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Author Wei Shen Lim

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Co-infections in people with COVID-19: a systematic review and meta-analysis.

Louise Lansbury, Benjamin Lim, Vadsala Baskaran, Wei Shen Lim,

OBJECTIVES:In previous influenza pandemics, bacterial co-infections have been a major cause of mortality. We aimed to evaluate the burden of co-infections in patients with COVID-19. METHODS:We systematically searched Embase, Medline, Cochrane Library, LILACS and CINAHL for eligible studies published from 1 January 2020 to 17 April 2020. We included patients ... Read more >>

J. Infect. (The Journal of infection)
[2020, :]

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Pneumonia—Overview.

Wei Shen Lim,

Pneumonia is very common and continues to exact a high burden on health. The Global Burden of Disease Study 2015 found lower respiratory infections (LRIs) were the leading infectious cause of death and the fifth leading cause of death overall. Pneumococcal pneumonia caused 55% of LRI deaths in all ages ... Read more >>

(Reference Module in Biomedical Sciences)
[2020, :]

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The UK hibernated pandemic influenza research portfolio: triggered for COVID-19.

Colin R Simpson, Benjamin D Thomas, Kirsty Challen, Daniela De Angelis, Ellen Fragaszy, Steve Goodacre, Andrew Hayward, Wei Shen Lim, G James Rubin, Malcolm G Semple, Marian Knight, ,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, :]

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Point of care testing of Influenza A/B and RSV in an adult respiratory assessment unit is associated with improvement in isolation practices and reduction in hospital length of stay.

Louise Berry, Louise Lansbury, Lydia Gale, Ann Marie Carroll, Wei Shen Lim,

Introduction. Every winter seasonal influenza and other viral respiratory infections increase pressure on the health services and are associated with nosocomial infection and morbidity.Aim. To compare provision of point-of-care (POC) testing with laboratory-based testing for influenza and RSV detection on an adult respiratory assessment unit to assess the impact on ... Read more >>

J. Med. Microbiol. (Journal of medical microbiology)
[2020, 69(5):697-704]

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Admission to hospital in the UK at a weekend does not influence the prognosis of adults with community-acquired pneumonia.

Hannah Lawrence, Tricia M McKeever, Wei Shen Lim, ,

Outcomes for adults with community-acquired pneumonia (CAP) admitted to hospital at the weekend were compared with those admitted during weekdays using data from the British Thoracic Society national CAP audits. Of 31 400 cases, 40.7% were weekend admissions; these patients were older (mean age 72 vs 71.3 years, p=0.001) and more ... Read more >>

Thorax (Thorax)
[2020, :]

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Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis.

Louise E Lansbury, Chamira Rodrigo, Jo Leonardi-Bee, Jonathan Nguyen-Van-Tam, Wei Shen Lim,

OBJECTIVES:Corticosteroids may be beneficial in sepsis, but uncertainty remains over their effects in severe influenza. This systematic review updates the current evidence regarding corticosteroids in the treatment of influenza and examines the effect of dose on outcome. DATA SOURCES:Electronic databases (MEDLINE, EMBASE, CINAHL, LILACS, CENTRAL, and Web of Science) and ... Read more >>

Crit. Care Med. (Critical care medicine)
[2020, 48(2):e98-e106]

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Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis.

Louise E Lansbury, Chamira Rodrigo, Jo Leonardi-Bee, Jonathan Nguyen-Van-Tam, Wei Shen Lim,

OBJECTIVES:Corticosteroids may be beneficial in sepsis, but uncertainty remains over their effects in severe influenza. This systematic review updates the current evidence regarding corticosteroids in the treatment of influenza and examines the effect of dose on outcome. DATA SOURCES:Electronic databases (MEDLINE, EMBASE, CINAHL, LILACS, CENTRAL, and Web of Science) and ... Read more >>

Crit. Care Med. (Critical care medicine)
[2019, :]

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Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial.

