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Author Vishal Patel

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Ventilation-Perfusion Scans After the COVID-19 Pandemic: Counterpoint-Ventilation Studies Are Here to Stay.

William C Lavely, Vishal K Patel,

AJR Am J Roentgenol (AJR. American journal of roentgenology)
[2021, :1-2]

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Enhancer and super-enhancer landscape in polycystic kidney disease

Ronak Lakhia, Abheepsa Mishra, Laurence Biggers, Venkat Malladi, Patricia Cobo-Stark, Sachin Hajarnis, Vishal Patel,

<h4>ABSTRACT</h4> Widespread aberrant gene expression is pathological hallmark of polycystic kidney disease (PKD). Numerous pathogenic signaling cascades, including c-Myc, Fos, and Jun are transactivated. However, the underlying epigenetic regulators are poorly defined. Here we show that H3K27ac, a histone modification that marks active enhancers, is elevated in mouse and human ... Read more >>

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McConnell's sign: Echocardiography in the management of acute pulmonary embolism.

Vishal I Patel, Michelle Miles, Sharareh Shahangian, John Javien,

Management of acute pulmonary embolism depends immensely on rapid diagnosis and early intervention. Transthoracic echocardiography has gained favorability in scenarios where diagnostic computed tomography angiography is not feasible. McConnell's sign, an echocardiographic finding of segmental right ventricular wall-motion abnormality with apical sparing, is highly specific and may guide therapeutic intervention. ... Read more >>

Clin Case Rep (Clinical case reports)
[2021, 9(10):e04994]

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Aberrant hepatic trafficking of gut-derived T-cells is not specific to primary sclerosing cholangitis.

Jonathon J Graham, Sujit Mukherjee, Muhammad Yuksel, Rebeca Sanabria Mateos, Tengfei Si, Zenlin Huang, Xiahong Huang, Hadil Arbuq, Vishal Patel, Mark J McPhail, Yoh Zen, Nigel D Heaton, Maria Serena Longhi, Michael A Heneghan, Rodrigo Liberal, Diego Vergani, Giorgina Mieli-Vergani, Yun Ma, Bu'Hussain Hayee,

<h4>Background & aims</h4>The 'gut-homing' hypothesis suggests the pathogenesis of primary sclerosing cholangitis (PSC) is driven by aberrant hepatic expression of gut adhesion molecules and subsequent recruitment of gut-derived T-cells to the liver. However, inconsistencies lie within this theory including an absence of investigations and comparisons with other chronic liver diseases ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, :]

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Shifting social media influences: Discussions about mechanical ventilation on Twitter during COVID-19.

Vishal R Patel, Sofia Gereta, Christopher J Blanton, Michael Mackert, Nico Nortjé, Christopher Moriates,

J Crit Care (Journal of critical care)
[2021, :]

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Intracranial neurenteric cyst with post-operative chemical meningitis and vagal nerve palsy.

Cassie Jia, Saif Azam, Jonathan Lee, Vishal Patel,

Intracranial neurenteric cysts are rare congenital lesions that, though benign, are difficult to diagnose radiologically given their similar imaging appearance to other intracranial cystic lesions. We present a case of a 21-year-old female with a pathologically proven, symptomatic neurenteric cyst in the premedullary cistern. Superimposed on this uncommon diagnosis were ... Read more >>

Radiol Case Rep (Radiology case reports)
[2021, 16(12):3887-3891]

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Prevalence of bleeding and thrombosis in critically ill patients with chronic liver disease.

Tsai-Wing Ow, Evangelia Fatourou, Liane Rabinowich, Bente Pernille van den Boom, Shirjit Nair, Vishal C Patel, Brian Hogan, Mark McPhail, Lara N Roberts, William Bernal,

<h4>Introduction</h4>Haemorrhage and venous thromboembolism (VTE) are recognised complications of chronic liver disease (CLD), but their prevalence and risk factors in critically ill patients is uncertain.<h4>Patients and methods</h4>We studied a retrospective cohort of patients with CLD non-electively admitted to a specialist intensive care unit determining the prevalence and timing of major ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2021, :]

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In vivo antidiabetic activity of nimesulide due to inhibition of amino acid transport.

