Full Text Journal Articles by
Author Vincenzo De Luca

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Can Integrated Care Help in Meeting the Challenges Posed on Our Health Care Systems by COVID-19? Some Preliminary Lessons Learned from the European VIGOUR Project.

Sonja Lindner, Lutz Kubitschke, Christos Lionis, Marilena Anastasaki, Ursula Kirchmayer, Simona Giacomini, Vincenzo De Luca, Guido Iaccarino, Maddalena Illario, Antonio Maddalena, Antonio Maritati, Diego Conforti, Isabella Roba, Daniele Musian, Antonio Cano, Monica Granell, Ana M Carriazo, Carmen M Lama, Susana Rodríguez, Agnieszka Guligowska, Tomasz Kostka, Annemieke Konijnendijk, Maria Vitullo, Alejandro García-Rudolph, Javier Solana Sánchez, Marcello Maggio, Giuseppe Liotta, Chariklia Tziraki, Regina Roller-Wirnsberger, ,

The COVID-19 pandemic puts health and care systems under pressure globally. This current paper highlights challenges arising in the care for older and vulnerable populations in this context and reflects upon possible perspectives for different systems making use of nested integrated care approaches adapted during the work of the EU-funded ... Read more >>

Int J Integr Care (International journal of integrated care)
[2020, 20(4):4]

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Investigation of accelerated epigenetic aging in individuals experiencing suicidal ideation.

Oluwagbenga Dada, Richie Jeremian, Nasia Dai, John Strauss, Clement Zai, Ariel Graff, Vincenzo De Luca,

Schizophr Res (Schizophrenia research)
[2020, :]

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Liver enzyme CYP2D6 gene and tardive dyskinesia.

Justin Y Lu, Arun K Tiwari, Natalie Freeman, Gwyneth C Zai, Vincenzo de Luca, Daniel J Müller, Maria Tampakeras, Deanna Herbert, Heather Emmerson, Sheraz Y Cheema, Nicole King, Aristotle N Voineskos, Steven G Potkin, Jeffrey A Lieberman, Herbert Y Meltzer, Gary Remington, James L Kennedy, Clement C Zai,

Background: Tardive dyskinesia (TD) is an iatrogenic involuntary movement disorder occurring after extended antipsychotic use with unclear pathogenesis. CYP2D6 is a liver enzyme involved in antipsychotic metabolism and a well-studied gene candidate for TD. Materials & methods: We tested predicted CYP2D6 metabolizer phenotype with TD occurrence and severity in our ... Read more >>

Pharmacogenomics (Pharmacogenomics)
[2020, 21(15):1065-1072]

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Rethinking palliative care in a public health context: addressing the needs of persons with non-communicable chronic diseases.

Chariklia Tziraki, Corrina Grimes, Filipa Ventura, Rónán O'Caoimh, Silvina Santana, Veronica Zavagli, Silvia Varani, Donatella Tramontano, João Apóstolo, Bart Geurden, Vincenzo De Luca, Giovanni Tramontano, Maria Rosaria Romano, Marilena Anastasaki, Christos Lionis, Rafael Rodríguez-Acuña, Manuel Luis Capelas, Tânia Dos Santos Afonso, David William Molloy, Giuseppe Liotta, Guido Iaccarino, Maria Triassi, Patrik Eklund, Regina Roller-Wirnsberger, Maddalena Illario,

Non-communicable chronic diseases (NCCDs) are the main cause of morbidity and mortality globally. Demographic aging has resulted in older populations with more complex healthcare needs. This necessitates a multilevel rethinking of healthcare policies, health education and community support systems with digitalization of technologies playing a central role. The European Innovation ... Read more >>

Prim Health Care Res Dev (Primary health care research & development)
[2020, 21:e32]

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Genome-wide methylation association with current suicidal ideation in schizophrenia.

Ali Bani-Fatemi, Christopher Adanty, Nasia Dai, Oluwagbenga Dada, John Strauss, Clement Zai, Philip Gerretsen, Ariel Graff, Vincenzo De Luca,

In this study, we investigate the epigenetic mechanisms associated with current suicidal ideation. Gene expression changes have been found in post-mortem brain of suicide victims. However, it is not clear how in-vivo gene expression change confers risk for suicide. DNA methylation is a form of epigenetic modification that regulates gene ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2020, 127(9):1315-1322]

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M199. COPY NUMBER VARIANCE (CNV) ANALYSIS TO DETERMINE OPTIMAL ANTIPSYCHOTIC DOSAGE IN SCHIZOPHRENIA: A PILOT STUDY.

