Full Text Journal Articles by
Author Wei Wang

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A peptide-drug hydrogel to enhance the anti-cancer activity of chlorambucil.

Qingxiang Guo, Yifan Liu, Ganen Mu, Lijun Yang, Wei Wang, Jinjian Liu, Jianfeng Liu,

The clinical applications of nitrogen mustard antitumor drugs are limited by their poor aqueous solubility, poor cellular uptake, lack of targeting, and severe side effects. Cyclen could be protonated under physiological conditions, which may be beneficial for increasing cell membrane affinity and cellular uptake. Herein, a novel self-assembling peptide-drug conjugate ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(20):5638-5646]

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A AuNP-capped cage fluorescent biosensor based on controlled-release and cyclic enzymatic amplification for ultrasensitive detection of ATP.

Wei Wang, Xin Li, Kai Tang, Zhiling Song, Xiliang Luo,

Gold nanodevices have attracted extensive interest in the detection of specific targets within cells. However, constructing gold sensing devices that can be activated by the simulation of remote applications remains a huge challenge. Here, we report a Au nanoparticle (AuNP)-capped cage fluorescent biosensor based on controlled-release and Exonuclease III (Exo ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(27):5945-5951]

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In situ self-assembled biosupramolecular porphyrin nanofibers for enhancing photodynamic therapy in tumors.

Yang Liu, Xiaomin Li, Xiaoyan Niu, Licheng Yu, Weizhou Sha, Wei Wang, Zhi Yuan,

Due to the complicated environment and high tissue hydraulic pressure in tumors that easily pumps the nanomedicines back to the systemic circulation, the concentration of released photosensitizers (PSs) retained in a tumor by a traditional nano-delivery system is very low, causing an unsatisfactory photodynamic therapy (PDT) effect. Therefore, we prepared ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(20):11119-11129]

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Non-oscillatory micromotors "learn" to oscillate on-the-fly from oscillating Ag micromotors.

Chao Zhou, Qizhang Wang, Xianglong Lv, Wei Wang,

The ability to learn new functionalities on-the-fly is highly desired for micromotors operating in a changing environment. Here, we demonstrate how non-oscillatory micromotors transform into spontaneous oscillators, superficially resembling students learning from teachers, via the diffusion then deposition of Ag ions that act as a speed-booster that periodically turns on. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(48):6499-6502]

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Bimetallic coatings synergistically enhance the speeds of photocatalytic TiO2 micromotors.

Zuyao Xiao, Jingyuan Chen, Shifang Duan, Xianglong Lv, Jizhuang Wang, Xing Ma, Jinyao Tang, Wei Wang,

The design of powerful, more biocompatible microrobots calls for faster catalytic reactions. Here we demonstrate a two-fold increase in the speed of photocatalytic TiO2-metal Janus micromotors via a Au/Ag bi-layered coating. Electrochemical measurements show that such a bimetallic coating is a better photocatalyst than either metal alone. Similarly, an additional ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(34):4728-4731]

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Magnetic hierarchical porous SiO2 microparticles from droplet microfluidics for water decontamination.

Mao-Jie Zhang, Ting Chen, Ping Zhang, Zhi-Lu Li, Li Chen, Yao-Yao Su, Lian-Di Qiu, Gang Peng, Wei Wang, Liang-Yin Chu,

A simple and flexible strategy based on droplet microfluidics is developed for controllable fabrication of uniform magnetic SiO2 microparticles with highly-interconnected hierarchical porous structures for enhanced water decontamination. Uniform precursor water droplets containing surfactants and homogenized fine oil droplets with a relatively high volume ratio are generated from microfluidics as ... Read more >>

Soft Matter (Soft matter)
[2020, 16(10):2581-2593]

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Au-Hg/rGO with enhanced peroxidase-like activity for sensitive colorimetric determination of H2O2.

Fen-Ying Kong, Lei Yao, Xin-Yang Lu, Heng-Ye Li, Zhong-Xia Wang, Hai-Lin Fang, Wei Wang,

The Au-Hg amalgam anchored on the surface of reduced graphene oxide nanosheets (Au-Hg/rGO) has been synthesized successfully and characterized by various techniques such as transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. The Au-Hg/rGO nanocomposites were found to possess excellent peroxidase-like catalytic activity and can quickly catalyze the oxidation ... Read more >>

Analyst (The Analyst)
[2020, 145(6):2191-2196]

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Association between the methylation status of PCDH17 and the efficacy of neoadjuvant chemotherapy in triple-negative breast cancer.

De-Di Kong, Rong-Zhan Fu, Liang Li, Wei Wang, Shi-Bing Wang,

The present study aimed to assess whether the methylation status of the protocadherin 17 gene (PCDH17) in triple-negative breast cancer (TNBC) tissues was associated with the efficacy of neoadjuvant chemotherapy (NAC). The present study included 280 patients diagnosed with TNBC using core needle biopsy. Tumor pathological diagnosis was determined via ... Read more >>

Oncol Lett (Oncology letters)
[2020, 20(2):1649-1656]

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Measuring Time-Sensitive and Topic-Specific Influence in Social Networks with LSTM and Self-Attention.

