Full Text Journal Articles by
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Neat1 decreases neuronal apoptosis after oxygen and glucose deprivation.

Wei-Na Chai, Yi-Fan Wu, Zhi-Min Wu, Yan-Feng Xie, Quan-Hong Shi, Wei Dan, Yan Zhan, Jian-Jun Zhong, Wei Tang, Xiao-Chuan Sun, Li Jiang,

Studies have shown that downregulation of nuclear-enriched autosomal transcript 1 (Neat1) may adversely affect the recovery of nerve function and the increased loss of hippocampal neurons in mice. Whether Neat1 has protective or inhibitory effects on neuronal cell apoptosis after secondary brain injury remains unclear. Therefore, the effects of Neat1 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):163-169]

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Structural characteristics of a highly branched and acetylated pectin from Portulaca oleracea L.

Wei Tang, Dan Liu, Yu Li, Ming-Yue Zou, Yu-Chen Shao, Jun-Yi Yin, Shao-Ping Nie,

The water-extracted polysaccharide from Portulaca oleracea L. mainly consisted of two pectic polysaccharides designated as POWP-H and POWP-L. The POWP-L was rich in linear homogalacturonan with GalA content of 77.6%, while POWP-H might be a rhamnogalacturonan I (RG-I) pectin composed of Rha (15.7%), Ara (31.7%), Gal (42.5%) and GalA (10.1%). ... Read more >>

(Food hydrocolloids.)
[2021, 116:Not Available]

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Monosaccharide composition analysis of polysaccharides from natural sources: Hydrolysis condition and detection method development

Dan Liu, Wei Tang, Jun-Yi Yin, Shao-Ping Nie, Ming-Yong Xie,

Monosaccharide composition analysis is indispensable for the structural characterization and bioactive studies of polysaccharides. Besides, it is also helpful for the quality control of functional polysaccharides. The process is usually carried out by hydrolyzing the polysaccharides into monosaccharides, and then detecting liberated monosaccharides or their derivatives. However, the accuracy is ... Read more >>

(Food hydrocolloids.)
[2021, 116:Not Available]

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CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

Zeyu Su, Yujia Li, Hang Lv, Xiaoyang Cui, Min Liu, Ziying Wang, Yan Zhang, Junhui Zhen, Wei Tang, Xiaojie Wang, Fan Yi,

Podocyte injury is a major determinant of focal segmental glomerular sclerosis (FSGS) and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance for the treatment of FSGS. CLEC14A is a single-pass transmembrane glycoprotein belonging to the vascular expressed C-type lectin family. CLEC14A is found to be ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21711]

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Fucoidan Extracted From Sporophyll of Undaria pinnatifida Grown in Weihai, China - Chemical Composition and Comparison of Antioxidant Activity of Different Molecular Weight Fractions.

Jing Yu, Qianqian Li, Jun Wu, Xiaotong Yang, Shiping Yang, Wei Zhu, Yang Liu, Wei Tang, Shaoping Nie, Amira Hassouna, William Lindsey White, Yu Zhao, Jun Lu,

Fucoidan is a multifunctional marine carbohydrate polymer that differs in its chemical composition and bioactivity both between seaweed species and within species from different locations across the globe. In this study, fucoidan was extracted from the sporophyll of <i>Undaria pinnatifida</i> grown in Weihai, Shandong Province, China. Fucoidan fractions with molecular ... Read more >>

Front Nutr (Frontiers in nutrition)
[2021, 8:636930]

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Synthesis and Pharmacological Evaluation of Tetrahydro-γ-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase.

Jing Tan, Bing Wu, Tingting Chen, Chen Fan, Jiannan Zhao, Chaodong Xiong, Chunlan Feng, Ruoxuan Xiao, Chunyong Ding, Wei Tang, Ao Zhang,

The activation of cyclic GMP-AMP synthase (cGAS) by double-stranded DNA is implicated in the pathogenesis of many hyperinflammatory and autoimmune diseases, and the cGAS-targeting small molecule has emerged as a novel therapeutic strategy for treating these diseases. However, the currently reported cGAS inhibitors are far beyond maturity, barely demonstrating in ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2021, 64(11):7667-7690]

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Discovery of chiral N-2'-aryletheryl-1'-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium.

