Full Text Journal Articles by
Author Weichen Wu


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Co-Infecting Pathogens Can Contribute to Inflammatory Responses and Severe Symptoms in COVID-19

Liping Chen, Lihan Shen, Weichen Wu, Wenda Guan, Jinchao Zhou, Gengyan Luo, Qimin Chen, Hongxia Zhou, Zhenxuan Deng, Yao-qing Chen, Wen-jing Zhao, Wenxiang Jin, Minshan Qiu, Qianwei Zheng, Chen Liu, Xiangxiang Bai, Deyin Guo, Edward Holmes, Nan-Shan Zhong, Mang Shi, Zifeng Yang,

Background: The current pandemic of COVID-19 is posing a major challenge to public health on a global scale. While it is generally believed severe COVID-19 results from over-expression of inflammatory mediators (i.e. a “cytokine storm”), it is still unclear whether and how co-infecting pathogens contribute to disease pathogenesis. To address ... Read more >>

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Fast automatic design method for freeform imaging systems through system construction and correction.

Weichen Wu, Hui Wang, Guofan Jin, Jun Zhu,

In traditional optical design, a starting point is selected and coefficients optimization is then performed using software. The process requires considerable time and the involvement of a human with design skills and experience. In this Letter, a fast automatic method for freeform imaging systems design is proposed. Using a plane ... Read more >>

Opt Lett (Optics letters)
[2020, 45(18):5140-5143]

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RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.

Liangjun Chen, Weiyong Liu, Qi Zhang, Ke Xu, Guangming Ye, Weichen Wu, Ziyong Sun, Fang Liu, Kailang Wu, Bo Zhong, Yi Mei, Wenxia Zhang, Yu Chen, Yirong Li, Mang Shi, Ke Lan, Yingle Liu,

From December 2019, an outbreak of unusual pneumonia was reported in Wuhan with many cases linked to Huanan Seafood Market that sells seafood as well as live exotic animals. We investigated two patients who developed acute respiratory syndromes after independent contact history with this market. The two patients shared common ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):313-319]

Cited: 126 times

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Role of systemic injection of rabies immunoglobulin in rabies vaccination.

Weichen Wu, Shuqing Liu, Pengcheng Yu, Xiaoyan Tao, Xuexin Lu, Jianghong Yan, Qian Wang, Zongshen Zhang, Wuyang Zhu,

To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably ... Read more >>

Arch Virol (Archives of virology)
[2017, 162(6):1701-1703]

Cited: 1 time

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[Advances in Application of Rabies Immunoglobulin].

Weichen Wu, Jingxia Luo, Weixian Liang, Jianghong Yan, Wuyang Zhu, Xinjun Lv,

China has the second highest number of rabies cases worldwide. There are millions of category III rabies exposure cases in China every year, which are treated with rabies immunoglobulin(RIG)and the rabies vaccine. The price of RIG is relatively expensive, and the application of RIG is relatively complicated. The rate of ... Read more >>

Bing Du Xue Bao (Bing du xue bao = Chinese journal of virology)
[2016, 32(5):666-670]

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Sorting of large-diameter semiconducting carbon nanotube and printed flexible driving circuit for organic light emitting diode (OLED).

Wenya Xu, Jianwen Zhao, Long Qian, Xianying Han, Liangzhuan Wu, Weichen Wu, Minshun Song, Lu Zhou, Wenming Su, Chao Wang, Shuhong Nie, Zheng Cui,

A novel approach was developed to sort a large-diameter semiconducting single-walled carbon nanotube (sc-SWCNT) based on copolyfluorene derivative with high yield. High purity sc-SWCNTs inks were obtained by wrapping arc-discharge SWCNTs with poly[2,7-(9,9-dioctylfluorene)-alt-4,7-bis(thiophen-2-yl)benzo-2,1,3-thiadiazole] (PFO-DBT) aided by sonication and centrifugation in tetrahydrofuran (THF). The sorted sc-SWCNT inks and nanosilver inks were ... Read more >>

Nanoscale (Nanoscale)
[2014, 6(3):1589-1595]

Cited: 21 times

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Vascular COX-2 modulates blood pressure and thrombosis in mice.

Ying Yu, Emanuela Ricciotti, Rosario Scalia, Soon Yew Tang, Gregory Grant, Zhou Yu, Gavin Landesberg, Irene Crichton, Weichen Wu, Ellen Puré, Colin D Funk, Garret A FitzGerald,

Prostacyclin (PGI(2)) is a vasodilator and platelet inhibitor, properties consistent with cardioprotection. More than a decade ago, inhibition of cyclooxygenase-2 (COX-2) by the nonsteroidal anti-inflammatory drugs (NSAIDs) rofecoxib and celecoxib was found to reduce the amount of the major metabolite of PGI(2) (PGI-M) in the urine of healthy volunteers. This ... Read more >>

Sci Transl Med (Science translational medicine)
[2012, 4(132):132ra54]

Cited: 96 times

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EBP, a program for protein identification using multiple tandem mass spectrometry datasets.

Thomas S Price, Margaret B Lucitt, Weichen Wu, David J Austin, Angel Pizarro, Anastasia K Yocum, Ian A Blair, Garret A FitzGerald, Tilo Grosser,

MS/MS combined with database search methods can identify the proteins present in complex mixtures. High throughput methods that infer probable peptide sequences from enzymatically digested protein samples create a challenge in how best to aggregate the evidence for candidate proteins. Typically the results of multiple technical and/or biological replicate experiments ... Read more >>

Mol Cell Proteomics (Molecular & cellular proteomics : MCP)
[2007, 6(3):527-536]

Cited: 34 times

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