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No Difference in Functional Outcome but Higher Revision Rate Among Smokers Undergoing Cervical Artificial Disc Replacement: Analysis of a Spine Registry.

Lee Wen-Shen, Maksim Lai Wern Sheng, William Yeo, Tan Seang Beng, Yue Wai Mun, Guo Chang Ming, Mohammad Mashfiqul Arafin Siddiqui,

<h4>Background</h4>Smoking is a known predictor of negative outcomes in spinal surgery. However, its effect on the functional outcomes and revision rates after ADR is not well-documented. This study is a retrospective analysis of prospectively collected data at a major tertiary center. The objective was to elucidate the impact of smoking ... Read more >>

Int J Spine Surg (International journal of spine surgery)
[2020, 14(6):916-923]

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Screening for Primary Aldosteronism is Underutilized in Patients with Obstructive Sleep Apnea.

Patricia C Conroy, Sophia Hernandez, Claire E Graves, Kathryn Chomsky-Higgins Menut, Sarah Pearlstein, Chienying Liu, Wen T Shen, Jessica Gosnell, Julie A Sosa, Sanziana Roman, Quan-Yang Duh, Insoo Suh,

<h4>Background</h4>Resistant hypertension is common in patients with primary aldosteronism and in those with obstructive sleep apnea. Primary aldosteronism treatment improves sleep apnea. Despite Endocrine Society guidelines' inclusion of sleep apnea and hypertension co-diagnosis as a primary aldosteronism screening indication, the state of screening implementation is unknown.<h4>Methods</h4>All hypertensive adult patients with ... Read more >>

Am J Med (The American journal of medicine)
[2021, :]

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One-stop preoperative assessment of renal vessels for living donors with 3.0 T non-contrast-enhanced magnetic resonance angiography: compared with computerized tomography angiography and surgical results.

Xiaotian Li, Fangjie Xia, Lihua Chen, Xiaodong Zhang, Chunbai Mo, Wen Shen,

<h4>Objective</h4>The study was to investigate the feasibility and accuracy of assessment for living renal donors before transplantation by using 3.0 T non-contrast-enhanced magnetic resonance angiography (NCE-MRA).<h4>Methods</h4>Thirty renal donors were investigated and underwent computed tomography angiography (CTA) and 3.0 T NCE-MRA before nephrectomy. Two radiologists independently assessed arterial and venous anatomy ... Read more >>

Br J Radiol (The British journal of radiology)
[2021, :20210589]

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Perfusion Analysis of Kidney Injury in Rats With Cirrhosis Induced by Common Bile Duct Ligation Using Arterial Spin Labeling MRI.

Yongquan Yu, Shuangshuang Xie, Kaiqi Wang, Fuzhi Zhang, Chao Jiang, Caixin Qiu, Jinxia Zhu, Wen Shen,

<h4>Background</h4>Arterial spin labeling (ASL) has been proven to be effective in ischemia-induced acute kidney injury (AKI); however, validation of ASL magnetic resonance imaging (MRI) is limited in AKI in the presence of cirrhosis.<h4>Purpose</h4>To investigate the feasibility of ASL in revealing renal blood flow (RBF) changes in kidney injury in the ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2021, :]

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In vivo evaluation of the levator ani muscle in primiparous women using diffusion tensor imaging and fiber tractography.

Can Cui, Yujiao Zhao, Dawei Cui, Na Li, Jiangfeng Pan, Wen Shen,

<h4>Objective</h4>To characterize the levator ani muscle (LAM) injury after first vaginal delivery and investigate the clinical application of diffusion tensor imaging (DTI) and fiber tractography in evaluating the LAM.<h4>Methods</h4>Fifty-eight primiparous women at 6 weeks after vaginal delivery and 27 nulliparous women as controls underwent T2-weighted sequence and DTI sequence of the ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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Renormalization of Thalamic Sub-Regional Functional Connectivity Contributes to Improvement of Cognitive Function after Liver Transplantation in Cirrhotic Patients with Overt Hepatic Encephalopathy.

Yue Cheng, Jing-Li Li, Jia-Min Zhou, Gao-Yan Zhang, Wen Shen, Xiao-Dong Zhang,

The role of preoperative overt hepatic encephalopathy (OHE) in the neurophysiological mechanism of cognitive improvement after liver transplantation (LT) remains elusive. This study aimed to explore changes in sub-regional thalamic functional connectivity (FC) after LT and their relationship with neuropsychological improvement using resting-state functional MRI (rs-fMRI) data in cirrhotic patients ... Read more >>

Korean J Radiol (Korean journal of radiology)
[2021, :]

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Increased cerebral blood flow is correlated with neurocognitive impairment in long-term hemodialysis patients: an arterial spin labeling MRI study.

