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Withaferin A Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress.

Tsu-Ming Chien, Kuang-Han Wu, Ya-Ting Chuang, Yun-Chiao Yeh, Hui-Ru Wang, Bi-Wen Yeh, Chia-Hung Yen, Tzu-Jung Yu, Wen-Jeng Wu, Hsueh-Wei Chang,

Withaferin A (WFA), the Indian ginseng bioactive compound, exhibits an antiproliferation effect on several kinds of cancer, but it was rarely reported in bladder cancer cells. This study aims to assess the anticancer effect and mechanism of WFA in bladder cancer cells. WFA shows antiproliferation to bladder cancer J82 cells ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(7):]

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How to manage patients with suspected upper tract urothelial carcinoma in the pandemic of COVID-19?

Hsiang-Ying Lee, Erica On-Ting Chan, Ching-Chia Li, David Leung, Wei-Ming Li, Hsin-Chih Yeh, Peter Ka-Fung Chiu, Hung-Lung Ke, Chi-Hang Yee, Joseph Hon-Ming Wong, Chi-Fai Ng, Jeremy Yuen-Chun Teoh, Wen-Jeng Wu,

<h4>Background</h4>The pandemic of COVID-19 has disrupted the clinical pathway for patients with suspected upper tract urothelial carcinoma (UTUC). This aims to investigate the optimal management of UTUC during the pandemic by determining 1) Whether a three-month delay of RNU leads to worsened overall survival, 2) Whether radical nephroureterectomy (RNU) can ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma.

Yung-Chun Su, Sheng-Chen Wen, Ching-Chia Li, Hsiao-Chun Su, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Chia-Yang Li, Sheau-Fang Yang, Hung-Pin Tu, Wen-Jeng Wu, Hsin-Chih Yeh,

The importance of blood cell markers in patients with malignant tumors has been studied, but there are few studies on the prognostic value of hemoglobin-to-red cell distribution width ratio (HRR) in cancer. This is the first study to investigate the effect of preoperative HRR on patients with upper tract urothelial ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(6):]

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How to manage patients with suspected upper tract urothelial carcinoma in the pandemic of COVID-19?

Hsiang-Ying Lee, Erica On-Ting Chan, Ching-Chia Li, David Leung, Wei-Ming Li, Hsin-Chih Yeh, Peter Ka-Fung Chiu, Hung-Lung Ke, Chi-Hang Yee, Joseph Hon-Ming Wong, Chi-Fai Ng, Jeremy Yuen-Chun Teoh, Wen-Jeng Wu,

<h4>Background</h4> The pandemic of COVID-19 has disrupted the clinical pathway for patients with suspected upper tract urothelial carcinoma (UTUC). This aims to investigate the optimal management of UTUC during the pandemic by determining 1) Whether a three-month delay of RNU leads to worsened overall survival, 2) Whether radical nephroureterectomy (RNU) ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Utility of EFEMP1 in the Prediction of Oncologic Outcomes of Urothelial Carcinoma.

Tzu-Ju Chen, Ti-Chun Chan, Wan-Shan Li, Chien-Feng Li, Hung-Lung Ke, Yu-Ching Wei, Wen-Jeng Wu, Wei-Ming Li,

Urothelial carcinoma (UC) of the upper tract (UTUC) and urinary bladder (UBUC) is a heterogeneous malignancy. Through transcriptomic profiling of the Gene Expression Omnibus UBUC dataset (GSE31684), we discovered that epidermal growth factor-containing fibulin-like extracellularmatrix protein 1 (<i>EFEMP1</i>) was the most upregulated gene during metastatic development. EFEMP1 is an important ... Read more >>

Genes (Basel) (Genes)
[2021, 12(6):]

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A retrospective study on sex difference in patients with urolithiasis: who is more vulnerable to chronic kidney disease?

Tsu-Ming Chien, Yen-Man Lu, Ching-Chia Li, Wen-Jeng Wu, Hsueh-Wei Chang, Yii-Her Chou,

<h4>Background</h4>Urolithiasis is considered a vital public health issue with a substantial burden on kidney function. Additionally, only few reports focused on the gender difference in patients with urolithiasis. Therefore, this study aimed to compare the clinical characteristics of sex difference and their potential risk for chronic kidney disease (CKD) in ... Read more >>

Biol Sex Differ (Biology of sex differences)
[2021, 12(1):40]

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Newly designed solid coupling medium for reducing trapped air pockets during extracorporeal shock wave lithotripsy_ a phantom study.

