Full Text Journal Articles by
Author Warren Porter

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Infrared thermography cannot be used to approximate core body temperature in wild primates.

Richard McFarland, Louise Barrett, Andrea Fuller, Robyn S Hetem, Warren P Porter, Christopher Young, S Peter Henzi,

Understanding the physiological processes that underpin primate performance is key if we are to assess how a primate might respond when navigating new and changing environments. Given the connection between a mammal's ability to thermoregulate and the changing demands of its thermal environment, increasing attention is being devoted to the ... Read more >>

Am J Primatol (American journal of primatology)
[2020, 82(12):e23204]

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Future winters present a complex energetic landscape of decreased costs and reduced risk for a freeze-tolerant amphibian, the Wood Frog (Lithobates sylvaticus).

Megan J Fitzpatrick, Warren P Porter, Jonathan N Pauli, Michael R Kearney, Michael Notaro, Benjamin Zuckerberg,

Winter climate warming is rapidly leading to changes in snow depth and soil temperatures across mid- and high-latitude ecosystems, with important implications for survival and distribution of species that overwinter beneath the snow. Amphibians are a particularly vulnerable group to winter climate change because of the tight coupling between their ... Read more >>

Glob Chang Biol (Global change biology)
[2020, :]

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Infrared thermography cannot be used to approximate core body temperature in wild primates

Richard McFarland, Louise Barrett, Andrea Fuller, Robyn Hetem, Warren Porter, Christopher Young, Peter Henzi,

ABSTRACT Understanding the physiological processes that underpin primate performance is key if we are to assess how a primate might respond when navigating new and changing environments. Given the connection between an animal’s ability to thermoregulate and the changing demands of its thermal environment, increasing attention is being devoted to ... Read more >>

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High accuracy gene expression profiling of sorted cell subpopulations from breast cancer PDX model tissue.

Warren Porter, Eileen Snowden, Friedrich Hahn, Mitchell Ferguson, Frances Tong, W Shannon Dillmore, Rainer Blaesius,

Intratumor Heterogeneity (ITH) is a functionally important property of tumor tissue and may be involved in drug resistance mechanisms. Although descriptions of ITH can be traced back to very early reports about cancer tissue, mechanistic investigations are still limited by the precision of analysis methods and access to relevant tissue ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238594]

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Modeling Dragons: Using linked mechanistic physiological and microclimate models to explore environmental, physiological, and morphological constraints on the early evolution of dinosaurs.

David M Lovelace, Scott A Hartman, Paul D Mathewson, Benjamin J Linzmeier, Warren P Porter,

We employed the widely-tested biophysiological modeling software, Niche Mapper™ to investigate the metabolic function of the Late Triassic dinosaurs Plateosaurus and Coelophysis during global greenhouse conditions. We tested a variety of assumptions about resting metabolic rate, each evaluated within six microclimate models that bound paleoenvironmental conditions at 12° N paleolatitude, ... Read more >>

PLoS One (PloS one)
[2020, 15(5):e0223872]

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Evaporative water loss simulation improves models' prediction of habitat suitability for a high-elevation forest skink.

Shu-Ping Huang, Ruth E Kearley, Kuan-Wei Hung, Warren P Porter,

Accurate evaluation of habitat availability for wildlife is relevant for ecological applications. Researchers have frequently used models to simulate habitats thermally suitable for reptiles, but these results have limited application for species highly selective for habitat humidity. Here, we use the biophysical Niche Mapper™ model to investigate impacts of vegetation ... Read more >>

Oecologia (Oecologia)
[2020, 192(3):657-669]

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Landscape scale thermoregulatory costs from sublethal exposure to Deep Water Horizon oil in the double-crested cormorant.

Brian S Dorr, Paul D Mathewson, Katie C Hanson-Dorr, Katherine A Healy, Katherine E Horak, Warren Porter,

Toxic effects of heavy oiling to wildlife are well known from oil spills, although sublethal oil exposure effects are poorly understood. We used Niche Mapper™, to compute spatially and temporally specific energetic and behavioral impacts of repeated sublethal oil exposure to double-crested cormorants (Phalacrocorax auritus). During winter (October-March) cormorants exposed ... Read more >>

Mar Pollut Bull (Marine pollution bulletin)
[2020, 152:110915]

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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.