Amit Joharapurkar, Samadhan Kshirsagar, Vishal Patel, Maulik Patel, Hardikkumar Savsani, Mukul Jain,

Inhibiting the intestinal and renal neutral amino acid transporter B0AT1 by genetic means has improved insulin sensitivity in mice, but there are no antagonists available for preclinical or clinical use. Since the anti-inflammatory agent nimesulide selectively inhibited B0AT1 in vitro, we hypothesized that nimesulide exhibits in vivo potential to restrict ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2021, :]

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Anatomic and Molecular MR Image Synthesis Using Confidence Guided CNNs.

Pengfei Guo, Puyang Wang, Rajeev Yasarla, Jinyuan Zhou, Vishal M Patel, Shanshan Jiang,

Data-driven automatic approaches have demonstrated their great potential in resolving various clinical diagnostic dilemmas in neuro-oncology, especially with the help of standard anatomic and advanced molecular MR images. However, data quantity and quality remain a key determinant, and a significant limit of the potential applications. In our previous work, we ... Read more >>

IEEE Trans Med Imaging (IEEE transactions on medical imaging)
[2021, 40(10):2832-2844]

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RISK FACTORS FOR THE DEVELOPMENT OF ACUTE KIDNEY INJURY OCCURRING IN PATIENTS WITH COVID-19 ADMITTED TO THE ICU

JOSE IGLESIAS, ANDREW VASSALLO, VISHAL PATEL, JESSE SULLIVAN, YASMINE ELBAGA, ABBAS ALSHAMI, ARDA ALOLUK, JERROLD LEVINE,

Chest (Chest)
[2021, 160(4):A1160-A1160]

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PNEUMOPERITONEUM IN SARS-COV-2: A RARE AND OMINOUS CLINICAL SIGN

SANKALP PATEL, CARLA WILLIAMS, ANSHIKA SINGH, VISHAL PATEL, DAVID LINDNER,

Chest (Chest)
[2021, 160(4):A788-A788]

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Rifaximin reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial.

Vishal Patel, Sunjae Lee, Mark McPhail, Kevin Da Silva, Susie Guilly, Ane Zamalloa, Elizabeth Witherden, Sidsel Støy, Godhev Kumar Manakkat Vijay, Nicolas Pons, Nathalie Galleron, Xaiohong Huang, Selin Gencer, Muireann Coen, Thomas Henry Tranah, Julia Alexis Wendon, Kenneth Bruce, Emmanuelle Le Chatelier, Stanislav Dusko Ehrlich, Lindsey Ann Edwards, Saeed Shoaie, Debbie Lindsay Shawcross,

<h4>Background</h4>Rifaximin is efficacious in the prevention of recurrent hepatic encephalopathy (HE) but its mechanism of action remains unclear. We postulated that rifaximin reduces gut microbiota-derived endotoxemia and systemic inflammation, a known driver of HE.<h4>Design</h4>A randomised placebo-controlled double-blind mechanistic study of rifaximin versus placebo was performed in cirrhotic patients with HE. ... Read more >>

J Hepatol (Journal of hepatology)
[2021, :]

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McConnell's sign: Echocardiography in the management of acute pulmonary embolism

Vishal I. Patel, Michelle Miles, Sharareh Shahangian, John Javien,

Abstract Management of acute pulmonary embolism depends immensely on rapid diagnosis and early intervention. Transthoracic echocardiography has gained favorability in scenarios where diagnostic computed tomography angiography is not feasible. McConnell's sign, an echocardiographic finding of segmental right ventricular wall‐motion abnormality with apical sparing, is highly specific and may guide therapeutic ... Read more >>

Clin Case Rep (Clinical case reports)
[2021, 9(10):]

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Over-and-Under Complete Convolutional RNN for MRI Reconstruction.