Chien-Sheng Wang, Ching-Chia Li, Wen-Jeng Wu, Wen-Chin Liou, Yusen Eason Lin, Wei-Chuan Chen,

<h4>Introduction</h4>Air pockets between the lithotripter head and body surface are almost inevitably generated when applying a handful of gel onto the contact portion of the treatment head and that on the patient's skin during coupling procedure. These air pockets can compromise the transmission of acoustic energy of shock wave and ... Read more >>

BMC Urol (BMC urology)
[2021, 21(1):79]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma.

Yi-Ru Wu, Yi-Chen Lee, Wei-Ming Li, Wei-Chi Hsu, Hui-Hui Lin, Lin-Li Chang, A-Mei Huang, Jhen-Hao Jhan, Wen-Jeng Wu, Ching-Chia Li, Hsiang-Ying Lee, Hsin-Chih Yeh, Hung-Lung Ke,

Upper tract urothelial carcinoma (UTUC) is a rare tumor with an incidence that varies greatly between Eastern and Western countries. Transaldolase 1 (TALDO1) is a rate-limiting enzyme of the pentose phosphate pathway. In humans, aberrant TALDO1 activity has been implicated in various autoimmune diseases and malignancies; however, the function of ... Read more >>

Pathol Int (Pathology international)
[2021, 71(7):463-470]

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Impact of cachexia on oncologic outcomes of sarcopenic patients with upper tract urothelial carcinoma after radical nephroureterectomy.

Hao-Wei Chen, Yu-Chen Chen, Li-Hwa Yang, Ming-Chen Paul Shih, Ching-Chia Li, Kuang-Shun Chueh, Wen-Jeng Wu, Yung-Shun Juan,

<h4>Objectives</h4>To investigate the prognostic significance of sarcopenic cachexia compared to sarcopenia without cachexia in the outcomes of upper urinary tract urothelial carcinoma (UTUC) patients treated with radical nephroureterectomy (RNU).<h4>Materials and methods</h4>Between 2011 and 2016, 163 patients with UTUC who received RNU at a tertiary medical center were included. Pre-operatively clinical ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250033]

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The impact of urine microbiota in patients with lower urinary tract symptoms.

Hsiang-Ying Lee, Jiunn-Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Sung Yong Cho, Hsin-Chih Yeh, Kuang-Shun Chueh, Wen-Jeng Wu, Deng-Chyang Wu,

<h4>Introduction</h4>Inflammation and infection are causative factors of benign prostatic hyperplasia (BPH). Urine is not sterile, and urine microbiota identified by DNA sequencing can play an important role in the development of BPH and can influence the severity of lower urinary tract symptoms (LUTS).<h4>Materials and methods</h4>We collected mid-stream voided urine samples ... Read more >>

Ann Clin Microbiol Antimicrob (Annals of clinical microbiology and antimicrobials)
[2021, 20(1):23]

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Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses.

Hsiang-Ying Lee, Ching-Chia Li, Wei-Ming Li, Ya-Ling Hsu, Hsin-Chih Yeh, Hung-Lung Ke, Bi Wen Yeh, Chun-Nung Huang, Chien-Feng Li, Po-Lin Kuo, Wen-Jeng Wu,

<h4>Background</h4>We aimed to identify prognostic biomarkers of upper tract urothelial carcinomas (UTUCs), including microRNAs (miRNAs) and genes which account for only 5% to 10% of all urothelial carcinomas (UCs). In Taiwan, this figure is markedly higher, where it can reach up to 30% of UC cases.<h4>Materials and methods</h4>Using next-generation sequencing ... Read more >>

PeerJ (PeerJ)
[2021, 9:e11343]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Fatty liver index is associated with the risk of testosterone deficiency in aging men without metabolic syndrome.

