Full Text Journal Articles by
Author Vincenzo Alfano

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Microstructural Changes in Motor Functional Conversion Disorder: Multimodal Imaging Approach on a Case.

Mariachiara Longarzo, Carlo Cavaliere, Giulia Mele, Stefano Tozza, Liberatore Tramontano, Vincenzo Alfano, Marco Aiello, Marco Salvatore, Dario Grossi,

BACKGROUND:Functional motor conversion disorders are characterized by neurological symptoms unrelated to brain structural lesions. The present study was conducted on a woman presenting motor symptoms causing motor dysfunction, using advanced multimodal neuroimaging techniques, electrophysiological and neuropsychological assessment. METHODS:The patient underwent fluorodeoxyglucose-positron emission tomography-computed tomography (FDG-PET-CT) and functional magnetic resonance imaging ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(6):]

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Multimodal neuroimaging in anorexia nervosa.

Vincenzo Alfano, Giulia Mele, Armando Cotugno, Mariachiara Longarzo,

Anorexia nervosa (AN) is a severe and complex psychiatric disorder characterized by intense fear about weight gain and finalized to food-related control behaviors. Growing interest has been demonstrated about neurobiological processes subtend to AN physiopathology. The present review aimed to collect neurostructural and neurofunctional available data from 2010 to 2019. ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2020, :]

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[18F]FDG uptake of the normal spinal cord in PET/MR imaging: comparison with PET/CT imaging.

Marco Aiello, Vincenzo Alfano, Elena Salvatore, Carlo Cavaliere, Marco Picardi, Roberta Della Pepa, Emanuele Nicolai, Andrea Soricelli, Alessandra Vella, Marco Salvatore, Mario Mascalchi,

BACKGROUND:The lack of visualization of the spinal cord hinders the evaluation of [18F]Fluoro-deoxy-glucose (FDG) uptake of the spinal cord in PET/CT. By exploiting the capability of MRI to precisely outline the spinal cord, we performed a retrospective study aimed to define normal pattern of spinal cord [18F]FDG uptake in PET/MRI. ... Read more >>

EJNMMI Res (EJNMMI research)
[2020, 10(1):91]

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The Efficacy of Lockdown Against COVID-19: A Cross-Country Panel Analysis.

Vincenzo Alfano, Salvatore Ercolano,

BACKGROUND:There has been much debate about the effectiveness of lockdown measures in containing COVID-19, and their appropriateness given the economic and social cost they entail. To the best of our knowledge, no existing contribution to the literature has attempted to gauge the effectiveness of lockdown measures over time in a ... Read more >>

Appl Health Econ Health Policy (Applied health economics and health policy)
[2020, 18(4):509-517]

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Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3'UTR binding.

Maria Giovanna Garone, Vincenzo Alfano, Beatrice Salvatori, Clarissa Braccia, Giovanna Peruzzi, Alessio Colantoni, Irene Bozzoni, Andrea Armirotti, Alessandro Rosa,

Increasing evidence suggests that in Amyotrophic Lateral Sclerosis (ALS) mutated RNA binding proteins acquire aberrant functions, leading to altered RNA metabolism with significant impact on encoded protein levels. Here, by taking advantage of a human induced pluripotent stem cell-based model, we aimed to gain insights on the impact of ALS ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):11827]

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[18F]FDG uptake of the normal spinal cord in PET/MR imaging: Comparison with PET/CT imaging

Marco Aiello, Vincenzo Alfano, Elena Salvatore, Carlo Cavaliere, Marco Picardi, Roberta Della Pepa, Emanuele Nicolai, Andrea Soricelli, Alessandra Vella, Marco Salvatore, Mario Mascalchi,

Abstract Background The lack of visualization of the spinal cord hinders the evaluation of [ 18 F]Fluoro-deoxy-glucose (FDG) uptake of the spinal cord in PET/CT. By exploiting the capability of MRI to precisely outline the spinal cord, we performed a retrospective study aimed to define normal pattern of spinal cord ... Read more >>

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Shut it down: a cross country panel analysis on the efficacy of lockdown measures

Vincenzo Alfano, Salvatore Ercolano,

Coronavirus pandemic outbreak from China in the December 2019 and since then has quickly spread all over the world. National governments introduced policies aimed to reduce the probability to contract the virus, such as lockdown measures, in order to limit the outbreak. Lockdown fostered a debate about the effective need ... Read more >>

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Gliosis and Neurodegenerative Diseases: The Role of PET and MR Imaging.

