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Author Weijia Sun

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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.

Yinlong Zhao, Shukuan Ling, Jianwei Li, Guohui Zhong, Ruikai Du, Youyou Li, Yanqing Wang, Caizhi Liu, Xiaoyan Jin, Wei Liu, Tong Liu, Yuheng Li, Dingsheng Zhao, Weijia Sun, Zizhong Liu, Zifan Liu, Junjie Pan, Xinxin Yuan, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li,

<h4>Aims</h4>3' untranslated region (3' UTR) of mRNA is more conserved than other non-coding sequences in vertebrate genomes, and its sequence space has substantially expanded during the evolution of higher organisms, which substantiates their significance in biological regulation. However, the independent role of 3' UTR in cardiovascular disease was largely unknown.<h4>Methods ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(36):3786-3799]

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

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The application of expanded noninvasive prenatal screening for genome-wide chromosomal abnormalities and genetic counseling.

Yun Chen, Yunli Lai, Fuben Xu, Haisong Qin, Yanqing Tang, Xiaoshan Huang, Lintao Meng, Jiasun Su, Weijia Sun, Yiping Shen, Hongwei Wei,

<h4>Objective</h4>To evaluate the clinical application of expanded noninvasive prenatal screening (eNIPS) for genome-wide large copy number variation (CNV), i.e. chromosomal deletion/duplication >5 Mb, and aneuploidy; also to provide practical information for counseling eNIPS positive cases.<h4>Method</h4>We recruited 34,620 women with singleton pregnancy for genome-wide cell-free plasma DNA sequencing. Screening positive cases were ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2021, 34(16):2710-2716]

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Mind-body interventions on stress management in pregnant women: A systematic review and meta-analysis of randomized controlled trials.

Pingping Guo, Xuehui Zhang, Na Liu, Jie Wang, Dandan Chen, Weijia Sun, Ping Li, Wei Zhang,

<h4>Aim</h4>To quantify the effect of mind-body interventions on stress in pregnant women.<h4>Design</h4>A systematic review and meta-analysis of randomized controlled trials was performed.<h4>Data sources</h4>PubMed, Embase, CENTRAL, Web of Science and PsycINFO were searched from each database inception to January 2020.<h4>Review methods</h4>Randomized controlled trials regarding mind-body interventions for stress in pregnant women ... Read more >>

J Adv Nurs (Journal of advanced nursing)
[2021, 77(1):125-146]

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The coupling of reduced type H vessels with unloading-induced bone loss and the protection role of Panax quinquefolium saponin in the male mice.

Shuai Liang, Shukuan Ling, Ruikai Du, Yuheng Li, Caizhi Liu, Junhe Shi, Jie Gao, Weijia Sun, Jianwei Li, Guohui Zhong, Zizhong Liu, Dingsheng Zhao, Huiyuan Sun, Yang Li, Xinxin Yuan, Hua Qu, Xiaoyan Jin, Dong Li, Dazhuo Shi, Yingxian Li,

Unloading-induced bone loss is a critical complication characterized by the imbalance of bone formation and resorption induced by long-term confinement in bed or spaceflight. CD31<sup>hi</sup>Emcn<sup>hi</sup> (type H) vessel is a specific subtype of capillary, which was coupled with osteogenesis. However, the change of type H vessel and its contributions to ... Read more >>

Bone (Bone)
[2021, 143:115712]

Cited: 1 time

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miR-214 stimulated by IL-17A regulates bone loss in patients with ankylosing spondylitis.

Zizhong Liu, Feng Huang, Gui Luo, Yiwen Wang, Ruikai Du, Weijia Sun, Jianwei Li, Xinxin Yuan, Dengchao Cao, Yuheng Li, Caizhi Liu, Shuai Liang, Xiaoyan Jin, Shukuan Ling, Deqing Wang, Yingxian Li,

<h4>Objective</h4>Bone loss is common in AS, and miR-214 plays an important role in regulating bone formation. The aim of this study was to investigate the effect of miR-214, the production of which is stimulated by IL-17A, on bone loss in AS.<h4>Methods</h4>Peripheral blood was obtained from 32 patients with AS and ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(5):1159-1169]

Cited: 3 times

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Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity.

