Full Text Journal Articles by
Author Wade V Welshons

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Is it time to reassess current safety standards for glyphosate-based herbicides?

Laura N Vandenberg, Bruce Blumberg, Michael N Antoniou, Charles M Benbrook, Lynn Carroll, Theo Colborn, Lorne G Everett, Michael Hansen, Philip J Landrigan, Bruce P Lanphear, Robin Mesnage, Frederick S Vom Saal, Wade V Welshons, John Peterson Myers,

Use of glyphosate-based herbicides (GBHs) increased ∼100-fold from 1974 to 2014. Additional increases are expected due to widespread emergence of glyphosate-resistant weeds, increased application of GBHs, and preharvest uses of GBHs as desiccants. Current safety assessments rely heavily on studies conducted over 30 years ago. We have considered information on GBH ... Read more >>

J Epidemiol Community Health (Journal of epidemiology and community health)
[2017, 71(6):613-618]

Cited: 12 times

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Comment on "Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology".

Richard W Stahlhut, Richard B van Breemen, Roy R Gerona, Julia A Taylor, Wade V Welshons, Frederick S vom Saal,

Environ Health Perspect (Environmental health perspectives)
[2016, 124(4):A66]

Cited: 1 time

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Endocrine disruptors: Manmade and natural oestrogens: opposite effects on assisted reproduction.

Frederick S vom Saal, Wade V Welshons,

Nat Rev Endocrinol (Nature reviews. Endocrinology)
[2016, 12(5):251-252]

Cited: 2 times

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Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement.

John Peterson Myers, Michael N Antoniou, Bruce Blumberg, Lynn Carroll, Theo Colborn, Lorne G Everett, Michael Hansen, Philip J Landrigan, Bruce P Lanphear, Robin Mesnage, Laura N Vandenberg, Frederick S Vom Saal, Wade V Welshons, Charles M Benbrook,

The broad-spectrum herbicide glyphosate (common trade name "Roundup") was first sold to farmers in 1974. Since the late 1970s, the volume of glyphosate-based herbicides (GBHs) applied has increased approximately 100-fold. Further increases in the volume applied are likely due to more and higher rates of application in response to the ... Read more >>

Environ Health (Environmental health : a global access science source)
[2016, 15:19]

Cited: 64 times

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Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of bisphenol A (BPA).

Annette M Hormann, Frederick S Vom Saal, Susan C Nagel, Richard W Stahlhut, Carol L Moyer, Mark R Ellersieck, Wade V Welshons, Pierre-Louis Toutain, Julia A Taylor,

Bisphenol A (BPA) is an endocrine disrupting environmental contaminant used in a wide variety of products, and BPA metabolites are found in almost everyone's urine, suggesting widespread exposure from multiple sources. Regulatory agencies estimate that virtually all BPA exposure is from food and beverage packaging. However, free BPA is applied ... Read more >>

PLoS One (PloS one)
[2014, 9(10):e110509]

Cited: 58 times

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Should oral gavage be abandoned in toxicity testing of endocrine disruptors?

Laura N Vandenberg, Wade V Welshons, Frederick S Vom Saal, Pierre-Louis Toutain, John Peterson Myers,

For decades, hazard assessments for environmental chemicals have used intra-gastric gavage to assess the effects of 'oral' exposures. It is now widely used--and in some cases required--by US federal agencies to assess potential toxicity of endocrine disrupting chemicals (EDCs). In this review we enumerate several reasons why gavage is not ... Read more >>

Environ Health (Environmental health : a global access science source)
[2014, 13(1):46]

Cited: 37 times

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Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures.

Frederick S Vom Saal, Catherine A VandeVoort, Julia A Taylor, Wade V Welshons, Pierre-Louis Toutain, Patricia A Hunt,

We measured serum dBPA in non-pregnant and pregnant female rhesus monkeys, fetuses and amniotic fluid. dBPA was administered by a daily oral bolus or sc implantation of Silastic capsules; both resulted in daily average serum unconjugated dBPA concentrations of <1ng/ml. We observed lower serum concentrations of unconjugated dBPA in pregnant ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2014, 45:105-116]

Cited: 21 times

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Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.