Christopher Adanty, Kevin Wang, Oluwagbenga Dada, Janice Wun, Ali Bani-Fatemi, Vincenzo De Luca,

AbstractBackgroundThe relationship between genetic polymorphisms of antipsychotic drug-metabolizing agents and drug response has been thoroughly investigated and analyzed. However, from a pharmacokinetic standpoint, few studies have explored the relationship between Copy number variants (CNV) and antipsychotic dosage. The aim of the present study is to test the association between antipsychotic ... Read more >>

Schizophr Bull (Bp) (Schizophrenia bulletin)
[2020, 46(Suppl 1):S212-S212]

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S17. GLOBAL DNA METHYLATION IN CURRENT AND EMERGENT SUICIDAL IDEATION: ANALYSIS IN SCHIZOPHRENIA.

Ali Bani-Fatemi, Roger Raymond, Jose Nobrega, Vincenzo De Luca,

AbstractBackgroundSeveral lines of evidence have shown that epigenetic mechanisms influence suicidal behavior, but do not indicate specific susceptibility variants. In a recent study, analysis of global methylation levels found that psychiatric patients with a history of suicide attempt (SA) had significantly higher levels of 5-methyl cytosine (5mC), suggesting that patients ... Read more >>

Schizophr Bull (Bp) (Schizophrenia bulletin)
[2020, 46(Suppl 1):S36-S37]

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Genome-wide association study of aggression and violence in schizophrenia.

Ali Bani-Fatemi, Anvesh Roy, Nasia Dai, Oluwagbenga Dada, Christopher Adanty, Lavaniya Kiruparajah, Nathan Kolla, John Strauss, Clement Zai, Ariel Graff, Philip Gerretsen, Vincenzo De Luca,

Schizophrenia patients are at higher risk of engaging in violent behavior than the general population. Schizophrenia is also regarded as a highly heritable disorder. This study aimed to analyze genome-wide the effect of SNPs on violence in schizophrenia. We recruited 205 subjects between the age of 18-75 from the Centre ... Read more >>

Neurosci Lett (Neuroscience letters)
[2020, 732:135061]

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Schizophrenia-associated gene dysbindin-1 and tardive dyskinesia.

Miriam S Maes, Justin Y Lu, Arun K Tiwari, Natalie Freeman, Vincenzo de Luca, Daniel J Müller, Aristotle N Voineskos, Steven G Potkin, Jeffrey A Lieberman, Herbert Y Meltzer, Gary Remington, James L Kennedy, Clement C Zai,

Tardive dyskinesia (TD) is a potentially irreversible movement disorder observed following long-term antipsychotic exposure. Its cause is unknown; however, a genetic component has been supported by studies of affected families. Dysbindin-1, encoded by the dystrobrevin-binding protein 1 DTNBP1 gene, has been associated with schizophrenia and is potentially involved in dopamine ... Read more >>

Drug Dev Res (Drug development research)
[2020, :]

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S14. ANALYSIS OF METHYLATION AGE AND BLOOD CELL COMPOSITION IN SUBJECTS WITH CURRENT SUICIDE IDEATION

Oluwagbenga Dada, Vincenzo De Luca, Ali Bani-Fatemi, Vincenzo De Luca,

Abstract Background Suicidal Ideation (SI) remain an important and common risk factor affecting people with SCZ, who eventually attempt or complete suicide. Then the question is, what if factors (such as stressful life events and related molecular biomarkers) known to be involved in the aetiology of SCZ could help in ... Read more >>

Schizophr Bull (Bp) (Schizophrenia bulletin)
[2020, 46(Suppl 1):S36-S36]

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Prediction of physical violence in schizophrenia with machine learning algorithms.

Kevin Z Wang, Ali Bani-Fatemi, Christopher Adanty, Ricardo Harripaul, John Griffiths, Nathan Kolla, Philip Gerretsen, Ariel Graff, Vincenzo De Luca,

Patients with schizophrenia have been shown to have an increased risk for physical violence. While certain features have been identified as risk factors, it has been difficult to integrate these variables to identify violent patients. The present study thus attempts to develop a clinically-relevant predictive tool. In a population of ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 289:112960]

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Journey in the Polyphenol Research World with Ragai Ibrahim.