Caizhi Liu, Guohui Zhong, Yuezhang Zhou, Yuchen Yang, Yingjun Tan, Yuheng Li, Xingcheng Gao, Weijia Sun, Jianwei Li, Xiaoyan Jin, Dengchao Cao, Xinxin Yuan, Zizhong Liu, Shuai Liang, Youyou Li, Ruikai Du, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Jinping Song, Shukuan Ling, Yingxian Li,

<h4>Objectives</h4>Cardiac Ca<sup>2+</sup> signalling plays an essential role in regulating excitation-contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca<sup>2+</sup> signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL-1 cardiomyocytes subjected to rotation-simulated microgravity and ... Read more >>

Cell Prolif (Cell proliferation)
[2020, 53(3):e12783]

Cited: 3 times

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Effects of spaceflight on the composition and function of the human gut microbiota.

Zizhong Liu, Gui Luo, Ruikai Du, Weijia Sun, Jianwei Li, Haiyun Lan, Pu Chen, Xinxin Yuan, Dengchao Cao, Yuheng Li, Caizhi Liu, Shuai Liang, Xiaoyan Jin, Ruifu Yang, Yujing Bi, Yanping Han, Ping Cao, Wei Zhao, Shukuan Ling, Yingxian Li,

Interaction between humans and the gut microbiota is important for human physiology. Here, the gut microbiota was analyzed via metagenomic sequencing, and the fluctuations in the gut microbiota under the conditions of spaceflight were characterized. The composition and function of the gut microbiota were substantially affected by spaceflight; however, individual ... Read more >>

Gut Microbes (Gut microbes)
[2020, 11(4):807-819]

Cited: 5 times

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Mutual Correlation Attentive Factors in Dyadic Fusion Networks for Speech Emotion Recognition.

Yue Gu, Xinyu Lyu, Weijia Sun, Weitian Li, Shuhong Chen, Xinyu Li, Marsic Ivan,

Emotion recognition in dyadic communication is challenging because: 1. Extracting informative modality-specific representations requires disparate feature extractor designs due to the heterogenous input data formats. 2. How to effectively and efficiently fuse unimodal features and learn associations between dyadic utterances are critical to the model generalization in actual scenario. 3. ... Read more >>

Proc ACM Int Conf Multimed (Proceedings of the ... ACM International Conference on Multimedia, with co-located Symposium & Workshops. ACM International Conference on Multimedia)
[2019, 2019:157-166]

Cited: 1 time

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AAV-Anti-miR-214 Prevents Collapse of the Femoral Head in Osteonecrosis by Regulating Osteoblast and Osteoclast Activities.

Cheng Wang, Weijia Sun, Shukuan Ling, Yu Wang, Xin Wang, Haoye Meng, Yuheng Li, Xueling Yuan, Jianwei Li, Ruoxi Liu, Dingsheng Zhao, Qiang Lu, Aiyuan Wang, Quanyi Guo, Shibi Lu, Hua Tian, Yingxian Li, Jiang Peng,

Osteonecrosis of the femoral head, an intractable but common disease that eventually triggers collapse of the femoral head, is characterized by increased osteoclast activity and markedly decreased osteoblast activity in the necrotic region of the femoral head. MicroRNA (miRNA)-214 (miR-214) may play important roles in vertebrate skeletal development by inhibiting ... Read more >>

Mol Ther Nucleic Acids (Molecular therapy. Nucleic acids)
[2019, 18:841-850]

Cited: 3 times

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Effects of home visits for pregnant and postpartum women on premature birth, low birth weight and rapid repeat birth: a meta-analysis and systematic review of randomized controlled trials.

Na Liu, Ping Li, Jie Wang, Dandan Chen, Weijia Sun, Wei Zhang,

<h4>Background</h4>Home visits seem promising for improving the health of women and infants during pregnancy and postpartum. This review aimed to quantitatively analyse the effects of home visits delivered during pregnancy and postpartum on premature birth (PTB), low birth weight (LBW) and rapid repeat birth (RRB).<h4>Methods</h4>Literature was retrieved from PubMed, EMBASE, ... Read more >>

Fam Pract (Family practice)
[2019, 36(5):533-543]

Cited: 0 times

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The mechanosensitive Piezo1 channel is required for bone formation.

Weijia Sun, Shaopeng Chi, Yuheng Li, Shukuan Ling, Yingjun Tan, Youjia Xu, Fan Jiang, Jianwei Li, Caizhi Liu, Guohui Zhong, Dengchao Cao, Xiaoyan Jin, Dingsheng Zhao, Xingcheng Gao, Zizhong Liu, Bailong Xiao, Yingxian Li,

Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer that is critical for various biological processes, plays ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 36 times

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TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling.