Brittany M Angle, Rylee Phuong Do, Davide Ponzi, Richard W Stahlhut, Bertram E Drury, Susan C Nagel, Wade V Welshons, Cynthia L Besch-Williford, Paola Palanza, Stefano Parmigiani, Frederick S vom Saal, Julia A Taylor,

Exposure to bisphenol A (BPA) is implicated in many aspects of metabolic disease in humans and experimental animals. We fed pregnant CD-1 mice BPA at doses ranging from 5 to 50,000μg/kg/day, spanning 10-fold below the reference dose to 10-fold above the currently predicted no adverse effect level (NOAEL). At BPA ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2013, 42:256-268]

Cited: 92 times

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Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology.

Laura N Vandenberg, Theo Colborn, Tyrone B Hayes, Jerrold J Heindel, David R Jacobs, Duk-Hee Lee, John Peterson Myers, Toshi Shioda, Ana M Soto, Frederick S vom Saal, Wade V Welshons, R Thomas Zoeller,

For years, scientists from various disciplines have studied the effects of endocrine disrupting chemicals (EDCs) on the health and wellbeing of humans and wildlife. Some studies have specifically focused on the effects of low doses, i.e. those in the range that are thought to be safe for humans and/or animals. ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2013, 38:1-15]

Cited: 56 times

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Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.

Laura N Vandenberg, Theo Colborn, Tyrone B Hayes, Jerrold J Heindel, David R Jacobs, Duk-Hee Lee, Toshi Shioda, Ana M Soto, Frederick S vom Saal, Wade V Welshons, R Thomas Zoeller, John Peterson Myers,

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of "the dose makes the poison," because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low ... Read more >>

Endocr. Rev. (Endocrine reviews)
[2012, 33(3):378-455]

Cited: 879 times

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Report of very low real-world exposure to bisphenol A is unwarranted based on a lack of data and flawed assumptions.

Frederick S Vom Saal, Gail S Prins, Wade V Welshons,

Toxicol. Sci. (Toxicological sciences : an official journal of the Society of Toxicology)
[2012, 125(1):318-20; author reply 321-5]

Cited: 7 times

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Role of p21 and cyclin E in normal and secalonic acid D-inhibited proliferation of human embryonic palatal mesenchymal cells.

Vamsidhara C Dhulipala, Kamala K Maddali, Bimal K Ray, Wade V Welshons, Chada S Reddy,

Secalonic acid D (SAD), a cleft palate-inducing teratogen, has been shown to inhibit proliferation/cell cycle progression in association with alteration in the levels of cell cycle regulators, p21 and cyclin E. These studies were conducted to test the hypotheses that p21 and cyclin E play an important functional role in ... Read more >>

Hum Exp Toxicol (Human & experimental toxicology)
[2011, 30(9):1222-1232]

Cited: 3 times

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Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: relevance for human exposure.

Julia A Taylor, Frederick S Vom Saal, Wade V Welshons, Bertram Drury, George Rottinghaus, Patricia A Hunt, Pierre-Louis Toutain, Céline M Laffont, Catherine A VandeVoort,

Daily adult human exposure to bisphenol A (BPA) has been estimated at <1 µg/kg, with virtually complete first-pass conjugation in the liver in primates but not in mice. We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration of ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2011, 119(4):422-430]

Cited: 139 times

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Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research.

