Full Text Journal Articles by
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Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release.

Wei Wei, Zhentao Sun, Shifeng He, Wanyue Zhang, Sai Chen, Ya-Nan Cao, Ning Wang,

Mechanical ventilation can induce lung injury and exacerbate brain injury due to lung-brain interaction. The current study sought to investigate the mechanism of lung-brain interaction induced by mechanical ventilation and offer theoretical insight into the management of ventilator-induced brain injury. The experimental mice were assigned into the spontaneously breathing group ... Read more >>

Bioengineered (Bioengineered)
[2022, 13(2):2346-2359]

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Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment.

Yuan Deng, Wei Wei, Peifu Tang,

With rapidly aging populations worldwide, osteoporosis has become a serious global public health problem. Caused by disordered systemic bone remodeling, osteoporosis manifests as progressive loss of bone mass and microarchitectural deterioration of bone tissue, increasing the risk of fractures and eventually leading to osteoporotic fragility fractures. As fracture risk increases, ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2022, :]

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A pilot study of function-based radiation therapy planning for lung cancer using hyperpolarized xenon-129 ventilation MRI.

Yi Ding, Lu Yang, Qian Zhou, Jianping Bi, Ying Li, Guoliang Pi, Wei Wei, Desheng Hu, Qiuchen Rao, Haidong Li, Li Zhao, An Liu, Dongsu Du, Xiao Wang, Xin Zhou, Guang Han, Kun Qing,

<h4>Purpose</h4>Radiation-induced lung injury (RILI) is a common side effect in patients with non-small cell lung cancer (NSCLC) treated with radiotherapy. Minimizing irradiation into highly functional areas of the lung may reduce the occurrence of RILI. The aim of this study is to evaluate the feasibility and utility of hyperpolarized xenon-129 ... Read more >>

J Appl Clin Med Phys (Journal of applied clinical medical physics)
[2022, :e13502]

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Dynamics and vector correlations of vacuum ultraviolet (VUV) photodissociation of CO2 at 155 nm.

Evangelia Sakkoula, Gautam Sharma, Xingan Wang, Simon W North, David H Parker, Wei Wei,

In this work, the CO<sub>2</sub> Vacuum Ultraviolet (VUV) photodissociation dynamics of the dominant O(<sup>1</sup>D) channel near 155 nm have been studied using Velocity Map Imaging (VMI) technique. Correlations among the transition dipole moment of the parent molecule, recoil velocity vector and rotational angular momentum vector of the photofragments were extracted ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2022, 24(4):2592-2600]

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Pediatric Tuina in children with autism spectrum disorder: a study protocol for a randomized controlled trial.

Xiang Feng, Quanrui Jiang, Yuxing Zhang, Tao Li, Wei Wei, Jun Yu, Wu Li, Jiangshan Li,

<h4>Background</h4>Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by repetitive stereotypical behavior and communication deficits. Currently, it lacks a specific clinical treatment method. Pediatric Tuina is a recent therapy in traditional Chinese medicine (TCM) and has been used to treat children with ASD. Nonetheless, it remains uncommon given the ... Read more >>

Trials (Trials)
[2022, 23(1):75]

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Quality of life following concurrent temozolomide-based chemoradiation therapy or observation in low-grade glioma.

Deborah Y Park, Martin C Tom, Wei Wei, Surabhi Tewari, Manmeet S Ahluwalia, Jennifer S Yu, Samuel T Chao, John H Suh, David Peereboom, Glen H J Stevens, Gene H Barnett, Lilyana Angelov, Alireza M Mohammadi, Thomas Hogan, Courtney Kissel, Brittany Lapin, Isabel Schuermeyer, Michael W Parsons, Richard Naugle, Erin S Murphy,

<h4>Purpose</h4>Low-grade glioma (LGG) exhibits longer median survival than high-grade brain tumors, and thus impact of our therapies on patient quality of life remains a crucial consideration. This study evaluated the effects of concurrent temozolomide-based chemoradiation (RT + TMZ) or observation on quality of life (QOL) in patients with low-grade glioma.<h4>Methods</h4>We completed a ... Read more >>

J Neurooncol (Journal of neuro-oncology)
[2022, :]

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Proton Pump Inhibitors Could Ameliorate Cachexia of Gastric Cancer by Down-regulating Vacuolar H+- ATPases and Disrupting PI3K/AKT/mTOR/HIF-1α/PKM2 Signaling Pathway