Chao Chai, Mengjie Zhang, Huiying Wang, Jinping Li, Tong Zhang, Yingying Han, Jinxia Zhu, Xianchang Zhang, Shuang Xia, Wen Shen,

The purpose of this study was to investigate cerebral blood flow (CBF) changes in hemodialysis patients with arterial spin labeling (ASL) and to correlate these changes with clinical risk factors and neurocognitive function. Thirty-two hemodialysis patients and 35 age-, sex-, and education-matched healthy controls (HCs) were recruited in this prospective ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2021, 15(4):1828-1839]

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A cost-utility analysis of 18F-fluorocholine-positron emission tomography imaging for localizing primary hyperparathyroidism in the United States.

Ava Yap, Thomas A Hope, Claire E Graves, Wouter Kluijfhout, Wen T Shen, Jessica E Gosnell, Julie A Sosa, Sanziana A Roman, Quan-Yang Duh, Insoo Suh,

<h4>Background</h4>Primary hyperparathyroidism historically necessitated bilateral neck exploration to remove abnormal parathyroid tissue. Improved localization allows for focused parathyroidectomy with lower complication risks. Recently, positron emission tomography using radiolabeled 18F-fluorocholine demonstrated high accuracy in detecting these lesions, but its cost-effectiveness has not been studied in the United States.<h4>Methods</h4>A decision tree modeled ... Read more >>

Surgery (Surgery)
[2021, :]

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Analysis of the polarization states of the alveolar macrophages in chronic obstructive pulmonary disease samples based on miRNA-mRNA network signatures.

Wen Shen, Shukun Wang, Ruili Wang, Yang Zhang, Hong Tian, Xiaolei Yang, Wei Wei,

<h4>Background</h4>Multiple gene expression studies have been performed to investigate the biomarkers of chronic obstructive pulmonary disease (COPD). However, few studies have related COPD to macrophage cells.<h4>Methods</h4>The gene expression levels of clinical samples of COPD smokers (COPD; n=6), healthy smokers (Smoke; n=11), and never smokers (Never; n=4) were downloaded from the ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(16):1333]

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Evaluation of the effect of transgenic Bt cotton on snails Bradybaena (Acusta) ravida and Bradybaena similaris (Ferussac).

Zhi Xiang Fang, Li Zhang, Wen Jing Shen, Lai Pan Liu, Biao Liu,

The impact of transgenic crops on non-target organisms is a key aspect of environmental safety assessment to transgenic crops. In the present study, we fed two snail species, Bradybaena (Acusta) ravida (B. ravida) and Bradybaena similaris (Ferussac)(B. similaris), with the leaves of transgenic Bt cotton Zhong 30 (Z30) and control ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2021, 223:112557]

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Different cerebral functional segregation in Sjogren's syndrome with or without systemic lupus erythematosus revealed by amplitude of low-frequency fluctuation.

Xiao-Dong Zhang, Jun Ke, Jing-Li Li, Yun-Yan Su, Jia-Min Zhou, Lin-Ru Zhao, Li-Xiang Huang, Yue Cheng, Wen Shen,

<h4>Background</h4>Sjögren's syndrome (SjS) associated with systemic lupus erythematosus (SjS-SLE) was considered a standalone but often-overlooked entity.<h4>Purpose</h4>To assess altered spontaneous brain activity in SjS-SLE and SjS using amplitude of low-frequency fluctuation (ALFF).<h4>Material and methods</h4>Sixteen patients with SjS-SLE, 17 patients with SjS, and 17 matched controls underwent neuropsychological tests and subsequent resting-state ... Read more >>

Acta Radiol (Acta radiologica (Stockholm, Sweden : 1987))
[2021, :2841851211032441]

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Implications of radiofrequency ablation in patients undergoing thyroid surgery for benign disease in the United States.

Jina Kim, Zhifei Sun, Marcus Cummins, Kevin C Donohue, Robin Lea, Claire E Graves, Wen T Shen, Jessica E Gosnell, Sanziana A Roman, Julie A Sosa, Quan-Yang Duh, Insoo Suh,

<h4>Background</h4>Radiofrequency ablation is an alternative strategy for the management of benign thyroid conditions. We analyzed the proportion of patients who underwent thyroid surgery for benign conditions who would be potentially eligible for radiofrequency ablation.<h4>Methods</h4>We identified patients who underwent thyroid surgery from 2015 to 2019 at the study institution for Bethesda ... Read more >>

Surgery (Surgery)
[2021, :]

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Superior sensitivity of 18F-fluorocholine: PET localization in primary hyperparathyroidism.

