Full Text Journal Articles by
Author Wan Amir Nizam Wan Ahmad

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Systematic Review of Medicinal Plants Used for Treatment of Diabetes in Human Clinical Trials: An ASEAN Perspective.

Nazurah Hamizah Salleh, Ihsan Nazurah Zulkipli, Hartini Mohd Yasin, Fairuzeta Ja'afar, Norhayati Ahmad, Wan Amir Nizam Wan Ahmad, Siti Rohaiza Ahmad,

Traditionally, there are some medicinal plants believed to treat diabetes, as they have been proven in research studies to possess antidiabetic properties, such as improved insulin sensitivity and hypoglycemic activities, due to their high level of phenolic compounds, flavonoids, terpenoids, alkaloids, and glycosides. We conducted a systematic review to identify ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2021, 2021:5570939]

Cited: 0 times

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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes.

Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi'u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar,

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions. Several pathophysiological conditions and pharmacological agents are known to disrupt ER homeostasis, thereby, causing ER stress. The cells react to ER stress by initiating ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(14):]

Cited: 1 time

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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes

Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi’u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar,

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions. Several pathophysiological conditions and pharmacological agents are known to disrupt ER homeostasis, thereby, causing ER stress. The cells react to ER stress by initiating ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(14):]

Cited: 0 times

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Current Updates on Potential Role of Flavonoids in Hypoxia/Reoxygenation Cardiac Injury Model.

Shafreena Shaukat Ali, Liza Noordin, Ruzilawati Abu Bakar, Satirah Zainalabidin, Zakiah Jubri, Wan Amir Nizam Wan Ahmad,

Clinically, timely reperfusion strategies to re-establish oxygenated blood flow in ischemic heart diseases seem to salvage viable myocardium effectively. Despite the remarkable improvement in cardiac function, reperfusion therapy could paradoxically trigger hypoxic cellular injury and dysfunction. Experimental laboratory models have been developed over the years to explain better the pathophysiology ... Read more >>

Cardiovasc Toxicol (Cardiovascular toxicology)
[2021, 21(8):605-618]

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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes

Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Muazzamu Aliyu, Rabi’u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar,

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis in insulin-secreting beta-cells is essential. Several pathophysiological conditions and pharmacological agents disrupt the ER homeostasis, thereby causing ER stress. The cells react to ER stress by initiating an adaptive ... Read more >>

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Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma.

Malagobadan Johnathan, Siti Aminah Muhamad, Siew Hua Gan, Johnson Stanslas, Wan Ezumi Mohd Fuad, Faezahtul Arbaeyah Hussain, Wan Amir Nizam Wan Ahmad, Asma Abdullah Nurul,

Lignosus rhinocerotis Cooke. (L. rhinocerotis) is a medicinal mushroom traditionally used in the treatment of asthma and several other diseases by the indigenous communities in Malaysia. In this study, the effects of L. rhinocerotis on allergic airway inflammation and hyperresponsiveness were investigated. L. rhinocerotis extract (LRE) was prepared by hot ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0249091]

Cited: 1 time

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Lipid peroxidation in the descending thoracic aorta of rats deprived of REM sleep using the inverted flowerpot technique.

Afifah Nawi, Koh Liew Eu, Asma Nadia Ahmad Faris, Wan Amir Nizam Wan Ahmad, Liza Noordin,

<h4>New findings</h4>What is the central question of this study? Deprivation of rapid eye movement (REM) sleep is associated with increased oxidative stress, but its effects on the blood vessels are poorly documented. We investigated whether REM sleep deprivation induces oxidative stress and causes lipid peroxidation in the aorta. What is ... Read more >>

Exp Physiol (Experimental physiology)
[2020, 105(8):1223-1231]

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Implication of dietary phenolic acids on inflammation in cardiovascular disease.

Shafreena Shaukat Ali, Wan Amir Nizam Wan Ahmad, Siti Balkis Budin, Satirah Zainalabidin,

In spite of medical advances, cardiovascular disease remains a significant concern, imposing a great burden upon the economy and public health of nations by causing the highest morbidity and mortality cases globally. Moreover, it is well established that inflammation is closely linked to the pathogenesis of cardiovascular diseases. Hence, targeting ... Read more >>

Rev Cardiovasc Med (Reviews in cardiovascular medicine)
[2020, 21(2):225-240]

Cited: 5 times

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Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review.