Jianwei Li, Caizhi Liu, Yuheng Li, Qiaoxia Zheng, Youjia Xu, Beibei Liu, Weijia Sun, Yuan Li, Shuhui Ji, Mingwei Liu, Jing Zhang, Dingsheng Zhao, Ruikai Du, Zizhong Liu, Guohui Zhong, Cuiwei Sun, Yanqing Wang, Jinping Song, Shu Zhang, Jun Qin, Shukuan Ling, Xianhua Wang, Yingxian Li,

Transmembrane and coiled-coil domains 1 (TMCO1) is a recently identified Ca<sup>2+</sup> leak channel in the endoplasmic reticulum. TMCO1 dysfunction in humans is associated with dysmorphism, mental retardation, glaucoma and the occurrence of cancer. Here we show an essential role of TMCO1 in osteogenesis mediated by local Ca<sup>2+</sup>/CaMKII signaling in osteoblasts. ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1589]

Cited: 7 times

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Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions.

Dengchao Cao, Jinping Song, Shukuan Ling, Shuaishuai Niu, Liang Lu, Zhengzhi Cui, Yuheng Li, Shanshan Hao, Guohui Zhong, Zhihong Qi, Weijia Sun, Xinxin Yuan, Hongxing Li, Dingsheng Zhao, Xiaoyan Jin, Caizhi Liu, Xiaorui Wu, Guanghan Kan, Hongqing Cao, Youmin Kang, Shuyang Yu, Yingxian Li,

Spaceflight leads to health risks including bone demineralization, skeletal muscle atrophy, cardiovascular dysfunction, and disorders of almost all physiologic systems. However, the impacts of microgravity on blood lineage cells and hematopoietic stem cells (HSCs) in vivo are largely unknown. In this study, we analyzed peripheral blood samples from 6 astronauts ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(6):6904-6918]

Cited: 6 times

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Self-efficacy and its influencing factors of breast cancer screening for female college students in China.

Tingting Xie, Weijia Sun, Dandan Chen, Na Liu, Xinbo Wang, Wei Zhang,

AIM:This investigation aimed to study the general self-efficacy level and its influential factors of breast cancer screening for the female college students in Changchun city of China. METHODS:A three-part questionnaire was designed to investigate 220 female college students' general self-efficacy for breast cancer screening and its associated factors and knowledge ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2019, 45(5):1026-1034]

Cited: 2 times

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Effects of nonpharmacological interventions on depressive symptoms and depression among nursing students: A systematic review and meta-analysis.

Dandan Chen, Weijia Sun, Na Liu, Jie Wang, Pingping Guo, Xuehui Zhang, Wei Zhang,

OBJECTIVES:We aim to examine whether nonpharmacological interventions could effectively improve depressive symptoms and depression to provide more treatment options for nursing students. METHODS:PubMed, the Cochrane Library, EMBase, Web of Science, PsycINFO, and three Chinese electronic databases were comprehensively searched for papers that were published from January 1990 through March 2018. ... Read more >>

Complement Ther Clin Pract (Complementary therapies in clinical practice)
[2019, 34:217-228]

Cited: 3 times

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Fear of Cancer Recurrence: A Systematic Review of Randomized, Controlled Trials.

Dandan Chen, Weijia Sun, Na Liu, Jie Wang, Jingxia Zhao, Yue Zhang, Jinquan Liu, Wei Zhang,

<h4>Problem identification</h4>Fear of cancer recurrence (FCR) is prevalent among people with cancer; therefore, it is important to determine whether interventions offered to this population are effective in alleviating FCR. This review summarizes randomized, controlled trials in the literature about the effect of psychosocial interventions on FCR in people with cancer.<h4>Literature ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2018, 45(6):703-712]

Cited: 5 times

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Efficacy comparisons of enteral nutrition and parenteral nutrition in patients with severe acute pancreatitis: a meta-analysis from randomized controlled trials.

Ping Wu, Liang Li, Weijia Sun,

We conducted a comprehensive analysis to evaluate the treatment efficacy and safety of enteral nutrition (EN) and parenteral nutrition (PN) in severe acute pancreatitis (SAP) patients, and to provide a basis for their evidence based application in a clinical setting. We conducted a systematic online search of the PubMed, Web ... Read more >>

Biosci Rep (Bioscience reports)
[2018, 38(6):]

Cited: 2 times

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Coping self-efficacy of nursing undergraduates with problem-based curricula.

