Full Text Journal Articles by
Author Walid Habre

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A decade later, there are still major issues to be addressed in paediatric anaesthesia.

Walid Habre, Nicola Disma,

<h4>Purpose of review</h4>Despite real advances in paediatric anaesthesia management, such as a growing awareness of the relevance of anaesthesia conduct as well as of the lack of evidence for neurotoxicity of anaesthetic agents, it must be said that there are still important questions in our specialty that remain unanswered. Standardization ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):271-275]

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Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE).

Nicola Disma, Francis Veyckemans, Katalin Virag, Tom G Hansen, Karin Becke, Pierre Harlet, Laszlo Vutskits, Suellen M Walker, Jurgen C de Graaff, Marzena Zielinska, Dusica Simic, Thomas Engelhardt, Walid Habre, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background</h4>Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown.<h4>Methods</h4>This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, :]

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Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study.

Nicola Disma, Katalin Virag, Thomas Riva, Jost Kaufmann, Thomas Engelhardt, Walid Habre, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background</h4>Neonates and infants are susceptible to hypoxaemia in the perioperative period. The aim of this study was to analyse interventions related to anaesthesia tracheal intubations in this European cohort and identify their clinical consequences.<h4>Methods</h4>We performed a secondary analysis of tracheal intubations of the European multicentre observational trial (NEonate and Children ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, :]

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Effect of Permissive Mild Hypercapnia on Cerebral Vasoreactivity in Infants: A Randomized Controlled Crossover Trial.

Leonore Schopfer, Walid Habre, Isabelle Pichon, Gergely H Fodor,

<h4>Background</h4>Mechanical ventilation interferes with cerebral perfusion via changes in intrathoracic pressure and/or as a consequence of alterations in CO2. Cerebral vascular vasoreactivity is dependent on CO2, and hypocapnia can potentially lead to vasoconstriction and subsequent decrease in cerebral blood flow. Thus, we aimed at characterizing whether protective ventilation with mild ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, :]

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Physiologically variable ventilation reduces regional lung inflammation in a pediatric model of acute respiratory distress syndrome.

Andre Dos Santos Rocha, Gergely H Fodor, Miklos Kassai, Loic Degrugilliers, Sam Bayat, Ferenc Petak, Walid Habre,

<h4>Background</h4>Benefits of variable mechanical ventilation based on the physiological breathing pattern have been observed both in healthy and injured lungs. These benefits have not been characterized in pediatric models and the effect of this ventilation mode on regional distribution of lung inflammation also remains controversial. Here, we compare structural, molecular ... Read more >>

Respir Res (Respiratory research)
[2020, 21(1):288]

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Physiologically variable ventilation in a rabbit model of asthma exacerbation.

André Dos Santos Rocha, Roberta Südy, Ferenc Peták, Walid Habre,

<h4>Background</h4>Mechanical ventilation during status asthmaticus is challenging and increases the risk of severe complications. We recently reported the value of physiologically variable ventilation (PVV) in healthy and acutely injured lungs. We investigated whether PVV provides benefits compared with pressure-controlled ventilation (PCV) in an experimental model of severe acute asthma.<h4>Methods</h4>Allergen-sensitised rabbits ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2020, 125(6):1107-1116]

Cited: 1 time

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End-expiratory lung volume assessment using helium and carbon dioxide in an experimental model of pediatric capnoperitoneum.

Jacob Karlsson, Gergely H Fodor, Andre Dos Santos Rocha, Na Lin, Walid Habre, Mats Wallin, Magnus Hallbäck, Ferenc Peták, Per-Arne Lönnqvist,

<h4>Background</h4>Capnoperitoneum during laparoscopy leads to cranial shift of the diaphragm, loss in lung volume, and risk of impaired gas exchange. Infants are susceptible to these changes and bedside assessment of lung volume during laparoscopy might assist with optimizing the ventilation. Thus, the primary aim was to investigate the monitoring value ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2020, 64(8):1106-1113]

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Determination of adequate positive end-expiratory pressure level required for carbon dioxide homeostasis in an animal model of infant laparoscopy.

Jacob Karlsson, Gergely H Fodor, Andre Dos Santos Rocha, Na Lin, Walid Habre, Mats Wallin, Magnus Hallbäck, Ferenc Peták, Per-Arne Lönnqvist,

BACKGROUND:Capnoperitoneum provides a ventilatory challenge due to reduction in end-expiratory lung volume and peritoneal carbon dioxide absorption in both children and adults. The primary aim of this controlled interventional trial was to determine the positive end-expiratory pressure (PEEP) level needed to ensure for adequate carbon dioxide clearance and preservation of ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2020, 64(8):1114-1119]

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Benefit of Physiologically Variable Over Pressure-Controlled Ventilation in a Model of Chronic Obstructive Pulmonary Disease: A Randomized Study.

