Full Text Journal Articles by
Author Wen An Pan


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The α-arrestin ARRDC3 is an Emerging Multifunctional Adaptor Protein in Cancer.

Helen Wedegaertner, Wen-An Pan, Carlos C Gonzalez, David J Gonzalez, Joann Trejo,

<h4>Significance</h4>Adaptor proteins control the spatial and temporal dynamics of cellular signaling. Dysregulation of adaptor protein function can cause aberrant cell signaling and promote cancer. The arrestin adaptor proteins are known to regulate signaling by the superfamily of G protein-coupled receptors (GPCRs). GPCRs are highly druggable and implicated in cancer progression. ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, :]

Cited: 0 times

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α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis.

Aleena K S Arakaki, Wen-An Pan, Helen Wedegaertner, Ivette Roca-Mercado, Logan Chinn, Taranjit S Gujral, JoAnn Trejo,

The α-arrestin domain containing protein 3 (ARRDC3) is a tumor suppressor in triple-negative breast carcinoma (TNBC), a highly metastatic subtype of breast cancer that lacks targeted therapies. Thus, understanding the mechanisms and targets of ARRDC3 in TNBC is important. ARRDC3 regulates trafficking of protease-activated receptor 1 (PAR1, also known as ... Read more >>

J Cell Sci (Journal of cell science)
[2021, 134(8):]

Cited: 1 time

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GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling.

Aleena K S Arakaki, Wen-An Pan, JoAnn Trejo,

G protein-coupled receptors (GPCRs) are a large diverse family of cell surface signaling receptors implicated in various types of cancers. Several studies indicate that GPCRs control many aspects of cancer progression including tumor growth, invasion, migration, survival and metastasis. While it is known that GPCR activity can be altered in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(7):]

Cited: 25 times

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The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein-coupled receptor lysosomal sorting and signaling.

Aleena K S Arakaki, Wen-An Pan, Huilan Lin, JoAnn Trejo,

Aberrant G protein-coupled receptor (GPCR) expression and activation has been linked to tumor initiation, progression, invasion, and metastasis. However, compared with other cancer drivers, the exploitation of GPCRs as potential therapeutic targets has been largely ignored, despite the fact that GPCRs are highly druggable. Therefore, to advance the potential status ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2018, 293(9):3350-3362]

Cited: 13 times

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The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.

Tsung-Chieh Lin, Chia-Yi Su, Pei-Yu Wu, Tsung-Ching Lai, Wen-An Pan, Yi-Hua Jan, Yu-Chang Chang, Chi-Tai Yeh, Chi-Long Chen, Luo-Ping Ger, Hong-Tai Chang, Chih-Jen Yang, Ming-Shyan Huang, Yu-Peng Liu, Yuan-Feng Lin, John Y-J Shyy, Ming-Daw Tsai, Michael Hsiao,

Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated. Here we show the clinical significance and metastatic mechanism of NIFK in lung cancer. NIFK expression is clinically associated with poor prognosis and metastasis. Furthermore, NIFK enhances ... Read more >>

Elife (eLife)
[2016, 5:]

Cited: 17 times

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The epidermal growth factor-like domain of CD93 is a potent angiogenic factor.

Yuan-Chung Kao, Shinn-Jong Jiang, Wen-An Pan, Kuan-Chieh Wang, Po-Ku Chen, Hsi-Ju Wei, Wei-Sheng Chen, Bi-Ing Chang, Guey-Yueh Shi, Hua-Lin Wu,

Human CD93, an epidermal growth factor (EGF)-like domain containing transmembrane protein, is predominantly expressed in the vascular endothelium. Studies have shown that AA4, the homolog of CD93 in mice, may mediate cell migration and angiogenesis in endothelial cells. Soluble CD93 has been detected in the plasma of healthy individuals. However, ... Read more >>

PLoS One (PloS one)
[2012, 7(12):e51647]

Cited: 25 times

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