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Author Wayne L Furman

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Phase I expansion cohort to evaluate the combination of bevacizumab, sorafenib and low-dose cyclophosphamide in children and young adults with refractory or recurrent solid tumours.

Sara M Federico, Kenneth J Caldwell, Mary B McCarville, Vinay M Daryani, Clinton F Stewart, Shenghua Mao, Jianrong Wu, Andrew M Davidoff, Victor M Santana, Wayne L Furman, Alberto S Pappo, Fariba Navid,

BACKGROUND:Angiogenesis is critical for tumour growth and metastasis. Dual inhibition of vascular endothelial growth factors and platelet-derived growth factor receptors suppresses angiogenesis. This expansion cohort of a phase I study targeted angiogenesis with sorafenib, bevacizumab and low-dose cyclophosphamide in children and young adults with recurrent solid tumours. METHODS:An expansion cohort ... Read more >>

Eur. J. Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 132:35-42]

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A phase 1 trial of everolimus and bevacizumab in children with recurrent solid tumors.

Victor M Santana, Natasha Sahr, Ruth G Tatevossian, Sujuan Jia, Olivia Campagne, April Sykes, Clinton F Stewart, Wayne L Furman, Lisa M McGregor,

BACKGROUND:The prognosis for children with recurrent solid tumors generally is poor. Targeting mammalian target of rapamycin (mTOR) and vascular endothelial growth factor A with everolimus and bevacizumab, respectively, synergistically improves progression-free survival and is well tolerated in adults with solid tumors. METHODS:In the current phase 1 study, a total of ... Read more >>

Cancer (Cancer)
[2020, 126(8):1749-1757]

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Clinically ascertained health outcomes, quality of life, and social attainment among adult survivors of neuroblastoma: A report from the St. Jude Lifetime Cohort.

Carmen L Wilson, Tara M Brinkman, Cathleen Cook, Sujuan Huang, Geehong Hyun, Daniel M Green, Wayne L Furman, Nickhill Bhakta, Matthew J Ehrhardt, Matthew J Krasin, Leslie L Robison, Kirsten K Ness, Melissa M Hudson,

BACKGROUND:The objective of this study was to characterize chronic disease, health-related quality of life (HRQOL), emotional distress, and social attainment among long-term survivors of neuroblastoma. METHODS:Chronic health conditions among 136 ≥10-year neuroblastoma survivors (median age, 31.9 years; range, 20.2-54.6 years) and 272 community controls (median age, 34.7 years; range, 18.3-59.6 years) were graded with ... Read more >>

Cancer (Cancer)
[2020, 126(6):1330-1338]

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Impact of MYCN status on response of high-risk neuroblastoma to neoadjuvant chemotherapy.

David Yanishevski, M Beth McCarville, Mikhail Doubrovin, Hannah R Spiegl, Xiwen Zhao, Zhaohua Lu, Sara M Federico, Wayne L Furman, Andrew J Murphy, Andrew M Davidoff,

BACKGROUND/PURPOSE:MYCN-amplification in neuroblastoma is associated with an aggressive clinical phenotype. We evaluated the association of MYCN amplification with tumor response to neoadjuvant chemotherapy. METHODS:Primary tumor response, assessed by percentage volume change on CT scan and degree of tumor resection, assessed by the operating surgeon, were retrospectively compared in 84 high-risk ... Read more >>

J. Pediatr. Surg. (Journal of pediatric surgery)
[2020, 55(1):130-134]

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Biochemical testing for neuroblastoma using plasma free 3-O-methyldopa, 3-methoxytyramine, and normetanephrine.

Mirko Peitzsch, Elizabeth R Butch, Elizabeth Lovorn, Anastasios Mangelis, Wayne L Furman, Victor M Santana, Barbara Hero, Frank Berthold, Barry L Shulkin, Angela Huebner, Graeme Eisenhofer,

BACKGROUND:Neuroblastoma, the most common extracranial solid tumor of childhood, produces catecholamines that are metabolized within tumor cells. Homovanillic acid (HVA) and vanillylmandelic acid (VMA), the end products of catecholamine metabolism, have limited accuracy for testing of the tumors. This study assessed whether metabolites produced in earlier steps of catecholamine metabolism ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(2):e28081]

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A Phase II Trial of Hu14.18K322A in Combination with Induction Chemotherapy in Children with Newly Diagnosed High-Risk Neuroblastoma.

