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Author Vittoria Rizzo

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Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region.

Licia Lugli, Marisa Pugliese, Carlotta Plessi, Alberto Berardi, Isotta Guidotti, Gina Ancora, Sara Grandi, Giancarlo Gargano, Silvia Braibanti, Fabrizio Sandri, Silvia Soffritti, Elisa Ballardini, Vittoria Arena, Marcello Stella, Serafina Perrone, Sabrina Moretti, Vittoria Rizzo, Fabrizio Ferrari, , Odoardo Picciolini, Roberto Bellù, Daniela Turoli, Luigi Tommaso Corvaglia, Gianpaolo Garani, Vittoria Paoletti, Giacomo Biasucci, Augusto Biasini, Belinda Benenati, Paolo Stagi, Cristina Magnani, Sara Dallaglio, Elisa DellaCasa Muttini, Maria Federica Roversi, Luca Bedetti, Laura Lucaccioni, Natascia Bertoncelli, Alessandra Boncompagni,

INTRODUCTION:The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of children at risk of neuro-developmental disabilities may increase access to intervention, potentially influencing the outcome. AIMS:Neuroprem is an area-based prospective ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):26]

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Epidemiology and complications of late-onset sepsis: an Italian area-based study.

Alberto Berardi, Francesca Sforza, Lorenza Baroni, Caterina Spada, Simone Ambretti, Giacomo Biasucci, Serenella Bolognesi, Mariagrazia Capretti, Edoardo Carretto, Matilde Ciccia, Marcello Lanari, Maria Federica Pedna, Vittoria Rizzo, Claudia Venturelli, Crisoula Tzialla, Laura Lucaccioni, Maria Letizia Bacchi Reggiani,

BACKGROUND:Most studies regarding late-onset sepsis (LOS) address selected populations (i.e., neonates with low birth weight or extremely preterm neonates). Studying all age groups is more suitable to assess the burden of single pathogens and their clinical relevance. METHODS:This is a retrospective regional study involving paediatric departments and NICUs in Emilia-Romagna ... Read more >>

PLoS ONE (PloS one)
[2019, 14(11):e0225407]

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Fatty Acid Desaturase Involvement in Non-Alcoholic Fatty Liver Disease Rat Models: Oxidative Stress Versus Metalloproteinases.

Giuseppina Palladini, Laura G Di Pasqua, Clarissa Berardo, Veronica Siciliano, Plinio Richelmi, Barbara Mannucci, Anna Cleta Croce, Vittoria Rizzo, Stefano Perlini, Mariapia Vairetti, Andrea Ferrigno,

We investigated changes in fatty acid desaturases, D5D, D6D, D9-16D and D9-18D, and their relationship with oxidative stress, matrix metalloproteinases (MMPs) and serum TNF-alpha in two rat models of non-alcoholic fatty liver disease NAFLD. Eight-week-old male Wistar rats fed for 3 weeks with methionine-choline⁻deficient (MCD) diet and eleven-week-old Obese male ... Read more >>

Nutrients (Nutrients)
[2019, 11(4):]

Cited: 2 times

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Group B Streptococcus early-onset disease and observation of well-appearing newborns.

Alberto Berardi, Caterina Spada, Maria Letizia Bacchi Reggiani, Roberta Creti, Lorenza Baroni, Maria Grazia Capretti, Matilde Ciccia, Valentina Fiorini, Lucia Gambini, Giancarlo Gargano, Irene Papa, Giancarlo Piccinini, Vittoria Rizzo, Fabrizio Sandri, Laura Lucaccioni, ,

BACKGROUND:International guidelines lack a substantial consensus regarding management of asymptomatic full-term and late preterm neonates at risk for early-onset disease (EOS). Large cohorts of newborns are suitable to increase the understanding of the safety and efficacy of a given strategy. METHODS:This is a prospective, area-based, cohort study involving regional birth ... Read more >>

PLoS ONE (PloS one)
[2019, 14(3):e0212784]

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Serum and Hepatic Autofluorescence as a Real-Time Diagnostic Tool for Early Cholestasis Assessment.