Leonard L Winneroski, Jon A Erickson, Steven J Green, Jose E Lopez, Stephanie L Stout, Warren J Porter, David E Timm, James E Audia, Mario Barberis, James P Beck, Leonard N Boggs, Anthony R Borders, Robert D Boyer, Richard A Brier, Erik J Hembre, Jörg Hendle, Pablo Garcia-Losada, Jose Miguel Minguez, Brian M Mathes, Patrick C May, Scott A Monk, Zoran Rankovic, Yuan Shi, Brian M Watson, Zhixiang Yang, Dustin J Mergott,

Inhibition of BACE1 has become an important strategy in the quest for disease modifying agents to slow the progression of Alzheimer's disease. We previously reported the fragment-based discovery of LY2811376, the first BACE1 inhibitor reported to demonstrate robust reduction of human CSF Aβ in a Phase I clinical trial. We ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2020, 28(1):115194]

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Modeling Dragons: Using linked mechanistic physiological and microclimate models to explore environmental, physiological, and morphological constraints on the early evolution of dinosaurs

David Lovelace, Scott Hartman, Paul Mathewson, Benjamin Linzmeier, Warren Porter,

Abstract We employed the widely-tested biophysiological modeling software, Niche Mapper™ to investigate the metabolic function of Late Triassic dinosaurs Plateosaurus and Coelophysis during global greenhouse conditions. We tested them under a variety of assumptions about resting metabolic rate, evaluated within six microclimate models that bound paleoenvironmental conditions at 12° N ... Read more >>

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Climate change could overturn bird migration: Transarctic flights and high-latitude residency in a sea ice free Arctic.

Manon Clairbaux, Jérôme Fort, Paul Mathewson, Warren Porter, Hallvard Strøm, David Grémillet,

Climate models predict that by 2050 the Arctic Ocean will be sea ice free each summer. Removing this barrier between the Atlantic and the Pacific will modify a wide range of ecological processes, including bird migration. Using published information, we identified 29 arctic-breeding seabird species, which currently migrate in the ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):17767]

Cited: 1 time

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Correction: Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue.

Moen Sen, Friedrich Hahn, Taylor A Black, Maureen DeMarshall, Warren Porter, Eileen Snowden, Stephanie S Yee, Frances Tong, Mitchell Ferguson, Emylee N Fleshman, Hiroshi Nakagawa, Gary W Falk, Gregory G Ginsberg, Michael L Kochman, Rainer Blaesius, Anil K Rustgi, Erica L Carpenter,

[This corrects the article DOI: 10.18632/oncotarget.26911.]. ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(49):5119]

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Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue.

Moen Sen, Friedrich Hahn, Taylor A Black, Maureen DeMarshall, Warren Porter, Eileen Snowden, Stephanie S Yee, Frances Tong, Mitchell Ferguson, Emylee N Fleshman, Hiroshi Nakagawa, Gary W Falk, Gregory G Ginsberg, Michael L Kochman, Rainer Blaesius, Anil K Rustgi, Erica L Carpenter,

Barrett's esophagus (BE) is metaplasia of the squamous epithelium to a specialized columnar epithelium. BE progresses through low- and high-grade dysplasia before developing into esophageal adenocarcinoma. The BE microenvironment is not well defined. We compare 12 human clinical BE and adjacent normal squamous epithelium biopsies using single cell immunophenotyping by ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(38):3592-3604]

Cited: 3 times

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Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain.

Kelly L Knopp, Rosa Maria A Simmons, Wenhong Guo, Benjamin L Adams, Kevin M Gardinier, Douglas L Gernert, Paul L Ornstein, Warren Porter, Jon Reel, Chunjin Ding, He Wang, Yuewei Qian, Kevin D Burris, Anne Need, Vanessa Barth, Steven Swanson, John Catlow, Jeffrey M Witkin, Ruud Zwart, Emanuele Sher, Kar-Chan Choong, Theron M Wall, Douglas Schober, Christian C Felder, Akihiko S Kato, David S Bredt, Eric S Nisenbaum,

Nonselective glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists are efficacious in chronic pain but have significant tolerability issues, likely arising from the ubiquitous expression of AMPA receptors in the central nervous system (CNS). Recently, LY3130481 has been shown to selectively block AMPA receptors coassembled with the auxiliary protein, transmembrane AMPA receptor ... Read more >>

J. Pharmacol. Exp. Ther. (The Journal of pharmacology and experimental therapeutics)
[2019, 369(3):345-363]

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Shifts in metabolic fuel use coincide with maximal rates of ventilation and body surface rewarming in an arousing hibernator.