Rahul Bhatnagar, Hania E G Piotrowska, Magda Laskawiec-Szkonter, Brennan C Kahan, Ramon Luengo-Fernandez, Justin C T Pepperell, Matthew D Evison, Jayne Holme, Mohamed Al-Aloul, Ioannis Psallidas, Wei Shen Lim, Kevin G Blyth, Mark E Roberts, Giles Cox, Nicola J Downer, Jurgen Herre, Pasupathy Sivasothy, Daniel Menzies, Mohammed Munavvar, Moe M Kyi, Liju Ahmed, Alex G West, Richard N Harrison, Benjamin Prudon, Gihan Hettiarachchi, Biswajit Chakrabarti, Ajikumar Kavidasan, Benjamin P Sutton, Natalie J Zahan-Evans, Jack L Quaddy, Anthony J Edey, Amelia O Clive, Steven P Walker, Matthew H R Little, Xue W Mei, John E Harvey, Clare E Hooper, Helen E Davies, Mark Slade, Merle Sivier, Robert F Miller, Najib M Rahman, Nick A Maskell,

Importance:Malignant pleural effusion (MPE) is challenging to manage. Talc pleurodesis is a common and effective treatment. There are no reliable data, however, regarding the optimal method for talc delivery, leading to differences in practice and recommendations. Objective:To test the hypothesis that administration of talc poudrage during thoracoscopy with local anesthesia ... Read more >>

JAMA (JAMA)
[2019, :]

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Pneumococcal serotype trends, surveillance and risk factors in UK adult pneumonia, 2013-18.

Harry Pick, Priya Daniel, Chamira Rodrigo, Thomas Bewick, Deborah Ashton, Hannah Lawrence, Vadsala Baskaran, Rochelle C Edwards-Pritchard, Carmen Sheppard, Seyi D Eletu, Samuel Rose, David Litt, Norman K Fry, Shamez Ladhani, Meera Chand, Caroline Trotter, Tricia M McKeever, Wei Shen Lim,

BACKGROUND:Changes over the last 5 years (2013-18) in the serotypes implicated in adult pneumococcal pneumonia and the patient groups associated with vaccine-type disease are largely unknown. METHODS:We conducted a population-based prospective cohort study of adults admitted to two large university hospitals with community-acquired pneumonia (CAP) between September 2013 and August ... Read more >>

Thorax (Thorax)
[2020, 75(1):38-49]

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Effect of tobacco smoking on the risk of developing community acquired pneumonia: A systematic review and meta-analysis.

Vadsala Baskaran, Rachael L Murray, Abby Hunter, Wei Shen Lim, Tricia M McKeever,

AIM:To summarise and quantify the effect of tobacco smoking on the risk of developing community acquired pneumonia (CAP) in adults. METHODS:We systematically searched MEDLINE, Embase, CINAHL, PsychINFO and Web of Science, from inception to October 2017, to identify case-control and cohort studies and reported in accordance with the Preferred Reporting ... Read more >>

PLoS ONE (PloS one)
[2019, 14(7):e0220204]

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The UK's pandemic influenza research portfolio: a model for future research on emerging infections.

Colin R Simpson, Dan Beever, Kirsty Challen, Daniela De Angelis, Ellen Fragaszy, Steve Goodacre, Andrew Hayward, Wei Shen Lim, G James Rubin, Malcolm G Semple, Marian Knight, ,

The 2009 influenza A H1N1 pandemic was responsible for considerable global morbidity and mortality. In 2009, several research studies in the UK were rapidly funded and activated for clinical and public health actions. However, some studies were too late for their results to have an early and substantial effect on ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2019, 19(8):e295-e300]

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Patient-reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review.

Harry J Pick, Charlotte E Bolton, Wei Shen Lim, Tricia M McKeever,

Symptomatic and functional recovery are important patient-reported outcome measures (PROMs) in community-acquired pneumonia (CAP) that are increasingly used as trial end-points. This systematic review summarises the literature on PROMs in CAP.Comprehensive searches in accordance with the PRISMA statement were conducted to March 2017. Eligible studies included adults discharged from hospital ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2019, 53(3):]

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Corticosteroids as adjunctive therapy in the treatment of influenza.

Louise Lansbury, Chamira Rodrigo, Jo Leonardi-Bee, Jonathan Nguyen-Van-Tam, Wei Shen Lim,

BACKGROUND:Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti-inflammatory and immunomodulatory properties. Although commonly prescribed for severe influenza, there is uncertainty over their potential benefits or harms. This is an update of ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2019, 2:CD010406]

Cited: 3 times

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Clinicians' attitude towards a placebo-controlled randomised clinical trial investigating the effect of neuraminidase inhibitors in adults hospitalised with influenza.

