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Prognostic Significance of ROR2 Expression in Patients with Urothelial Carcinoma.

Cheng-Fa Yeh, Ti-Chun Chan, Hung-Lung Ke, Tzu-Ju Chen, Li-Ching Wu, Hsiang-Ying Lee, Yu-Ching Wei, Wen-Jeng Wu, Chien-Feng Li, Wei-Ming Li,

We investigated the association of receptor tyrosine kinase-like orphan receptor 2 (ROR2) expression with clinicopathological features and oncologic outcomes in large urothelial carcinoma (UC) of the upper tract (UTUC) and urinary bladder (UBUC) cohorts. Through transcriptomic profiling of a published dataset (GSE31684), ROR2 was discovered to be the most upregulated ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(8):]

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A fenestrated persistent primitive hypoglossal artery harboring a ruptured aneurysm: A case report.

Sen He, Ming-Li Wei, Fei Xie, Seidu A Richard,

<h4>Rationale</h4>Persistent primitive hypoglossal artery (PPHA) is a rare and permanent carotid-vertebrobasilar anastomoses. Patients with PPHA usually have higher changes of developing intracranial aneurysms due the high intracranial hemodynamics. Although cases of PPHA alone and PPHA with aneurysms have been reported in literature, cases of fenestrated PPHA harboring a ruptured aneurysm ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(32):e26904]

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Fucoidan from Sargassum Hemiphyllum Inhibits Infection and Inflammation of Helicobacter Pylori

Bo-Rui Chen, Wei-Ming Li, Tsung-Lin Li, Yi-Lin Chan, Chang-Jer Wu,

When infected by Helicobacter pylori , it often causes gastritis, gastric ulcer, or gastric cancer. Antibiotics are used to treat H. pylori infection, as they inhibit or kill H. pylori often ex-tending to reduce the incidences of gastric adenoma and cancer. However, H. pylori has developed drug resistance to many ... Read more >>

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Molecular epidemiologic study of citrin deficiency by screening for four reported pathogenic SLC25A13 variants in the Shaanxi and Guangdong provinces, China.

Wei-Xia Lin, Muhammad Rauf Yaqub, Zhan-Hui Zhang, Man Mao, Han-Shi Zeng, Feng-Ping Chen, Wei-Ming Li, Wen-Zhe Cai, Ying-Qiang Li, Zhi-Yong Tan, Wei Sheng, Zhi-Min Li, Xiao-Ling Tao, Yuan-Xia Li, Jun-Ping Zhang, Yao-Bin Han, Yan Li, Wu-Qiong Duan, Bao-Ni Ye, Ya-Rong Li, Yuan-Zong Song,

<h4>Background</h4>Citrin deficiency (CD) is an autosomal recessive disease resulting from biallelic mutations of the <i>SLC25A13</i> gene. This study aimed to investigate the molecular epidemiological features of CD in the Guangdong and Shaanxi provinces of China.<h4>Methods</h4>A total of 3,409 peripheral blood samples from Guangdong and 2,746 such samples from Shaanxi province ... Read more >>

Transl Pediatr (Translational pediatrics)
[2021, 10(6):1658-1667]

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How to manage patients with suspected upper tract urothelial carcinoma in the pandemic of COVID-19?

Hsiang-Ying Lee, Erica On-Ting Chan, Ching-Chia Li, David Leung, Wei-Ming Li, Hsin-Chih Yeh, Peter Ka-Fung Chiu, Hung-Lung Ke, Chi-Hang Yee, Joseph Hon-Ming Wong, Chi-Fai Ng, Jeremy Yuen-Chun Teoh, Wen-Jeng Wu,

<h4>Background</h4>The pandemic of COVID-19 has disrupted the clinical pathway for patients with suspected upper tract urothelial carcinoma (UTUC). This aims to investigate the optimal management of UTUC during the pandemic by determining 1) Whether a three-month delay of RNU leads to worsened overall survival, 2) Whether radical nephroureterectomy (RNU) can ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(10):733.e11-733.e16]

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Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma.

Yung-Chun Su, Sheng-Chen Wen, Ching-Chia Li, Hsiao-Chun Su, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Chia-Yang Li, Sheau-Fang Yang, Hung-Pin Tu, Wen-Jeng Wu, Hsin-Chih Yeh,

The importance of blood cell markers in patients with malignant tumors has been studied, but there are few studies on the prognostic value of hemoglobin-to-red cell distribution width ratio (HRR) in cancer. This is the first study to investigate the effect of preoperative HRR on patients with upper tract urothelial ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(6):]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Utility of EFEMP1 in the Prediction of Oncologic Outcomes of Urothelial Carcinoma.