Cheng Zheng, Qin Zhang, Guodong Long, Chengqi Zhang, Sean D Young, Wei Wang,

Influence measurement in social networks is vital to various real-world applications, such as online marketing and political campaigns. In this paper, we investigate the problem of measuring time-sensitive and topic-specific influence based on streaming texts and dynamic social networks. A user's influence can change rapidly in response to a new ... Read more >>

IEEE Access (IEEE access : practical innovations, open solutions)
[2020, 8:82481-82492]

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SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.

Carmine Fedele, Shuai Li, Kai Wen Teng, Connor J R Foster, David Peng, Hao Ran, Paolo Mita, Mitchell J Geer, Takamitsu Hattori, Akiko Koide, Yubao Wang, Kwan Ho Tang, Joshua Leinwand, Wei Wang, Brian Diskin, Jiehui Deng, Ting Chen, Igor Dolgalev, Ugur Ozerdem, George Miller, Shohei Koide, Kwok-Kin Wong, Benjamin G Neel,

KRAS is the most frequently mutated human oncogene, and KRAS inhibition has been a longtime goal. Recently, inhibitors were developed that bind KRASG12C-GDP and react with Cys-12 (G12C-Is). Using new affinity reagents to monitor KRASG12C activation and inhibitor engagement, we found that an SHP2 inhibitor (SHP2-I) increases KRAS-GDP occupancy, enhancing ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2021, 218(1):]

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The observed topological vortex domains and the rotating magnetocaloric effect in the hexagonal RMnO3 (R = Ho, Er, and Yb) crystals.

Wei Wang, Ye Li, Leiyu Li, Qianjie Li, Dongdong Wang, Jiangyuan Zhu, Jin Li, Min Zeng,

Hexagonal RMnO3 (R = Er, Ho and Yb) single crystals were grown and their unique vortex domain structures, magnetic properties and magnetocaloric effect (MCE) were comprehensively investigated. The topological vortex domains/structures were clearly illustrated by polarized optical microscope and piezo response force microscopy, confirming a high quality of the crystals. ... Read more >>

J Phys Condens Matter (Journal of physics. Condensed matter : an Institute of Physics journal)
[2021, 33(1):015802]

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Highly stereoselective synthesis of aryl/heteroaryl-C-nucleosides via the merger of photoredox and nickel catalysis.

Yingying Ma, Shihui Liu, Yifan Xi, Hongrui Li, Kai Yang, Zhihao Cheng, Wei Wang, Yongqiang Zhang,

A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2019, 55(97):14657-14660]

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One-pot green and simple synthesis of actinian nickel-doped carbon nanoflowers for ultrasensitive sensing of quercetin.

Yuan-Fei Gao, Xing Jin, Fen-Ying Kong, Zhong-Xia Wang, Wei Wang,

In this contribution, a one-pot method possessing the advantages of easy preparation, rapidness, efficiency and environmental friendliness has been developed for the first time for the facile synthesis of highly fluorescent actinian nickel-doped carbon nanoflowers (Ni-CNFWs) by using nickel(ii)acetylacetonate as a metal-carbon source. Various characterization studies indicate that metal nickel ... Read more >>

Analyst (The Analyst)
[2019, 144(24):7283-7289]

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LncRNA SNHG4 regulates miR-10a/PTEN to inhibit the proliferation of acute myeloid leukemia cells.

Zhongtao Yuan, Wei Wang,

ABSTRACTObjectives: Long non-coding RNA (lncRNA) small nucleolar RNA host gene 4 (SNHG4) is a characterized oncogenic lncRNA in osteosarcoma. The analysis of the TCGA dataset suggested the downregulation of SNHG4 in acute myeloid leukemia (AML), indicating its possible involvement in this disease. Therefore, this study was performed to analyze the ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):160-164]

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Combined freezing-thawing pretreatment and microbial electrolysis cell for enhancement of highly concentrated organics degradation from dewatered sludge.

Kai Hu, Shuo-Qiu Jia, Cheng Yang, Xing Sun, Wei Chen, Wei Wang, Feng Han,

The influence of freezing-thawing (F/T) pretreatment on the degradation of highly concentrated organic matters from dewatered sludge (DS) in microbial electrolysis cell (MEC) was investigated in this study. Extended freezing disintegrated the DS matrix and resulted in accelerated hydrolysis rate. The biogas production and stabilization were increased due to the ... Read more >>

Bioengineered (Bioengineered)
[2020, 11(1):301-310]

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Exploring the 'cold/hot' properties of traditional Chinese medicine by cell temperature measurement.

Suyun Yu, Can Li, Yushi Ding, Shuai Huang, Wei Wang, Yuanyuan Wu, Fangxu Wang, Aiyun Wang, Yuexia Han, Zhiguang Sun, Yin Lu, Ning Gu,

Context: It is common sense that chewing a mint leaf can cause a cooling feeling, while chewing ginger root will produce a burning feeling. In Traditional Chinese Medicine (TCM), this phenomenon is referred to as 'cold/hot' properties of herbs. Herein, it is reported that TCM with different "cold/hot" properties have ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):208-218]

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Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors.