Wayne L Furman, Sara M Federico, Mary Beth McCarville, Barry L Shulkin, Andrew M Davidoff, Matthew J Krasin, Natasha Sahr, April Sykes, Jianrong Wu, Rachel C Brennan, Michael William Bishop, Sara Helmig, Elizabeth Stewart, Fariba Navid, Brandon Triplett, Victor M Santana, Armita Bahrami, Gwendolyn Anthony, Alice L Yu, Jacquelyn Hank, Stephen D Gillies, Paul M Sondel, Wing H Leung, Alberto S Pappo,

PURPOSE:We sought to evaluate whether combining a humanized antidisialoganglioside mAb (hu14.18K322A) with induction chemotherapy improves early responses and outcomes in children with newly diagnosed high-risk neuroblastoma. PATIENTS AND METHODS:We conducted a prospective nonrandomized, single-arm, two-stage, phase II clinical trial. Six courses of induction chemotherapy were coadministered with hu14.18K322A and followed ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(21):6320-6328]

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Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.

Zachary E Stiles, Andrew J Murphy, Doralina L Anghelescu, Christina-Lin Brown, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Michael W Bishop, Wayne L Furman, Alberto S Pappo, John T Lucas, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents and young adults. Cytoreduction, hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), and adjuvant radiotherapy may improve local control. We review our experience with patients who undergo CRS/HIPEC and adjuvant radiotherapy for DSRCT. METHODS:A retrospective review was performed for ... Read more >>

Ann. Surg. Oncol. (Annals of Surgical Oncology)
[2020, 27(1):171-178]

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Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial.

Howard M Katzenstein, Max R Langham, Marcio H Malogolowkin, Mark D Krailo, Alexander J Towbin, Mary Beth McCarville, Milton J Finegold, Sarangarajan Ranganathan, Stephen Dunn, Eugene D McGahren, Gregory M Tiao, Allison F O'Neill, Muna Qayed, Wayne L Furman, Caihong Xia, Carlos Rodriguez-Galindo, Rebecka L Meyers,

BACKGROUND:Hepatoblastoma treatment with curative intent requires surgical resection, but only about a third of newly diagnosed patients with hepatoblastoma have resectable disease at diagnosis. Patients who have upfront resection typically receive a total of 4-6 cycles of adjuvant chemotherapy post-surgery, with the combination of cisplatin, fluorouracil, and vincristine. We aimed ... Read more >>

Lancet Oncol. (The Lancet. Oncology)
[2019, 20(5):719-727]

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Serum Alanine Aminotransferase Elevations in Survivors of Childhood Cancer: A Report From the St. Jude Lifetime Cohort Study.

Daniel M Green, Mingjuan Wang, Matthew J Krasin, DeoKumar Srivastava, Mary V Relling, Carrie R Howell, Kirsten K Ness, Sue C Kaste, William Greene, Dennis W Jay, Israel Fernandez-Pineda, Ching-Hon Pui, Sima Jeha, Michael W Bishop, Wayne L Furman, Leslie L Robison, Melissa M Hudson,

The purpose of this study was to define the prevalence of and risk factors for elevated serum alanine aminotransferase (ALT) level among adult childhood cancer survivors (CCS). The study cohort comprised 2,751 CCS from the St. Jude Lifetime Cohort Study (>10 years postdiagnosis, age ≥18 years). Serum ALT level was ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2019, 69(1):94-106]

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Managing local-regional failure in children with high-risk neuroblastoma: A single institution experience.

Austin P Dove, Bogdan-Alexandru Manole, Daniel V Wakefield, Shane J Cross, Michael Doubrovin, Barry L Shulkin, Thomas E Merchant, Andrew M Davidoff, Wayne L Furman, Matthew J Krasin, Victor M Santana, John T Lucas,

BACKGROUND:Intensification of systemic therapy for high-risk neuroblastoma (HRNB) has resulted in improved local control and overall survival (OS) leaving potential for de-escalation of primary site radiotherapy. The utility of primary site de-escalation should be evaluated in the context of potential for successful local-regional salvage. We evaluated salvage strategies and outcomes ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2018, 65(12):e27408]

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Genitopatellar syndrome and neuroblastoma: The multidisciplinary management of a previously unreported association.

Samantha Knight, Lisa VanHouwelingen, David Cervi, Michael R Clay, Mark Corkins, Stacy Hines-Dowell, Kayla V Hamilton, Roya Mostafavi, Jewell Ward, Wayne L Furman, Andrew Jackson Murphy,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2018, 65(12):e27373]

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Rapid decrease of serum alpha-fetoprotein and tumor volume predicts outcome in children with hepatoblastoma treated with neoadjuvant chemotherapy.

