan Xing, Jia Li, Lele Ji, Jinliang Xing, Xin Sun, Haifeng Zhang,

<h4>Background</h4>Endothelial dysfunction is an important factor in the pathogenesis of diabetes related vascular complications, and acute alpha-linolenic acid (ALA) intake can increase flow-mediated dilation of the diabetic artery at 4 h postprandially. However, whether chronic ALA supplementation may prevent endothelial dysfunction in the process of diabetes and underlying mechanisms remains ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2013, 42(6):421-428]

Cited: 14 times

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Upregulation of caveolin-1 contributes to aggravated high-salt diet-induced endothelial dysfunction and hypertension in type 1 diabetic rats.

Xu Li, Wenjuan Xing, Yang Wang, Chunjuan Mi, Zhengrui Zhang, Heng Ma, Haifeng Zhang, Feng Gao,

<h4>Aims</h4>Endothelial dysfunction and hypertension is more common in individuals with diabetes than in the general population. This study was aimed to investigate the underlying mechanisms responsible for endothelial dysfunction of type 1 diabetic rats fed with high-salt diet.<h4>Main methods</h4>Type 1 diabetes (DM) was induced by intraperitoneal injection of streptozotocin (70 ... Read more >>

Life Sci (Life sciences)
[2014, 113(1-2):31-39]

Cited: 7 times

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Semen cassiae attenuates myocardial ischemia and reperfusion injury in high-fat diet streptozotocin-induced type 2 diabetic rats.

Feng Fu, Fei Tian, Heping Zhou, Weifeng Lv, Ru Tie, Lele Ji, Rong Li, Zhenwei Shi, Liming Yu, Xiangyan Liang, Wenjuan Xing, Jinliang Xing, Jun Yu, Lijun Sun, Hailong Zhu, Haifeng Zhang,

Obese patients with type 2 diabetes mellitus (T2DM), which is characterized by hyperglycemia, are liable to more severe myocardial infarction. Semen Cassiae is proven to reduce serum lipid levels. This study investigated whether the Semen Cassiae extract (SCE) reduces myocardial ischemia and reperfusion (MI/R) injury with or without diabetes and ... Read more >>

Am J Chin Med (The American journal of Chinese medicine)
[2014, 42(1):95-108]

Cited: 12 times

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Quaternary ammonium salt of U50488H, a new κ-opioid receptor agonist, protects rat heart against ischemia/reperfusion injury.

Qianmei Wang, Yang Sun, Juan Li, Wenjuan Xing, Shumiao Zhang, Xiaoming Gu, Na Feng, Lei Zhao, Rong Fan, Yuemin Wang, Wen Yin, Jianming Pei,

To keep U50488H from going through the blood-brain barrier, U50488H, a selective κ-opioid receptor agonist, was structurally transformed into its quaternary ammonium salt (Q-U50488H). The effect of Q-U50488H on ischemic/reperfused myocardium and its underlying mechanisms were also investigated. U50488H was transformed into Q-U50488H, which was identified with mass spectrometry. The ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2014, 737:177-184]

Cited: 10 times

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Response to hypoadiponectinemia and endogenous nitric oxide synthase inhibitor in hypertension.

Wenjuan Xing, Lele Ji, Youyou Li, Feng Gao, Wenjun Yan, Peilin Liu, Lu Sun, Ling Tao, Haifeng Zhang,

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2013, 62(2):e5]

Cited: 0 times

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Achyranthes bidentata polypeptides reduces oxidative stress and exerts protective effects against myocardial ischemic/reperfusion injury in rats.

Ru Tie, Lele Ji, Ying Nan, Wenqing Wang, Xiangyan Liang, Fei Tian, Wenjuan Xing, Miaozhang Zhu, Rong Li, Haifeng Zhang,

Achyranthes bidentata, a Chinese medicinal herb, is reported to be neuroprotective. However, its role in cardioprotection remains largely unknown. Our present study aimed to investigate the effects of Achyranthes bidentata polypeptides (ABPP) preconditioning on myocardial ischemia/reperfusion (MI/R) injury and to test the possible mechanisms. Rats were treated with ABPP (10 ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2013, 14(10):19792-19804]

Cited: 16 times

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Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats.

Wenjuan Xing, Youyou Li, Haifeng Zhang, Chunjuan Mi, Zuoxu Hou, Michael J Quon, Michael J Quon, Feng Gao,

Exercise training lowers blood pressure and is a recommended nonpharmacological strategy and useful adjunctive therapy for hypertensive patients. Studies demonstrate that physical activity attenuates progression of hypertension. However, underlying mechanisms remain elusive. Vascular insulin resistance and endothelial dysfunction plays a critical role in the development of hypertension. The present study ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2013, 305(8):H1111-9]

Cited: 19 times

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