Md Rizman Md Lazin Md Lazim, Amilia Aminuddin, Kalaivani Chellappan, Azizah Ugusman, Adila A Hamid, Wan Amir Nizam Wan Ahmad, Mohd Shawal Faizal Mohamad,

Finger photoplethysmography (PPG) waveform is blood volume change of finger microcirculation that reflects vascular function. Reflection index (RI), stiffness index (SI) and second derivative of photoplethysmogram (SDPPG) are derived from PPG waveforms proposed as cardiovascular disease (CVD) markers. Heart rate (HR) is a known factor that affects vascular function. Individual ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(7):]

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Supplementation of Stingless Bee Honey from Heterotrigona itama Improves Antiobesity Parameters in High-Fat Diet Induced Obese Rat Model.

Ahmad Zulkifli Mohd Rafie, Amir Syahir, Wan Amir Nizam Wan Ahmad, Mohd Zulkifli Mustafa, Abdul Razak Mariatulqabtiah,

<i>Heterotrigona itama</i> is a common stingless bee species found in Southeast Asia. Studies on the health benefits of its honey are limited in comparison with other stingless bee species. This study examines the antiobesity benefits found in stingless bee honey (SBH) from <i>H. itama</i>. The parameters used to measure the ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2018, 2018:6371582]

Cited: 6 times

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Autonomic Receptors and Nitric-Oxide Involvements in Mediating Vasorelaxation Effect Induced by Syzygium polyanthum Leaves Extract.

Azlini Ismail, Wan Amir Nizam Wan Ahmad,

Context:Syzygium polyanthum (Wight) Walp leaves are traditionally used by Malays for treating hypertension. Our previous study showed that aqueous extract of S. polyanthum (AESP) and methanolic extract of S. polyanthum (MESP) extracts of S. polyanthum leaves significantly reduced blood pressure of normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Aims:This ... Read more >>

Pharmacognosy Res (Pharmacognosy research)
[2017, 9(Suppl 1):S9-S14]

Cited: 0 times

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Incorporation of dietary fibre-rich oyster mushroom (Pleurotus sajor-caju) powder improves postprandial glycaemic response by interfering with starch granule structure and starch digestibility of biscuit.

Sze Han Ng, Sathyasurya Daniel Robert, Wan Amir Nizam Wan Ahmad, Wan Rosli Wan Ishak,

The purpose of this study was to determine the effects of Pleurotus sajor-caju (PSC) powder addition at 0, 4, 8 and 12% levels on the nutritional values, pasting properties, thermal characteristics, microstructure, in vitro starch digestibility, in vivo glycaemic index (GI) and sensorial properties of biscuits. Elevated incorporation levels of ... Read more >>

Food Chem (Food chemistry)
[2017, 227:358-368]

Cited: 13 times

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Knowledge and Attitude about Stem Cells and Their Application in Medicine among Nursing Students in Universiti Sains Malaysia, Malaysia.

Jee Leng Lye, Lean Keng Soon, Wan Amir Nizam Wan Ahmad, Suat Cheng Tan,

<h4>Background</h4>Stem cell research has been extensively explored worldwide to enhance human health in medical setting. Nevertheless, there is currently no full understanding of the stem cell knowledge and attitude levels among student nurses in Malaysia. This study aimed to assess the level of stem cell knowledge, attitude toward stem cell ... Read more >>

Malays J Med Sci (The Malaysian journal of medical sciences : MJMS)
[2015, 22(4):23-31]

Cited: 5 times

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Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats.

Sze Han Ng, Mohd Shazwan Mohd Zain, Fatariah Zakaria, Wan Rosli Wan Ishak, Wan Amir Nizam Wan Ahmad,

<h4>Introduction</h4>Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological properties. Objective. To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC aqueous extract in normal and diabetic rats.<h4>Materials and methods</h4>A single dose of 500, 750, or 1000 mg/kg of the PSC ... Read more >>

Biomed Res Int (BioMed research international)
[2015, 2015:214918]

Cited: 2 times

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