Anna C Croce, Giovanni Bottiroli, Laura G Di Pasqua, Clarissa Berardo, Veronica Siciliano, Vittoria Rizzo, Mariapia Vairetti, Andrea Ferrigno,

While it is well established that various factors can impair the production and flow of bile and lead to cholestatic disease in hepatic and extrahepatic sites, an enhanced assessment of the biomarkers of the underlying pathophysiological mechanisms is still needed to improve early diagnosis and therapeutic strategies. Hence, we investigated ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(9):]

Cited: 1 time

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The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury.

Andrea Ferrigno, Laura Giuseppina Di Pasqua, Clarissa Berardo, Veronica Siciliano, Vittoria Rizzo, Luciano Adorini, Plinio Richelmi, Mariapia Vairetti,

BACKGROUND:We previously showed that increased asymmetric dimethylarginine (ADMA) biliary excretion occurs during hepatic ischemia/reperfusion (I/R), prompting us to study the effects of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) on bile, serum and tissue levels of ADMA after I/R. MATERIAL AND METHODS:Male Wistar rats were orally administered 10mg/kg/day ... Read more >>

PLoS ONE (PloS one)
[2018, 13(1):e0191430]

Cited: 2 times

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Liver Graft Susceptibility during Static Cold Storage and Dynamic Machine Perfusion: DCD versus Fatty Livers.

Andrea Ferrigno, Laura G Di Pasqua, Clarissa Berardo, Veronica Siciliano, Vittoria Rizzo, Barbara Mannucci, Plinio Richelmi, Anna Cleta Croce, Mariapia Vairetti,

We compared static preservation (cold storage, CS, 4 °C) with dynamic preservation (machine perfusion, MP, 20 °C) followed by reperfusion using marginal livers: a model of donation after cardiac death (DCD) livers and two models of fatty livers, the methionine-choline deficient (MCD) diet model, and obese Zucker (fa/fa) rats. CS ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 19(1):]

Cited: 2 times

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Machine Perfusion at 20°C Prevents Ischemic Injury and Reduces Hypoxia-Inducible Factor-1α Expression During Rat Liver Preservation.

Clarissa Berardo, Laura Giuseppina Di Pasqua, Veronica Siciliano, Vittoria Rizzo, Plinio Richelmi, Andrea Ferrigno, Mariapia Vairetti,

BACKGROUND Ischemic cholangitis is the main cause of liver failure after transplantation and subnormothermic machine perfusion may represent a better strategy than conventional cold storage, minimizing preservation injury. We compared livers preserved by machine perfusion at 20°C (MP20) or by cold storage at 4°C (CS4) with regard to hypoxia-inducible factor ... Read more >>

Ann. Transplant. (Annals of transplantation)
[2017, 22:581-589]

Cited: 2 times

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Fatty liver oxidative events monitored by autofluorescence optical diagnosis: Comparison between subnormothermic machine perfusion and conventional cold storage preservation.

Anna Cleta Croce, Andrea Ferrigno, Vittorio Bertone, Valeria Maria Piccolini, Clarissa Berardo, Laura Giuseppina Di Pasqua, Vittoria Rizzo, Giovanni Bottiroli, Mariapia Vairetti,

Livers with moderate steatosis are currently recruited as marginal organs to face donor shortage in transplantation, even though lipid excess and oxidative stress increase preservation injury risk. Sensitive, real-time detection of liver metabolism engagement could help donor selection and preservation procedures, ameliorating the graft outcome. Hence, we investigated endogenous biomolecules ... Read more >>

Hepatol. Res. (Hepatology research : the official journal of the Japan Society of Hepatology)
[2017, 47(7):668-682]

Cited: 6 times

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MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.