Weihui Gou, Weijia Sun, Dandan Chen, Zhen Zhang, Jingxia Zhao, Yue Zhang, Jingquan Liu, Wei Zhang,

<i>Background</i>: Few studies have examined whether nursing undergraduates can cope with a problem-based learning curriculum and its associated factors.<i>Objectives</i>: We studied nursing undergraduates' evaluations and attitudes related to the problem-based learning teaching method and their associated factors in the Chinese context, and evaluated their self-efficacy for coping with the problem-based ... Read more >>

Contemp Nurse (Contemporary nurse)
[2019, 55(4-5):288-302]

Cited: 1 time

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Association between vitamin D deficiency and antepartum and postpartum depression: a systematic review and meta-analysis of longitudinal studies.

Jie Wang, Na Liu, Weijia Sun, Dandan Chen, Jingxia Zhao, Wei Zhang,

<h4>Purpose</h4>The two previous reviews performed on the association of vitamin D deficiency in pregnancy with antepartum and postpartum depression were limited in reporting forms as they were both systematic reviews and the conclusions were also deemed to be inconclusive. Considering the high prevalence of vitamin D deficiency and depression during ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2018, 298(6):1045-1059]

Cited: 6 times

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Physical activity and body image dissatisfaction among pregnant women: A systematic review and meta-analysis of cohort studies.

Weijia Sun, Dandan Chen, Jie Wang, Na Liu, Wei Zhang,

Body image dissatisfaction has increased among pregnant women, affecting their mental and physical activities. Previous systematic reviews only found significant results existed in cross-sectional design instead of longitudinal designs. This meta-analytic review of cohort studies aimed to report the relationships and moderator variables about body image dissatisfaction and physical activity ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2018, 229:38-44]

Cited: 2 times

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Panax quinquefolium saponin attenuates cardiac remodeling induced by simulated microgravity.

Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Yang Li, Guohui Zhong, Ming Guo, Yuheng Li, Lin Yang, Jianpeng Du, Yuezhang Zhou, Jianwei Li, Shuai Liang, Yanqing Wang, Xingcheng Gao, Yating Zhang, Dengchao Cao, Caizhi Liu, Xiaoyan Jin, Zizhong Liu, Weijia Sun, Xiaorui Wu, Jinping Song, Yingxian Li, Dazhuo Shi,

<h4>Background</h4>Cardiac atrophy and reduced cardiac distensibility have been reported following space flight. Cardiac function is correspondingly regulated in response to changes in loading conditions. Panax quinquefolium saponin (PQS) improves ventricular remodeling after acute myocardial infarction by alleviating endoplasmic reticulum stress and Ca<sup>2+</sup>overload. However, whether PQS can ameliorate cardiac atrophy following ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2019, 56:83-93]

Cited: 2 times

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Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse.

Cheng Wang, Haoye Meng, Yu Wang, Bin Zhao, Chenyang Zhao, Weijia Sun, Yun Zhu, Bingxing Han, Xueling Yuan, Ruoxi Liu, Xin Wang, Aiyuan Wang, Quanyi Guo, Jiang Peng, Shibi Lu,

We explored the mechanism of early stage osteonecrotic femoral head collapse by analyzing and comparing different regions in human osteonecrotic femoral head samples. Eight osteonecrotic femoral heads (ARCO II-III) were obtained from patients undergoing total hip arthroplasty. Bone structure was observed and evaluated by micro-computed tomography (CT) scans and pathology. ... Read more >>

Int J Biol Sci (International journal of biological sciences)
[2018, 14(2):156-164]

Cited: 9 times

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LncRNA BC032020 suppresses the survival of human pancreatic ductal adenocarcinoma cells by targeting ZNF451.

Zhipeng Zhang, Hongxi Chen, Yebin Lu, Tiecheng Feng, Weijia Sun,

This study examined the effects of long non‑coding RNA (lncRNA) BC032020 on the development of human pancreatic ductal adenocarcinoma (PDAC), and the potential molecular mechanisms responsible for these effects. The expression of BC032020 was assessed in 20 pairs of PDAC tumor tissues and adjacent normal tissues. The overexpression of BC032020 was ... Read more >>

Int J Oncol (International journal of oncology)
[2018, 52(4):1224-1234]

Cited: 3 times

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