Huan Han, Qingfeng Ma, Cong Li, Rui Liu, Li Zhao, Wei Wang, Pingan Zhang, Xinghui Liu, Guosheng Gao, Fang Liu, Yingan Jiang, Xiaoming Cheng, Chengliang Zhu, Yuchen Xia,

Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1123-1130]

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Zwitterionic chitooligosaccharide-modified ink-blue titanium dioxide nanoparticles with inherent immune activation for enhanced photothermal therapy.

Yahui Zhang, Weizhou Sha, Xiaolei Zhang, Mingbo Cheng, Qiang Wu, Wei Wang, Zhi Yuan,

Photothermal therapy (PTT) can trigger massive apoptosis of cancer cells, and this sharply increasing local apoptotic rate may recruit plenty of tumor-associated macrophages (TAMs). Although TAMs are recognized to display an M2-like subtype, which encourages tumor ontogenesis, they can be re-educated to a tumoricidal M1-like subtype by immunomodulatory reagents. Chitooligosaccharides ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(12):5027-5034]

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Parathyroid Hormone and Bone Mineral Density: A Mendelian Randomization Study.

Zihao Qu, Fangkun Yang, Jianqiao Hong, Wei Wang, Shigui Yan,

PURPOSE:Accumulating evidence implicates parathyroid hormone (PTH) in the development of osteoporosis. However, the causal effect of PTH on bone mineral density (BMD) remains unclear. Thus, this study is aimed at exploring the association between the concentrations of serum PTH and BMD. METHODS:The instrumental variables for PTH were selected from a ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(11):]

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Prognostic implications of programmed death ligand 1 expression in resected lung adenocarcinoma: a systematic review and meta-analysis.

Donglai Chen, Yiming Mao, Qifeng Ding, Wei Wang, Feng Zhu, Chang Chen, Yongbing Chen,

OBJECTIVES:Conflicting results have been reported about the prognostic value of programmed death ligand 1 (PD-L1) protein and gene expression in lung adenocarcinoma. METHODS:We performed a comprehensive online search to explore the association between PD-L1 expression (protein and messenger RNA) and overall survival (OS) or disease-free survival. Outcomes also included pooled ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2020, 58(5):888-898]

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Cell division requires RNA eviction from condensing chromosomes.

Judith A Sharp, Carlos Perea-Resa, Wei Wang, Michael D Blower,

During mitosis, the genome is transformed from a decondensed, transcriptionally active state to a highly condensed, transcriptionally inactive state. Mitotic chromosome reorganization is marked by the general attenuation of transcription on chromosome arms, yet how the cell regulates nuclear and chromatin-associated RNAs after chromosome condensation and nuclear envelope breakdown is ... Read more >>

J Cell Biol (The Journal of cell biology)
[2020, 219(11):]

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Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma.

Wei Wang, Chaojie Wei, Zhenshun Cheng, Jiong Yang,

PURPOSE:Allergen exposure induces aberrant T helper (Th) 2 immune responses in patients with allergic asthma, but not in sensitized asymptomatic and nonallergic subjects. Interleukin (IL)-35-induced regulatory T (iTr35) cells are a new subset of regulatory T cells with immunoregulatory properties. These cells can significantly suppress Th2 responses in seasonal allergic ... Read more >>

Allergy Asthma Immunol Res (Allergy, asthma & immunology research)
[2020, 12(6):1029-1045]

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Green preparation of core-shell [email protected] nanoparticles with chitosan for glucose detection

Fengxia Wang, Xu Ding, Xiaobo Niu, Xianyi Liu, Wei Wang, Ji Zhang,

Although core-shell structure is favored by many applications, preparing it with green way is rarely been reported. Herein, a core-shell structured [email protected] nanocomposite is greenly fabricated utilizing a natural chitosan and applied to glucose detection. As-obtained [email protected] nanoparticles were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and ... Read more >>

(Carbohydrate polymers.)
[2020, 247:Not Available]

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The Impact of Surgical Boot Camp and Subsequent Repetitive Practice on the Surgical Skills and Confidence of Residents.

Wei Wang, Hucheng Ma, Haozhen Ren, Zhongxia Wang, Liang Mao, Ningning He,

BACKGROUND:Boot camp can enable residents to acquire surgical skills and confidence, but they can lose these skills over time if they do not use them. The purpose of this study was to explore whether boot camp and subsequent repetitive practice could strengthen residents' clinical skills and self-confidence. METHODS:This is a ... Read more >>

World J Surg (World journal of surgery)
[2020, 44(11):3607-3615]

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Long noncoding RNA TTTY15 promotes growth and metastasis of esophageal squamous cell carcinoma by sponging microRNA-337-3p to upregulate the expression of JAK2.

Wei Wang, Junbo Yang,

Long noncoding RNA (lncRNA) testis-specific transcript, Y-linked 15 (TTTY15) plays an important regulatory role in prostate cancer, but its role in esophageal squamous cell carcinoma (ESCC) remains unclear. This study aimed to explore the expression pattern, biological function and underlying mechanism of TTTY15 in ESCC. Quantitative real-time PCR (qRT-PCR) was ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2020, 31(10):1038-1045]

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