Laura G Di Pasqua, Clarissa Berardo, Vittoria Rizzo, Plinio Richelmi, Anna Cleta Croce, Mariapia Vairetti, Andrea Ferrigno,

Using an experimental model of NASH induced by a methionine-choline-deficient (MCD) diet, we investigated whether changes occur in serum and tissue levels of asymmetric dimethylarginine (ADMA). Male Wistar rats underwent NASH induced by 8-week feeding with an MCD diet. Serum and hepatic biopsies at 2, 4 and 8 weeks were taken, ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2016, 419(1-2):147-155]

Cited: 1 time

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The burden of early-onset sepsis in Emilia-Romagna (Italy): a 4-year, population-based study.

Alberto Berardi, Lorenza Baroni, Maria Letizia Bacchi Reggiani, Simone Ambretti, Giacomo Biasucci, Serenella Bolognesi, Maria Grazia Capretti, Edoardo Carretto, Matilde Ciccia, Valentina Fiorini, Cinzia Fortini, Giancarlo Gargano, Maria Federica Pedna, Vittoria Rizzo, Roberta Creti, Fabrizio Ferrari, ,

OBJECTIVE:To provide the first Italian data on pathogens causing early-onset sepsis (EOS) and their antimicrobial susceptibility, after the successfully prevention of Group B streptococcus (GBS) EOS. METHODS:Retrospective area-based cohort study from Emilia-Romagna (Italy). Cases of EOS registered (from 2009 to 2012) in all gestational age neonates were reviewed. RESULTS:Live births ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2016, 29(19):3126-3131]

Cited: 8 times

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Changes in Biliary Levels of Arginine and its Methylated Derivatives after Hepatic Ischaemia/Reperfusion.

Andrea Ferrigno, Laura Giuseppina Di Pasqua, Clarissa Berardo, Vittoria Rizzo, Plinio Richelmi, Mariapia Vairetti,

Arginine (Arg) can be methylated to form symmetrical dimethylarginine (SDMA) and asymmetrical dimethylarginine (ADMA), the latter an endogenous inhibitor of nitric oxide synthase (NOS). SDMA is excreted in the urine, while ADMA is mainly subjected to degradation in the liver. Arg competes with ADMA and SDMA for cellular transport across ... Read more >>

Basic Clin. Pharmacol. Toxicol. (Basic & clinical pharmacology & toxicology)
[2016, 119(1):101-109]

Cited: 4 times

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Selective blockade of mGlu5 metabotropic glutamate receptors is protective against hepatic mitochondrial dysfunction in 6-OHDA lesioned Parkinsonian rats.

Andrea Ferrigno, Andrea Ferrigno, Mariapia Vairetti, Giulia Ambrosi, Vittoria Rizzo, Plinio Richelmi, Fabio Blandini, Marie-Therese Fuzzati-Armentero,

Non-motor symptoms including those involving the splanchnic district are present in Parkinson's disease (PD). The authors previously reported that PD-like rats, bearing a lesion of the nigrostriatal pathway induced by the injection of 6-hydroxydopamine (6-OHDA), have impaired hepatic mitochondrial function. Glutamate intervenes at multiple levels in PD and liver pathophysiologies. ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2015, 42(6):695-703]

Cited: 9 times

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Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.

Andrea Ferrigno, Andrea Ferrigno, Giuseppina Palladini, Alberto Bianchi, Vittoria Rizzo, Laura G Di Pasqua, Stefano Perlini, Plinio Richelmi, Mariapia Vairetti,

We investigated the effects of obstructive cholestasis in different hepatic lobes by evaluating asymmetric dimethylarginine (ADMA) (a nitric oxide synthase inhibitor), protein methyltransferase (PRMT) and dimethylarginine dimethylaminohydrolase (DDAH) (enzymes involved, resp., in its synthesis and degradation), the cationic transporter (CAT), and metalloproteinase (MMP) activity. Sixteen male Wistar rats underwent a ... Read more >>

Biomed Res Int (BioMed research international)
[2014, 2014:327537]

Cited: 8 times

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Lung matrix metalloproteinase activation following partial hepatic ischemia/reperfusion injury in rats.