Matthew D Regan, Edna Chiang, Sandra L Martin, Warren P Porter, Fariba M Assadi-Porter, Hannah V Carey,

It is well established that hibernating mammals rely predominantly on lipid stores to fuel metabolism throughout the hibernation season. However, it is unclear if other endogenous fuels contribute to the rapid, ~400-fold increase in metabolic rate during the early phase of arousal from torpor. To investigate this issue, we used ... Read more >>

Am J Physiol Regul Integr Comp Physiol (American journal of physiology. Regulatory, integrative and comparative physiology)
[2019, 316(6):R764-R775]

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Mechanistic modeling of environmental drivers of woolly mammoth carrying capacity declines on St. Paul Island.

Yue Wang, Warren Porter, Paul D Mathewson, Paul A Miller, Russell W Graham, John W Williams,

On St. Paul Island, a remnant of the Bering Land Bridge, woolly mammoths persisted until 5,600 yr BP with no known predators or competitors, providing a natural system for studying hypothesized environmental drivers of extinction. These include overheating due to rising temperatures, starvation, and drought. Here, we test these hypotheses using ... Read more >>

Ecology (Ecology)
[2018, 99(12):2721-2730]

Cited: 0 times

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Experimental and modeled thermoregulatory costs of repeated sublethal oil exposure in the Double-crested Cormorant, Phalacrocorax auritus.

Paul D Mathewson, Katie C Hanson-Dorr, Warren P Porter, Steven J Bursian, Karen M Dean, Kate Healy, Katherine Horak, Jane E Link, K E Harr, Brian S Dorr,

To fully understand the impact of oil exposure, it is important to understand sublethal effects like how increased thermoregulatory costs may affect survival and reproduction. However, it is difficult and time-consuming to measure these effects in wild animals. We present a novel use of a bioenergetics model, Niche Mapper™, to ... Read more >>

Mar Pollut Bull (Marine pollution bulletin)
[2018, 135:216-223]

Cited: 1 time

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Reflection of near-infrared light confers thermal protection in birds.

Iliana Medina, Elizabeth Newton, Michael R Kearney, Raoul A Mulder, Warren P Porter, Devi Stuart-Fox,

Biologists have focused their attention on the optical functions of light reflected at ultraviolet and human-visible wavelengths. However, most radiant energy in sunlight occurs in 'unseen' near-infrared (NIR) wavelengths. The capacity to reflect solar radiation at NIR wavelengths may enable animals to control heat gain and remain within their critical ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):3610]

Cited: 4 times

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An ecophysiological perspective on likely giant panda habitat responses to climate change.

Yuke Zhang, Paul D Mathewson, Qiongyue Zhang, Warren P Porter, Jianghong Ran,

Threatened and endangered species are more vulnerable to climate change due to small population and specific geographical distribution. Therefore, identifying and incorporating the biological processes underlying a species' adaptation to its environment are important for determining whether they can persist in situ. Correlative models are widely used to predict species' distribution ... Read more >>

Glob Chang Biol (Global change biology)
[2018, 24(4):1804-1816]

Cited: 1 time

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Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptors.

Jeffrey M Witkin, Jennifer Li, Gary Gilmour, Stephen N Mitchell, Guy Carter, Scott D Gleason, Wesley F Seidel, Brian J Eastwood, Andrew McCarthy, Warren J Porter, Jon Reel, Kevin M Gardinier, Akihiko S Kato, Keith A Wafford,

6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has been characterized as a potent and efficacious anticonvulsant in an array of acute and chronic epilepsy models in rodents. The present set of experiments was designed to assess ... Read more >>

Neuropharmacology (Neuropharmacology)
[2017, 126:257-270]

Cited: 4 times

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Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue.