Claire E Graves, Thomas A Hope, Jina Kim, Miguel H Pampaloni, Wouter Kluijfhout, Carolyn D Seib, Jessica E Gosnell, Wen T Shen, Sanziana A Roman, Julie A Sosa, Quan-Yang Duh, Insoo Suh,

<h4>Background</h4>Preoperative parathyroid imaging guides surgeons during parathyroidectomy. This study evaluates the clinical impact of <sup>18</sup>F-fluorocholine positron emission tomography for preoperative parathyroid localization on patients with primary hyperparathyroidism.<h4>Methods</h4>Patients with primary hyperparathyroidism and indications for parathyroidectomy had simultaneous <sup>18</sup>F-fluorocholine positron emission tomography imaging/magnetic resonance imaging. In patients who underwent subsequent parathyroidectomy, cure ... Read more >>

Surgery (Surgery)
[2021, :]

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Ex vivo intact tissue analysis reveals alternative calcium-sensing behaviors in parathyroid adenomas.

James Koh, Run Zhang, Sanziana Roman, Quan-Yang Duh, Jessica Gosnell, Wen Shen, Insoo Suh, Julie A Sosa,

<h4>Context</h4>The biochemical basis for clinical variability in primary hyperparathyroidism (PHPT) is poorly understood.<h4>Objectives</h4>To define parathyroid tumor biochemical properties associated with calcium sensing failure in PHPT patients, and to relate differences in these profiles to variations in clinical presentation.<h4>Design</h4>Pre-operative clinical data were evaluated for correlation to parathyroid tumor biochemical behavior.<h4>Setting</h4>An endocrine ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, :]

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Perspectives on virtual interviews-A follow-up study of the Comprehensive Endocrine Surgery Fellowship interview process.

Alaina D Geary, Tracy S Wang, Brenessa Lindeman, Jennifer H Kuo, Melanie L Lyden, Wen T Shen, Lilah F Morris-Wiseman, Sally E Carty, Frederick Thurston Drake,

<h4>Background</h4>The American Association of Endocrine Surgeons Comprehensive Endocrine Surgery Fellowship interview stakeholders previously favored in-person interviews, despite time and expense. This study assessed perception changes given mandated virtual interviews because of coronavirus disease 2019.<h4>Methods</h4>Immediately after the 2020 Match, anonymous surveys were distributed to applicants (n = 37) and program directors (n = ... Read more >>

Surgery (Surgery)
[2021, :]

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Screening for primary aldosteronism in the hypertensive obstructive sleep apnea population is cost-saving.

Kathryn Chomsky-Higgins Menut, Sarah Sims Pearlstein, Patricia C Conroy, Sanziana A Roman, Wen T Shen, Jessica Gosnell, Julie Ann Sosa, Quan-Yang Duh, Insoo Suh,

<h4>Background</h4>Guidelines recommend screening for primary aldosteronism in patients diagnosed with hypertension and obstructive sleep apnea. Recent studies have shown that adherence to these recommendations is extremely low. It has been suggested that cost is a barrier to implementation. No analysis has been done to rigorously evaluate the cost-effectiveness of widespread ... Read more >>

Surgery (Surgery)
[2021, :]

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Methyltransferase-like 3 contributes to inflammatory pain by targeting TET1 in YTHDF2-dependent manner.

Zhiqiang Pan, Qi Zhang, Xiaodan Liu, Huimin Zhou, Tong Jin, Ling-Yun Hao, Ling Xie, Ming Zhang, Xiao-Xiao Yang, Meng-Lan Sun, Zhou-Ya Xue, Yang Tao, Xin-Chun Ye, Wen Shen, Jun-Li Cao,

<h4>Abstract</h4>The methyltransferase-like 3 (Mettl3) is a key component of the large N6-adenosine-methyltransferase complex in mammalian responsible for RNA N6-methyladenosine (m6A) modification, which plays an important role in gene post-transcription modulation. Although RNA m6A is enriched in mammalian neurons, its regulatory function in nociceptive information processing remains elusive. Here, we reported ... Read more >>

Pain (Pain)
[2021, 162(7):1960-1976]

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Neuromarkers from Whole-Brain Functional Connectivity Reveal the Cognitive Recovery Scheme for Overt Hepatic Encephalopathy after Liver Transplantation.

Yue Cheng, Wen Shen, Junhai Xu, Rachel C Amey, Li-Xiang Huang, Xiao-Dong Zhang, Jing-Li Li, Cameron Akhavan, Ben A Duffy, Julia Pia Simon, Wenjuan Jiang, Mengting Liu, Hosung Kim,

Neurocognitive impairment is present in cirrhosis and may be more severe in cirrhosis with overt hepatic encephalopathy (OHE). Liver transplantation (LT) can restore liver function, but how it reverses the impaired brain function is still unclear. MRI of resting-state functional connectivity can help reveal the underlying mechanisms that lead to ... Read more >>

eNeuro (eNeuro)
[2021, 8(4):]

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Combined use of calcium phosphate cement, mesenchymal stem cells and platelet-rich plasma for bone regeneration in critical-size defect of the femoral condyle in mini-pigs.