Bo Li, Heng Li, Zhengdan Zhu, Caigui Xiang, Zhijian Xu, Chen Fan, Yitian Zhao, Chunlan Feng, Haiguo Sun, Yong Zhang, Tingting Cai, Wei Tang, Weiliang Zhu,

Herein we disclosed the novel nucleophilic addition reactions of the thiophenols and oxazolinium (DCZ0358) to produce N-2'-aryletheryl-1'-alkoxy-ethyl substituted arylisoquinolones. After evaluating the anti-inflammatory activity in vitro, 2d was found having significant anti-TNFα activity. Through the amplified synthesis of 2d, four monomers (3a-b and 4a-d) were obtained by chiral separation of the ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2021, 222:113583]

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Anatomical basis of the support of fibula to tibial plateau and its clinical significance.

Wen-Bin Jiang, Shi-Zhu Sun, Chan Li, Philip Adds, Wei Tang, Wei Chen, Sheng-Bo Yu, Hong-Jin Sui,

<h4>Background</h4>The fibula is only indirectly involved in the composition of the human knee joint and has therefore been neglected in the research on knee osteoarthritis. Nonuniform settlement of the proximal tibia plateau is clinically defined as when the height of the medial tibial plateau is lower than that of the ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2021, 16(1):346]

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Structural characteristics of three pectins isolated from white kidney bean.

Wei Tang, An-Qi Li, Jun-Yi Yin, Shao-Ping Nie,

Three water-soluble pectic polysaccharides (WKBP-P2, P3 and P4) were isolated from white kidney bean by ion exchange combined with size-exclusion methods. The structural features were characterized by GC-MS, NMR spectroscopy and HPSEC-MALLS-RI. It was found that three pectic polysaccharides were the major water-extracted polysaccharides in white kidney bean. All the ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 182:2151-2161]

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Rhodomentosones A and B: Two Pairs of Enantiomeric Phloroglucinol Trimers from Rhodomyrtus tomentosa and Their Asymmetric Biomimetic Synthesis.

Lu-Ming Deng, Li-Jun Hu, Yang-Ting-Zhi Bai, Jie Wang, Guan-Qiu Qin, Qiao-Yun Song, Jun-Cheng Su, Xiao-Jun Huang, Ren-Wang Jiang, Wei Tang, Yao-Lan Li, Chuang-Chuang Li, Wen-Cai Ye, Ying Wang,

Rhodomentosones A and B (<b>1</b> and <b>2</b>), two pairs of novel enantiomeric phloroglucinol trimers featuring a unique 6/5/5/6/5/5/6-fused ring system were isolated from <i>Rhodomyrtus tomentosa</i>. Their structures with absolute configurations were elucidated by NMR spectroscopy, X-ray crystallography, and ECD calculation. The bioinspired syntheses of <b>1</b> and <b>2</b> were achieved in ... Read more >>

Org Lett (Organic letters)
[2021, 23(11):4499-4504]

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A taxonomy of the brain’s white matter: Twenty-one major tracts for the twenty-first century

Daniel Bullock, Elena Hayday, Mark Grier, Wei Tang, Franco Pestilli, Sarah Heilbronner,

<p>The functional and computational properties of brain areas are determined, in large part, by their connectivity profiles. Advances in neuroimaging and network neuroscience allow us to characterize the human brain noninvasively and in vivo, but a comprehensive understanding of the human brain demands an account of the anatomy of brain ... Read more >>

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Weakly Supervised Temporal Action Localization through Contrast based Evaluation Networks.

Ziyi Liu, Le Wang, Qilin Zhang, Wei Tang, Nanning Zheng, Gang Hua,

Given only video-level action categorical labels during training, weakly-supervised temporal action localization (WS-TAL) learns to detect action instances and locates their temporal boundaries in untrimmed videos. Compared to its fully supervised counterpart, WS-TAL is more cost-effective in data labeling and thus favorable in practical applications. However, the coarse video-level supervision ... Read more >>

IEEE Trans Pattern Anal Mach Intell (IEEE transactions on pattern analysis and machine intelligence)
[2021, PP:]

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Sensing of joint and spinal bending or stretching via a retractable and wearable badge reel.

