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Gut microbiota and sepsis: from pathogenesis to novel treatments.

Robert F J Kullberg, W Joost Wiersinga, Bastiaan W Haak,

<h4>Purpose of review</h4>This review summarizes recent progress in our understanding of the role of the gut microbiota in sepsis pathogenesis and outlines the potential role of microbiota-targeted therapies.<h4>Recent findings</h4>The composition of the gut microbiome is profoundly distorted during sepsis, with a loss of commensal bacteria and an overgrowth of potential ... Read more >>

Curr Opin Gastroenterol (Current opinion in gastroenterology)
[2021, 37(6):578-585]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Time since SARS-CoV-2 infection and humoral immune response following BNT162b2 mRNA vaccination.

Brent Appelman, Karlijn van der Straten, A H Ayesha Lavell, Michiel Schinkel, Marleen A Slim, Meliawati Poniman, Judith A Burger, Melissa Oomen, Khadija Tejjani, Alexander P J Vlaar, W Joost Wiersinga, Yvo M Smulders, Lonneke A van Vught, Rogier W Sanders, Marit J van Gils, Marije K Bomers, Jonne J Sikkens, ,

<h4>Background</h4>To optimise the use of available SARS-CoV-2 vaccines, some advocate delaying second vaccination for individuals infected within six months. We studied whether post-vaccination immune response is equally potent in individuals infected over six months prior to vaccination.<h4>Methods</h4>We tested serum IgG binding to SARS-CoV-2 spike protein and neutralising capacity in 110 ... Read more >>

EBioMedicine (EBioMedicine)
[2021, 72:103589]

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Rectal bacteriome and virome signatures and clinical outcomes in community-acquired pneumonia: An exploratory study.

Robert F J Kullberg, Floor Hugenholtz, Xanthe Brands, Cormac M Kinsella, Hessel Peters-Sengers, Joe M Butler, Martin Deijs, Michelle Klein, Daniël R Faber, Brendon P Scicluna, Tom Van der Poll, Lia Van der Hoek, W Joost Wiersinga, Bastiaan W Haak,

Background Bacterial intestinal communities interact with the immune system and may contribute to protection against community-acquired pneumonia (CAP). Intestinal viruses are closely integrated with these bacterial communities, yet the composition and clinical significance of these communities in CAP patients are unknown. The aims of this exploratory study were to characterise ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2021, 39:101074]

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An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration.

Xanthe Brands, Bastiaan W Haak, Augustijn M Klarenbeek, Joe Butler, Fabrice Uhel, Wanhai Qin, Natasja A Otto, Marja E Jakobs, Daniël R Faber, René Lutter, W Joost Wiersinga, Tom van der Poll, Brendon P Scicluna,

<h4>Background</h4>The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory tract infections in humans is not well understood. Here, we sought to identify epigenetic and transcriptomic features ... Read more >>

Genome Med (Genome medicine)
[2021, 13(1):131]

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Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia.

Alex R Schuurman, Tom DY Reijnders, Anno Saris, Ivan Ramirez Moral, Michiel Schinkel, Justin de Brabander, Christine van Linge, Louis Vermeulen, Brendon P Scicluna, W Joost Wiersinga, Felipe A Vieira Braga, Tom van der Poll,

The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease controls. The scarcity of single-cell investigations in the broader population of patients with CAP renders it difficult to distinguish immune features unique to COVID-19 from the common characteristics of a ... Read more >>

Elife (eLife)
[2021, 10:]

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Pulmonary and intestinal microbiota dynamics during Gram-negative pneumonia-derived sepsis.

Nora S Wolff, Max C Jacobs, W Joost Wiersinga, Floor Hugenholtz,

<h4>Background</h4>The gut microbiome plays a protective role in the host defense against pneumonia. The composition of the lung microbiota has been shown to be predictive of clinical outcome in critically ill patients. However, the dynamics of the lung and gut microbiota composition over time during severe pneumonia remains ill defined. ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):35]

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X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