Eileen Snowden, Warren Porter, Friedrich Hahn, Mitchell Ferguson, Frances Tong, Joel S Parker, Aaron Middlebrook, Smita Ghanekar, W Shannon Dillmore, Rainer Blaesius,

Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment. Genomic tools applied to biopsies in bulk fail to account for this tumor heterogeneity, whereas single-cell imaging methods limit the number of cells which can be assessed or are very resource ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2017, 15(4):429-438]

Cited: 4 times

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Targeted Blockade of TARP-γ8-Associated AMPA Receptors: Anticonvulsant Activity with the Selective Antagonist LY3130481 (CERC-611).

Jeffrey M Witkin, Douglas A Schober, Scott D Gleason, John T Catlow, Warren J Porter, Jon Reel, Xiaoming Jin, Jonathan Hobbs, Donald Gehlert, Douglas L Gernert, Kevin M Gardinier, Akihiko S Kato, Xingjie Ping, Jodi L Smith,

BACKGROUND & OBJECTIVE:6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]- 3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8 that is under development for epilepsy. The present study provided a broad inquiry into its anticonvulsant properties. LY3130481 was anticonvulsant in multiple acute seizure provocation models in mice ... Read more >>

CNS Neurol Disord Drug Targets (CNS & neurological disorders drug targets)
[2017, 16(10):1099-1110]

Cited: 3 times

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Foraging Activity Pattern Is Shaped by Water Loss Rates in a Diurnal Desert Rodent.

Ofir Levy, Tamar Dayan, Warren P Porter, Noga Kronfeld-Schor,

Although animals fine-tune their activity to avoid excess heat, we still lack a mechanistic understanding of such behaviors. As the global climate changes, such understanding is particularly important for projecting shifts in the activity patterns of populations and communities. We studied how foraging decisions vary with biotic and abiotic pressures. ... Read more >>

Am Nat (The American naturalist)
[2016, 188(2):205-218]

Cited: 6 times

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Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.

Akihiko S Kato, Kevin D Burris, Kevin M Gardinier, Douglas L Gernert, Warren J Porter, Jon Reel, Chunjin Ding, Yuan Tu, Douglas A Schober, Matthew R Lee, Beverly A Heinz, Thomas E Fitch, Scott D Gleason, John T Catlow, Hong Yu, Stephen M Fitzjohn, Francesca Pasqui, He Wang, Yuewei Qian, Emanuele Sher, Ruud Zwart, Keith A Wafford, Kurt Rasmussen, Paul L Ornstein, John T R Isaac, Eric S Nisenbaum, David S Bredt, Jeffrey M Witkin,

Pharmacological manipulation of specific neural circuits to optimize therapeutic index is an unrealized goal in neurology and psychiatry. AMPA receptors are important for excitatory synaptic transmission, and their antagonists are antiepileptic. Although efficacious, AMPA-receptor antagonists, including perampanel (Fycompa), the only approved antagonist for epilepsy, induce dizziness and motor impairment. We ... Read more >>

Nat. Med. (Nature medicine)
[2016, 22(12):1496-1501]

Cited: 21 times

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Color Change for Thermoregulation versus Camouflage in Free-Ranging Lizards.

Kathleen R Smith, Viviana Cadena, John A Endler, Michael R Kearney, Warren P Porter, Devi Stuart-Fox,

Animal coloration has multiple functions including thermoregulation, camouflage, and social signaling, and the requirements of each function may sometimes conflict. Many terrestrial ectotherms accommodate the multiple functions of color through color change. However, the relative importance of these functions and how color-changing species accommodate them when they do conflict are ... Read more >>

Am. Nat. (The American naturalist)
[2016, 188(6):668-678]

Cited: 11 times

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Mechanistic variables can enhance predictive models of endotherm distributions: the American pika under current, past, and future climates.

Paul D Mathewson, Lucas Moyer-Horner, Erik A Beever, Natalie J Briscoe, Michael Kearney, Jeremiah M Yahn, Warren P Porter,

How climate constrains species' distributions through time and space is an important question in the context of conservation planning for climate change. Despite increasing awareness of the need to incorporate mechanism into species distribution models (SDMs), mechanistic modeling of endotherm distributions remains limited in this literature. Using the American pika ... Read more >>

Glob Chang Biol (Global change biology)
[2017, 23(3):1048-1064]

Cited: 5 times

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