Wang Zhuoting, Wang Yunrong, Wei Wei, Sun Wenqi, Wu Xinrong, Min Chen,

<h4>Objective: </h4> : Our study aimed to investigate whether PPIs could alleviate cachexia of gastric cancer by inhibiting the expression of V-ATPases, downregulating the PI3K/AKT/mTOR/HIF-1α signaling pathway and then inhibiting PKM2. <h4>Methods: </h4>: Human gastric cancer cell lines SGC7901, BGC823 and MKN28 were treated by PPIs or downregulated related factors, ... Read more >>

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Class I histone deacetylases (HDAC1-3) are histone lysine delactylases.

Carlos Moreno-Yruela, Di Zhang, Wei Wei, Michael Bæk, Wenchao Liu, Jinjun Gao, Daniela Danková, Alexander L Nielsen, Julie E Bolding, Lu Yang, Samuel T Jameson, Jiemin Wong, Christian A Olsen, Yingming Zhao,

Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with functions that are different from the widely studied histone acetylation. While K(L-la) can be introduced by the acetyltransferase p300, histone delactylases enzymes remained unknown. Here, we ... Read more >>

Sci Adv (Science advances)
[2022, 8(3):eabi6696]

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Treatment Outcomes with Purine Nucleoside Analog Alone or with Rituximab for Hairy Cell Leukemia at First Relapse.

Rachel Hu, Wei Wei, Agrima Mian, Kristen Gonter-Aubin, Charlene Kabel, Anthony Mato, Deborah M Stephens, Ashley Hanlon, Sirin Khajavian, Mazyar Shadman, Danielle Brander, Yazan Madanat, Jae H Park, Martin Tallman, Javier Pinilla-Ibarz, Brian T Hill,

<h4>Introduction</h4>Frontline treatment of hairy cell leukemia (HCL) with a single course of the purine nucleoside analog (PNA) produces a high rate of complete remission (CR) with prolonged durations. At the time of relapse, although treatment guidelines recommend re-treatment with a PNA alone or in combination with rituximab (R), practice patterns ... Read more >>

Eur J Haematol (European journal of haematology)
[2022, :]

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Cross-modality LGE-CMR Segmentation using Image-to-Image Translation based Data Augmentation.

Wei Wang, Xinhua Yu, Bo Fang, Dianna-Yue Zhao, Yongyong Chen, Wei Wei, Junxin Chen,

Accurate segmentation of ventricle and myocardium from the late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) is an important tool for myocardial infarction (MI) analysis. However, the complex enhancement pattern of LGE-CMR and the lack of labeled samples make its automatic segmentation difficult to be implemented. In this paper, we ... Read more >>

IEEE/ACM Trans Comput Biol Bioinform (IEEE/ACM transactions on computational biology and bioinformatics)
[2022, PP:]

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The risk of perchlorate and iodine on the incidence of thyroid tumors and nodular goiter: a case-control study in southeastern China.

Huirong Wang, Yousheng Jiang, Jiayi Song, Huiwen Liang, Yuan Liu, Jiewu Huang, Pengliang Yin, Dongting Wu, Hang Zhang, Xinjie Liu, Dongxian Zhou, Wei Wei, Lin Lei, Ji Peng, Jianqing Zhang,

<h4>Background</h4>The incidence rates of thyroid tumors and nodular goiter show an upward trend worldwide. There are limited reports on the risk of perchlorate and iodine on thyroid tumors, but evidence from population studies is scarce, and their impact on thyroid function is still uncertain. Therefore, the objective of this study ... Read more >>

Environ Health (Environmental health : a global access science source)
[2022, 21(1):4]

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Antibiotic resistomes in water supply reservoirs sediments of central China: main biotic drivers and distribution pattern.

