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Author Vytautas Usonis

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Circadian changes in the composition of human milk macronutrients depending on pregnancy duration: a cross-sectional study.

Ieva Jura Paulaviciene, Arunas Liubsys, Alma Molyte, Audrone Eidukaite, Vytautas Usonis,

BACKGROUND:The purpose of this study was to evaluate the circadian variation of human milk macronutrients and energy content depending upon pregnancy duration. METHODS:One hundred eighty fresh human milk samples from 45 mothers (27 of preterm and 18 of full-term newborns) were collected on a single day chosen between the 14th ... Read more >>

Int Breastfeed J (International breastfeeding journal)
[2020, 15(1):49]

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul T Heath, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

BACKGROUND:The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, recruited in single centres or countries, evaluated antibiotics not in clinical use anymore ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229380]

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Burden of varicella in Central and Eastern Europe: findings from a systematic literature review.

Zsófia Mészner, Jacek Wysocki, Darko Richter, Dace Zavadska, Inga Ivaskeviciene, Vytautas Usonis, Marko Pokorn, Atanas Mangarov, Ligita Jancoriene, Sorin C Man, Zuzana Kristufkova, Milos Jesenak, Goran Tešović, Justyna Pluta, Lara J Wolfson,

INTRODUCTION:Vaccination against varicella rapidly reduces disease incidence, resulting in reductions in both individual burden and societal costs. Despite these benefits, there is no standardization of varicella immunization policies in Europe, including countries in Central and Eastern Europe (CEE). AREAS COVERED:This systematic literature review identified publications on the epidemiology of varicella, ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2019, 18(3):281-293]

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Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: 10-year follow-up of a phase 3 multicentre, observer-blind, randomised, controlled trial.

Michael Povey, Ouzama Henry, Marianne A Riise Bergsaker, Roman Chlibek, Susanna Esposito, Carl-Erik Flodmark, Leif Gothefors, Sorin Man, Sven-Arne Silfverdal, Mária Štefkovičová, Vytautas Usonis, Jacek Wysocki, Paul Gillard, Roman Prymula,

BACKGROUND:The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2019, 19(3):287-297]

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Expert panel diagnosis demonstrated high reproducibility as reference standard in infectious diseases.

Chantal B van Houten, Christiana A Naaktgeboren, Liat Ashkenazi-Hoffnung, Shai Ashkenazi, Wim Avis, Irena Chistyakov, Teresa Corigliano, Annick Galetto, Iker Gangoiti, Alain Gervaix, Daniel Glikman, Inga Ivaskeviciene, Amir A Kuperman, Laurence Lacroix, Yvette Loeffen, Fanny Luterbacher, Clemens B Meijssen, Santiago Mintegi, Basheer Nasrallah, Cihan Papan, Annemarie M C van Rossum, Henriette Rudolph, Michal Stein, Roie Tal, Tobias Tenenbaum, Vytautas Usonis, Wouter de Waal, Stefan Weichert, Joanne G Wildenbeest, Karin M de Winter-de Groot, Tom F W Wolfs, Niv Mastboim, Tanya M Gottlieb, Asi Cohen, Kfir Oved, Eran Eden, Paul D Feigin, Liran Shani, Louis J Bont, ,

OBJECTIVE:If a gold standard is lacking in a diagnostic test accuracy study, expert diagnosis is frequently used as reference standard. However, interobserver and intraobserver agreements are imperfect. The aim of this study was to quantify the reproducibility of a panel diagnosis for pediatric infectious diseases. STUDY DESIGN AND SETTING:Pediatricians from ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2019, 112:20-27]

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): a randomised controlled trial

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul Heath Frcpch, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

Abstract Background The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, were single centre or country, insufficiently powered, evaluated antibiotics not in ... Read more >>

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Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey.

Ann Versporten, Peter Zarb, Isabelle Caniaux, Marie-Françoise Gros, Nico Drapier, Mark Miller, Vincent Jarlier, Dilip Nathwani, Herman Goossens, ,

BACKGROUND:The Global Point Prevalence Survey (Global-PPS) established an international network of hospitals to measure antimicrobial prescribing and resistance worldwide. We aimed to assess antimicrobial prescribing and resistance in hospital inpatients. METHODS:We used a standardised surveillance method to collect detailed data about antimicrobial prescribing and resistance from hospitals worldwide, which were ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2018, 6(6):e619-e629]

Cited: 25 times

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Clinical and laboratory features of children with community-acquired pneumonia are associated with distinct radiographic presentations.