Andre Dos Santos Rocha, Roberta Südy, Davide Bizzotto, Miklos Kassai, Tania Carvalho, Raffaele L Dellacà, Ferenc Peták, Walid Habre,

<h4>Introduction</h4>The advantages of physiologically variable ventilation (PVV) based on a spontaneous breathing pattern have been demonstrated in several respiratory conditions. However, its potential benefits in chronic obstructive pulmonary disease (COPD) have not yet been characterized. We used an experimental model of COPD to compare respiratory function outcomes after 6 h ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:625777]

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Epidemiology of regional anesthesia in children: Lessons learned from the European Multi-Institutional Study APRICOT.

Christophe Dadure, Francis Veyckemans, Sophie Bringuier, Walid Habre,

<h4>Background</h4>Recently, the European prospective observational multicenter cohort study, APRICOT, reported anesthesia techniques and complications in more than 31 000 pediatric procedures. The main objective of this study was to analyze the current practice in regional anesthesia in the 33 countries that participated to APRICOT.<h4>Methods</h4>Data on regional anesthesia techniques were extracted from ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(11):1128-1135]

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Feasibility of forced oscillatory assessment of respiratory mechanics across a laryngeal mask airway in rabbits.

Andre Dos Santos Rocha, Roberta Südy, Gergely H Fodor, Walid Habre, Ferenc Peták,

<h4>Objectives</h4>The forced oscillation technique (FOT) is the method of choice for assessment of respiratory tissue mechanics. A laryngeal mask airway (LMA) is increasingly used to secure the airways in subjects under sedation or general anesthesia. While FOT is routinely performed using an endotracheal tube (ETT), the accuracy of information about ... Read more >>

Physiol Meas (Physiological measurement)
[2019, 40(6):065001]

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Variable Ventilation Is Equally Effective as Conventional Pressure Control Ventilation for Optimizing Lung Function in a Rabbit Model of ARDS.

Gergely H Fodor, Sam Bayat, Gergely Albu, Na Lin, Aurélie Baudat, Judit Danis, Ferenc Peták, Walid Habre,

<h4>Background</h4>Introducing mathematically derived variability (MVV) into the otherwise monotonous conventional mechanical ventilation has been suggested to improve lung recruitment and gas exchange. Although the application of a ventilation pattern based on variations in physiological breathing (PVV) is beneficial for healthy lungs, its value in the presence of acute respiratory distress ... Read more >>

Front Physiol (Frontiers in physiology)
[2019, 10:803]

Cited: 3 times

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Reversing Cholinergic Bronchoconstriction by Common Inotropic Agents: A Randomized Experimental Trial on Isolated Perfused Rat Lungs.

Gergely H Fodor, Sam Bayat, Barna Babik, Walid Habre, Ferenc Peták,

<h4>Background</h4>The ability of inotropic agents to alter airway reactivity and lung tissue mechanics has not been compared in a well-controlled experimental model. Therefore, we compared the potential to alter lung tissue viscoelasticity and bronchodilator effects of commonly used inotropic agents in an isolated perfused rat lung model.<h4>Methods</h4>After achieving steady state ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2019, 129(3):745-752]

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"Neonatal ventilation; What we don't know, can't hurt… right?"

Meghan Cooney, Walid Habre,

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(7):670-671]

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Effect of PEEP and I:E ratio on cerebral oxygenation in ARDS: an experimental study in anesthetized rabbit.

Federica Lovisari, Gergely H Fodor, Ferenc Peták, Walid Habre, Sam Bayat,

<h4>Background</h4>Although PEEP and inversed I:E ratio have been shown to improve gas exchange in ARDS, both can adversely affect systemic hemodynamics and cerebral perfusion. The goal of this study was to assess how changes in PEEP and I:E ratio affect systemic and cerebral oxygenation and perfusion in normal and injured ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2019, 19(1):110]

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Different contributions from lungs and chest wall to respiratory mechanics in mice, rats, and rabbits.

Roberta Südy, Gergely H Fodor, André Dos Santos Rocha, Álmos Schranc, József Tolnai, Walid Habre, Ferenc Peták,

Changes in lung mechanics are frequently inferred from intact-chest measures of total respiratory system mechanics without consideration of the chest wall contribution. The participation of lungs and chest wall in respiratory mechanics has not been evaluated systematically in small animals commonly used in respiratory research. Thus, we compared these contributions ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2019, 127(1):198-204]

Cited: 2 times

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Risk associated with anesthesia for noncardiac surgery in children with congenital heart disease.