Giuseppina Palladini, Andrea Ferrigno, Andrea Ferrigno, Vittoria Rizzo, Eleonora Tarantola, Vittorio Bertone, Isabel Freitas, Stefano Perlini, Plinio Richelmi, Mariapia Vairetti,

Warm hepatic ischemia-reperfusion (I/R) injury can lead to multiorgan dysfunction. The aim of the present study was to investigate whether acute liver I/R does affect the function and/or structure of remote organs such as lung, kidney, and heart via modulation of extracellular matrix remodelling.Male Sprague-Dawley rats were subjected to 30 min ... Read more >>

ScientificWorldJournal (TheScientificWorldJournal)
[2014, 2014:867548]

Cited: 7 times

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Establishment, operation and development of a donor human milk bank.

Augusto Biasini, Marcello Stella, Laura Malaigia, Mariachiara China, Milena Azzalli, Maria Chiara Laguardia, Vittoria Rizzo,

Human milk is very valuable in premature infant nutrition. The collection, screening, processing and distribution of donor human milk are described in this report. These activities take place in the Donor Human Milk Bank (DHMB) of the Large Romagna Area (LRA) in Italy, the development of which is also described ... Read more >>

Early Hum. Dev. (Early human development)
[2013, 89 Suppl 2:S7-9]

Cited: 2 times

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Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers.

Giuseppina Palladini, Andrea Ferrigno, Andrea Ferrigno, Vittoria Rizzo, Eleonora Boncompagni, Plinio Richelmi, Isabel Freitas, Stefano Perlini, Mariapia Vairetti,

Studies assessing the effects of partial-hepatic ischemia/reperfusion (I/R) injury focused on the damage to the ischemic-lobe, whereas few data are available on non-ischemic lobe. This study investigated whether acute liver I/R does affect non-ischemic lobe function via modulation of extracellular matrix remodeling. Male Sprague-Dawley rats underwent left lateral- and median-lobe ... Read more >>

Toxicol Pathol (Toxicologic pathology)
[2012, 40(5):722-730]

Cited: 18 times

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Impaired hepatic function and central dopaminergic denervation in a rodent model of Parkinson's disease: a self-perpetuating crosstalk?

Mariapia Vairetti, Andrea Ferrigno, Andrea Ferrigno, Vittoria Rizzo, Giulia Ambrosi, Alberto Bianchi, Plinio Richelmi, Fabio Blandini, Marie-Therese Armentero,

In Parkinson's disease (PD), aside from the central lesion, involvement of visceral organs has been proposed as part of the complex clinical picture of the disease. The issue is still poorly understood and relatively unexplored. In this study we used a classic rodent model of nigrostriatal degeneration, induced by the ... Read more >>

Biochim. Biophys. Acta (Biochimica et biophysica acta)
[2012, 1822(2):176-184]

Cited: 9 times

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Machine perfusion at 20°C reduces preservation damage to livers from non-heart beating donors.

Andrea Ferrigno, Andrea Ferrigno, Vittoria Rizzo, Eleonora Boncompagni, Alberto Bianchi, Enrico Gringeri, Daniele Neri, Plinio Richelmi, Isabel Freitas, Umberto Cillo, Mariapia Vairetti,

We previously reported that machine perfusion (MP) performed at 20°C enhanced the preservation of steatotic rat livers. Here, we tested whether rat livers retrieved 30 min after cardiac arrest (NHBDs) were better protected by MP at 20°C than with cold storage. We compared the recovery of livers from NHBDs with ... Read more >>

Cryobiology (Cryobiology)
[2011, 62(2):152-158]

Cited: 33 times

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Different susceptibility of liver grafts from lean and obese Zucker rats to preservation injury.