Oana G Falup-Pecurariu, Javier Diez-Domingo, Susanna Esposito, Adam Finn, Fernanda Rodrigues, Vana Spoulou, George A Syrogiannopoulos, Vytautas Usonis, David Greenberg, ,

Chest radiographs from children with community-acquired pneumonia (CAP) were categorized into three distinct presentations and each presentation was correlated to clinical and laboratory findings. Children < 59 months with CAP presenting to pediatric emergency rooms during two years were enrolled prospectively in eight centers across Europe. Clinical and laboratory data were documented and ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2018, 177(7):1111-1120]

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Factors Determining Parents' Decisions to Bring Their Children to the Pediatric Emergency Department for a Minor Illness.

Sigita Burokienė, Juozas Raistenskis, Emilija Burokaitė, Rimantė Čerkauskienė, Vytautas Usonis,

BACKGROUND The number of children visiting Emergency Departments (EDs) is increasing in Lithuania; therefore, the aim of this study was to determine the factors influencing the parental decision to bring their child to the ED for a minor illness that could be managed in a primary healthcare setting, and to ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2017, 23:4141-4148]

Cited: 1 time

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Seroprevalence and susceptibility to hepatitis A in the European Union and European Economic Area: a systematic review.

Paloma Carrillo-Santisteve, Lara Tavoschi, Ettore Severi, Sandro Bonfigli, Michael Edelstein, Emma Byström, Pierluigi Lopalco, ,

Most of the European Union (EU) and European Economic Area (EEA) is considered a region of very low hepatitis A virus (HAV) endemicity; however, geographical differences exist. We did a systematic review with the aim of describing seroprevalence and susceptibility in the general population or special groups in the EU ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2017, 17(10):e306-e319]

Cited: 11 times

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Unscheduled return visits to a pediatric emergency department.

Sigita Burokienė, Ignė Kairienė, Marius Strička, Liutauras Labanauskas, Rimantė Čerkauskienė, Juozas Raistenskis, Emilija Burokaitė, Vytautas Usonis,

Return visits (RVs) to a pediatric emergency department (ED) within a short period after discharge have an influence on overcrowding of the ED and reveal some weaknesses of the health care system. The aim of this study was to determine the rate of RVs and factors related to RVs to ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2017, 53(1):66-71]

Cited: 2 times

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Prescription of antibiotics in Riga and Vilnius tertiary children's hospitals.

Inese Sviestina, Vytautas Usonis, Vilija Gurksniene, Sigita Burokiene, Inga Ivaskeviciene, Dzintars Mozgis,

Objectives:The aim of this study was to compare the use of antibiotics among hospitalised children in Riga (Latvia) and in Vilnius (Lithuania) at two tertiary paediatric centres. Methods:A point prevalence survey (PPS) was conducted using validated and standardised Antibiotic Resistance and Prescribing in European Children (ARPEC) project methodology during November ... Read more >>

Eur J Hosp Pharm (European journal of hospital pharmacy : science and practice)
[2018, 25(4):189-194]

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Respiratory syncytial virus infection in a selected sample of infants hospitalized for lower respiratory tract infection in Lithuania and Estonia.

Nijolė Drazdienė, Mari Laan, Jolanta Zaikauskienė, Vytautas Usonis,

The study presents data on a sample of children under one year of age hospitalized with lower respiratory tract infections (LRTIs) in Lithuania and Estonia.This large, retrospective, cross-sectional, observational epidemiologic survey was conducted in 12 countries in Central and Eastern Europe. Eligible subjects were under one year of age, hospitalized ... Read more >>

Acta Med Litu (Acta medica Lituanica)
[2017, 24(4):191-198]

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Antibiotic resistance of Streptococcus pneumoniae, isolated from nasopharynx of preschool children with acute respiratory tract infection in Lithuania.