Dan Taylor, Walid Habre,

Database analysis has indicated that perioperative cardiac arrest occurs with increased frequency in children with congenital heart disease. Several case series and large datasets from ACS NSQIP have identified subgroups at the highest risk. Consistently, patients with single ventricle physiology (especially prior to cavopulmonary anastomosis), severe/supra-systemic pulmonary hypertension, complex lesions, ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(5):426-434]

Cited: 1 time

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Classification of postoperative behavior disturbances in preschool children: A qualitative study.

Ursula Lopez, Jennifer Martin, Mitsouko van Assche, Aline Fleury Schubert, Maryll Fournet, Vincent Quartier, Walid Habre, Martial Van der Linden,

<h4>Background/aim</h4>Negative postoperative changes in children are frequent and have been described for decades. However, there is currently no theoretical framework, nor any consensual operational criteria for identifying them. This study aims at characterizing the many dimensions involved in postoperative behavioral disturbances in early childhood, using a qualitative analysis applied for ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(7):712-720]

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High inspired oxygen fraction impairs lung volume and ventilation heterogeneity in healthy children: a double-blind randomised controlled trial.

Béatrice de la Grandville, Ferenc Petak, Gergely Albu, Sam Bayat, Isabelle Pichon, Walid Habre,

BACKGROUND:Although a high inspired oxygen fraction (FiO2) is commonly used in paediatric anaesthesia, the impact on postoperative lung function is unclear. We compared lung volume, ventilation heterogeneity, and respiratory mechanics in anaesthetised children randomised to receive low or high FiO2 intraoperatively. METHODS:In a double-blind randomised controlled trial, children scheduled for ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2019, 122(5):682-691]

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Epidemiology and incidence of severe respiratory critical events in ear, nose and throat surgery in children in Europe: A prospective multicentre observational study.

Katalin Virag, Nada Sabourdin, Mark Thomas, Francis Veyckemans, Walid Habre, ,

<h4>Background</h4>Ear, nose and throat (ENT) surgery, the most frequently performed surgical procedure in children, is a strong predictor for peri-operative respiratory complications. However, there is no clear information about peri-operative respiratory severe critical events (SCEs) associated with anaesthesia management of ENT children in Europe.<h4>Objective</h4>To characterise the epidemiology and incidence of ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2019, 36(3):185-193]

Cited: 2 times

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Optimal crystalloid volume ratio for blood replacement for maintaining hemodynamic stability and lung function: an experimental randomized controlled study.

Gergely H Fodor, Walid Habre, Adam L Balogh, Roberta Südy, Barna Babik, Ferenc Peták,

<h4>Background</h4>Crystalloids are first line in fluid resuscitation therapy, however there is a lack of evidence-based recommendations on the volume to be administered. Therefore, we aimed at comparing the systemic hemodynamic and respiratory effects of volume replacement therapy with a 1:1 ratio to the historical 1:3 ratio.<h4>Methods</h4>Anesthetized, ventilated rats randomly included ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2019, 19(1):21]

Cited: 1 time

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Volumetric but Not Time Capnography Detects Ventilation/Perfusion Mismatch in Injured Rabbit Lung.

József Tolnai, Gergely H Fodor, Barna Babik, André Dos Santos Rocha, Sam Bayat, Ferenc Peták, Walid Habre,

Whereas time capnography (Tcap) is routinely displayed during mechanical ventilation, the volumetric representation (Vcap) is seldom used. We compared the diagnostic value of indices derived from Tcap and Vcap following ventilation to perfusion ratio () mismatch subsequent to experimentally induced acute respiratory distress syndrome (ARDS), and alveolar recruitment by elevating ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:1805]

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MacGyver or Machiavellian approaches to delivery of sevoflurane in neonates.

Ferenc Petak, Walid Habre,

Paediatr Anaesth (Paediatric anaesthesia)
[2018, 28(9):756-757]

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Blockade of the cholinergic system during sensitization enhances lung responsiveness to allergen in rats.

Iliona Malaspinas, Ferenc Petak, Aurélie Baudat, Camille Doras, Philippe A Eigenmann, Walid Habre,

Although acute prophylactic administration of atropine modulates airway responsiveness, the role of the parasympathetic nervous system in the pathogenesis of sensitization and in antigen-induced bronchoconstriction remains unclear. The aim of the present study is to determine whether blocking muscarinic receptors during chronic allergen exposure modulates lung responsiveness to the specific ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2018, 45(12):1293-1301]

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Pediatric anesthesia after APRICOT (Anaesthesia PRactice In Children Observational Trial): who should do it?

Walid Habre,

This review highlights the requirements for harmonization of training, certification and continuous professional development and discusses the implications for anesthesia management of children in Europe.A large prospective cohort study, Anaesthesia PRactice In Children Observational Trial (APRICOT), revealed a high incidence of perioperative severe critical events and a large variability of ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2018, 31(3):292-296]

Cited: 2 times

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