Rosa Nguyen, M Beth McCarville, April Sykes, Shenghua Mao, Jianrong Wu, Max R Langham, Wayne L Furman,

BACKGROUND:Neoadjuvant chemotherapy is given to children with unresectable hepatoblastoma to increase the rate and safety of curative complete surgical resection. Elevated levels of serum alpha-fetoprotein (sAFP) decline with tumor shrinkage. In this single-institution retrospective study, we determined early dynamic changes of sAFP levels and tumor volume in children during therapy ... Read more >>

Int. J. Clin. Oncol. (International journal of clinical oncology)
[2018, 23(5):900-907]

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Alveolar soft part sarcoma in children and young adults: A report of 69 cases.

Ricardo J Flores, Douglas J Harrison, Noah C Federman, Wayne L Furman, Winston W Huh, Emily G Broaddus, Mehmet F Okcu, Rajkumar Venkatramani,

BACKGROUND:Alveolar soft part sarcoma (ASPS) is a rare mesenchymal tumor characterized by ASPL-TFE3 translocation. Apart from complete surgical resection, there is no standard management strategy. PROCEDURE:The clinical data of 69 children and young adults less than 30 years old with ASPS diagnosed from 1980-2014 were retrospectively collected from four major institutions. ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2018, 65(5):e26953]

Cited: 6 times

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Characterization of Pulmonary Metastases in Children With Hepatoblastoma Treated on Children's Oncology Group Protocol AHEP0731 (The Treatment of Children With All Stages of Hepatoblastoma): A Report From the Children's Oncology Group.

Allison F O'Neill, Alexander J Towbin, Mark D Krailo, Caihong Xia, Yun Gao, M Beth McCarville, Rebecka L Meyers, Eugene D McGahren, Greg M Tiao, Stephen P Dunn, Max R Langham, Christopher B Weldon, Milton J Finegold, Sarangarajan Ranganathan, Wayne L Furman, Marcio Malogolowkin, Carlos Rodriguez-Galindo, Howard M Katzenstein,

Purpose To determine whether the pattern of lung nodules in children with metastatic hepatoblastoma (HB) correlates with outcome. Methods Thirty-two patients with metastatic HB were enrolled on Children's Oncology Group Protocol AHEP0731 and treated with vincristine and irinotecan (VI). Responders to VI received two additional cycles of VI intermixed with ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2017, 35(30):3465-3473]

Cited: 7 times

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A Pilot Trial of Humanized Anti-GD2 Monoclonal Antibody (hu14.18K322A) with Chemotherapy and Natural Killer Cells in Children with Recurrent/Refractory Neuroblastoma.

Sara M Federico, M Beth McCarville, Barry L Shulkin, Paul M Sondel, Jacquelyn A Hank, Paul Hutson, Michael Meagher, Aaron Shafer, Catherine Y Ng, Wing Leung, William E Janssen, Jianrong Wu, Shenghua Mao, Rachel C Brennan, Victor M Santana, Alberto S Pappo, Wayne L Furman,

Purpose: Anti-GD2 mAbs, acting via antibody-dependent cell-mediated cytotoxicity, may enhance the effects of chemotherapy. This pilot trial investigated a fixed dose of a unique anti-GD2 mAb, hu14.18K322A, combined with chemotherapy, cytokines, and haploidentical natural killer (NK) cells.Experimental Design: Children with recurrent/refractory neuroblastoma received up to six courses of hu14.18K322A (40 ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2017, 23(21):6441-6449]

Cited: 13 times

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Upfront window vincristine/irinotecan treatment of high-risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 study committee.

Howard M Katzenstein, Wayne L Furman, Marcio H Malogolowkin, Mark D Krailo, M Beth McCarville, Alexander J Towbin, Greg M Tiao, Milton J Finegold, Sarangarajan Ranganathan, Stephen P Dunn, Max R Langham, Eugene D McGahren, Carlos Rodriguez-Galindo, Rebecka L Meyers,

The identification of new therapies for high-risk (HR) hepatoblastoma is challenging. Children's Oncology Group study AHEP0731 included a HR stratum to explore the efficacy of novel agents. Herein, the authors report the response rate to the combination of vincristine (V) and irinotecan (I) and the outcome of patients with high-risk ... Read more >>

Cancer (Cancer)
[2017, 123(12):2360-2367]

Cited: 6 times

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Patients with retinoblastoma and chromosome 13q deletions have increased chemotherapy-related toxicities.

Rachel C Brennan, Ibrahim Qaddoumi, Catherine A Billups, Tracy Kaluzny, Wayne L Furman, Matthew W Wilson,

A total of 5-10% of patients with retinoblastoma (RB) harbor deletion of the long arm (q) chromosome 13 (13q-). The treatment-related toxicities in this population have not been described.Sixty-eight RB patients on a single institutional protocol (RET5) from 2005 to 2010 were reviewed. Genetic screening identified 11 patients (seven female) ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2016, 63(11):1954-1958]

Cited: 1 time

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Feasibility of Pegylated Interferon in Children and Young Adults With Resected High-Risk Melanoma.