Chia-Chu Liu, Shu-Pin Huang, Tusty-Jiuan Hsieh, Cheng-Hsueh Lee, Kai-Hung Cheng, Tsung-Yi Huang, Jiun-Hung Geng, Ching-Chia Li, Wen-Jeng Wu, Yung-Chin Lee,

<h4>Objectives</h4>Non-alcoholic fatty liver disease (NAFLD) is suggested to be a precursor of metabolic syndrome (MetS) and could influence the risk of testosterone deficiency (TD). Fatty liver index (FLI) is a simple and useful screening tool for NAFLD. We determined the association between the risk of NAFLD assessed by FLI and ... Read more >>

Andrology (Andrology)
[2021, 9(3):863-872]

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Comparison of Transperitoneal and Retroperitoneal Laparoendoscopic Single-site Donor Nephrectomy

Chung-Yu Lin, Ching-Chia Li, Hung-Lung Ke, Wen-Jeng Wu, Yii-Her Chou, Sheng-Chen Wen,

<h4>Background: </h4> Laparoscopic living-donor nephrectomy is the standard technique at high-volume renal transplant centers. Laparoendoscopic single-site donor nephrectomy (LESS-DN) is a relatively novel minimally invasive surgery, which was differed to transperitoneal and retroperitoneal approaches. We present a retrospective analysis of our single-institution donor nephrectomy series comparing the transperitoneal to retroperitoneal ... Read more >>

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The metabolic syndrome is associated with the risk of urothelial carcinoma from a health examination database.

Hsiang-Ying Lee, Jia-Hong Tang, Yen-Hsu Chen, Wen-Jeng Wu, Yung-Shun Juan, Wei-Ming Li, Ta-Chien Chan,

<h4>Purpose</h4>The metabolic syndrome was associated with bladder cancer in the previous studies. However, there have no large-scale cohort studies to elucidate the relationship between metabolic syndromes and urothelial carcinoma including urinary bladder urothelial carcinoma (UBUC) and upper tract urothelial carcinoma (UTUC).<h4>Methods</h4>We analyze a population-based cohort study by using physical examination ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, 26(3):569-577]

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Prognostic Significance of Primary Tumor Location in Upper Tract Urothelial Carcinoma Treated with Nephroureterectomy: A Retrospective, Multi-Center Cohort Study in Taiwan.

Lian-Ching Yu, Chao-Hsiang Chang, Chi-Ping Huang, Chao-Yuan Huang, Jian-Hua Hong, Ta-Yao Tai, Han-Yu Weng, Chi-Wen Lo, Chung-You Tsai, Yu-Khun Lee, Yao-Chou Tsai, Thomas Y Hsueh, Yung-Tai Chen, I-Hsuan Chen, Bing-Juin Chiang, Jen-Shu Tseng, Chia-Chang Wu, Wei-Yu Lin, Tsu-Ming Chien, Zai-Lin Sheu, Ching-Chia Li, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Wen-Jeng Wu, Hsin-Chih Yeh,

We sought to examine the effect of tumor location on the prognosis of patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). This retrospective study came from the Taiwan UTUC Collaboration Group, which consisted of 2658 patients at 15 institutions in Taiwan from 1988 to 2019. Patients ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(12):]

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Single-Site Sutureless Partial Nephrectomy for Small Exophytic Renal Tumors.

Ching-Chia Li, Tsu-Ming Chien, Shu-Pin Huang, Hsin-Chih Yeh, Hsiang-Ying Lee, Hung-Lung Ke, Sheng-Chen Wen, Wei-Che Chang, Yung-Shun Juan, Yii-Her Chou, Wen-Jeng Wu,

Partial nephrectomy (PN) is the standard procedure for most patients with localized renal cancer. Laparoscopy has become the preferred surgical approach to target this cancer, but the steep learning curve with laparoscopic PN (LPN) remains a concern. In LPN intracorporeal suturing, the operation time is further extended even under robot ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

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Prognostic Utility of FBLN2 Expression in Patients With Urothelial Carcinoma.

Wei-Ming Li, Ti-Chun Chan, Steven Kuan-Hua Huang, Wen-Jeng Wu, Hung-Lung Ke, Peir-In Liang, Yu-Ching Wei, Yow-Ling Shiue, Chien-Feng Li,

<b>Background:</b> Abnormal extracellular matrix (ECM) remodeling plays an essential role in urothelial carcinoma (UC) invasiveness and metastasis. Focusing on the ECM structural constituent (GO: 0005201), we recognized a significant upregulation of the fibulin 2 gene (<i>FBLN2</i>) during UC progression in a published UC transcriptome (GSE31684). Thus, we aimed to investigate ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:570340]

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Preoperative predictors of enucleation time during en bloc 'no-touch' holmium laser enucleation of the prostate.