Carlo Cavaliere, Liberatore Tramontano, Dario Fiorenza, Vincenzo Alfano, Marco Aiello, Marco Salvatore,

Glial activation characterizes most neurodegenerative and psychiatric diseases, often anticipating clinical manifestations and macroscopical brain alterations. Although imaging techniques have improved diagnostic accuracy in many neurological conditions, often supporting diagnosis, prognosis prediction and treatment outcome, very few molecular imaging probes, specifically focused on microglial and astrocytic activation, have been translated ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2020, 14:75]

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A Rare Case of Sigmoid Colon Carcinoma in Incarcerated Inguinal Hernia.

Dario Baldi, Vincenzo Alfano, Bruna Punzo, Liberatore Tramontano, Simona Baselice, Gianluca Spidalieri, Osvaldo Micera, Carlo Cavaliere,

Incarcerated inguinal hernia is a common diagnosis in patients presenting a painful and nonreducible groin mass. Although the diagnosis is usually made by physical examination, the content of the hernia sac and the extent of the surgical operation may vary and can require multimodal imaging integration (e.g., ultrasonography, computed tomography); ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(2):]

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Cerebral microstructural abnormalities in impulsivity: a magnetic resonance study.

Vincenzo Alfano, Mariachiara Longarzo, Marco Aiello, Andrea Soricelli, Carlo Cavaliere,

Studies that investigated neurobiological parameters subtended to impulsivity trait found their relationship with structural and functional brain alterations. No studies investigated the white matter microstructural attributes of impulsivity in a large sample of healthy subjects. In the present study 1007 subjects from Human Connectome Project public dataset were divided in ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2020, :]

Cited: 1 time

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Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.

Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri,

OBJECTIVE:The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. DESIGN:We explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA ... Read more >>

Gut (Gut)
[2020, :]

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SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors.

Marialaura Petroni, Maria Sahùn Roncero, Valentina Ramponi, Francesca Fabretti, Vittoria Nicolis Di Robilant, Marta Moretti, Vincenzo Alfano, Alessandro Corsi, Simone De Panfilis, Maria Giubettini, Stefano Di Giulio, Carlo Capalbo, Francesca Belardinilli, Anna Coppa, Francesca Sardina, Valeria Colicchia, Flaminia Pedretti, Paola Infante, Beatrice Cardinali, Alessandra Tessitore, Gianluca Canettieri, Enrico De Smaele, Giuseppe Giannini,

Growth and patterning of the cerebellum is compromised if granule cell precursors do not properly expand and migrate. During embryonic and postnatal cerebellar development, the Hedgehog pathway tightly regulates granule cell progenitors to coordinate appropriate foliation and lobule formation. Indeed, granule cells impairment or defects in the Hedgehog signaling are ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):19623]

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Simultaneous EEG-fMRI for Functional Neurological Assessment.

Giulia Mele, Carlo Cavaliere, Vincenzo Alfano, Mario Orsini, Marco Salvatore, Marco Aiello,

The increasing incidence of neurodegenerative and psychiatric diseases requires increasingly sophisticated tools for their diagnosis and monitoring. Clinical assessment takes advantage of objective parameters extracted by electroencephalogram and magnetic resonance imaging (MRI) among others, to support clinical management of neurological diseases. The complementarity of these two tools can be now ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:848]

Cited: 3 times

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Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis.