Takaki Asano, Bertrand Boisson, Fanny Onodi, Daniela Matuozzo, Marcela Moncada-Velez, Majistor Raj Luxman Maglorius Renkilaraj, Peng Zhang, Laurent Meertens, Alexandre Bolze, Marie Materna, Sarantis Korniotis, Adrian Gervais, Estelle Talouarn, Benedetta Bigio, Yoann Seeleuthner, Kaya Bilguvar, Yu Zhang, Anna-Lena Neehus, Masato Ogishi, Simon J Pelham, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Pere Soler-Palacín, Roger Colobran, Andrea Martin-Nalda, Jacques G Rivière, Yacine Tandjaoui-Lambiotte, Khalil Chaïbi, Mohammad Shahrooei, Ilad Alavi Darazam, Nasrin Alipour Olyaei, Davood Mansouri, Nevin Hatipoğlu, Figen Palabiyik, Tayfun Ozcelik, Giuseppe Novelli, Antonio Novelli, Giorgio Casari, Alessandro Aiuti, Paola Carrera, Simone Bondesan, Federica Barzaghi, Patrizia Rovere-Querini, Cristina Tresoldi, Jose Luis Franco, Julian Rojas, Luis Felipe Reyes, Ingrid G Bustos, Andres Augusto Arias, Guillaume Morelle, Kyheng Christèle, Jesús Troya, Laura Planas-Serra, Agatha Schlüter, Marta Gut, Aurora Pujol, Luis M Allende, Carlos Rodriguez-Gallego, Carlos Flores, Oscar Cabrera-Marante, Daniel E Pleguezuelo, Rebeca Pérez de Diego, Sevgi Keles, Gokhan Aytekin, Ozge Metin Akcan, Yenan T Bryceson, Peter Bergman, Petter Brodin, Daniel Smole, C I Edvard Smith, Anna-Carin Norlin, Tessa M Campbell, Laura E Covill, Lennart Hammarström, Qiang Pan-Hammarström, Hassan Abolhassani, Shrikant Mane, Nico Marr, Manar Ata, Fatima Al Ali, Taushif Khan, András N Spaan, Clifton L Dalgard, Paolo Bonfanti, Andrea Biondi, Sarah Tubiana, Charles Burdet, Robert Nussbaum, Amanda Kahn-Kirby, Andrew L Snow, , , , , , , , , , Jacinta Bustamante, Anne Puel, Stéphanie Boisson-Dupuis, Shen-Ying Zhang, Vivien Béziat, Richard P Lifton, Paul Bastard, Luigi D Notarangelo, Laurent Abel, Helen C Su, Emmanuelle Jouanguy, Ali Amara, Vassili Soumelis, Aurélie Cobat, Qian Zhang, Jean-Laurent Casanova,

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked <i>TLR7</i> variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) from a cohort of 1,202 male ... Read more >>

Sci Immunol (Science immunology)
[2021, 6(62):]

Cited: 2 times

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Predicting mortality of individual patients with COVID-19: a multicentre Dutch cohort.

Maarten C Ottenhoff, Lucas A Ramos, Wouter Potters, Marcus L F Janssen, Deborah Hubers, Shi Hu, Egill A Fridgeirsson, Dan Piña-Fuentes, Rajat Thomas, Iwan C C van der Horst, Christian Herff, Pieter Kubben, Paul W G Elbers, Henk A Marquering, Max Welling, Suat Simsek, Martijn D de Kruif, Tom Dormans, Lucas M Fleuren, Michiel Schinkel, Peter G Noordzij, Joop P van den Bergh, Caroline E Wyers, David T B Buis, W Joost Wiersinga, Ella H C van den Hout, Auke C Reidinga, Daisy Rusch, Kim C E Sigaloff, Renee A Douma, Lianne de Haan, Niels C Gritters van den Oever, Roger J M W Rennenberg, Guido A van Wingen, Marcel J H Aries, Martijn Beudel, ,

<h4>Objective</h4>Develop and validate models that predict mortality of patients diagnosed with COVID-19 admitted to the hospital.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>A multicentre cohort across 10 Dutch hospitals including patients from 27 February to 8 June 2020.<h4>Participants</h4>SARS-CoV-2 positive patients (age ≥18) admitted to the hospital.<h4>Main outcome measures</h4>21-day all-cause mortality evaluated by the area under ... Read more >>

BMJ Open (BMJ open)
[2021, 11(7):e047347]

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Bacterial and viral respiratory tract microbiota and host characteristics in adults with lower respiratory tract infections: a case-control study.

Bastiaan W Haak, Xanthe Brands, Mark Davids, Hessel Peters-Sengers, Robert F J Kullberg, Robin van Houdt, Floor Hugenholtz, Daniël R Faber, Hans L Zaaijer, Brendon P Scicluna, Tom van der Poll, W Joost Wiersinga,

<h4>Background</h4>Viruses and bacteria from the nasopharynx are capable of causing community-acquired pneumonia (CAP), which can be difficult to diagnose. We aimed to investigate whether shifts in the composition of these nasopharyngeal microbial communities can be used as diagnostic biomarkers for CAP in adults.<h4>Methods</h4>We collected nasopharyngeal swabs from adult CAP patients ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

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Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.

Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Jérémy Manry, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat, Lucy Bizien, Alba Parra-Martínez, Rui Yang, Liis Haljasmägi, Mélanie Migaud, Karita Särekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles-Edouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesus Troya, Sophie Trouillet-Assant, Alexandre Belot, Kahina Saker, Pierre Garçon, Jacques G Rivière, Jean-Christophe Lagier, Stéphanie Gentile, Lindsey B Rosen, Elana Shaw, Tomohiro Morio, Junko Tanaka, David Dalmau, Pierre-Louis Tharaux, Damien Sene, Alain Stepanian, Bruno Megarbane, Vasiliki Triantafyllia, Arnaud Fekkar, James R Heath, José Luis Franco, Juan-Manuel Anaya, Jordi Solé-Violán, Luisa Imberti, Andrea Biondi, Paolo Bonfanti, Riccardo Castagnoli, Ottavia M Delmonte, Yu Zhang, Andrew L Snow, Steven M Holland, Catherine Biggs, Marcela Moncada-Vélez, Andrés Augusto Arias, Lazaro Lorenzo, Soraya Boucherit, Boubacar Coulibaly, Dany Anglicheau, Anna M Planas, Filomeen Haerynck, Sotirija Duvlis, Robert L Nussbaum, Tayfun Ozcelik, Sevgi Keles, Ahmed A Bousfiha, Jalila El Bakkouri, Carolina Ramirez-Santana, Stéphane Paul, Qiang Pan-Hammarström, Lennart Hammarström, Annabelle Dupont, Alina Kurolap, Christine N Metz, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Fabio Ciceri, Lucila A Barreiros, Elena Dominguez-Garrido, Mateus Vidigal, Mayana Zatz, Diederik van de Beek, Sabina Sahanic, Ivan Tancevski, Yurii Stepanovskyy, Oksana Boyarchuk, Yoko Nukui, Miyuki Tsumura, Loreto Vidaur, Stuart G Tangye, Sonia Burrel, Darragh Duffy, Lluis Quintana-Murci, Adam Klocperk, Nelli Y Kann, Anna Shcherbina, Yu-Lung Lau, Daniel Leung, Matthieu Coulongeat, Julien Marlet, Rutger Koning, Luis Felipe Reyes, Angélique Chauvineau-Grenier, Fabienne Venet, Guillaume Monneret, Michel C Nussenzweig, Romain Arrestier, Idris Boudhabhay, Hagit Baris-Feldman, David Hagin, Joost Wauters, Isabelle Meyts, Adam H Dyer, Sean P Kennelly, Nollaig M Bourke, Rabih Halwani, Narjes Saheb Sharif-Askari, Karim Dorgham, Jérome Sallette, Souad Mehlal Sedkaoui, Suzan AlKhater, Raúl Rigo-Bonnin, Francisco Morandeira, Lucie Roussel, Donald C Vinh, Sisse Rye Ostrowski, Antonio Condino-Neto, Carolina Prando, Anastasiia Bonradenko, András N Spaan, Laurent Gilardin, Jacques Fellay, Stanislas Lyonnet, Kaya Bilguvar, Richard P Lifton, Shrikant Mane, , , , , , , , , , , , , , , , , , , , , Mark S Anderson, Bertrand Boisson, Vivien Béziat, Shen-Ying Zhang, Evangelos Vandreakos, Olivier Hermine, Aurora Pujol, Pärt Peterson, Trine H Mogensen, Lee Rowen, James Mond, Stéphanie Debette, Xavier de Lamballerie, Xavier Duval, France Mentré, Marie Zins, Pere Soler-Palacin, Roger Colobran, Guy Gorochov, Xavier Solanich, Sophie Susen, Javier Martinez-Picado, Didier Raoult, Marc Vasse, Peter K Gregersen, Lorenzo Piemonti, Carlos Rodríguez-Gallego, Luigi D Notarangelo, Helen C Su, Kai Kisand, Satoshi Okada, Anne Puel, Emmanuelle Jouanguy, Charles M Rice, Pierre Tiberghien, Qian Zhang, Aurélie Cobat, Laurent Abel, Jean-Laurent Casanova,

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 ... Read more >>

Sci Immunol (Science immunology)
[2021, 6(62):]

Cited: 6 times

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Serologic Surveillance and Phylogenetic Analysis of SARS-CoV-2 Infection Among Hospital Health Care Workers.