Guangjun Li, Wen Shen, Xing Tang, Guowei Mo, Liqin Yao, Jixing Wang,

<b>Aim:</b> To investigate the outcome of autologous bone marrow mesenchymal stem cells (BMMSCs) and platelet-rich plasma in combination with calcium phosphate cement (CPC) scaffold to reconstruct femoral critical bone defects in mini-pigs. <b>Materials & methods:</b> Scanning electron microscopy, micro-computed tomography evaluation and quantitative histological assessment were used. <b>Results & conclusion:</b> ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(5):451-464]

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The Effect of Amiloride on Proteinuria in Patients with Proteinuric Kidney Disease.

Wen Shen, Mohammed Alshehri, Sameer Desale, Christopher Wilcox,

<h4>Introduction</h4>Proteinuric kidney diseases share an aggressive clinical course of developing end-stage renal disease. However, the treatment is limited. Amiloride, an epithelial sodium channel (ENaC) inhibitor, was reported to reduce proteinuria in animal studies and case reports independent of ENaC inhibition. We hypothesized that amiloride not triamterene (an analog of amiloride) ... Read more >>

Am J Nephrol (American journal of nephrology)
[2021, 52(5):368-377]

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Regional Cerebral Gray Matter Atrophy Is Associated With Cognitive Impairment in Hemodialysis Patients: a Cross-sectional and Longitudinal Voxel-based Morphological Mri Study

Huiying Wang, Lixiang Huang, Gemuer Wu, Jinping Li, Lei Liu, Tong Zhang, Jinxia Zhu, Xianchang Zhang, Wen Shen, Chao Chai, Shuang Xia,

To explore changes of cerebral gray matter volumes (GMV) in hemodialysis patients, the clinical risk factors for GMV changes, and the relationship between GMV changes and neuropsychological tests results. Eighty-eight hemodialysis patients and seventy-six healthy controls (HCs) were recruited in this study. Fifty patients underwent follow-up magnetic resonance, blood biochemical ... Read more >>

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A simplified primary aldosteronism surgical outcome score is a useful prediction model when target organ damage is unknown - Retrospective cohort study.

Diederik P D Suurd, Wouter P Visscher, Wessel M C M Vorselaars, Dirk-Jan van Beek, Wilko Spiering, Inne H M Borel Rinkes, Gerlof D Valk, Menno R Vriens, ,

<h4>Background</h4>Cure of hypertension after adrenalectomy for primary aldosteronism is no certainty and therefore preoperative patient counseling is essential. The Primary Aldosteronism Surgical Outcome (PASO) Score is a useful prediction model with an area under the curve (AUC) of 0.839. The PASO Score includes 'Target Organ Damage' (TOD) (i.e., left ventricular ... Read more >>

Ann Med Surg (Lond) (Annals of medicine and surgery (2012))
[2021, 65:102333]

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AutoGGN: A Gene Graph Network AutoML Tool for Multi-Omics Research

Lei Zhang, Ping Li, Wen Shen, Chi Xu, Denghui Liu, Wenjun He, Zhimeng Xu, Chenyi Zhang, Nan Qiao,

Omics data identifies biological characteristics from genetic to phenotypic levels during the life span. Molecular interaction networks have a fundamental impact on life activities. Integrating omics data and molecular interaction networks will help researchers delve into comprehensive information underlying the data. Here, we proposed a new multimodal method called AutoGGN ... Read more >>

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Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides.

Thazha P Prakash, Jinghua Yu, Wen Shen, Cheryl Li De Hoyos, Andres Berdeja, Hans Gaus, Xue-Hai Liang, Stanley T Crooke, Punit P Seth,

Site-specific incorporation of 2'-modifications and neutral linkages in the deoxynucleotide gap region of toxic phosphorothioate (PS) gapmer ASOs can enhance therapeutic index and safety. In this manuscript, we determined the effect of introducing 2',5'-linked RNA in the deoxynucleotide gap region on toxicity and potency of PS ASOs. Our results demonstrate ... Read more >>

ACS Med Chem Lett (ACS medicinal chemistry letters)
[2021, 12(6):922-927]

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Identification of minimal hepatic encephalopathy based on dynamic functional connectivity.

Yue Cheng, Gaoyan Zhang, Xiaodong Zhang, Yuexuan Li, Jingli Li, Jiamin Zhou, Lixiang Huang, Shuangshuang Xie, Wen Shen,

To investigate whether dynamic functional connectivity (DFC) metrics can better identify minimal hepatic encephalopathy (MHE) patients from cirrhotic patients without any hepatic encephalopathy (noHE) and healthy controls (HCs). Resting-state functional MRI data were acquired from 62 patients with cirrhosis (MHE, n = 30; noHE, n = 32) and 41 HCs. We used the sliding ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2021, :]

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