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Knockout of Sirt2 alleviates traumatic brain injury in mice.

Wei Wang, Qiu-Yuan Gong, Lin Cai, Yao Jing, Dian-Xu Yang, Fang Yuan, Hao Chen, Heng-Li Tian,

Sirtuin 2 (SIRT2) inhibition or Sirt2 knockout in animal models protects against the development of neurodegenerative diseases and cerebral ischemia. However, the role of SIRT2 in traumatic brain injury (TBI) remains unclear. In this study, we found that knockout of Sirt2 in a mouse model of TBI reduced brain edema, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2023, 18(2):350-356]

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Delphinidin-3-O-glucoside, an active compound of Hibiscus sabdariffa calyces, inhibits oxidative stress and inflammation in rabbits with atherosclerosis.

Bo Sun, Fangda Li, Xu Zhang, Wei Wang, Jiang Shao, Yuehong Zheng,

<h4>Context</h4>Delphinidin-3-<i>O</i>-glucoside (DP) is a bioactive compound of <i>Hibiscus sabdariffa</i> L. (Malvaceae) (Roselle) calyces and exerts endothelial protection and lipid-lowering activities, which provided a basis for the prevention and treatment of cardiovascular diseases.<h4>Objectives</h4>To investigate the therapeutic effects of DP against atherosclerosis.<h4>Materials and methods</h4>A rabbit model of atherosclerosis (AS) was established by ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):247-254]

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