Pengfei Guo, Jeya Maria Jose Valanarasu, Puyang Wang, Jinyuan Zhou, Shanshan Jiang, Vishal M Patel,

Reconstructing magnetic resonance (MR) images from under-sampled data is a challenging problem due to various artifacts introduced by the under-sampling operation. Recent deep learning-based methods for MR image reconstruction usually leverage a generic auto-encoder architecture which captures low-level features at the initial layers and high-level features at the deeper layers. ... Read more >>

Med Image Comput Comput Assist Interv (Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention)
[2021, 12906:13-23]

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Retrospective analysis of anti-inflammatory therapies during the first wave of COVID-19 at a community hospital.

Jose I Iglesias, Andrew V Vassallo, Jesse B Sullivan, Yasmine Elbaga, Vishal V Patel, Nikunjkumar Patel, Lydia Ayad, Payam Benson, Marina Pittiglio, Emad Gobran, Alexander Clark, Wajahat Khan, Kaliope Damalas, Rajesh Mohan, Satyendra P Singh,

<h4>Background</h4>Our understanding of the severe acute respiratory syndrome coronavirus 2 has evolved since the first reported cases in December 2019, and a greater emphasis has been placed on the hyper-inflammatory response in severely ill patients. The purpose of this study was to determine risk factors for mortality and the impact ... Read more >>

World J Crit Care Med (World journal of critical care medicine)
[2021, 10(5):244-259]

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Takotsubo cardiomyopathy in elderly female trauma patients: a case series.

Vishal Patel, Shuli Levy, Iqbal Malik, Michael B Fertleman, Louis J Koizia,

<h4>Background</h4>Takotsubo cardiomyopathy is a syndrome characterized by acute left ventricular wall motion abnormalities leading to left ventricular systolic dysfunction. It remains an important differential diagnosis for acute coronary syndrome.<h4>Case presentations</h4>Here we describe three cases of Takotsubo cardiomyopathy occurring in three Caucasian female trauma patients (aged 79, 81, and 82 years ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2021, 15(1):451]

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A Consensus Study: Generational Differences in Neurosurgeons' Perception of Retirement and Practice Limits.

Megan Rajagopal, Joseph Boyle, Vishal Patel, Charles Opalak, Dennis J Rivet, John Reavey-Cantwell,

<h4>Background</h4>Concerns about the changing demographics in the United States and the aging of the neurosurgical workforce exist. Both the importance and inherent risk of surgical responsibilities suggest that thought be given to whether workloads should change later in surgeons' careers. We sought to assess current neurosurgeons' expectations concerning their late-stage ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 155:e716-e726]

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Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery: The AFFINITY Randomized Clinical Trial.

Osvaldo P Almeida, Graeme J Hankey, Andrew Ford, Christopher Etherton-Beer, Leon Flicker, Maree Hackett, ,

<h4>Importance</h4>One in 3 adults experiences clinically significant symptoms of depression during the first year after a stroke, but evidence to support the use of antidepressants in this population remains scant.<h4>Objective</h4>To investigate whether daily treatment with 20 mg of fluoxetine hydrochloride reduces the proportion of people affected by clinically significant symptoms ... Read more >>

JAMA Neurol (JAMA neurology)
[2021, 78(9):1072-1079]

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Lateral orbital wall anomaly in a patient with thyroid eye disease.

Sukriti Mohan, Lily Koo Lin, Tiffany C Ho, Sandy Zhang-Nunes, Vishal Patel, Jessica R Chang,

An isolated defect in the lateral orbital wall is an uncommon occurrence, although cases of orbital floor, roof, and medial wall spontaneous dehiscence have been described in the literature. Here, we describe a lateral orbital wall defect in a patient with thyroid eye disease - which may be related to ... Read more >>

Orbit (Orbit (Amsterdam, Netherlands))
[2021, :1-4]

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Emerging therapies for rare cutaneous cancers: A systematic review.