Tzu-Ju Chen, Ti-Chun Chan, Wan-Shan Li, Chien-Feng Li, Hung-Lung Ke, Yu-Ching Wei, Wen-Jeng Wu, Wei-Ming Li,

Urothelial carcinoma (UC) of the upper tract (UTUC) and urinary bladder (UBUC) is a heterogeneous malignancy. Through transcriptomic profiling of the Gene Expression Omnibus UBUC dataset (GSE31684), we discovered that epidermal growth factor-containing fibulin-like extracellularmatrix protein 1 (<i>EFEMP1</i>) was the most upregulated gene during metastatic development. EFEMP1 is an important ... Read more >>

Genes (Basel) (Genes)
[2021, 12(6):]

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Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses.

Hsiang-Ying Lee, Ching-Chia Li, Wei-Ming Li, Ya-Ling Hsu, Hsin-Chih Yeh, Hung-Lung Ke, Bi Wen Yeh, Chun-Nung Huang, Chien-Feng Li, Po-Lin Kuo, Wen-Jeng Wu,

<h4>Background</h4>We aimed to identify prognostic biomarkers of upper tract urothelial carcinomas (UTUCs), including microRNAs (miRNAs) and genes which account for only 5% to 10% of all urothelial carcinomas (UCs). In Taiwan, this figure is markedly higher, where it can reach up to 30% of UC cases.<h4>Materials and methods</h4>Using next-generation sequencing ... Read more >>

PeerJ (PeerJ)
[2021, 9:e11343]

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High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma.

Yi-Ru Wu, Yi-Chen Lee, Wei-Ming Li, Wei-Chi Hsu, Hui-Hui Lin, Lin-Li Chang, A-Mei Huang, Jhen-Hao Jhan, Wen-Jeng Wu, Ching-Chia Li, Hsiang-Ying Lee, Hsin-Chih Yeh, Hung-Lung Ke,

Upper tract urothelial carcinoma (UTUC) is a rare tumor with an incidence that varies greatly between Eastern and Western countries. Transaldolase 1 (TALDO1) is a rate-limiting enzyme of the pentose phosphate pathway. In humans, aberrant TALDO1 activity has been implicated in various autoimmune diseases and malignancies; however, the function of ... Read more >>

Pathol Int (Pathology international)
[2021, 71(7):463-470]

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Impact of Prior Digestive System Disease on In-Hospital Gastrointestinal Bleeding in Patients with Acute Myocardial Infarction.

Yu Liu, Le-Feng Wang, Li-Hong Liu, Xin-Chun Yang, Zheng-Hong Ren, Kui-Bao Li, Mu-Lei Chen, Hong-Shi Wang, Jiu-Chang Zhong, Li Xu, Zhu-Hua Ni, Wei-Ming Li, Kun Xia, Da-Peng Zhang, Hao Sun, Zong-Sheng Guo, Yong-Hui Chi, Ji-Fang He, Zhi-Yong Zhang, Feng Jiang,

<h4>Objective</h4>Patients presenting with acute myocardial infarction (AMI) with prior digestive system disease are more likely to suffer from gastrointestinal (GI) bleeding than those without these diseases. However, few articles reported how the different conditions of the digestive tract produced different risks of GI bleeding.<h4>Methods</h4>A single-center study on 7464 patients admitted ... Read more >>

Risk Manag Healthc Policy (Risk management and healthcare policy)
[2021, 14:1233-1239]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Effects of Potassium Deficiency on Growth of Pakchoi in Cold and Dry Areas

Shi-Heng LI, Wei-Ming LI, Ling-Hao BU,

[Background] To reveal the effect of potassium deficiency on the growth and development of pakchoi in cold and dry areas.[Results] The effect of potassium deficiency on the growth status of P. pakchoi in cold and dry areas was significant. P. pakchoi treated with potassium-free nutrient solution had the best growth, ... Read more >>

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Arsenic trioxide replacing or reducing chemotherapy in consolidation therapy for acute promyelocytic leukemia (APL2012 trial).