Indrė Stacevičienė, Sigita Petraitienė, Daiva Vaičiūnienė, Tomas Alasevičius, Jūratė Kirslienė, Vytautas Usonis,

Increasing pneumococcal resistance to commonly used antibiotics and multidrug resistance is a serious public health concern. Data on distribution of resistant Streptococcus pneumoniae (SPn) strains among children in Lithuania are limited. We evaluated the circulation of SPn serotypes and antimicrobial susceptibility among preschool children in Lithuania before the introduction of ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2016, 16:216]

Cited: 4 times

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Sternal Osteomyelitis after Bacillus Calmette-Guérin Vaccination.

Rolandas Selvestravičius, Elena Sučilienė, Kęstutis Saniukas, Odeta Bobelytė, Vytautas Usonis,

Presented here is the case of a nine-month-old boy with the osteomyelitis of the upper area sternum caused by bacillus Calmette-Guerin (BCG), the Danish 1331 strain vaccine against tuberculosis. Upon examination, a swelling of approximately 2×3 cm diameter was observed in the upper sternal area. The mass was hard, fixed ... Read more >>

Pediatr Rep (Pediatric reports)
[2016, 8(3):6626]

Cited: 0 times

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Comparison between diagnosis and treatment of community-acquired pneumonia in children in various medical centres across Europe with the United States, United Kingdom and the World Health Organization guidelines.

Vytautas Usonis, Rimvydas Ivaskevicius, Javier Diez-Domingo, Susanna Esposito, Oana G Falup-Pecurariu, Adam Finn, Fernanda Rodrigues, Vana Spoulou, George A Syrogiannopoulos, David Greenberg, ,

The aim of this study was to review the current status and usage of guidelines in the diagnosis and treatment of community-acquired pneumonia (CAP) in European countries and to compare to established guidelines in the United States (US), United Kingdom (UK), and the World Health Organization (WHO).A questionnaire was developed ... Read more >>

Pneumonia (Nathan) (Pneumonia (Nathan Qld.))
[2016, 8:5]

Cited: 3 times

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Incidence of acute otitis media in children below 6 years of age seen in medical practices in five East European countries.

Vytautas Usonis, Teresa Jackowska, Sigita Petraitiene, Alicja Sapala, Andrea Neculau, Izabella Stryjewska, Raghavendra Devadiga, Monica Tafalla, Katsiaryna Holl,

Although acute otitis media (AOM) remains a major public health problem worldwide and brings economic burden on health care system and caregivers, little information is available about its epidemiology in Eastern Europe.We conducted an epidemiological, prospective, observational, multi-centre cohort study (NCT01365390) in five East European countries (Estonia, Lithuania, Poland, Romania ... Read more >>

BMC Pediatr (BMC Pediatrics)
[2016, 16:108]

Cited: 6 times

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Comparative Epidemiologic Characteristics of Pertussis in 10 Central and Eastern European Countries, 2000-2013.

Ulrich Heininger, Philippe André, Roman Chlibek, Zuzana Kristufkova, Kuulo Kutsar, Atanas Mangarov, Zsófia Mészner, Aneta Nitsch-Osuch, Vladimir Petrović, Roman Prymula, Vytautas Usonis, Dace Zavadska,

We undertook an epidemiological survey of the annual incidence of pertussis reported from 2000 to 2013 in ten Central and Eastern European countries to ascertain whether increased pertussis reports in some countries share common underlying drivers or whether there are specific features in each country. The annual incidence of pertussis ... Read more >>

PLoS ONE (PloS one)
[2016, 11(6):e0155949]

Cited: 6 times

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The Worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: developing hospital-quality indicators of antibiotic prescribing for children.

Ann Versporten, Julia Bielicki, Nico Drapier, Mike Sharland, Herman Goossens, ,

Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide.A standardized antimicrobial PPS method was employed. ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2016, 71(4):1106-1117]

Cited: 45 times

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In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13.

Daniel Hungerford, Roberto Vivancos, , Jonathan M Read, Virginia E Pitzer, Nigel Cunliffe, Neil French, Miren Iturriza-Gómara,

The EuroRotaNet surveillance network has conducted rotavirus genotype surveillance since 2007 in 16 European countries. Using epidemiological and microbiological data from 39,786 genotyped rotavirus-positive specimens collected between September 2007 and August 2013, we assessed genotype distribution and age distribution of rotavirus gastroenteritis (RVGE) cases in and out of peak season ... Read more >>

Euro Surveill. (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2016, 21(2):]

Cited: 3 times

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The influence of Streptococcus pneumoniae nasopharyngeal colonization on the clinical outcome of the respiratory tract infections in preschool children.