Jonne J Sikkens, David T P Buis, Edgar J G Peters, Mireille Dekker, Michiel Schinkel, Tom D Y Reijnders, Alex R Schuurman, Justin de Brabander, A H Ayesha Lavell, Jaap J Maas, Jelle Koopsen, Alvin X Han, Colin A Russell, Janke Schinkel, Marcel Jonges, Sébastien Matamoros, Suzanne Jurriaans, Rosa van Mansfeld, W Joost Wiersinga, Yvo M Smulders, Menno D de Jong, Marije K Bomers,

<h4>Importance</h4>It is unclear when, where, and by whom health care workers (HCWs) working in hospitals are infected with SARS-CoV-2.<h4>Objective</h4>To determine how often and in what manner nosocomial SARS-CoV-2 infection occurs in HCW groups with varying exposure to patients with COVID-19.<h4>Design, setting, and participants</h4>This cohort study comprised 4 weekly measurements of ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(7):e2118554]

Cited: 3 times

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Sepsis: deriving biological meaning and clinical applications from high-dimensional data.

Alex R Schuurman, Tom D Y Reijnders, Robert F J Kullberg, Joe M Butler, Tom van der Poll, W Joost Wiersinga,

The pathophysiology of sepsis is multi-facetted and highly complex. As sepsis is a leading cause of global mortality that still lacks targeted therapies, increased understanding of its pathogenesis is vital for improving clinical care and outcomes. An increasing number of investigations seeks to unravel the complexity of sepsis through high-dimensional ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):27]

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Clinical features and prognostic factors in Covid-19: A prospective cohort study.

Sanne de Bruin, Lieuwe D Bos, Marian A van Roon, Anita M Tuip-de Boer, Alex R Schuurman, Marleen J A Koel-Simmelinck, Harm Jan Bogaard, Pieter Roel Tuinman, Michiel A van Agtmael, Jörg Hamann, Charlotte E Teunissen, W Joost Wiersinga, A H Koos Zwinderman, Matthijs C Brouwer, Diederik van de Beek, Alexander P J Vlaar, ,

<h4>Background</h4>Mortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight in pathways associated with unfavourable outcome may lead to new treatment strategies.<h4>Methods</h4>We performed a prospective cohort study of patients with COVID-19 admitted to general ward or ICU who underwent serial blood sampling. To ... Read more >>

EBioMedicine (EBioMedicine)
[2021, 67:103378]

Cited: 2 times

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Integrative Transkingdom Analysis of the Gut Microbiome in Antibiotic Perturbation and Critical Illness.

Bastiaan W Haak, Ricard Argelaguet, Cormac M Kinsella, Robert F J Kullberg, Jacqueline M Lankelma, Martin Deijs, Michelle Klein, Maarten F Jebbink, Floor Hugenholtz, Sarantos Kostidis, Martin Giera, Theodorus B M Hakvoort, Wouter J de Jonge, Marcus J Schultz, Tom van Gool, Tom van der Poll, Willem M de Vos, Lia M van der Hoek, W Joost Wiersinga,

Bacterial microbiota play a critical role in mediating local and systemic immunity, and shifts in these microbial communities have been linked to impaired outcomes in critical illness. Emerging data indicate that other intestinal organisms, including bacteriophages, viruses of eukaryotes, fungi, and protozoa, are closely interlinked with the bacterial microbiota and ... Read more >>

mSystems (mSystems)
[2021, 6(2):]

Cited: 3 times

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Association of clinical sub-phenotypes and clinical deterioration in COVID-19: further cluster analyses.

Michiel Schinkel, Brent Appelman, Joe Butler, Alex Schuurman, W Joost Wiersinga, ,

Intensive Care Med (Intensive care medicine)
[2021, 47(4):482-484]

Cited: 0 times

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Serologic Surveillance and Phylogenetic Analysis of SARS-CoV-2 Infection in Hospital Health Care Workers

Jonne Sikkens, David T.P. Buis, Edgar J.G. Peters, Mireille Dekker, Michiel Schinkel, Tom. D.Y. Reijnders, Alex. Schuurman, Justin de Brabander, Ayesha H.A. Lavell, Jaap. Maas, Jelle Koopsen, Alvin Han, Colin Russell, Janke Schinkel, Marcel Jonges, Sebastien P.F. Matamoros, Suzanne Jurriaans, Rosa van Mansfeld, Joost Wiersinga, Yvo Smulders, Menno de Jong, Marije Bomers,