Fariba Navid, Cynthia E Herzog, John Sandoval, Vinay M Daryani, Clinton F Stewart, Jami Gattuso, Belinda Mandrell, Sean Phipps, Wassim Chemaitilly, April Sykes, Andrew M Davidoff, Barry L Shulkin, Armita Bahrami, Wayne L Furman, Shenghua Mao, Jianrong Wu, Deborah Schiff, Bhaskar Rao, Alberto Pappo,

Pegylated interferon α-2b (IFN α-2b) improves disease-free survival in adults with resected stage III melanoma. We conducted a study to determine the feasibility and safety of incorporating pegylated IFN α-2b as adjuvant therapy in the treatment of children and adolescents with high-risk melanoma. Pharmacokinetic studies of IFN α-2b and neuropsychological ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2016, 63(7):1207-1213]

Cited: 5 times

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Two-Year-Old Boy With Leukocoria and Strabismus.

Rosa Nguyen, Matthew W Wilson, Israel Fernandez-Pineda, Rachel C Brennan, Wayne L Furman,

Clin Pediatr (Phila) (Clinical pediatrics)
[2016, 55(12):1187-1189]

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Multimodality Treatment of Pediatric Esthesioneuroblastoma.

Rajkumar Venkatramani, Hubert Pan, Wayne L Furman, Jonathan M Marron, Josephine Haduong, Paola Friedrich-Medina, Anita Mahajan, Abhishek Bavle, Hao Wu, Murali Chintagumpala,

Esthesioneuroblastoma (ENB) is a rare cancer of the nasal cavity in children. Radical surgery followed by postoperative radiation is considered the standard of care in adults. A similar approach in children can lead to significant long-term morbidity.A retrospective multi-institutional review of patients less than 21 years of age diagnosed with ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2016, 63(3):465-470]

Cited: 4 times

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Rare Tumors in Children: Progress Through Collaboration.

Alberto S Pappo, Wayne L Furman, Kris A Schultz, Andrea Ferrari, Lee Helman, Mark D Krailo,

Rare pediatric tumors account for approximately 10% of all childhood cancers, which in themselves are a rare entity. The diverse histologies and clinical behaviors of rare pediatric tumors pose challenges to the investigation of their biologic and clinical features. National and international cooperative groups such as the Rare Tumor Committee ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2015, 33(27):3047-3054]

Cited: 10 times

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Phase I clinical trial of ifosfamide, oxaliplatin, and etoposide (IOE) in pediatric patients with refractory solid tumors.

Catherine G Lam, Wayne L Furman, Chong Wang, Sheri L Spunt, Jianrong Wu, Percy Ivy, Victor M Santana, Lisa M McGregor,

Oxaliplatin, although related to cisplatin and carboplatin, has a more favorable toxicity profile and may offer advantages in combination regimens. We combined oxaliplatin, ifosfamide, and etoposide (IOE) and estimated the regimen's maximum tolerated dose (MTD) in children with refractory solid tumors. Dose-limiting toxicity (DLT) and MTD were assessed at 3 ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2015, 37(1):e13-8]

Cited: 1 time

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The role of chest computed tomography (CT) as a surveillance tool in children with high-risk neuroblastoma.

Sara M Federico, Samuel L Brady, Alberto Pappo, Jianrong Wu, Shenghua Mao, Valerie J McPherson, Alison Young, Wayne L Furman, Robert Kaufman, Sue Kaste,

Standardization of imaging obtained in children with neuroblastoma is not well established. This study examines chest CT in pediatric patients with high-risk neuroblastoma.Medical records and imaging from 88 patients with high-risk neuroblastoma, diagnosed at St. Jude Children's Research Hospital between January, 2002 and December, 2009, were reviewed. Surveillance imaging was ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2015, 62(6):976-981]

Cited: 6 times

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Response: should initial investigations for neoplastic causes of precocious puberty include serum beta-human chorionic gonadotropin and alpha-fetoprotein?

Susanne Wendt, Karen Wright, Wayne L Furman,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2015, 62(3):546]

Cited: 0 times

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Current Management of Neonatal Liver Tumors.

Max R Langham, Wayne L Furman, Israel Fernandez-Pineda,

This review is focused on the special issues and challenges confronting physicians and surgeons caring for an unborn child, or a newborn with a liver tumor. Liver tumors at this age are very rare and they make it difficult for pediatric surgeons to gain experience necessary to obtain good results. ... Read more >>

Curr Pediatr Rev (Current pediatric reviews)
[2015, 11(3):195-204]

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