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Author Vinod Krishnappa

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Association of pulse pressure, pulse pressure index, and ambulatory arterial stiffness index with kidney function in a cross-sectional pediatric chronic kidney disease cohort from the CKiD study.

Rupesh Raina, Shyam Polaconda, Nikhil Nair, Ronith Chakraborty, Sidharth Sethi, Vinod Krishnappa, Gaurav Kapur, Maroun Mhanna, Kirsten Kusumi,

The morbidity and mortality of adult and pediatric chronic kidney disease (CKD) and end-stage renal disease (ESRD) populations are mainly driven by cardiovascular disease (CVD). Improving CVD outcomes focuses on risk assessment of factors including diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular mass index (LVMI), pulse pressure ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2020, 22(6):1059-1069]

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An Overview of Rickets in Children.

Rahul Chanchlani, Paul Nemer, Rajiv Sinha, Lena Nemer, Vinod Krishnappa, Etienne Sochett, Fayez Safadi, Rupesh Raina,

Rickets is a common bone disease worldwide that is associated with disturbances in calcium and phosphate homeostasis and can lead to short stature and joint deformities. Rickets can be diagnosed based on history and physical examination, radiological features, and biochemical tests. It can be classified into 2 major groups based ... Read more >>

Kidney Int Rep (Kidney International Reports)
[2020, 5(7):980-990]

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Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.

Rupesh Raina, Jirair K Bedoyan, Uta Lichter-Konecki, Philippe Jouvet, Stefano Picca, Nicholas Ah Mew, Marcel C Machado, Ronith Chakraborty, Meghana Vemuganti, Manpreet K Grewal, Timothy Bunchman, Sidharth Kumar Sethi, Vinod Krishnappa, Mignon McCulloch, Khalid Alhasan, Arvind Bagga, Rajit K Basu, Franz Schaefer, Guido Filler, Bradley A Warady,

Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in ... Read more >>

Nat Rev Nephrol (Nature reviews. Nephrology)
[2020, 16(8):471-482]

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The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.

Rupesh Raina, Abigail Chauvin, Ronith Chakraborty, Nikhil Nair, Haikoo Shah, Vinod Krishnappa, Kirsten Kusumi,

Background:Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine signaling pathways tied to regulation of aldosterone, catecholamines, and angiotensin. In the kidney, ET-1 is critical to maintaining ... Read more >>

Kidney Dis (Basel) (Kidney Diseases)
[2020, 6(1):22-34]

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Dextran-Sulfate Plasma Adsorption Lipoprotein Apheresis in Drug Resistant Primary Focal Segmental Glomerulosclerosis Patients: Results From a Prospective, Multicenter, Single-Arm Intervention Study.

Rupesh Raina, Vinod Krishnappa, Cheryl Sanchez-Kazi, Alejandro Quiroga, Katherine E Twombley, Robert Mathias, Megan Lo, Ronith Chakraborty, Shefali Mahesh, Julia Steinke, Timothy Bunchman, Joshua Zaritsky,

Background: Focal segmental glomerulosclerosis (FSGS) causes end stage renal disease (ESRD) in significant proportion of patients worldwide. Primary FSGS carries poor prognosis and management of FSGS patients, refractory to standard treatments or resistant to steroids, remains a major challenge. Lipoprotein apheresis is a therapeutic approach for drug resistant primary FSGS ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:454]

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

BACKGROUND:Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS:We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

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Overview of Monogenic or Mendelian Forms of Hypertension.

Rupesh Raina, Vinod Krishnappa, Abhijit Das, Harshesh Amin, Yeshwanter Radhakrishnan, Nikhil R Nair, Kirsten Kusumi,

Monogenic or Mendelian forms of hypertension are described as a group of conditions characterized by insults to the normal regulation of blood pressure by the kidney and adrenal gland. These alterations stem from single mutations that lead to maladaptive overabsorption of electrolytes with fluid shift into the vasculature, and consequent ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:263]

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Endothelin-1 as a therapeutic target in autosomal dominant polycystic kidney disease
.

Rupesh Raina, Abigail Chauvin, Ramya Vajapey, Anshika Khare, Vinod Krishnappa,

AIMS:Endothelin-1 (ET-1) is associated with the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD) via cyst progression. Elevated concentrations of ET-1 in ADPKD correlate with many phenotypic changes in the kidney such as renal cyst development, interstitial fibrosis, and glomerulosclerosis. In addition, an imbalance between renal ETA and ETB receptors ... Read more >>

Clin. Nephrol. (Clinical nephrology)
[2019, 91(6):370-379]

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Role of Lipoprotein Apheresis in Cardiovascular Disease Risk Reduction.

