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Author Wassim Kassouf

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Stereotactic Ablative Radiotherapy for the Treatment of Upper Urinary Tract Urothelial Carcinoma.

Julia Khriguian, Horacio Patrocinio, Sero Andonian, Armen Aprikian, Wassim Kassouf, Simon Tanguay, Fabio L Cury,

<h4>Purpose</h4>Urothelial carcinomas (UC), also known as transitional cell carcinomas, account for the majority of upper urinary tract tumors. The gold-standard therapy for operable patients with localized disease is radical nephroureterectomy. However, some patients are not surgical candidates. Data on the use of modern radiotherapy (RT) for upper urinary tract UC ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2021, :]

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Identifying the Optimal Number of Neoadjuvant Chemotherapy Cycles in Patients with Muscle Invasive Bladder Cancer.

David D'Andrea, Peter C Black, Homayoun Zargar, Colin P Dinney, Francesco Soria, Michael S Cookson, Jeffrey S Montgomery, Wassim Kassouf, Marc A Dall'Era, Srikala S Sridhar, John S McGrath, Jonathan L Wright, Andrew C Thorpe, Jeff M Holzbeierlein, Diego M Carrión, Ettore Di Trapani, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Bas W van Rhijn, Siamak Daneshmand, Philippe E Spiess, Shahrokh F Shariat,

<h4>Purpose</h4>We investigated the pathological response rates and survival associated with 3 vs 4 cycles of cisplatin-based neoadjuvant chemotherapy (NAC) in patients with cT2-4N0M0 muscle invasive bladder cancer.<h4>Materials and methods</h4>In this cohort study we analyzed clinical data of 828 patients treated with NAC and radical cystectomy between 2000 and 2020. A ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000002190]

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Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer.

David D'Andrea, Peter C Black, Homayoun Zargar, Kamran Zargar-Shoshtari, Francesco Soria, Adrian S Fairey, Laura S Mertens, Colin P Dinney, Maria C Mir, Laura-Maria Krabbe, Michael S Cookson, Niels-Erik Jacobsen, Jeffrey S Montgomery, Nikhil Vasdev, Evan Y Yu, Evanguelos Xylinas, Nicholas J Campain, Wassim Kassouf, Marc A Dall'Era, Jo-An Seah, Cesar E Ercole, Simon Horenblas, Srikala S Sridhar, John S McGrath, Jonathan Aning, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeff M Holzbeierlein, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Philippe E Spiess, Shahrokh F Shariat,

<h4>Purpose</h4>To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC).<h4>Materials and methods</h4>We analyzed data from 1105 patients with MIBC. Patients age was evaluated as continuous variable and stratified in quartiles. Pathologic objective response (pOR; ypT0-Ta-Tis-T1N0) and pathologic complete response (pCR; ypT0N0), ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Adjuvant Immune Checkpoint Inhibition in Muscle-invasive Bladder Cancer: Is It Ready for Prime Time?

Adi Kartolo, Wassim Kassouf, Francisco E Vera-Badillo,

We discuss results from the Checkmate-274 and IMvigor010 trials on adjuvant immune checkpoint inhibitor (ICI) therapy in muscle-invasive bladder cancer (MIBC) with or without neoadjuvant chemotherapy (NAC), and conclude that adjuvant ICI (nivolumab but not atezolizumab) should be considered for patients with resected high-risk MIBC, especially for those who have ... Read more >>

Eur Urol (European urology)
[2021, :]

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Canadian Urological Association guideline on the management of non-muscle-invasive bladder cancer – Abridged version

Bimal Bhindi, Ronald Kool, Girish S. Kulkarni, D. Robert Siemens, Armen G. Aprikian, Rodney H. Breau, Fadi Brimo, Adrian Fairey, Christopher French, Nawar Hanna, Jonathan I. Izawa, Louis Lacombe, Victor McPherson, Ricardo A. Rendon, Bobby Shayegan, Alan I. So, Alexandre R. Zlotta, Peter C. Black, Wassim Kassouf,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(8):230-239]

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Canadian Urological Association guideline on the management of non-muscle-invasive bladder cancer - Full-text.

Bimal Bhindi, Ronald Kool, Girish S Kulkarni, D Robert Siemens, Armen G Aprikian, Rodney H Breau, Fadi Brimo, Adrian Fairey, Christopher French, Nawar Hanna, Jonathan I Izawa, Louis Lacombe, Victor McPherson, Ricardo A Rendon, Bobby Shayegan, Alan I So, Alexandre R Zlotta, Peter C Black, Wassim Kassouf,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(8):E424-E460]

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In Reply to Khalifa and Sargos.

Gautier Marcq, Luis Souhami, Wassim Kassouf,

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 110(3):917-918]

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Poster Exhibit 2: Non-prostate Genitourinary Cancers.

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(6 Suppl 2):S84-S98]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer.