Chengyu Li, Di Liu, Chaoqun Xu, Ziming Wang, Sheng Shu, Zhuoran Sun, Wei Tang, Zhong Lin Wang,

Human motions, such as joint/spinal bending or stretching, often contain information that is useful for orthopedic/neural disease diagnosis, rehabilitation, and prevention. Here, we show a badge-reel-like stretch sensing device with a grating-structured triboelectric nanogenerator exhibiting a stretching sensitivity of 8 V mm<sup>-1</sup>, a minimum resolution of 0.6 mm, a low hysteresis, and a ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2950]

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Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling.

Heng Cai, Xiyun Bian, Liangyu Chen, Nan Zhang, Lili Li, Wei Tang, Xiaozhi Liu, Zhiqing Li,

<h4>Background</h4>Although it is well known that selective intra-arterial cooling (SI-AC) elicits cerebral protection against ischemia/reperfusion (I/R) injury, the underlying mechanism remains unclear. This study aimed to determine whether SI-AC can protect against cerebral I/R injury by inhibiting oxidative stress and mitochondrial dysfunction through regulation of Sirt3 deSUMOylation via SENP1.<h4>Methods</h4>All mice ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2021, 171:272-283]

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The Rise and Fall of Hydroxychloroquine with the COVID-19 Pandemic: Narrative Review of Selected Data.

Wei Tang, Leila Khalili, Jon Giles, Yevgeniya Gartshteyn, Teja Kapoor, Cathy Guo, Tommy Chen, Deborah Theodore, Anca Askanase,

Since the first outbreak of Coronavirus Disease-2019 (COVID-19) in January 2020, the medical community has been pursuing effective countermeasures. Early in the pandemic, several small clinical and in vitro studies from France and China reported on the efficacy of chloroquine (CQ) and hydroxychloroquine (HCQ) against SARS-CoV-2 infections, which generated global ... Read more >>

Rheumatol Ther (Rheumatology and therapy)
[2021, :]

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Correction to: Exosomes from tamoxifen-resistant breast cancer cells transmit drug resistance partly by delivering miR-9-5p.

Jianhui Liu, Shaoliang Zhu, Wei Tang, Qinghua Huang, Yan Mei, Huawei Yang,

Cancer Cell Int (Cancer cell international)
[2021, 21(1):240]

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Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell-dominant T-cell responses in asthma.

Meng Zhang, Qianying Yu, Wei Tang, Yujiao Wu, JiaJia Lv, Lin Sun, Guochao Shi, Min Wu, Jieming Qu, Caixia Di, Zhenwei Xia,

<h4>Background</h4>Exosomes have emerged as a vital player in cell-cell communication; however, whether airway epithelial cell (AEC)-generated exosomes participate in asthma development remains unknown.<h4>Objective</h4>Our aims were to characterize the AEC-secreted exosomes and the potentially functional protein(s) that may contribute to the proinflammatory effects of AEC exosomes in the dendritic cell (DC)-dominant ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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ZIF-Derived Carbon Nanoframes as a Polysulfide Anchor and Conversion Mediator for High-Performance Lithium-Sulfur Cells.

Rui Wang, Wei Tang, Manqin Tang, Qian Wu, Jing Li,

Improving the redox kinetics of sulfur species, while suppressing the "shuttle effects" to achieve stable cycling under high sulfur loading is an inevitable problem for lithium-sulfur (Li-S) cells to commercialization. Herein, the three-dimensional Zn, Co, and N codoped carbon nanoframe (3DZCN-C) was successfully synthesized by calcining precursor which protected by ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(18):21544-21555]

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A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage.

Suling Huang, Yanwei Wu, Zhuohui Zhao, Bing Wu, Kai Sun, Haoyu Wang, Li Qin, Fang Bai, Ying Leng, Wei Tang,

<h4>Objective</h4>Obeticholic acid (OCA) has been proved to play potential therapeutic effect on nonalcoholic steatohepatitis (NASH). Up to now, the study of OCA on NLRP3 inflammasome activation in macrophage is still blank and merits great attention. Here, we aimed to better characterize the role and mechanism of OCA on NASH treatment ... Read more >>

Metabolism (Metabolism: clinical and experimental)
[2021, 120:154797]

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Study on the Anti-Aging Physiological Characteristics and Molecular Mechanism of Camellia Oleifera