Li Chen, Hong-Ming Zhu, Yan Li, Qi-Fa Liu, Yu Hu, Jian-Feng Zhou, Jie Jin, Jian-Da Hu, Ting Liu, De-Pei Wu, Jie-Ping Chen, Yong-Rong Lai, Jian-Xiang Wang, Juan Li, Jian-Yong Li, Xin Du, Xin Wang, Ming-Zhen Yang, Jin-Song Yan, Gui-Fang Ouyang, Li Liu, Ming Hou, Xiao-Jun Huang, Xiao-Jing Yan, Dan Xu, Wei-Ming Li, Deng-Ju Li, Yin-Jun Lou, Zheng-Jun Wu, Ting Niu, Ying Wang, Xiao-Yang Li, Jian-Hua You, Hui-Jin Zhao, Yú Chen, Yang Shen, Qiu-Sheng Chen, Yù Chen, Jian Li, Bing-Shun Wang, Wei-Li Zhao, Jian-Qing Mi, Kan-Kan Wang, Jiong Hu, Zhu Chen, Sai-Juan Chen, Jun-Min Li,

As all-<i>trans</i> retinoic acid (ATRA) and arsenic trioxide (ATO) are widely accepted in treating acute promyelocytic leukemia (APL), deescalating toxicity becomes a research hotspot. Here, we evaluated whether chemotherapy could be replaced or reduced by ATO in APL patients at different risks. After achieving complete remission with ATRA-ATO-based induction therapy, ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(6):]

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A randomised controlled study on the effects of hernial sac stump fenestration on ultrasound seroma prevention in laparoscopic Type III inguinal hernia repair.

Wei-Ming Li, Yan-Bo Sun, Yi-Jun Li, Peng-Yuan Xu, Qing-Wen Xu, Li-Li Ding,

<h4>Background</h4>The incidence of ultrasound seromas has significantly increased after large hernial sac surgery. Several methods are available for preventing ultrasound seromas, but the clinical results are poor. It has also been demonstrated that hernial sac stump fenestration during laparoscopic incisional hernia repair surgery can significantly decrease the incidence of ultrasound ... Read more >>

J Minim Access Surg (Journal of minimal access surgery)
[2021, :]

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The long-term impact of a chronic total occlusion in a non-infarct-related artery on acute ST-segment elevation myocardial infarction after primary coronary intervention.

Yu Liu, Le-Feng Wang, Xin-Chun Yang, Chang-Lin Lu, Kui-Bao Li, Mu-Lei Chen, Na Li, Hong-Shi Wang, Jiu-Chang Zhong, Li Xu, Zhu-Hua Ni, Wei-Ming Li, Kun Xia, Da-Peng Zhang, Hao Sun, Zong-Sheng Guo, Yong-Hui Chi, Ji-Fang He, Zhi-Yong Zhang, Feng Jiang, Hong-Jiang Wang,

<h4>Objectives</h4>To investigate the long-term outcome of patients with acute ST-segment elevation myocardial infarction (STEMI) and a chronic total occlusion (CTO) in a non-infarct-related artery (IRA) and the risk factors for mortality.<h4>Methods</h4>The enrolled cohort comprised 323 patients with STEMI and multivessel diseases (MVD) that received a primary percutaneous coronary intervention between ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2021, 21(1):59]

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Prognostic Significance of Primary Tumor Location in Upper Tract Urothelial Carcinoma Treated with Nephroureterectomy: A Retrospective, Multi-Center Cohort Study in Taiwan.

Lian-Ching Yu, Chao-Hsiang Chang, Chi-Ping Huang, Chao-Yuan Huang, Jian-Hua Hong, Ta-Yao Tai, Han-Yu Weng, Chi-Wen Lo, Chung-You Tsai, Yu-Khun Lee, Yao-Chou Tsai, Thomas Y Hsueh, Yung-Tai Chen, I-Hsuan Chen, Bing-Juin Chiang, Jen-Shu Tseng, Chia-Chang Wu, Wei-Yu Lin, Tsu-Ming Chien, Zai-Lin Sheu, Ching-Chia Li, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Wen-Jeng Wu, Hsin-Chih Yeh,

We sought to examine the effect of tumor location on the prognosis of patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). This retrospective study came from the Taiwan UTUC Collaboration Group, which consisted of 2658 patients at 15 institutions in Taiwan from 1988 to 2019. Patients ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(12):]

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The metabolic syndrome is associated with the risk of urothelial carcinoma from a health examination database.