Andrew Garcia, Kamaria Nelson, Vishal Patel,

<h4>Background</h4>Rare cutaneous cancers require early management given their aggressive nature; however, few therapeutic options exist for managing these rare cancers.<h4>Objective</h4>To identify emerging therapies for extramammary Paget's disease, Merkel cell carcinoma, sebaceous gland carcinoma, microcystic adnexal carcinoma, Kaposi sarcoma and cutaneous angiosarcoma.<h4>Methods</h4>A systematic review was conducted using PubMed database from October ... Read more >>

Cancer Treat Rev (Cancer treatment reviews)
[2021, 100:102266]

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Repair of an Extensive Central Chest Defect.

Sailesh Konda, Vishal A Patel,

Dermatol Surg (Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.])
[2021, 47(8):1103-1105]

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Hepcidin inhibition improves iron homeostasis in ferrous sulfate and LPS treatment model in mice.

Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Maulik Patel, Hiren Patel, Hardikkumar Savsani, Mukul Jain,

<h4>Background</h4>Hepcidin, a liver-derived peptide, regulates the absorption, distribution, and circulation of iron in the body. Inflammation or iron overload stimulates hepcidin release, which causes the accumulation of iron in tissues. The inadequate levels of iron in circulation impair erythropoiesis. Inhibition of hepcidin may increase iron in circulation and improve efficient ... Read more >>

Drug Res (Stuttg) (Drug research)
[2021, 71(9):528-534]

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Semi-Supervised Image Deraining Using Gaussian Processes.

Rajeev Yasarla, Vishwanath A Sindagi, Vishal M Patel,

Recent CNN-based methods for image deraining have achieved excellent performance in terms of reconstruction error as well as visual quality. However, these methods are limited in the sense that they can be trained only on fully labeled data. Due to various challenges in obtaining real world fully-labeled image deraining datasets, ... Read more >>

IEEE Trans Image Process (IEEE transactions on image processing : a publication of the IEEE Signal Processing Society)
[2021, 30:6570-6582]

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The American Society of Pain and Neuroscience (ASPN) Best Practices and Guidelines for the Interventional Management of Cancer-Associated Pain.

Mansoor M Aman, Ammar Mahmoud, Timothy Deer, Dawood Sayed, Jonathan M Hagedorn, Shane E Brogan, Vinita Singh, Amitabh Gulati, Natalie Strand, Jacqueline Weisbein, Johnathan H Goree, Fangfang Xing, Ali Valimahomed, Daniel J Pak, Antonios El Helou, Priyanka Ghosh, Krishna Shah, Vishal Patel, Alexander Escobar, Keith Schmidt, Jay Shah, Vishal Varshney, William Rosenberg, Sanjeet Narang,

Moderate to severe pain occurs in many cancer patients during their clinical course and may stem from the primary pathology, metastasis, or as treatment side effects. Uncontrolled pain using conservative medical therapy can often lead to patient distress, loss of productivity, shorter life expectancy, longer hospital stays, and increase in ... Read more >>

J Pain Res (Journal of pain research)
[2021, 14:2139-2164]

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The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury.

Ugo Soffientini, Nigel Beaton, Sukriti Baweja, Emmanuel Weiss, Chhagan Bihari, Abeba Habtesion, Vishal Patel, Valerie Paradis, Archana Sharma, Tu Vinh Luong, Andrew Hall, Aida Nadar, Shiv Sarin, Shilpa Chokshi, Roger Williams, Benedicte Py, Richard Moreau, Rajiv Jalan, Gautam Mehta,

<h4>Background and aims</h4>The development of multi-organ injury in cirrhosis is associated with increased intestinal permeability, translocation of gut-derived bacterial products [e.g., lipopolysaccharide (LPS)] into the circulation, and increased non-apoptotic hepatocyte cell death. Pyroptosis is a non-apoptotic, lytic form of cell death mediated by the LPS-sensing caspase(s)-4/11 (caspase-4 in humans, caspase-11 ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:668459]

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