Naomi Bradbury, Jonathan Nguyen-Van-Tam, Wei Shen Lim,

BACKGROUND:The value of neuraminidase inhibitors (NAIs) in reducing severe clinical outcomes from influenza is debated. A clinical trial to generate better evidence is desirable. However, it is unknown whether UK clinicians would support a placebo-controlled trial. A survey was conducted to determine the attitude of clinicians towards a clinical trial ... Read more >>

BMC Health Serv Res (BMC health services research)
[2018, 18(1):311]

Cited: 1 time

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Healthcare reconsultation in working-age adults following hospitalisation for community-acquired pneumonia.

Priya Daniel, Thomas Bewick, Tricia M McKeever, Mark Roberts, Deborah Ashton, Daniel Smith, Lenny Latip, Wei Shen Lim,

Community-acquired pneumonia (CAP) is associated with prolonged symptom persistence during recovery. However, the effect of the residual symptom load on healthcare utilisation is unknown. The aim of this study was to quantify healthcare reconsultation within 28 days of hospital discharge for an index episode of CAP, and explore reasons for these ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2018, 18(1):41-46]

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13-Valent vaccine serotype pneumococcal community acquired pneumonia in adults in high clinical risk groups.

Priya Daniel, Chamira Rodrigo, Thomas Bewick, Carmen Sheppard, Sonia Greenwood, Tricia M McKeever, Caroline Trotter, Wei Shen Lim,

There is debate regarding the value of vaccinating adults with the 13-valent pneumococcal conjugate vaccine (PCV-13). This analysis was conducted to investigate the risk of PCV-13 serotype community acquired pneumonia (CAP) in hospitalised adults with co-morbid disease and risk factors for pneumococcal disease in the UK. Consecutive adults hospitalised (2008-2013) ... Read more >>

Vaccine (Vaccine)
[2018, 36(12):1614-1620]

Cited: 0 times

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Improving readiness for recruitment through simulated trial activation: the Adjuvant Steroids in Adults with Pandemic influenza (ASAP) trial.

Wei Shen Lim, Garry Meakin, Clare Brittain, Thomas Bewick, Lelia Duley,

BACKGROUND:Research in public health emergencies requires trials to be set up in readiness for activation at short notice and in anticipation of limited timelines for patient recruitment. We conducted a simulated activation of a hibernating pandemic influenza clinical trial in order to test trial processes and to determine the value ... Read more >>

Trials (Trials)
[2017, 18(1):546]

Cited: 0 times

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Propionibacterium acnes pleural empyema following medical thoracoscopy.

Hannah Lawrence, Thomas Moore, Karmel Webb, Wei Shen Lim,

Propionibacterium acnes (P. acnes) is a Gram-positive anaerobic rod and a common skin commensal that colonizes sebaceous glands. It has infrequently been associated with invasive opportunistic infections and can cause implant-associated infections through a biofilm mode of growth. Medical thoracoscopy is a common procedure for diagnosis and treatment of exudative ... Read more >>

Respirol Case Rep (Respirology case reports)
[2017, 5(5):e00249]

Cited: 1 time

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Adults miscoded and misdiagnosed as having pneumonia: results from the British Thoracic Society pneumonia audit.

Priya Daniel, Thomas Bewick, Sally Welham, Tricia M Mckeever, Wei Shen Lim, ,

A key objective of the British Thoracic Society national community-acquired pneumonia (CAP) audit was to determine the clinical characteristics and outcomes of hospitalised adults given a primary discharge code of pneumonia but who did not fulfil accepted diagnostic criteria for pneumonia. Adults miscoded as having pneumonia (n=1251) were older compared ... Read more >>

Thorax (Thorax)
[2017, 72(4):376-379]

Cited: 1 time

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Increased incidence of adult pneumococcal pneumonia during school holiday periods.

Priya Daniel, Chamira Rodrigo, Thomas Bewick, Carmen Sheppard, Sonia Greenwood, Tricia M McKeever, Mary Slack, Wei Shen Lim,

Child contact is a recognised risk factor for adult pneumococcal disease. Peaks in invasive pneumococcal disease incidence observed during winter holidays may be related to changes in social dynamics. This analysis was conducted to examine adult pneumococcal community-acquired pneumonia (CAP) incidence during school holiday periods. Between September 2008 and 2013, ... Read more >>

ERJ Open Res (ERJ open research)
[2017, 3(1):]

Cited: 1 time

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Mortality reduction in adult community-acquired pneumonia in the UK (2009-2014): results from the British Thoracic Society audit programme.