Surashri Shinde-Jadhav, Jose Joao Mansure, Roni F Rayes, Gautier Marcq, Mina Ayoub, Rodrigo Skowronski, Ronald Kool, France Bourdeau, Fadi Brimo, Jonathan Spicer, Wassim Kassouf,

Radiation therapy (RT) is used in the management of several cancers; however, tumor radioresistance remains a challenge. Polymorphonuclear neutrophils (PMNs) are recruited to the tumor immune microenvironment (TIME) post-RT and can facilitate tumor progression by forming neutrophil extracellular traps (NETs). Here, we demonstrate a role for NETs as players in ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2776]

Cited: 1 time

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Sex- and age-related differences in the distribution of bladder cancer metastases.

Giuseppe Rosiello, Carlotta Palumbo, Marina Deuker, Lara Franziska Stolzenbach, Thomas Martin, Zhe Tian, Andrea Gallina, Francesco Montorsi, Peter Black, Wassim Kassouf, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Pierre I Karakiewicz,

<h4>Objective</h4>Our objective was to investigate age- and sex-related differences in the distribution of metastases in patients with metastatic bladder cancer.<h4>Methods</h4>Within the National Inpatient Sample database (2008-2015), we identified 7040 patients with metastatic bladder cancer. Trend test and Chi-square test analyses were used to evaluate the relationship between age and site ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(6):976-983]

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Erectile function after partial penectomy for penile cancer.

Leonardo L Monteiro, Rodrigo Skowronski, Fadi Brimo, Paulo da C Carvalho, Romulo A L Vasconcelos, Charley R C V Pacheco, Adriano A Calado, Wassim Kassouf,

<h4>Purpose</h4>To evaluate the erectile function in patients who underwent partial penectomy and identify factors associated with penile functional status.<h4>Materials and methods</h4>We identified patients who underwent partial penectomy due to penile cancer between 2009 and 2014. Clinical and pathological characteristics included patient age at the time of diagnosis, obesity, hypertension, dyslipidemia, ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2021, 47(3):515-522]

Cited: 2 times

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Radical Cystectomy vs. Multimodality Treatment in T2N0M0 Bladder Cancer: A Population-based, Age-matched Analysis.

Marina Deuker, Marieke J Krimphove, L Franziska Stolzenbach, Claudia Collà Ruvolo, Luigi Nocera, Mila Mansour, Zhe Tian, Frederik C Roos, Andreas Becker, Luis A Kluth, Shahrokh F Shariat, Peter C Black, Wassim Kassouf, Derya Tilki, Fred Saad, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>Controversy still exists regarding efficacy of multimodality treatment (MMT) vs. radical cystectomy (RC) for urothelial carcinoma of the urinary bladder (UCUB).<h4>Methods</h4>Within the SEER database (2004-2016), we retrospectively identified patients with stage T2N0M0 UCUB. Competing risks regression (CRR) tested cancer-specific mortality (CSM) and adjusted for other-cause mortality after MMT vs. RC. ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, 19(4):e264-e271]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Surgical challenges and considerations in Tri-modal therapy for muscle invasive bladder cancer.

Adam S Feldman, Girish S Kulkarni, Trinity J Bivalacqua, Peter C Black, Scott Delacroix, Seth P Lerner, Ashish M Kamat, Wassim Kassouf,

Trimodal therapy (TMT) for muscle invasive bladder cancer has become an accepted alternative to radical cystectomy and has become integrated into national guidelines as standard a treatment option. The urologist plays a critical role in proper patient selection, thorough transurethral resection, ongoing cystoscopic surveillance and management of local recurrences. There ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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The Use of 5-Alpha Reductase Inhibitors and Alpha-1 Blockers Does Not Improve Clinical Outcome in Male Patients Undergoing Radical Cystectomy for Bladder Cancer in Quebec, Canada.

Michel D Wissing, Ana O'Flaherty, Alice Dragomir, Simon Tanguay, Wassim Kassouf, Armen G Aprikian,

<h4>Background</h4>Existing literature suggests that bladder cancer (BC) outcome may be improved when patients use 5α-reductase inhibitors and/or α<sub>1</sub>-blockers, but such a conclusion may be subject to publication bias. We evaluated whether preoperative use of 5α-reductase inhibitors or α<sub>1</sub>-blockers was associated with improved clinical outcomes in a cohort of patients with ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, 19(4):371-371.e9]

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Postoperative ileus: A systematic pathway for radical cystectomy candidates?

Gautier Marcq, Wassim Kassouf,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(2):40-41]

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Phase 1 Trial of Atezolizumab Plus Trimodal Therapy in Patients With Localized Muscle-Invasive Bladder Cancer.

Gautier Marcq, Luis Souhami, Fabio L Cury, Afsar Salimi, Armen Aprikian, Simon Tanguay, Marie Vanhuyse, Raghu Rajan, Fadi Brimo, José João Mansure, Wassim Kassouf,

<h4>Purpose</h4>Immune checkpoint programmed death-ligand 1 inhibitor therapy has shown response in metastatic muscle invasive bladder cancer (MIBC). We evaluated the safety and tolerability of atezolizumab (anti-programmed death-ligand 1) in combination with trimodal therapy in patients with localized MIBC.<h4>Methods and materials</h4>A prospective nonrandomized phase 1 study using a 3 + 3 ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 110(3):738-741]

Cited: 3 times

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Multiparametric magnetic resonance imaging for bladder cancer: a comprehensive systematic review of the Vesical Imaging-Reporting and Data System (VI-RADS) performance and potential clinical applications.