Chun-Hsuan Lin, Wen-Jeng Wu, Ching-Chia Li, Sheng-Chen Wen,

<h4>Background</h4>To evaluate preoperative predictors of enucleation time during en bloc 'no-touch' holmium laser enucleation of the prostate (HoLEP) METHODS: We enrolled 135 patients with symptomatic benign prostatic hyperplasia (BPH) treated with en bloc 'no-touch' HoLEP from July 2017 to March 2019 by a single surgeon. Preoperative, perioperative, and postoperative clinical ... Read more >>

BMC Urol (BMC urology)
[2020, 20(1):185]

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The Impact of Urine Microbiota in Patients With Lower Urinary Tract Symptoms

Hsiang ying Lee, Jiunn‐Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Sung Yong Cho, Hsin-Chih Yeh, Kuang-Shun Chueh, Wen-Jeng Wu, Deng‐Chyang Wu,

<h4>Introduction: </h4> Inflammation and infection are causative factors of benign prostatic hyperplasia (BPH). Urine is not sterile, and urine microbiota identified by DNA sequencing can play an important role in the development of BPH and can influence the severity of lower urinary tract symptoms (LUTS).Materials and methodsWe collected mid-stream voided ... Read more >>

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Preoperative predictors of enucleation time during en bloc no-touch holmium laser enucleation of the prostate

Chun-Hsuan Lin, Ching-Chia Li, Wen-Jeng Wu, Sheng-Chen Wen,

<h4>Background: </h4> To evaluate preoperative predictors of enucleation time during en bloc ‘no-touch’ holmium laser enucleation of the prostate (HoLEP) <h4>Methods: </h4>: We enrolled 135 patients with symptomatic benign prostatic hyperplasia (BPH) treated with en bloc ‘no-touch’ HoLEP from July 2017 to March 2019 by a single surgeon. Preoperative, perioperative, ... Read more >>

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Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer.

Maha Hussain, Joaquin Mateo, Karim Fizazi, Fred Saad, Neal Shore, Shahneen Sandhu, Kim N Chi, Oliver Sartor, Neeraj Agarwal, David Olmos, Antoine Thiery-Vuillemin, Przemyslaw Twardowski, Guilhem Roubaud, Mustafa Özgüroğlu, Jinyu Kang, Joseph Burgents, Christopher Gresty, Claire Corcoran, Carrie A Adelman, Johann de Bono, ,

<h4>Background</h4>We previously reported that olaparib led to significantly longer imaging-based progression-free survival than the physician's choice of enzalutamide or abiraterone among men with metastatic castration-resistant prostate cancer who had qualifying alterations in homologous recombination repair genes and whose disease had progressed during previous treatment with a next-generation hormonal agent. The ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(24):2345-2357]

Cited: 26 times

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5α-reductase inhibitors impact prognosis of urothelial carcinoma.

Chien-Sheng Wang, Ching-Chia Li, Yung-Shun Juan, Wen-Jeng Wu, Hsiang-Ying Lee,

<h4>Background</h4>5α-reductase inhibitors (5-ARIs) inhibit the pathway of converting the testosterone to dihydrotestosterone and are widely used in benign prostatic hyperplasia patients. Since androgen receptor activation may play a role in urothelial tumorigenesis, we conducted this retrospective cohort study to determine whether 5α-reductase inhibitors (5-ARIs) administration is associated with bladder cancer ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):872]

Cited: 3 times

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Comparative analysis of patients with upper urinary tract urothelial carcinoma in black-foot disease endemic and non-endemic area

Che-Wei Chang, Chien-Hui Ou, Chih-Chin Yu, Chi-Wen Lo, Chung-You Tsai, Pai-Yu Cheng, Yung-Tai Chen, Hsu-Che Huang, Chia-Chang Wu, Wen-Jeng Wu, Ching-Chia Li, Wei-Ming Li, Hung-Lung Ke, Hsiang-Ying Lee,

<h4>Objective: </h4> High incidence of upper urinary tract urothelial carcinoma has been reported in South- Western area of Taiwan, where arsenic water contamination was considered to be the main cause. However, there is no definite proof to show the correlation between the arsenic water contamination and upper urinary tract urothelial ... Read more >>

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