Full Text Journal Articles by
Author Wade S Samowitz

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Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients.

Danielle C Sample, N Jewel Samadder, Lisa M Pappas, Kenneth M Boucher, Wade S Samowitz, Therese Berry, Michelle Westover, Deepika Nathan, Priyanka Kanth, Kathryn R Byrne, Randall W Burt, Deborah W Neklason,

BACKGROUND:Patients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from duodenal surgeries are the main cause of morbidity. Our objective was to prospectively describe the duodenal and gastric polyp phenotype in a ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2018, 18(1):115]

Cited: 0 times

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The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs.

Andrew J Pellatt, Lila E Mullany, Jennifer S Herrick, Lori C Sakoda, Roger K Wolff, Wade S Samowitz, Martha L Slattery,

BACKGROUND:The TGFβ-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been seen as key events in CRC progression. METHODS:In this study we comprehensively evaluate differential gene expression (RNASeq) of 81 ... Read more >>

J Transl Med (Journal of translational medicine)
[2018, 16(1):191]

Cited: 8 times

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Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers.

Roger K Wolff, Michael D Hoffman, Erica C Wolff, Jennifer S Herrick, Lori C Sakoda, Wade S Samowitz, Martha L Slattery,

Colorectal cancer (CRC) accounts for about 8% of all new cancer cases diagnosed in the US. We used whole exome sequence data from triplet samples (colon carcinoma, colon adenoma, and normal tissue) from 18 individuals to assess gene mutation rates. Of the 2 204 genes that were mutated, APC, TTN, TP53, ... Read more >>

Genes Chromosomes Cancer (Genes, chromosomes & cancer)
[2018, 57(7):366-376]

Cited: 13 times

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The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs.

Martha L Slattery, Lila E Mullany, Roger K Wolff, Lori C Sakoda, Wade S Samowitz, Jennifer S Herrick,

INTRODUCTION:We examined expression of genes in the p53-signaling pathway. We determine if genes that have significantly different expression in carcinoma tissue compared to normal mucosa also have significantly differentially expressed miRNAs. We utilize a sample of 217 CRC cases. METHODS:We focused on fold change (FC) > 1.50 or <0.67 for genes and ... Read more >>

Genomics (Genomics)
[2019, 111(4):762-771]

Cited: 11 times

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Dysregulated genes and miRNAs in the apoptosis pathway in colorectal cancer patients.

Martha L Slattery, Lila E Mullany, Lori C Sakoda, Roger K Wolff, Wade S Samowitz, Jennifer S Herrick,

Apoptosis is genetically regulated and involves intrinsic and extrinsic pathways. We examined 133 genes within these pathways to identify whether they are expressed differently in colorectal carcinoma (CRC) and normal tissue (N = 217) and if they are associated with similar differential miRNA expression. Gene expression data (RNA-Seq) and miRNA expression data ... Read more >>

Apoptosis (Apoptosis : an international journal on programmed cell death)
[2018, 23(3-4):237-250]

Cited: 12 times

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Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.

Somaye Dehghanizadeh, Vahid Khoddami, Timothy L Mosbruger, Sue S Hammoud, Kornelia Edes, Therese S Berry, Michelle Done, Wade S Samowitz, James A DiSario, Daniel G Luba, Randall W Burt, David A Jones,

Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the polyps. The underlying genetic and epigenetic basis for the emergence of ... Read more >>

PLoS One (PloS one)
[2018, 13(3):e0192499]

Cited: 3 times

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The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs.

Martha L Slattery, Lila E Mullany, Lori C Sakoda, Roger K Wolff, Wade S Samowitz, Jennifer S Herrick,

Mitogen-activated protein kinase (MAPK) pathways regulate many cellular functions including cell proliferation and apoptosis. We examined associations of differential gene and microRNA (miRNA) expression between carcinoma and paired normal mucosa for 241 genes in the KEGG-identified MAPK-signaling pathway among 217 colorectal cancer (CRC) cases. Gene expression data (RNA-Seq) and miRNA ... Read more >>

(Cancer informatics)
[2018, 17:1176935118766522]

Cited: 8 times

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Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype.

Martha L Slattery, Frances Y Lee, Andrew J Pellatt, Lila E Mullany, John R Stevens, Wade S Samowitz, Roger K Wolff, Jennifer S Herrick,

This corrects the article DOI: 10.1038/modpathol.2017.38. ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2018, 31(1):209]

Cited: 3 times

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The PI3K/AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer.

Martha L Slattery, Lila E Mullany, Lori C Sakoda, Roger K Wolff, John R Stevens, Wade S Samowitz, Jennifer S Herrick,

The PI3K/AKT-signaling pathway is one of the most frequently activated signal-transduction pathways in cancer. We examined how dysregulated gene expression is associated with miRNA expression in this pathway in colorectal cancer (CRC). We used data from 217 CRC cases to evaluate differential pathway gene expression between paired carcinoma and normal ... Read more >>

Mol Carcinog (Molecular carcinogenesis)
[2018, 57(2):243-261]

Cited: 17 times

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Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer.