Frederick S vom Saal, Benson T Akingbemi, Scott M Belcher, David A Crain, David Crews, Linda C Guidice, Patricia A Hunt, Csaba Leranth, John Peterson Myers, Angel Nadal, Nicholas Olea, Vasantha Padmanabhan, Cheryl S Rosenfeld, Alan Schneyer, Gilbert Schoenfelder, Carlos Sonnenschein, Ana M Soto, Richard W Stahlhut, Shanna H Swan, Laura N Vandenberg, Hong-Sheng Wang, Cheryl S Watson, Wade V Welshons, Robert T Zoeller,

Toxicol. Sci. (Toxicological sciences : an official journal of the Society of Toxicology)
[2010, 115(2):612-613]

Cited: 29 times

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Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations.

Stephanie L Nott, Yanfang Huang, Xiaodong Li, Brian R Fluharty, Xing Qiu, Wade V Welshons, Shuyuan Yeh, Mesut Muyan,

Estrogen (E2) signaling is conveyed by the transcription factors estrogen receptor (ER) alpha and beta. ERs modulate the expression of genes involved in cellular proliferation, motility, and death. The regulation of transcription by E2-ERalpha through binding to estrogen-responsive elements (EREs) in DNA constitutes the ERE-dependent signaling pathway. E2-ERalpha also modulates ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2009, 284(22):15277-15288]

Cited: 11 times

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Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A.

John Peterson Myers, Frederick S vom Saal, Benson T Akingbemi, Koji Arizono, Scott Belcher, Theo Colborn, Ibrahim Chahoud, D Andrew Crain, Francesca Farabollini, Louis J Guillette, Terry Hassold, Shuk-mei Ho, Patricia A Hunt, Taisen Iguchi, Susan Jobling, Jun Kanno, Hans Laufer, Michele Marcus, John A McLachlan, Angel Nadal, Jörg Oehlmann, Nicolás Olea, Paola Palanza, Stefano Parmigiani, Beverly S Rubin, Gilbert Schoenfelder, Carlos Sonnenschein, Ana M Soto, Chris E Talsness, Julia A Taylor, Laura N Vandenberg, John G Vandenbergh, Sarah Vogel, Cheryl S Watson, Wade V Welshons, R Thomas Zoeller,

In their safety evaluations of bisphenol A (BPA), the U.S. Food and Drug Administration (FDA) and a counterpart in Europe, the European Food Safety Authority (EFSA), have given special prominence to two industry-funded studies that adhered to standards defined by Good Laboratory Practices (GLP). These same agencies have given much ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2009, 117(3):309-315]

Cited: 112 times

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Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both.

Richard W Stahlhut, Wade V Welshons, Shanna H Swan,

It is commonly stated in the literature on human exposure to bisphenol A (BPA) that food is the predominant BPA exposure source, and that BPA is rapidly and completely cleared from the body. If this is correct, BPA levels in fasting individuals should decrease with increased fasting time.We set out ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2009, 117(5):784-789]

Cited: 177 times

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Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 mice.

Rachel L Ruhlen, Kembra L Howdeshell, Jiude Mao, Julia A Taylor, Franklin H Bronson, Retha R Newbold, Wade V Welshons, Frederick S vom Saal,

Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful.We compared reproductive and metabolic characteristics in male and female mice reared and maintained on non-soy low-phytoestrogen feed or soy-based high-phytoestrogen feed.The low-phytoestrogen diet was non-soy PMI 5K96 ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2008, 116(3):322-328]

Cited: 57 times

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No effect of route of exposure (oral; subcutaneous injection) on plasma bisphenol A throughout 24h after administration in neonatal female mice.

Julia A Taylor, Wade V Welshons, Frederick S Vom Saal,

Route of administration of chemicals in adults is an important factor in pharmacokinetics of chemicals such as bisphenol A (BPA), the monomer with estrogenic activity used to make polycarbonate plastic products and to line food and beverage cans. Based on findings in adults it has been proposed (CERHR, 2007) that ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2008, 25(2):169-176]

Cited: 53 times

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Lack of skeletal effect of soy isoflavones in intact growing, female rats may be explained by constant serum estrogenic activity despite reduced serum estradiol.