Denis Séguier, Philippe Puech, Ronald Kool, Léa Dernis, Héléna Gabert, Wassim Kassouf, Arnauld Villers, Gautier Marcq,

<h4>Background</h4>The Vesical Imaging-Reporting and Data System (VI-RADS) score is a novel standardized approach to image and report bladder cancer (BC) with multiparametric MRI (mpMRI).<h4>Objectives</h4>To describe and evaluate the performance of the VI-RADS score using mpMRI and assess its potential clinical applications and limitations.<h4>Methods</h4>A systematic review was conducted using the MEDLINE ... Read more >>

Ther Adv Urol (Therapeutic advances in urology)
[2021, 13:17562872211039583]

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Bladder-sparing protocols in the treatment of muscle-invasive bladder cancer.

Côme Tholomier, Luis Souhami, Wassim Kassouf,

Bladder-sparing protocols (BSP) have been gaining widespread popularity as an attractive alternative to radical cystectomy (RC) for muscle-invasive bladder cancer. Unimodal therapies are inferior to multimodal regimens. The most promising regimen is trimodal therapy (TMT), which is a combination of maximal transurethral resection of bladder tumor (TURBT), radiotherapy, and chemotherapy. ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(6):2920-2937]

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Neoadjuvant chemotherapy plus radical cystectomy versus radical cystectomy alone in clinical T2 bladder cancer without hydronephrosis.

Francesco Soria, Peter C Black, Adrian S Fairey, Michael S Cookson, Evan Y Yu, Wassim Kassouf, Marc A Dall'Era, Srikala S Sridhar, John S McGrath, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Siamak Daneshmand, Jeff M Holzbeierlein, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Jay B Shah, Bas W van Rhijn, Philippe E Spiess, Shahrokh F Shariat, Paolo Gontero,

<h4>Objectives</h4>To assess the efficacy of neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) in a retrospective multicentre cohort of patients with cT2N0M0 bladder cancer (BCa) without preoperative hydronephrosis.<h4>Patients and methods</h4>This was a propensity-based analysis of 619 patients. Of these, 316 were treated with NAC followed by RC and 303 with upfront ... Read more >>

BJU Int (BJU international)
[2021, 128(1):79-87]

Cited: 2 times

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Racial differences in the distribution of bladder cancer metastases: a population-based analysis.

Giuseppe Rosiello, Carlotta Palumbo, Marina Deuker, Lara Franziska Stolzenbach, Thomas Martin, Zhe Tian, Andrea Gallina, Francesco Montorsi, Peter Black, Wassim Kassouf, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Pierre I Karakiewicz,

<h4>Introduction</h4>Bladder cancer is the second most common genitourinary malignancy in the United States. The incidence of bladder cancer rises with age, and it is two times more common in Caucasians than in African-Americans (23.1 vs. 12.6 cases/100,000 persons). We aimed to investigate the racial and age-related differences in the distribution ... Read more >>

Cent European J Urol (Central European journal of urology)
[2020, 73(4):407-415]

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Role of prehabilitation following major uro-oncologic surgery: a narrative review.

Enrico Maria Minnella, Francesco Carli, Wassim Kassouf,

<h4>Purpose</h4>Functional status and physical independence play a key role in terms of quality of life, access to treatment, and continuity of care. Surgery, a central component of cancer treatments, leads to detrimental effects on functional capacity, which can be peculiarly relevant in vulnerable patients undergoing major procedures. Prehabilitation is a ... Read more >>

World J Urol (World journal of urology)
[2020, :]

Cited: 2 times

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Building a Canadian Translational Bladder Cancer Research Network.

Madhuri Koti, David M Berman, D Robert Siemens, Dirk Lange, Edwin Wang, Paul Toren, Bernhard J Eigl, Céline Hardy, Robert Purves, Vincent Fradet, Yves Fradet, Jose Mansure, Wassim Kassouf, Peter C Black, ,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2020, 14(10):E475-E481]

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Refining assessment of response to radiation-based therapy for muscle-invasive bladder cancer: Is post-treatment tumor bed biopsy always necessary?

Ronald Kool, Gautier Marcq, Adnan El-Achkar, Jose Joao Mansure, Marie Vanhuyse, Armen Aprikian, Simon Tanguay, Fabio L Cury, Fadi Brimo, Luis Souhami, Wassim Kassouf,

<h4>Introduction</h4>Radiation-based therapy (RT) has emerged as a suitable alternative to radical cystectomy (RC) and pelvic lymph node dissection for muscle-invasive bladder cancer (MIBC) patients. Routine biopsy after RT to rule out residual disease remains inconsistent across guidelines. Our objective was to review the significance of a bladder biopsy in terms ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(5):299.e7-299.e14]

Cited: 1 time

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