Rupesh Raina, Claire Young, Vinod Krishnappa, Rahul Chanchlani,

BACKGROUND AND AIM:Elevated low-density lipoprotein cholesterol and/or lipoprotein(a) are established risk factors for cardiovascular disease (CVD). Management of hypercholesterolemia consists of drug therapies, including statins and proprotein convertase subtilisin/kexin type 9 inhibitors. In patients with familial hypercholesterolemia (FH), lipoprotein apheresis (LA) is utilized to control lipid levels. However, LA is ... Read more >>

Blood Purif. (Blood purification)
[2019, 47(4):301-316]

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Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup.

Rupesh Raina, Stephanie Lam, Hershita Raheja, Vinod Krishnappa, Daljit Hothi, Andrew Davenport, Deepa Chand, Gaurav Kapur, Franz Schaefer, Sidharth Kumar Sethi, Mignon McCulloch, Arvind Bagga, Timothy Bunchman, Bradley A Warady,

Intradialytic hypotension (IDH) is a common adverse event resulting in premature interruption of hemodialysis, and consequently, inadequate fluid and solute removal. IDH occurs in response to the reduction in blood volume during ultrafiltration and subsequent poor compensatory mechanisms due to abnormal cardiac function or autonomic or baroreceptor failure. Pediatric patients ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(5):925-941]

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Palliative care for acute kidney injury patients in the intensive care unit.

Vinod Krishnappa, William Hein, Daniel DelloStritto, Mona Gupta, Rupesh Raina,

Patients with acute kidney injury (AKI) in the intensive care unit (ICU) are often suitable for palliative care due to the high symptom burden. The role of palliative medicine in this patient population is not well defined and there is a lack of established guidelines to address this issue. Because ... Read more >>

World J Nephrol (World journal of nephrology)
[2018, 7(8):148-154]

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Dermatologic manifestations in end stage renal disease.

Taryn Blaha, Sagar Nigwekar, Sara Combs, Urvashi Kaw, Vinod Krishnappa, Rupesh Raina,

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2019, 23(1):3-18]

Cited: 1 time

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Atypical Hemolytic-Uremic Syndrome: An Update on Pathophysiology, Diagnosis, and Treatment.

Rupesh Raina, Vinod Krishnappa, Taryn Blaha, Taylor Kann, William Hein, Linda Burke, Arvind Bagga,

Atypical hemolytic uremic syndrome (aHUS), a rare variant of thrombotic microangiopathy, is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. The condition is associated with poor clinical outcomes with high morbidity and mortality. Atypical HUS predominantly affects the kidneys but has the potential to cause multi-organ system dysfunction. This ... Read more >>

Ther Apher Dial (Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy)
[2019, 23(1):4-21]

Cited: 4 times

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Fluid Overload in Critically Ill Children.

Rupesh Raina, Sidharth Kumar Sethi, Nikita Wadhwani, Meghana Vemuganti, Vinod Krishnappa, Shyam B Bansal,

Background: A common practice in the management of critically ill patients is fluid resuscitation. An excessive administration of fluids can lead to an imbalance in fluid homeostasis and cause fluid overload (FO). In pediatric critical care patients, FO can lead to a multitude of adverse effects and increased risk of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2018, 6:306]

Cited: 1 time

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An update on LDL apheresis for nephrotic syndrome.

Rupesh Raina, Vinod Krishnappa,

Low-density lipoprotein (LDL) apheresis has been used increasingly in clinical practice for the treatment of renal diseases with nephrotic syndrome (NS), specifically focal segmental glomerulosclerosis (FSGS). Persistent hyperlipidemia for prolonged periods is nephrotoxic and leads to chronic progressive glomerular and tubulointerstitial injury. Effective management of hyperlipidemia with HMG-CoA reductase inhibitors ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(10):1655-1669]

Cited: 5 times

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Antibiotic Dosing in Sustained Low-Efficiency Dialysis in Critically Ill Patients.

Sidharth Kumar Sethi, Vinod Krishnappa, Nisha Nangethu, Paul Nemer, Lawrence A Frazee, Rupesh Raina,

Sustained low-efficiency dialysis (SLED) is increasingly used as a renal replacement modality in critically ill patients with acute kidney injury (AKI) and hemodynamic instability. There is, therefore, a greater need for the understanding of the antibiotic dosage and pharmacokinetics in these patients, to provide them with optimal therapy.PubMed/Medline, Embase, and ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2018, 5:2054358118792229]

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Effect of Immunosuppressive Therapy on the Occurrence of Atypical Hemolytic Uremic Syndrome in Renal Transplant Recipients.

Rupesh Raina, Abigail Chauvin, Kelli Fox, Natasha Kesav, Mustafa Ascha, Tushar J Vachharajani, Vinod Krishnappa,

BACKGROUND Atypical hemolytic uremic syndrome (aHUS), a rare thrombotic microangiopathy, is characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Caused by genetic mutations in the alternative complement cascade, aHUS often will culminate in end-stage renal disease and occasionally death. Renal transplantation in aHUS patients has been contraindicated in the ... Read more >>

Ann. Transplant. (Annals of transplantation)
[2018, 23:631-638]

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The Impact of Admission Serum Creatinine on Major Adverse Clinical Events in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.