Catherine A Peterson, Karen L Kubas, Stephanie J Hartman, George E Rottinghaus, Julia A Taylor, Wade V Welshons,

BACKGROUND/AIMS: Scarce data exist on the effects of soy isoflavones (IF) on bone during peripuberty, a known 'window of opportunity' for bone consolidation. Our aim was to determine the skeletal, reproductive, and serum estradiol (E(2))/estrogenic activity response of consuming naturally-occurring soy protein-associated IF during peripuberty. METHODS: Weanling (approximately 3 weeks ... Read more >>

Ann. Nutr. Metab. (Annals of nutrition & metabolism)
[2008, 52(1):48-57]

Cited: 3 times

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Human exposure to bisphenol A (BPA).

Laura N Vandenberg, Russ Hauser, Michele Marcus, Nicolas Olea, Wade V Welshons,

The plastic monomer and plasticizer bisphenol A (BPA) is one of the highest volume chemicals produced worldwide. BPA is used in the production of polycarbonate plastics and epoxy resins used in many consumer products. Here, we have outlined studies that address the levels of BPA in human tissues and fluids. ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2007, 24(2):139-177]

Cited: 845 times

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Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure.

Frederick S vom Saal, Benson T Akingbemi, Scott M Belcher, Linda S Birnbaum, D Andrew Crain, Marcus Eriksen, Francesca Farabollini, Louis J Guillette, Russ Hauser, Jerrold J Heindel, Shuk-Mei Ho, Patricia A Hunt, Taisen Iguchi, Susan Jobling, Jun Kanno, Ruth A Keri, Karen E Knudsen, Hans Laufer, Gerald A LeBlanc, Michele Marcus, John A McLachlan, John Peterson Myers, Angel Nadal, Retha R Newbold, Nicolas Olea, Gail S Prins, Catherine A Richter, Beverly S Rubin, Carlos Sonnenschein, Ana M Soto, Chris E Talsness, John G Vandenbergh, Laura N Vandenberg, Debby R Walser-Kuntz, Cheryl S Watson, Wade V Welshons, Yelena Wetherill, R Thomas Zoeller,

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2007, 24(2):131-138]

Cited: 288 times

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Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells.

Catherine A Richter, Julia A Taylor, Rachel L Ruhlen, Wade V Welshons, Frederick S Vom Saal,

Hormonal alterations during development have lifelong effects on the prostate gland. Endogenous estrogens, including 17beta-estradiol (E(2)), and synthetic estrogenic endocrine disruptors, such as bisphenol A (BPA), have similar effects on prostate development. Increasing exposure to estrogens within the low-dose, physiologic range results in permanent increases in the size and androgen ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2007, 115(6):902-908]

Cited: 67 times

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Cell cycle proteins in normal and chemically induced abnormal secondary palate development: a review.

Vamsidhara C Dhulipala, Wade V Welshons, Chada S Reddy,

Cell cycle progression and thus proper cell number is essential for normal development of organs and organisms. Craniofacial tissues including the secondary palate are vulnerable to disruption of cell cycle progression and proliferation by many chemicals including mycotoxin, secalonic acid D (SAD), glucocorticoids, retinoic acid and 2,3,7,8-tetrachlorodibenzodioxin. Induction of cleft ... Read more >>

Hum Exp Toxicol (Human & experimental toxicology)
[2006, 25(11):675-682]

Cited: 12 times

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Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure.

Wade V Welshons, Susan C Nagel, Frederick S vom Saal,

Over 6 billion pounds per year of the estrogenic monomer bisphenol A (BPA) are used to manufacture polycarbonate plastic products, in resins lining metal cans, in dental sealants, and in blends with other types of plastic products. The ester bond linking BPA molecules in polycarbonate and resins undergoes hydrolysis, resulting ... Read more >>

Endocrinology (Endocrinology)
[2006, 147(6 Suppl):S56-69]

Cited: 383 times

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