Martha L Slattery, Lila E Mullany, Lori C Sakoda, Wade S Samowitz, Roger K Wolff, John R Stevens, Jennifer S Herrick,

The Wnt-signaling pathway functions in regulating cell growth and thus is involved in the carcinogenic process of several cancers, including colorectal cancer. We tested the hypothesis that multiple genes in this signaling pathway are dysregulated and that miRNAs are associated with these dysregulated genes. We used data from 217 colorectal ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(5):6075-6085]

Cited: 4 times

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The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression.

Martha L Slattery, Lila E Mullany, Lori Sakoda, Wade S Samowitz, Roger K Wolff, John R Stevens, Jennifer S Herrick,

BACKGROUND:The nuclear factor-kappa B (NF-κB) signalling pathway is a regulator of immune response and inflammation that has been implicated in the carcinogenic process. We examined differentially expressed genes in this pathway and miRNAs to determine associations with colorectal cancer (CRC). METHODS:We used data from 217 CRC cases to evaluate differences ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2018, 144(2):269-283]

Cited: 16 times

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The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer.

Martha L Slattery, Jennifer S Herrick, Lila E Mullany, Wade S Samowitz, John R Sevens, Lori Sakoda, Roger K Wolff,

Tumor suppressor genes (TSGs) and oncogenes (OG) are involved in carcinogenesis. MiRNAs also contribute to cellular pathways leading to cancer. We use data from 217 colorectal cancer (CRC) cases to evaluate differences in TSGs and OGs expression between paired CRC and normal mucosa and evaluate how TSGs and OGs are ... Read more >>

Genes Chromosomes Cancer (Genes, chromosomes & cancer)
[2017, 56(11):769-787]

Cited: 25 times

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Infrequently expressed miRNAs influence survival after diagnosis with colorectal cancer.

Martha L Slattery, Andrew J Pellatt, Frances Y Lee, Jennifer S Herrick, Wade S Samowitz, John R Stevens, Roger K Wolff, Lila E Mullany,

Half of miRNAs expressed in colorectal tissue are expressed < 50% of the population. Many infrequently expressed miRNAs have low levels of expression. We hypothesize that less frequently expressed miRNAs, when expressed at higher levels, influence both disease stage and survival after diagnosis with colorectal cancer (CRC); low levels of ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(48):83845-83859]

Cited: 11 times

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Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype.

Martha L Slattery, Frances Y Lee, Andrew J Pellatt, Lila E Mullany, John R Stevens, Wade S Samowitz, Roger K Wolff, Jennifer S Herrick,

We have previously shown that commonly expressed miRNAs influenced tumor molecular phenotype in colorectal cancer. We hypothesize that infrequently expressed miRNAs, when showing higher levels of expression, help to define tumor molecular phenotype. In this study, we examine 304 miRNAs expressed in at least 30 individuals, but in <50% of ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2017, 30(8):1152-1169]

Cited: 11 times

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Colorectal cancer molecular profiling: from IHC to NGS in search of optimal algorithm.

Larissa V Furtado, Wade S Samowitz,

Advances in defining the mutational landscape of colorectal cancer (CRC) over the past decades have revolutionized the molecular understanding and clinical testing algorithms for this disease. Mutation testing is standard of care for the work-up of CRCs. This review focuses on the current indications and strategies for molecular testing in ... Read more >>

Virchows Arch. (Virchows Archiv : an international journal of pathology)
[2017, 471(2):235-242]

Cited: 2 times

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A Clinicopathologic Evaluation of Incidental Fundic Gland Polyps With Dysplasia: Implications for Clinical Management.

Isaac E Lloyd, Wendy K Kohlmann, Keith Gligorich, Amy Hall, Elaine Lyon, Erinn Downs-Kelly, Wade S Samowitz, Mary P Bronner,

Fundic gland polyps (FGPs) can rarely exhibit dysplasia of the surface epithelium. Based on retrospective data, FGPs with dysplasia (FGPDs) are thought to be a strong marker for familial adenomatous polyposis (FAP), although sporadic, non-syndromic FGPDs also occur. Owing to the significant syndromic association, diagnosis of an apparently sporadic FGPD ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2017, 112(7):1094-1102]

Cited: 3 times

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Feasibility of Large-Scale Identification of Sessile Serrated Polyp Patients Using Electronic Records: A Utah Study.

Kajsa Affolter, Keith Gligorich, Niloy Jewel Samadder, Wade S Samowitz, Karen Curtin,

The serrated pathway accounts for 15-25% of sporadic colorectal cancer (CRC). In our study, we sought to accurately characterize sessile serrated polyps (SSP) in a population by electronically interrogating colonoscopy patients' endoscopy and pathology reports using a rules-based text search of pre-defined SSP-related terms. To this aim, we compared a ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2017, 62(6):1455-1463]

Cited: 1 time

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Diagnostic Challenges Caused by Endoscopic Biopsy of Colonic Polyps: A Systematic Evaluation of Epithelial Misplacement With Review of Problematic Polyps From the Bowel Cancer Screening Program, United Kingdom.