Kai Zhang, Kuangjia Li, Rui Xin, Ya Han, Ziwei Guo, Wei Zou, Wei Wei, Xiangchao Cui, Zhongshuai Zhang, Ying Zhang,

Water supply reservoirs form one of the critical drinking water resources. Their water quality directly affects human health. However, reservoir sediments have not received adequate attention in antibiotic resistance genes (ARGs) dissemination, though they reflect long-term ARGs contamination of water supply reservoirs. Moreover, the physicochemical parameters in water supply reservoir ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2022, :]

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Using the UniFrac metric on Whole Genome Shotgun data

Wei Wei, David Koslicki,

The UniFrac metric has proven useful in revealing diversity across metagenomic communities. Due to the phylogeny-based nature of this measurement, UniFrac has historically only been applied to 16S rRNA data. Simultaneously, Whole Genome Shotgun (WGS) metagenomics has been increasingly widely employed and proven to provide more information than 16S data, ... Read more >>

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Endothelial Leakiness Induced by Amyloid Protein Aggregation

Yuhuan Li, Nengyi Ni, Myeongsang Lee, Wei Wei, Nikolaos Andrikopoulos, Aleksandr Kakinen, Thomas Davis, Yang Song, Feng Ding, David Leong, Pu Chun Ke,

Alzheimer’s disease (AD) is a major cause of dementia debilitating the global ageing population. Current understanding of the AD pathophysiology implicates the aggregation of amyloid beta (Aβ) as causative to neurodegeneration, with tauopathies and neuroinflammation considered as other major culprits. Curiously, vascular endothelial barrier dysfunction is strongly associated with Aβ ... Read more >>

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The information-motivation-behavioral skills (IMB) model of antiretroviral therapy (ART) adherence among people living with HIV in Shanghai.

Zihe Peng, Hui Chen, Wei Wei, Yuelin Yu, Yujie Liu, Rongxi Wang, Xiaoyue Yu, Chen Xu, Rusi Long, Yongchun Hou, Zhenyu Sun, Ying Wang, Zhang Lin, Zhou Ying, Kechun Zhang, Huachun Zou, Yong Cai,

The Information-Motivation-Behavioral skills (IMB) model of antiretroviral therapy (ART) adherence was applied in people living with HIV/AIDS in Shanghai, China to understand how adherence-related information, motivation and behavioral skills would affect ART adherence. The LifeWindows Information-Motivation-Behavioral Skills ART Adherence Questionnaire (LW-IMB-AAQ) was translated into Chinese and used. The IMB model ... Read more >>

AIDS Care (AIDS care)
[2021, :1-6]

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Modification of mesenchymal stem cells by HMGB1 promotes the activity of Cav3.2 T-type calcium channel via PKA/β-catenin/γ-cystathionase pathway.

Hao Wu, Xiaodong Xie, Mingyang Sun, Min Chen, Xuan Tao, Xin Fang, Xiaohu Meng, Wei Wei, Min Yu,

<h4>Background</h4>Mesenchymal stem cells (MSC) hold great promise for treating cardiovascular disease. Recently, we genetically modified MSCs with high mobility group box 1 (HMGB1), and these cells demonstrated high mobility by efficient migrating and homing to target neointima. The possible mechanism was investigated in the current study.<h4>Methods</h4>Rat MSCs were transfected with ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2022, 13(1):4]

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Risks and Association of Impaired Cerebral Autoregulation With Outcomes in Aortic Arch Surgery: A Single-center, Retrospective Cohort Study

Ling Peng, Dan Guo, Yinhui Shi, Jiapei Yang, Wei Wei,

<h4>Background: </h4> Impairment of cerebral autoregulation (CA) has been observed in patients undergoing cardiopulmonary bypass (CPB), but little is known about its risks and associations with outcomes. The objective of this study was to analyze the risks of impaired CA, based on cerebral oximetry index (COx), in patients undergoing total ... Read more >>

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Eccentric Compressive Behavior of Round-Ended Rectangular Concrete-Filled Steel Tubes with Different Central Angles.

Zhigang Ren, Qi Li, Gaoyu Wang, Wei Wei, Mohammed A A M Abbas,

The application of round-ended rectangular concrete-filled steel tubes (RRCFSTs) in high-rise buildings or bridge structures is increasing, improving structural performance and meeting aesthetic requirements. Researching this novel steel-concrete composite helps to fully utilize the properties of the materials. In this study, 15 specimens were tested for analysis of the behaviors ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2022, 15(2):]

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Diagnostic accuracy of anthropometric indices for discriminating elevated blood pressure in pediatric population: a systematic review and a meta-analysis.