Denis Barron, Pierre Laflamme, Vincenzo De Luca,

Dr. Ragai K. Ibrahim, Professor Emeritus at Concordia University, Montréal, Canada, passed away on the November 19, 2017 at the age of 88 years. Dr. Ibrahim dedicated his entire professional life to polyphenols and spent most of his academic career (1967-1997) at the Department of Biology of Concordia University in ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2020, 68(10):2849-2860]

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Early-life stressful events and suicide attempt in schizophrenia: Machine learning models.

Samia Tasmim, Oluwagbenga Dada, Kevin Z Wang, Ali Bani-Fatemi, John Strauss, Christopher Adanty, Ariel Graff, Philip Gerretsen, Clement Zai, Carol Borlido, Vincenzo De Luca,

Childhood abuse and neglect predicts suicide attempt. Furthermore, other early-life stressful events may predict lifetime suicide attempt in psychiatric disorders. We assessed 189 schizophrenics for suicide attempt and stressful life events. Early-life stressful events were used as predictors of lifetime suicide attempt in three machine learning models. In our sample, ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, 218:329-331]

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Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB.

Laura M Best, Belinda Williams, Bernard Le Foll, Esmaeil Mansouri, Richard P Bazinet, Lin Lin, Vincenzo De Luca, Dina Lagzdins, Pablo Rusjan, Rachel F Tyndale, Alan A Wilson, Christian S Hendershot, Markus Heilig, Sylvain Houle, Junchao Tong, Stephen J Kish, Isabelle Boileau,

The endocannabinoid enzyme, fatty acid amide hydrolase (FAAH), has been proposed as a therapeutic target for alcohol use disorder (AUD) and co-morbid psychiatric illnesses. Investigating this target in the living human brain and its relationship to clinical outcome is a critical step of informed drug development. Our objective was to ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2020, 45(8):1289-1296]

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Editorial: Neurobiology, Clinical Course, and Therapeutic Approaches of Treatment-Resistant Schizophrenia: Toward an Integrated View.

Felice Iasevoli, Vincenzo De Luca, Frederick Charles Nucifora,

Front Psychiatry (Frontiers in psychiatry)
[2019, 10:870]

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Independent effect of childhood trauma and recent stress as predictors for current suicidal ideation in schizophrenia.

Liang-Ching Hwang, Oluwagbenga Dada, Christopher Adanty, Ali Bani Fatemi, Ariel Graff, John Strauss, Samia Tasmim, Philip Gerretsen, Clement Zai, Carol Borlido, Vincenzo De Luca,

Gen Hosp Psychiatry (General hospital psychiatry)
[2020, 64:115-116]

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Managing Peripheral Artery Disease in Diabetic Patients: A Questionnaire Survey from Vascular Centers of the Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS).

Umberto Marcello Bracale, Raffaele Pio Ammollo, Emad A Hussein, Jamal J Hoballah, Olivier Goeau-Brissonniere, Maurizio Taurino, Carlo Setacci, Felice Pecoraro, Giancarlo Bracale, ,

BACKGROUND:The Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS) was founded on October 1, 2018, to enhance cooperation among vascular professionals within Mediterranean countries. Due to its prominent social and economic impact on national health systems, diabetic arteriopathy has been selected as the very first topic to be investigated ... Read more >>

Ann Vasc Surg (Annals of vascular surgery)
[2020, 64:239-245]

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Childhood trauma predicts multiple, high lethality suicide attempts in patients with schizophrenia.

Sauliha Alli, Samia Tasmim, Christopher Adanty, Ariel Graff, John Strauss, Clement Zai, Philip Gerretsen, Carol Borlido, Vincenzo De Luca,

Childhood trauma has been shown to increase the risk of suicide attempts in individuals with schizophrenia. However, previous literature has been limited by considerable heterogeneity within the category of suicide attempters. Here we tested the predictive effect of childhood maltreatment on lifetime suicide attempt in a homogeneous sample of 650 ... Read more >>

Psychiatry Res (Psychiatry research)
[2019, 281:112567]

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Modulation of brain activity with transcranial direct current stimulation: Targeting regions implicated in impaired illness awareness in schizophrenia.

Julia Kim, Eric Plitman, Shinichiro Nakajima, Youssef Alshehri, Yusuke Iwata, Jun Ku Chung, Fernando Caravaggio, Mahesh Menon, Daniel M Blumberger, Bruce G Pollock, Gary Remington, Vincenzo De Luca, Ariel Graff-Guerrero, Philip Gerretsen,

BACKGROUND:Impaired illness awareness or insight into illness (IIA) is a common feature of schizophrenia that contributes to medication nonadherence and poor clinical outcomes. Neuroimaging studies suggest IIA may arise from interhemispheric imbalance in frontoparietal regions, particularly in the posterior parietal area (PPA) and the dorsolateral prefrontal cortex (dlPFC). In this ... Read more >>

Eur Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2019, 61:63-71]

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Mini-Mental State Examination: new normative values on subjects in Southern Italy.