Yongzhong Chen, Jianjun Chen, Zhen Zhang, Yanming Xu, Zhilong He, Caixia Liu, Rui Wang, Xiangnan Wang, Yinghe Peng, Shaofeng Peng, Longshen Chen, Li Ma, Zhigang Li, Wei Tang,

To study the physiological and molecular regulating mechanism of ancient Camellia oleifera which kept a exuberant vitality for more than one hundred years, leaves of 30a year old and > 100 year old Camellia oleifera were selected as targets. On the basis of the study of the generation and the clearance ... Read more >>

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Clinical application of "Double R" anastomosis technique in laparoscopic pancreaticoduodenectomy procedure.

Wei Tang, Jian-Guo Qiu, Gui-Zhong Li, Yu-Fei Zhao, Cheng-You Du,

<h4>Abstract</h4>Laparoscopic pancreaticoduodenectomy (LPD) is widely used as a treatment for periampullary tumors and pancreatic head tumors. However, postoperative pancreatic fistula (POPF), which significantly affects mortality and length of hospital stay of patients, remains one of the most common and serious complications following LPD. Though numerous technical modifications for pancreaticojejunostomy (PJ) ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(21):e26204]

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A Programmed Cell-Mimicking Nanoparticle Driven by Potato Alkaloid for Targeted Cancer Chemoimmunotherapy.

Jie Li, Wei Tang, Yi Yang, Qing Shen, Yang Yu, Xiaoyou Wang, Yu Fu, Chong Li,

Membrane camouflaged-nanoparticles (CM-NPs) have been exploited to inherit desired functionalities from source cells. Despite those advantages, membrane cloak may play a "double-edged sword" role in tumor-targeting therapy, as the intact membrane coating may hinder function-exertion of loaded drugs after reaching predetermined site. Therefore, further optimization of CM-NPs is still needed ... Read more >>

Adv Healthc Mater (Advanced healthcare materials)
[2021, :e2100311]

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Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36α signaling pathway.

Qing Qi, Qian Li, Hongwen Zhu, Huimin Lu, Xiaoqian Yang, Yanwei Wu, Chunlan Feng, Chen Fan, Heng Li, Bing Wu, Yuanzhuo Gao, Zongwang Zhang, Hu Zhou, Jianping Zuo, Wei Tang,

Triptolide has shown a good immunosuppressive effect on autoimmune diseases. However, the toxicity limited its widely clinical practice. In this study, we investigated the effects and underlying mechanisms of (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, on a murine psoriasis-like dermatitis model and related cell lines. Here, we showed that LLDT-8 ... Read more >>

Pharmacol Res (Pharmacological research)
[2021, 169:105678]

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Association between gonadal hormones and osteoporosis in schizophrenia patients undergoing risperidone monotherapy: a cross-sectional study.

Yi Chen, Yaoyao Zhang, Kaili Fan, Weiqian Xu, Chao Teng, Shuangshuang Wang, Wei Tang, Xiaomin Zhu,

<h4>Objective</h4>Patients with schizophrenia are at increased risk of osteoporosis. This study first determined the osteoporosis rate in patients with schizophrenia and then then explored the association between serum gonadal hormone levels and osteoporosis among these patients.<h4>Methods</h4>A total of 250 patients with schizophrenia and 288 healthy controls were recruited. Osteoporosis was ... Read more >>

PeerJ (PeerJ)
[2021, 9:e11332]

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Isolation and structure characterization of a low methyl-esterified pectin from the tuber of Dioscorea opposita Thunb.

Wei Tang, Dan Liu, Jun-Qiao Wang, Xiao-Jun Huang, Jun-Yi Yin, Fang Geng, Shao-Ping Nie,

A low methyl-esterified pectin (33.2% methyl-esterification degree) was isolated from the tuber of Dioscorea opposita Thunb., which was an edible and medicinal material in China. This pectin (M<sub>w</sub> of 1.3 × 10<sup>4</sup> g/mol) contained the ~59.1% homogalacturonan (HG) and ~38.1% highly branched rhamnogalacturonan I (RG-I) region with possible side chains embracing arabinogalactan ... Read more >>

Food Chem (Food chemistry)
[2021, 359:129899]

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