Poornima Vinod, Taylor Kann, Shyam Polaconda, Alibel Bello, Mohamed Khayata, Fernando Munoz, Vinod Krishnappa, Rupesh Raina,

Impaired renal function has been shown in previous studies to be an independent predictor of cardiovascular adverse events amongst patients admitted for percutaneous coronary intervention (PCI) following ST-segment elevation myocardial infarction (STEMI). This study investigates the impact of admission serum creatinine (SCr) on major cardiovascular outcomes among STEMI patients undergoing ... Read more >>

Cardiol Res (Cardiology research)
[2018, 9(2):94-98]

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The use of eculizumab in gemcitabine induced thrombotic microangiopathy.

Vinod Krishnappa, Mohit Gupta, Haikoo Shah, Abhijit Das, Natthavat Tanphaichitr, Robert Novak, Rupesh Raina,

Thrombotic microangiopathy (TMA) secondary to gemcitabine therapy (GiTMA) is a very rare pathology that carries a poor prognosis, with nearly half of the cases progressing to end stage renal disease. GiTMA is most commonly associated with adenocarcinomas, most notably pancreatic cancers. The mainstay of management is withdrawal of the offending ... Read more >>

BMC Nephrol (BMC nephrology)
[2018, 19(1):9]

Cited: 3 times

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Atypical Hemolytic Uremic Syndrome: A Meta-Analysis of Case Reports Confirms the Prevalence of Genetic Mutations and the Shift of Treatment Regimens.

Vinod Krishnappa, Mohit Gupta, Mohamed Elrifai, Bahar Moftakhar, Michael J Ensley, Tushar J Vachharajani, Sidharth Kumar Sethi, Rupesh Raina,

Atypical hemolytic uremic syndrome (aHUS) is a rare life-threatening thrombotic microangiopathy (TMA) affecting multiple organ systems. Recently, aHUS has been shown to be associated with uncontrolled complement activation due to mutations in the alternative pathway of complement components paving the way for targeted drug therapy. By meta-analysis of case reports, ... Read more >>

Ther Apher Dial (Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy)
[2018, 22(2):178-188]

Cited: 4 times

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Hemodialysis in neonates and infants: A systematic review.

Rupesh Raina, Prashanth Vijayaraghavan, Gaurav Kapur, Sidharth Kumar Sethi, Vinod Krishnappa, Deepak Kumar, Timothy E Bunchman, Shari D Bolen, Deepa Chand,

Hemodialysis (HD) in neonates and infants poses unique challenges due to high risks of mortality attributable to obligatory small blood flow volumes. Although HD is often necessary in neonates, its effectiveness and feasibility are poorly understood. The aim of this review is to describe in detail the few studies reporting ... Read more >>

Semin Dial (Seminars in dialysis)
[2018, 31(3):289-299]

Cited: 1 time

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Pediatric Renal Transplantation: Focus on Current Transition Care and Proposal of the "RISE to Transition" Protocol.

Rupesh Raina, Joseph Wang, Vinod Krishnappa, Maria Ferris,

The transition from pediatric to adult medical services is an important time in the life of an adolescent or young adult with a renal transplant. Failure of proper transition can lead to medical non-adherence and subsequent loss of graft and/or return to dialysis. The aim of this study was to ... Read more >>

Ann. Transplant. (Annals of transplantation)
[2018, 23:45-60]

Cited: 1 time

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Management of pain in end-stage renal disease patients: Short review.

Rupesh Raina, Vinod Krishnappa, Mona Gupta,

Pain management in end stage renal disease (ESRD) patients is a complex and challenging task to accomplish, and effective pain and symptom control improves quality of life. Pain is prevalent in more than 50% of hemodialysis patients and up to 75% of these patients are treated ineffectively due to its ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2018, 22(3):290-296]

Cited: 1 time

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Structured Transition Protocol for Children with Cystinosis.

Rupesh Raina, Joseph Wang, Vinod Krishnappa,

The transition from pediatric to adult medical services has a greater impact on the care of adolescents or young adults with chronic diseases such as cystinosis. This transition period is a time of psychosocial development and new responsibilities placing these patients at increased risk of non-adherence. This can lead to ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2017, 5:191]

Cited: 2 times

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Cystic Diseases of Childhood: A Review.

Shivani Kwatra, Vinod Krishnappa, Christiane Mhanna, Taryn Murray, Robert Novak, Sidharth Kumar Sethi, Deepak Kumar, Rupesh Raina,

Renal cystic lesions are considered the most common abnormality associated with the kidneys. Most renal cysts are usually uncomplicated simple cysts that are not life-threatening; however, fatal renal cystic diseases can develop from these space-occupying lesions. Although renal cystic diseases are similar in presentation, they possess distinct features, variable prognoses, ... Read more >>

Urology (Urology)
[2017, 110:184-191]

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