Jun-Min Tao, Wei Wei, Xiao-Yang Ma, Ying-Xiang Huo, Meng-Die Hu, Xiao-Feng Li, Xin Chen,

<h4>Background</h4>Childhood obesity is more likely to increase the chance of many adult health problems. Numerous studies have shown obese children to be more prone to elevated blood pressure (BP) and hypertension. It is important to identify an obesity anthropometric index with good discriminatory power for them in pediatric population.<h4>Methods</h4>MEDLINE/PubMed, Web ... Read more >>

BMC Pediatr (BMC pediatrics)
[2022, 22(1):19]

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Attenuated sensitivity of ozone to precursors in Beijing-Tianjin-Hebei region with the continuous NOx reduction within 2014-2018.

Wei Wei, Xingfeng Wang, Xiaoqi Wang, Rui Li, Chunyan Zhou, Shuiyuan Cheng,

Facing the elevated surface summer O<sub>3</sub> over North China in recent years with the continuous NO<sub>x</sub> reduction, we conducted the ozone-precursor sensitivity study in summer (July) in Beijing-Tianjin-Hebei region (BTH) under the 2018 and 2014 emissions, based on WRF-Chem model. On 2018 emission condition, 30% precursor reduction simulations presented the ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 813:152589]

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Skeleton-Based Abnormal Behavior Detection Using Secure Partitioned Convolutional Neural Network Model.

Jiefan Qiu, Xinlei Yan, Wei Wang, Wei Wei, Kai Fang,

The abnormal behavior detection is the vital for evaluation of daily-life health status of the patient with cognitive impairment. Previous studies about abnormal behavior detection indicate that convolution neural network (CNN)-based computer vision owns the high robustness and accuracy for detection. However, executing CNN model on the cloud possible incurs ... Read more >>

IEEE J Biomed Health Inform (IEEE journal of biomedical and health informatics)
[2021, PP:]

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Repetitive transcranial magnetic stimulation modulates cortical-subcortical connectivity in sensorimotor network.

Jing Chen, Yanzi Fan, Wei Wei, Luoyu Wang, Xiaoyu Wang, Fengmei Fan, Zejuan Jia, Mengting Li, Jinhui Wang, Qihong Zou, Bing Chen, Yating Lv,

Repetitive transcranial magnetic stimulation (rTMS) holds the ability to modulate the connectivity within the stimulated network. However, whether and how the rTMS targeted over the primary motor cortex (M1) could affect the connectivity within the sensorimotor network (SMN) is not fully elucidated. Hence, in this study, we investigated the after-effects ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2022, 55(1):227-243]

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Autotrophic denitrification of NO for effectively recovering N2O through using thiosulfate as sole electron donor.

Lan Wu, Li-Kun Wang, Wei Wei, Bing-Jie Ni,

To reclaim nitrous oxide (N<sub>2</sub>O) as an energy resource economically, this study developed an autotrophic denitrification-based system with thiosulfate (S<sub>2</sub>O<sub>3</sub><sup>2-</sup>) and nitric oxide (NO) as electron donor and acceptor, respectively. NO from flue gases is absorbed on Fe(II)EDTA to overcome its low solubility in liquid phase by forming Fe(II)EDTA-NO. Short-term ... Read more >>

Bioresour Technol (Bioresource technology)
[2022, 347:126681]

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Evaluation of the anti-tumor activities of Sulfonylurea Derivatives

Sen Lu, Chenchen Guo, Lei Wu, Zhanying Zheng, Xuewen Hua, Wei Wei, Wenqin Zhang, Shaa Zhou, Ruo Li, Sha Zhou,

This study prepared 25 sulfonylurea compounds to evaluate anti-tumor activity. Through experimental investigations in MDA-MB-231 and MCF-7, i.e., cell lines of breast carcinoma of human, we have concluded that some compounds can significantly suppress breast carcinoma cells from growing and proliferating. Moreover, the compound M’s inhibitory effect on cells of ... Read more >>

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The enzymatic synthesis of EPA-rich medium- and long-chain triacylglycerol improves the digestion behavior of MCFA and EPA: evidence on in vitro digestion.

Yandan Wang, Minjie Cao, Ruijie Liu, Ming Chang, Wei Wei, Qingzhe Jin, Xingguo Wang,

Medium-chain triglyceride (MCT) and eicosapentaenoic acid (EPA) have been widely applied in nutritional supplementation. However, when administered individually or mixed, they were unable to maximize their nutritional value. Hence, EPA-rich medium- and long-chain triacylglycerol (MLCT) was synthesized from MCT and EPA-rich fish oil (FO) by enzymatic transesterification. The fatty acids ... Read more >>

Food Funct (Food & function)
[2022, 13(1):131-142]

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