Michele Carpinelli Mazzi, Alessandro Iavarone, Gennaro Russo, Caterina Musella, Graziella Milan, Francesco D'Anna, Elisabetta Garofalo, Sergio Chieffi, Maria Sannino, Maddalena Illario, Vincenzo De Luca, Alfredo Postiglione, Pasquale Abete, ,

OBJECTIVE:The aims of the present study were: (a) to obtain new normative data of the Italian version of the Mini-Mental Examination State (MMSE) (Measso et al. in Dev Neuropsychol 9:77-85, 1993) by administering the tool to a sample of normal Italian individuals more representative of the current Italian population; (b) ... Read more >>

Aging Clin Exp Res (Aging clinical and experimental research)
[2020, 32(4):699-702]

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Investigation of accelerated epigenetic aging in individuals suffering from schizophrenia in the context of lifetime suicide attempt.

Richie Jeremian, Ali Bani-Fatemi, John S Strauss, Samia Tasmim, Oluwagbenga Dada, Ariel Graff-Guerrero, Philip Gerretsen, Vincenzo De Luca,

Schizophr Res (Schizophrenia research)
[2019, :]

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The assembly of (+)-vincadifformine- and (-)-tabersonine-derived monoterpenoid indole alkaloids in Catharanthus roseus involves separate branch pathways.

Danielle Williams, Yang Qu, Razvan Simionescu, Vincenzo De Luca,

The biological activity of monoterpenoid indole alkaloids (MIAs) has led to their use in cancer treatment and other medical applications. Their biosynthesis has involved the formation of reactive intermediates by responsible enzymes to elaborate several different chemical scaffolds. Modification of scaffolds through different substitution reactions has produced chemically diverse MIAs ... Read more >>

Plant J (The Plant journal : for cell and molecular biology)
[2019, 99(4):626-636]

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Insight and medication adherence in schizophrenia: An analysis of the CATIE trial.

Julia Kim, Miracle Ozzoude, Shinichiro Nakajima, Parita Shah, Fernando Caravaggio, Yusuke Iwata, Vincenzo De Luca, Ariel Graff-Guerrero, Philip Gerretsen,

Adherence to antipsychotic medication is critical for the treatment of patients with schizophrenia. Impaired insight into illness is one of the principal drivers of medication nonadherence, which contributes to negative clinical outcomes. The aims of this study were to examine the relationships between impaired insight and (1) rates of antipsychotic ... Read more >>

Neuropharmacology (Neuropharmacology)
[2020, 168:107634]

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Meta-Analysis of Neuropsychological Studies in Panic Disorder Patients: Evidence of Impaired Performance during the Emotional Stroop Task.

Lillian Harber, Reza Hamidian, Ali Bani-Fatemi, Kevin Z Wang, Oluwagbenga Dada, Giovanni Messina, Marcellino Monda, Sergio Chieffi, Vincenzo De Luca,

BACKGROUND:Recent investigations have highlighted significant differences in verbal recall between patients with panic disorder (PD) and controls. These studies have highlighted that verbal memory and working memory could be impaired in PD. OBJECTIVES:The objective of the present meta-analysis is to confirm this hypothesis, reviewing the studies that have investigated neurocognitive ... Read more >>

Neuropsychobiology (Neuropsychobiology)
[2019, 78(1):7-13]

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F14. GENOME-WIDE METHYLATION EFFECT ON CURRENT AND EMERGENT SUICIDAL IDEATION: AN EPIGENOME-WIDE ASSOCIATION ANALYSIS IN SCHIZOPHRENIA.

Ali Bani-Fatemi, De Luca Vincenzo,

AbstractBackgroundSuicide is one of the causes of reduced life expectancy in patients with schizophrenia (SCZ). Despite the importance of suicidal ideation (SI) in predicting future suicide attempts, little empirical research has been conducted on its patterns. Therefore, there is an urgent need to provide a better prediction of SI for ... Read more >>

Schizophr Bull (Bp) (Schizophrenia bulletin)
[2019, 45(Suppl 2):S259-S259]

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