Nicole C Panarelli, Thusitha Somarathna, Wade S Samowitz, Susan Kornacki, Scott A Sanders, Marco R Novelli, Neil A Shepherd, Rhonda K Yantiss,

Endoscopic mucosal biopsy may misplace mucosal elements into the submucosa of colonic adenomas, mimicking invasive adenocarcinoma. Biopsy-related misplacement can be more challenging to recognize than typical misplaced epithelium (pseudoinvasion) in pedunculated polyps. We compared the features of 16 polyps with biopsy-related misplaced epithelium with those of 10 adenomas with pseudoinvasion ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2016, 40(8):1075-1083]

Cited: 8 times

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MicroRNA profiles in colorectal carcinomas, adenomas and normal colonic mucosa: variations in miRNA expression and disease progression.

Martha L Slattery, Jennifer S Herrick, Daniel F Pellatt, John R Stevens, Lila E Mullany, Erica Wolff, Michael D Hoffman, Wade S Samowitz, Roger K Wolff,

MiRNAs are small, non-protein-coding RNA molecules that regulate gene expression either by post-transcriptionally suppressing mRNA translation or by mRNA degradation. We examine differentially expressed miRNAs in colorectal carcinomas, adenomas and normal colonic mucosa. Data come from population-based studies of colorectal cancer conducted in Utah and the Kaiser Permanente Medical Care ... Read more >>

Carcinogenesis (Carcinogenesis)
[2016, 37(3):245-261]

Cited: 51 times

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Sporadic microsatellite instability-high colon cancers rarely display immunohistochemical evidence of Wnt signaling activation.

Nicole C Panarelli, Cecily P Vaughn, Wade S Samowitz, Rhonda K Yantiss,

Most sporadic colonic adenocarcinomas are microsatellite stable (MSS) and arise from conventional adenomas by dysregulation of the APC/β-catenin/Wnt signaling pathway. Sporadic adenocarcinomas with a high degree of microsatellite instability (MSI) likely arise from sessile serrated polyps through the serrated neoplastic pathway. These polyps contain BRAF mutations and are prone to ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2015, 39(3):313-317]

Cited: 12 times

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Evaluation of colorectal cancers for Lynch syndrome: practical molecular diagnostics for surgical pathologists.

Wade S Samowitz,

Lynch syndrome is the most common inherited colorectal cancer syndrome, accounting for 2-4% of all colorectal cancer cases. This review focuses on the tissue workup of Lynch syndrome, including methods to determine whether or not a tumor is mismatch repair deficient, and whether a mismatch repair-deficient tumor is sporadic or ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2015, 28 Suppl 1:S109-13]

Cited: 7 times

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Template for reporting results of biomarker testing of specimens from patients with carcinoma of the colon and rectum.

Angela N Bartley, Stanley R Hamilton, Randa Alsabeh, Edward P Ambinder, Michael Berman, Elaine Collins, Patrick L Fitzgibbons, Donna M Gress, Jan A Nowak, Wade S Samowitz, S Yousuf Zafar, ,

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2014, 138(2):166-170]

Cited: 13 times

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Molecular Pathology of Gastrointestinal Cancer.

Rhonda K Yantiss, Wade S Samowitz,

The purpose of this review is to discuss important molecular changes that aid decision making in patient management and play a role in emerging treatment strategies for gastrointestinal malignancies. Although screening and surveillance practices have had an impact on the natural history of some tumor types, gastric carcinoma is a ... Read more >>

Surg Pathol Clin (Surgical pathology clinics)
[2012, 5(4):821-842]

Cited: 0 times

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The frequency of previously undetectable deletions involving 3' Exons of the PMS2 gene.

Cecily P Vaughn, Christine L Baker, Wade S Samowitz, Jeffrey J Swensen,

Lynch syndrome is characterized by mutations in one of four mismatch repair genes, MLH1, MSH2, MSH6, or PMS2. Clinical mutation analysis of these genes includes sequencing of exonic regions and deletion/duplication analysis. However, detection of deletions and duplications in PMS2 has previously been confined to Exons 1-11 due to gene ... Read more >>

Genes Chromosomes Cancer (Genes, chromosomes & cancer)
[2013, 52(1):107-112]

Cited: 18 times

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Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer.

Jorja D Warren, Wei Xiong, Ashley M Bunker, Cecily P Vaughn, Larissa V Furtado, William L Roberts, John C Fang, Wade S Samowitz, Karen A Heichman,

BACKGROUND:About half of Americans 50 to 75 years old do not follow recommended colorectal cancer (CRC) screening guidelines, leaving 40 million individuals unscreened. A simple blood test would increase screening compliance, promoting early detection and better patient outcomes. The objective of this study is to demonstrate the performance of an ... Read more >>

BMC Med (BMC medicine)
[2011, 9:133]

Cited: 164 times

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