Sigita Petraitiene, Tomas Alasevicius, Indre Staceviciene, Daiva Vaiciuniene, Tomas Kacergius, Vytautas Usonis,

Streptococcus pneumoniae (SPn) is an important pathogen causing a variety of clinical manifestations. The effects of SPn nasopharyngeal colonization on respiratory tract infections are poorly studied. We evaluated the association of SPn colonization with features of respiratory tract infections.Children under the age of 6 years who visited a primary care ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2015, 15:403]

Cited: 7 times

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European Society for Paediatric Infectious Diseases consensus recommendations for rotavirus vaccination in Europe: update 2014.

Timo Vesikari, Pierre Van Damme, Carlo Giaquinto, Ron Dagan, Alfredo Guarino, Hania Szajewska, Vytautas Usonis,

The first evidence-based recommendations for rotavirus (RV) vaccination in Europe were prepared at the time of licensure of 2 live oral RV vaccines (Rotarix, GlaxoSmithKline Biologicals, and RotaTeq, Sanofi Pasteur MSD) in 2006 and published in 2008. Since then several countries in Europe and more globally have adopted universal RV ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2015, 34(6):635-643]

Cited: 17 times

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Immunization of high-risk paediatric populations: Central European Vaccination Awareness Group recommendations.

Darko Richter, Ioana Anca, Francis E André, Mustafa Bakir, Roman Chlibek, Milan Čižman, Atanas Mangarov, Zsófia Mészner, Marko Pokorn, Roman Prymula, Nuran Salman, Pavol Simurka, Eda Tamm, Goran Tešović, Ingrid Urbančíková, Vytautas Usonis, Jacek Wysocki, Dace Zavadska, Central European Vaccination Awareness Group,

Over the last decade, childhood immunization has substantially reduced morbidity and mortality from vaccine-preventable diseases. However, particular paediatric risk groups, such as those with comorbidities, may not be adequately vaccinated despite being more susceptible to complications and death from certain infectious diseases. This may be due to lack of immunization ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2014, 13(6):801-815]

Cited: 1 time

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Current management of late onset neonatal bacterial sepsis in five European countries.

Irja Lutsar, Corine Chazallon, Francesca Ippolita Calò Carducci, Ursula Trafojer, Ben Abdelkader, Vincent Meiffredy de Cabre, Susanna Esposito, Carlo Giaquinto, Paul T Heath, Mari-Liis Ilmoja, Aspasia Katragkou, Carine Lascoux, Tuuli Metsvaht, George Mitsiakos, Emmanuelle Netzer, Lorenza Pugni, Emmanuel Roilides, Yacine Saidi, Kosmas Sarafidis, Mike Sharland, Vytautas Usonis, Jean-Pierre Aboulker, ,

Late onset neonatal sepsis (LOS) has a high mortality and the optimal management is poorly defined. We aimed to evaluate new expert panel-derived criteria to define LOS and characterize the current management and antibiotic susceptibility of LOS-causing organisms in Europe. A prospective observational study enrolled infants aged 4 to 90 days ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2014, 173(8):997-1004]

Cited: 15 times

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Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine versus one dose of monovalent varicella vaccine: a multicentre, observer-blind, randomised, controlled trial.

Roman Prymula, Marianne Riise Bergsaker, Susanna Esposito, Leif Gothefors, Sorin Man, Nadezhda Snegova, Mária Štefkovičova, Vytautas Usonis, Jacek Wysocki, Martine Douha, Ventzislav Vassilev, Ouzama Nicholson, Bruce L Innis, Paul Willems,

BACKGROUND:Rates of varicella have decreased substantially in countries implementing routine varicella vaccination. Immunisation is possible with monovalent varicella vaccine or a combined measles-mumps-rubella-varicella vaccine (MMRV). We assessed protection against varicella in naive children administered one dose of varicella vaccine or two doses of MMRV. METHODS:This study was done in ten ... Read more >>

Lancet (Lancet (London, England))
[2014, 383(9925):1313-1324]

Cited: 34 times

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