Riccardo De Santis, Vincenzo Alfano, Valeria de Turris, Alessio Colantoni, Laura Santini, Maria Giovanna Garone, Giuseppe Antonacci, Giovanna Peruzzi, Emma Sudria-Lopez, Emanuel Wyler, Jasper J Anink, Eleonora Aronica, Markus Landthaler, R Jeroen Pasterkamp, Irene Bozzoni, Alessandro Rosa,

Amyotrophic lateral sclerosis (ALS) has been genetically linked to mutations in RNA-binding proteins (RBPs), including FUS. Here, we report the RNA interactome of wild-type and mutant FUS in human motor neurons (MNs). This analysis identified a number of RNA targets. Whereas the wild-type protein preferentially binds introns, the ALS mutation ... Read more >>

Cell Rep (Cell reports)
[2019, 27(13):3818-3831.e5]

Cited: 1 time

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Correction to: IRE1α deficiency promotes tumor cell death and eIF2α degradation through PERK-dependent autophagy.

Antonello Storniolo, Vincenzo Alfano, Sabino Carbotta, Elisabetta Ferretti, Livia Di Renzo,

[This corrects the article DOI: 10.1038/s41420-017-0002-9.]. ... Read more >>

Cell Death Discov (Cell death discovery)
[2018, 4:19]

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IRE1α deficiency promotes tumor cell death and eIF2α degradation through PERK dipendent autophagy.

Antonello Storniolo, Vincenzo Alfano, Sabino Carbotta, Elisabetta Ferretti, Livia Di Renzo,

Sensors of endoplasmic reticulum (ER) stress function in a co-ordinated manner. In the present study we investigated the relationship between IRE1α and PERK pathways and survival of ER stressed U937 cells and BC3 cells. To this end, we investigated the effects of a subcytotoxic concentration of Tunicamycin in IRE1α-proficient and ... Read more >>

Cell Death Discov (Cell death discovery)
[2018, 4:3]

Cited: 4 times

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FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis.

Riccardo De Santis, Laura Santini, Alessio Colantoni, Giovanna Peruzzi, Valeria de Turris, Vincenzo Alfano, Irene Bozzoni, Alessandro Rosa,

The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous RNA-binding protein, and the mechanisms leading to selective motoneuron loss downstream of ALS-linked mutations are largely unknown. We report the transcriptome analysis of human purified motoneurons, obtained from FUS wild-type or mutant isogenic induced pluripotent ... Read more >>

Stem Cell Reports (Stem cell reports)
[2017, 9(5):1450-1462]

Cited: 19 times

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Pappi of cardoon (Cynara cardunculus L.): The use of wetting during the harvesting aimed at recovering for the biorefinery

Luigi Pari, Enrico Santangelo, Paolo Mattei, Vincenzo Alfano,

The pappi of cardoon (Cynara cardunculus L.) flowers form a crown of plumose filaments which aid the wind dispersal of the seeds connected to them. The high cellulose content of this fraction can be a valuable raw material for fiber or pulp products. During threshing, the pappi are discharged together ... Read more >>

(Industrial crops and products.)
[2017, 108:722-728]

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The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity.

Pietro Laneve, Agnese Po, Annarita Favia, Ivano Legnini, Vincenzo Alfano, Jessica Rea, Valerio Di Carlo, Valeria Bevilacqua, Evelina Miele, Angela Mastronuzzi, Andrea Carai, Franco Locatelli, Irene Bozzoni, Elisabetta Ferretti, Elisa Caffarelli,

Long noncoding RNAs (lncRNAs) are major regulators of physiological and disease-related gene expression, particularly in the central nervous system. Dysregulated lncRNA expression has been documented in several human cancers, and their tissue-specificity makes them attractive candidates as diagnostic/prognostic biomarkers and/or therapeutic agents. Here we show that linc-NeD125, which we previously ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(19):31003-31015]

Cited: 15 times

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β-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest.