Priya Daniel, Mark Woodhead, Sally Welham, Tricia M Mckeever, Wei Shen Lim, ,

Community-acquired pneumonia (CAP) is a leading cause of death in the UK. In this analysis of 23 315 cases from the British Thoracic Society national CAP audit, an overall reduction in 30-day inpatient mortality over 6 years was observed-2014 compared with 2009 adjusted OR 0.86 (95% CI 0.68 to 1.08, p for ... Read more >>

Thorax (Thorax)
[2016, 71(11):1061-1063]

Cited: 7 times

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From latent to active TB: are IGRAs of any use?

Wei Shen Lim,

Thorax (Thorax)
[2016, 71(7):585-586]

Cited: 1 time

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Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.

Stella G Muthuri, Sudhir Venkatesan, Puja R Myles, Jo Leonardi-Bee, Wei Shen Lim, Abdullah Al Mamun, Ashish P Anovadiya, Wildo N Araújo, Eduardo Azziz-Baumgartner, Clarisa Báez, Carlos Bantar, Mazen M Barhoush, Matteo Bassetti, Bojana Beovic, Roland Bingisser, Isabelle Bonmarin, Victor H Borja-Aburto, Bin Cao, Jordi Carratala, María R Cuezzo, Justin T Denholm, Samuel R Dominguez, Pericles A D Duarte, Gal Dubnov-Raz, Marcela Echavarria, Sergio Fanella, James Fraser, Zhancheng Gao, Patrick Gérardin, Maddalena Giannella, Sophie Gubbels, Jethro Herberg, Anjarath L Higuera Iglesias, Peter H Hoeger, Matthias Hoffmann, Xiaoyun Hu, Quazi T Islam, Mirela F Jiménez, Amr Kandeel, Gerben Keijzers, Hossein Khalili, Gulam Khandaker, Marian Knight, Gabriela Kusznierz, Ilija Kuzman, Arthur M C Kwan, Idriss Lahlou Amine, Eduard Langenegger, Kamran B Lankarani, Yee-Sin Leo, Rita Linko, Pei Liu, Faris Madanat, Toshie Manabe, Elga Mayo-Montero, Allison McGeer, Ziad A Memish, Gokhan Metan, Dragan Mikić, Kristin G I Mohn, Ahmadreza Moradi, Pagbajabyn Nymadawa, Bulent Ozbay, Mehpare Ozkan, Dhruv Parekh, Mical Paul, Wolfgang Poeppl, Fernando P Polack, Barbara A Rath, Alejandro H Rodríguez, Marilda M Siqueira, Joanna Skręt-Magierło, Ewa Talarek, Julian W Tang, Antoni Torres, Selda H Törün, Dat Tran, Timothy M Uyeki, Annelies van Zwol, Wendy Vaudry, Daiva Velyvyte, Tjasa Vidmar, Paul Zarogoulidis, , Jonathan S Nguyen-Van-Tam,

BACKGROUND:The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. METHODS:A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 ... Read more >>

Influenza Other Respir Viruses (Influenza and other respiratory viruses)
[2016, 10(3):192-204]

Cited: 13 times

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Corticosteroids as adjunctive therapy in the treatment of influenza.

Chamira Rodrigo, Jo Leonardi-Bee, Jonathan Nguyen-Van-Tam, Wei Shen Lim,

BACKGROUND:Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti-inflammatory and immunomodulatory properties. Although commonly prescribed for severe influenza, there is uncertainty over their potential benefit or harm. OBJECTIVES:To systematically assess the effectiveness ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2016, 3:CD010406]

Cited: 18 times

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Conducting a randomised trial during an influenza pandemic: an example of a trial set up and ‘hibernated’ ready to activate and recruit within 4 weeks.

Clare Brittain, Garry Meakin, Margo Childs, Lelia Duley, Wei Shen Lim,

Trials (Trials)
[2015, 16(Suppl 2):O14-O14]

Cited: 0 times

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