Hsiang-Ying Lee, Jia-Hong Tang, Yen-Hsu Chen, Wen-Jeng Wu, Yung-Shun Juan, Wei-Ming Li, Ta-Chien Chan,

<h4>Purpose</h4>The metabolic syndrome was associated with bladder cancer in the previous studies. However, there have no large-scale cohort studies to elucidate the relationship between metabolic syndromes and urothelial carcinoma including urinary bladder urothelial carcinoma (UBUC) and upper tract urothelial carcinoma (UTUC).<h4>Methods</h4>We analyze a population-based cohort study by using physical examination ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, 26(3):569-577]

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Corrigendum to "MSC-derived exosomal miR-34a/c-5p and miR-29b-3p improve intestinal barrier function by targeting the Snail/Claudins signaling pathway" [Life Science, 2020; 257: 118017].

Yi-Jun Li, Qing-Wen Xu, Peng-Yuan Xu, Wei-Ming Li,

Life Sci (Life sciences)
[2020, 262:118625]

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Prognostic Utility of FBLN2 Expression in Patients With Urothelial Carcinoma.

Wei-Ming Li, Ti-Chun Chan, Steven Kuan-Hua Huang, Wen-Jeng Wu, Hung-Lung Ke, Peir-In Liang, Yu-Ching Wei, Yow-Ling Shiue, Chien-Feng Li,

<b>Background:</b> Abnormal extracellular matrix (ECM) remodeling plays an essential role in urothelial carcinoma (UC) invasiveness and metastasis. Focusing on the ECM structural constituent (GO: 0005201), we recognized a significant upregulation of the fibulin 2 gene (<i>FBLN2</i>) during UC progression in a published UC transcriptome (GSE31684). Thus, we aimed to investigate ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:570340]

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Visible-Light-Induced Regio- and Stereoselective C(sp2)-H Trifluoroethylation of Enamides with 2,2,2-Trifluoroethyl Iodide.

Kai Zhao, Ze-Yu Zhang, Xian-Lu Cui, Ying-Xue Wang, Xian-Dan Wu, Wei-Ming Li, Jia-Xu Wu, Li-Li Zhao, Jing-Yu Guo, Teck-Peng Loh,

A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups. ... Read more >>

Org Lett (Organic letters)
[2020, 22(22):9029-9035]

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Development of pancytopenia in a patient with COVID-19.

Yi Zhao, Jingsong He, Jiasheng Wang, Wei-Ming Li, Mi Xu, Xu Yu, Wei Wu, Chunyin Sun, Zherong Xu, Weifang Zhang, Yu Hu, He Huang,

J Med Virol (Journal of medical virology)
[2021, 93(3):1219-1220]

Cited: 3 times

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Monotropein alleviates H2O2‑induced inflammation, oxidative stress and apoptosis via NF‑κB/AP‑1 signaling.

Feng Jiang, Xiao-Rong Xu, Wei-Ming Li, Kun Xia, Le-Feng Wang, Xin-Chun Yang,

Aging is a major risk factor in cardiovascular disease (CVD). Oxidative stress and inflammation are involved in the pathogenesis of CVD, and are closely associated with senescent vascular endothelial cells. Monotropein (Mtp) exerts various bioactive roles, including anti‑inflammatory and antioxidative effects. The aim of the present study was to investigate ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2020, 22(6):4828-4836]

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Comparative analysis of patients with upper urinary tract urothelial carcinoma in black-foot disease endemic and non-endemic area

Che-Wei Chang, Chien-Hui Ou, Chih-Chin Yu, Chi-Wen Lo, Chung-You Tsai, Pai-Yu Cheng, Yung-Tai Chen, Hsu-Che Huang, Chia-Chang Wu, Wen-Jeng Wu, Ching-Chia Li, Wei-Ming Li, Hung-Lung Ke, Hsiang-Ying Lee,

<h4>Objective: </h4> High incidence of upper urinary tract urothelial carcinoma has been reported in South- Western area of Taiwan, where arsenic water contamination was considered to be the main cause. However, there is no definite proof to show the correlation between the arsenic water contamination and upper urinary tract urothelial ... Read more >>

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The protoapigenone analog WYC0209 targets CD133+ cells: A potential adjuvant agent against cancer stem cells in urothelial cancer therapy.

Bi-Wen Yeh, Liang-En Yu, Ching-Chia Li, Juan-Cheng Yang, Wei-Ming Li, Yang-Chang Wu, Yu-Ching Wei, Hsueh-Te Lee, Mei-Lang Kung, Wen-Jeng Wu,

Urothelial carcinoma (UC) is one of the highest incidence cancers that rank the fourth commonly diagnosed tumors worldwide. The unresectable lesions that are resistant to therapeutic interventions is the major cause leading to death. Previous studies had shown that the resistance and metastatic consequence may arise from cancer stem-like cells ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2020, 402:115129]

Cited: 1 time

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