Agnese Po, Federica Begalli, Luana Abballe, Vincenzo Alfano, Zein Mersini Besharat, Giuseppina Catanzaro, Alessandra Vacca, Maddalena Napolitano, Marco Tafani, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti, Evelina Miele,

Cell development is regulated by a complex network of mRNA-encoded proteins and microRNAs, all funnelling onto the modulation of self-renewal or differentiation genes. How intragenic microRNAs and their host genes are transcriptionally coregulated and their functional relationships for the control of neural stem cells (NSCs) are poorly understood. We propose ... Read more >>

Stem Cells Int (Stem cells international)
[2017, 2017:5274171]

Cited: 1 time

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MB-34CIRCULATING microRNAs IN GROUP 4 MEDULLOBLASTOMA PATIENTS.

Evelina Miele, Vincenzo Alfano, Zein Mersini Besharat, Giuseppina Catanzaro, Angela Mastronuzzi, Andrea Carai, Agnese Po, Antonella Cacchione, Luana Abballe, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti,

Neuro-oncology (Neuro-oncology)
[2016, 18(Suppl 3):iii104-iii104]

Cited: 0 times

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IDO1 involvement in mTOR pathway: a molecular mechanism of resistance to mTOR targeting in medulloblastoma.

Valentina Folgiero, Evelina Miele, Andrea Carai, Elisabetta Ferretti, Vincenzo Alfano, Agnese Po, Valentina Bertaina, Bianca Maria Goffredo, Maria Chiara Benedetti, Francesca Diomedi Camassei, Antonella Cacchione, Franco Locatelli, Angela Mastronuzzi,

Medulloblastoma (MB) is the most common malignant brain tumor in children. Despite therapeutic advancements, high-risk groups still present significant mortality. A deeper knowledge of the signaling pathways contributing to MB formation and aggressiveness would help develop new successful therapies. The target of rapamycin, mTOR signaling, is known to be involved ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(33):52900-52911]

Cited: 7 times

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LG-38MicroRNA PROFILING OF PEDIATRIC LOW-GRADE GLIOMAS (pLGGs).

Giuseppina Catanzaro, Zein Mersini Besharat, Angela Mastronuzzi, Andrea Carai, Evelina Miele, Agnese Po, Vincenzo Alfano, Marianna Silvano, Manila Antonelli, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti,

Neuro-oncology (Neuro-oncology)
[2016, 18(Suppl 3):iii87-iii87]

Cited: 0 times

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MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs.

Giuseppina Catanzaro, Zein Mersini Besharat, Neha Garg, Maurizio Ronci, Luisa Pieroni, Evelina Miele, Angela Mastronuzzi, Andrea Carai, Vincenzo Alfano, Agnese Po, Isabella Screpanti, Franco Locatelli, Andrea Urbani, Elisabetta Ferretti,

Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers. Among them, stem-like cells (hMB-SLCs) represent a fraction of the tumor cell population with the potential of self-renewal and proliferation and have been associated with tumor poor ... Read more >>

Stem Cells Int (Stem cells international)
[2016, 2016:2683042]

Cited: 6 times

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Characterization of medulloblastoma in Fanconi Anemia: a novel mutation in the BRCA2 gene and SHH molecular subgroup.

Evelina Miele, Angela Mastronuzzi, Agnese Po, Andrea Carai, Vincenzo Alfano, Annalisa Serra, Giovanna Stefania Colafati, Luisa Strocchio, Manila Antonelli, Francesca Romana Buttarelli, Massimo Zani, Sergio Ferraro, Amelia Buffone, Alessandra Vacca, Isabella Screpanti, Felice Giangaspero, Giuseppe Giannini, Franco Locatelli, Elisabetta Ferretti,

Fanconi Anemia (FA) is an inherited disorder characterized by the variable presence of multiple congenital somatic abnormalities, bone marrow failure and cancer susceptibility. Medulloblastoma (MB) has been described only in few cases of FA with biallelic inactivation in the tumor suppressor gene BRCA2/FANCD1 or its associated gene PALB2/FANCN. We report ... Read more >>

Biomark Res (Biomarker research)
[2015, 3:13]

Cited: 6 times

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