<h4>BACKGROUND</h4> It is unclear how, when and where health care workers (HCW) working in hospitals are infected with SARS-CoV-2. <h4>METHODS</h4> Prospective cohort study comprising 4-weekly measurement of SARS-CoV-2 specific antibodies and questionnaires from March to June 2020. We compared SARS-CoV-2 incidence between HCW working in Covid-19 patient care, HCW working ... Read more >>

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[, :]

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[Clinical course of COVID-19 in the Netherlands: an overview of 2607 patients in hospital during the first wave].

Marcel J H Ariës, Joop P van den Bergh, Martijn Beudel, Wim Boersma, Tom Dormans, Renee A Douma, Annet Eerens, Paul W G Elbers, Lucas M Fleuren, Niels C Gritters van den Oever, Lianne de Haan, Iwan J C C van der Horst, Shi Hu, Deborah Hubers, Marcus L F Janssen, Martijn de Kruif, Pieter L Kubben, Sander M J van Kuijk, Peter G Noordzij, Maarten Ottenhoff, Dan A I Piña-Fuentes, Wouter V Potters, Auke C Reidinga, Roos S C Renckens, Sander Rigter, Daisy Rusch, Michiel Schinkel, Kim C E Sigaloff, Suat Simsek, Patricia Stassen, Robert Stassen, Rajat M Thomas, Guido A van Wingen, Anton Vonk Noordegraaf, Max Welling, W Joost Wiersinga, Marije D J Wolvers, Caroline E Wyers,

<h4>Objective</h4>To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands.<h4>Design</h4>Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2021, 165:]

Cited: 0 times

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Platelets are Hyperactivated but Show Reduced Glycoprotein VI Reactivity in COVID-19 Patients.

Valentine Léopold, Liza Pereverzeva, Alex R Schuurman, Tom D Y Reijnders, Anno Saris, Justin de Brabander, Christine C A van Linge, Renée A Douma, Osoul Chouchane, Rienk Nieuwland, W Joost Wiersinga, Cornelis van 't Veer, Tom van der Poll,

Thromb Haemost (Thrombosis and haemostasis)
[2021, 121(9):1258-1262]

Cited: 3 times

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What Sepsis Researchers Can Learn from COVID-19.

Michiel Schinkel, Harjeet S Virk, Prabath W B Nanayakkara, Tom van der Poll, W Joost Wiersinga,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(1):125-127]

Cited: 1 time

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Author Correction: Uncovering hidden antimicrobial resistance patterns within the hospital microbiome.

Bastiaan W Haak, W Joost Wiersinga,

A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-0919-z. ... Read more >>

Nat Med (Nature medicine)
[2020, 26(12):1950]

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Corrigendum: Concurrent Immune Suppression and Hyperinflammation in Patients With Community-Acquired Pneumonia.

Xanthe Brands, Bastiaan W Haak, Augustijn M Klarenbeek, Natasja A Otto, Daniël R Faber, René Lutter, Brendon P Scicluna, W Joost Wiersinga, Tom van der Poll,

[This corrects the article .]. ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:626667]

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Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial.

Alexander P J Vlaar, Sanne de Bruin, Matthias Busch, Sjoerd A M E G Timmermans, Ingeborg E van Zeggeren, Rutger Koning, Liora Ter Horst, Esther B Bulle, Frank E H P van Baarle, Marcel C G van de Poll, E Marleen Kemper, Iwan C C van der Horst, Marcus J Schultz, Janneke Horn, Frederique Paulus, Lieuwe D Bos, W Joost Wiersinga, Martin Witzenrath, Simon Rueckinger, Korinna Pilz, Matthijs C Brouwer, Ren-Feng Guo, Leo Heunks, Pieter van Paassen, Niels C Riedemann, Diederik van de Beek,

<h4>Background</h4>Severe COVID-19 is characterised by inflammation and coagulation in the presence of complement system activation. We aimed to explore the potential benefit and safety of selectively blocking the anaphylatoxin and complement protein C5a with the monoclonal antibody IFX-1 (vilobelimab), in patients with severe COVID-19.<h4>Methods</h4>We did an exploratory, open-label, randomised phase ... Read more >>

Lancet Rheumatol (The Lancet. Rheumatology)
[2020, 2(12):e764-e773]

Cited: 38 times

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