Andrea Ferrigno, Andrea Ferrigno, Filippo Carlucci, Antonella Tabucchi, Valentina Tommassini, Vittoria Rizzo, Plinio Richelmi, Enrico Gringeri, Daniele Neri, Eleonora Boncompagni, Isabel Freitas, Umberto Cillo, Mariapia Vairetti,

We compared the susceptibility of liver grafts from lean and obese Zucker rats to preservation injury, using two organ-preservation techniques: conventional static preservation (SP) and machine perfusion (MP) preservation. SP: livers preserved by UW solution at 4, 8 or 20 degrees C for 6-h. MP: livers perfused for 6-h with ... Read more >>

Cryobiology (Cryobiology)
[2009, 59(3):327-334]

Cited: 16 times

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Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase?

Mariapia Vairetti, Andrea Ferrigno, Andrea Ferrigno, Filippo Carlucci, Antonella Tabucchi, Vittoria Rizzo, Eleonora Boncompagni, Daniele Neri, Enrico Gringeri, Isabel Freitas, Umberto Cillo,

We tested whether rat liver preservation performed by machine perfusion (MP) at 20 degrees C can enhance the functional integrity of steatotic livers versus simple cold storage. We also compared MP at 20 degrees C with hypothermic MP at 8 degrees C, and 4 degrees C. Obese and lean male ... Read more >>

Liver Transpl. (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2009, 15(1):20-29]

Cited: 57 times

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Correlation between the liver temperature employed during machine perfusion and reperfusion damage: role of Ca2+.

Mariapia Vairetti, Andrea Ferrigno, Andrea Ferrigno, Vittoria Rizzo, Eleonora Boncompagni, Amedeo Carraro, Enrico Gringeri, Gloria Milanesi, Sergio Barni, Isabel Freitas, Umberto Cillo,

This study compares the effects of machine perfusion (MP) at different temperatures with simple cold storage. In addition, the role of Ca(2+) levels in the MP medium was evaluated. For MP, rat livers were perfused for 6 hours with Krebs-Henseleit (KH) solution (with 1.25 or 2.5 mM CaCl(2)) at 4 ... Read more >>

Liver Transpl. (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2008, 14(4):494-503]

Cited: 20 times

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Ventricular cerebrospinal fluid melatonin concentrations investigated with an endoscopic technique.

Pierluigi Longatti, Alessandro Perin, Vittoria Rizzo, Stefano Comai, Pietro Giusti, Carlo Virgilio Luigi Costa,

The role of melatonin in humans still remains unclear. Uncertainties persist about its effects on neurophysiology regarding its levels in human cerebrospinal fluid (CSF), as the bulk of knowledge on this subject mainly derives from studies conducted on animals. In this study, CSF was micro-sampled with a simple, new method ... Read more >>

J. Pineal Res. (Journal of pineal research)
[2007, 42(2):113-118]

Cited: 22 times

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A study of tryptophan metabolism via serotonin in ventricular cerebrospinal fluid in HIV-1 infection using a neuroendoscopic technique.

Pierluigi Longatti, Alessandro Perin, Stefano Comai, Antonella Bertazzo, Vittoria Rizzo, Carlo Virgilio Luigi Costa, Graziella Allegri,

In this paper we report the study of tryptophan metabolism via serotonin in ventricular CSF in HIV-1 infection in order to investigate the origin of tryptophan metabolites in the human brain. The patients (n=4) were affected with non-communicating hydrocephalus. One of these also was suffering from HIV-1 infection. The CSF ... Read more >>

Curr. HIV Res. (Current HIV research)
[2007, 5(2):267-272]

Cited: 2 times

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In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia.

Isabel Freitas, Vittorio Bertone, Catia Guarnaschelli, Andrea Ferrigno, Andrea Ferrigno, Eleonora Boncompagni, Vittoria Rizzo, Russel J Reiter, Sergio Barni, Mariapia Vairetti,

In a previous investigation, reperfusion with a melatonin-containing medium was demonstrated to enhance bile production and tissue ATP levels in rat livers, cold-preserved with University of Wisconsin (UW) or Celsior solutions, with respect to melatonin-free reperfusion; lipid peroxidation products in the perfusate were not influenced by the indole. This was ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2006, 20(2):229-237]

Cited: 17 times

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