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Author Vincent Mallet

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Augmented base pairing networks encode RNA-small molecule binding preferences.

Carlos Oliver, Vincent Mallet, Roman Sarrazin Gendron, Vladimir Reinharz, William L Hamilton, Nicolas Moitessier, Jérôme Waldispühl,

RNA-small molecule binding is a key regulatory mechanism which can stabilize 3D structures and activate molecular functions. The discovery of RNA-targeting compounds is thus a current topic of interest for novel therapies. Our work is a first attempt at bringing the scalability and generalization abilities of machine learning methods to ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2020, :]

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OptiMol : Optimization of binding affinities in chemical space for drug discovery

Jacques Boitreaud, Carlos Oliver, Vincent Mallet, Jerome Waldispühl,

Abstract Ligand-based drug design has recently benefited from the boost of deep generative models. These models enable extensive explorations of the chemical space, and provide a platform for molecular optimization. However, current state of the art methods do not leverage the structure of the target, which is known to play ... Read more >>

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The Burden of Hyperbilirubinemia in Critically Ill Patients with Hematological Malignancies: Post-hoc Analysis of a Prospective Multicenter Multinational Study

Magali Bisbal, Michael Darmon, Colombe Saillard, Vincent Mallet, Charlotte Mouliade, Virginie Lemiale, Frederic Pene, Achille Kouatchet, Alexandre Demoule, Francois Vincent, Martine Nyunga, Fabrice Bruneel, Christine Lebert, Anne Renault, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Merce Jourdain, Elie Azoulay, Djamel Mokart,

Abstract Background The evidence on the clinical significance of hyperbilirubinemia (HB) in critically ill patients with hematological malignancies is scarce. We therefore studied its burden in a 2010-2011 Franco-Belgian multicenter prospective study designed to evaluate the prognosis of these patients. Patients and methods The cohort comprised 893 patients from 17 ... Read more >>

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Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study.

François Dépret, Clément Hoffmann, Laura Daoud, Camille Thieffry, Laure Monplaisir, Jules Creveaux, Djillali Annane, Erika Parmentier, Daniel Mathieu, Sandrine Wiramus, Dominique Demeure DIt Latte, Aubin Kpodji, Julien Textoris, Florian Robin, Kada Klouche, Emmanuel Pontis, Guillaume Schnell, François Barbier, Jean-Michel Constantin, Thomas Clavier, Damien du Cheyron, Nicolas Terzi, Bertrand Sauneuf, Emmanuel Guerot, Thomas Lafon, Alexandre Herbland, Bruno Megarbane, Thomas Leclerc, Vincent Mallet, Romain Pirracchio, Matthieu Legrand,

BACKGROUND:The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Intravenous hydroxocobalamin has however been shown to cause oxalate nephropathy in a single-center study. The impact of hydroxocobalamin on the risk of acute kidney injury (AKI) and survival after smoke inhalation in a multicenter ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):421]

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Identification of an Endoglin Variant Associated With HCV-Related Liver Fibrosis Progression by Next-Generation Sequencing.

Frédégonde About, Stéphanie Bibert, Emmanuelle Jouanguy, Bertrand Nalpas, Lazaro Lorenzo, Vimel Rattina, Mohammed Zarhrate, Sylvain Hanein, Mona Munteanu, Beat Müllhaupt, David Semela, Nasser Semmo, Jean-Laurent Casanova, Ioannis Theodorou, Philippe Sultanik, Thierry Poynard, Stanislas Pol, Pierre-Yves Bochud, Aurélie Cobat, Laurent Abel, , ,

Despite the astonishing progress in treating chronic hepatitis C virus (HCV) infection with direct-acting antiviral agents, liver fibrosis remains a major health concern in HCV infected patients, in particular due to the treatment cost and insufficient HCV screening in many countries. Only a fraction of patients with chronic HCV infection ... Read more >>

Front Genet (Frontiers in genetics)
[2019, 10:1024]

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Reply to: "Burden of hepatitis E infection and associated healthcare resource utilization among hematological malignancy-related hospitalizations: A national perspective in the United States, 2007-2014".

Johann von Felden, Vincent Mallet, Sven Pischke,

J. Hepatol. (Journal of hepatology)
[2019, 71(6):1268-1269]

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[FIB-4 index to rule-out advanced liver fibrosis in NAFLD patients].

Vincent Mallet, Lucia Parlati, Anaïs Vallet-Pichard, Benoit Terris, Emmanuel Tsochatzis, Philippe Sogni, Stanislas Pol,

The FIB-4 index is a biomarker of advanced hepatic fibrosis in a context of fatty liver disease. The calculation of the FIB-4 index requires of age, serum ALT and AST transaminase levels and platelet count. A FIB-4 index<1.45 in a context of fatty liver disease excludes clinically significant hepatic fibrosis. Additional explorations are mandatory ... Read more >>

Presse Med (Presse medicale (Paris, France : 1983))
[2019, 48(12):1484-1488]

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[The overlooked burden of hepatitis E in hematological patients].

Alienor Xhaard, Vincent Mallet,

Presse Med (Presse medicale (Paris, France : 1983))
[2019, 48(11 Pt 1):1210-1212]

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Reply to: "Potential role of ketamine in burn-associated cholestasis".

Matthieu Legrand, Christian de Tymowski, Kyann Hodjat, Vincent Mallet,

J. Hepatol. (Journal of hepatology)
[2019, 71(6):1276-1277]

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Management of Burns.

Matthieu Legrand, François Dépret, Vincent Mallet,

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(12):1188-1189]

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MRI presentation of hepatocellular carcinoma in non-alcoholic steatohepatitis (NASH).

Fatima Al-Sharhan, Anthony Dohan, Maxime Barat, Adlane Feddal, Benoit Terris, Stanislas Pol, Vincent Mallet, Philippe Soyer,

PURPOSE:To describe the magnetic resonance imaging (MRI) features of hepatocellular carcinoma (HCC) in patients with non-alcoholic steatohepatitis (NASH). METHODS:MRI examinations of 21 patients with HCC and NASH were analyzed by two observers. There were 18 men and 3 women with a mean age of 67.9 ± 10.2 (SD) years (range: 36-85 years). Images ... Read more >>

Eur J Radiol (European journal of radiology)
[2019, 119:108648]

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Transfusion-Transmitted Hepatitis E Virus Infection in France.

Pierre Gallian, Elodie Pouchol, Rachid Djoudi, Sébastien Lhomme, Lina Mouna, Sylvie Gross, Philippe Bierling, Azzedine Assal, Nassim Kamar, Vincent Mallet, Anne-Marie Roque-Afonso, Jacques Izopet, Pierre Tiberghien,

There is growing concern regarding the risk of transfusion- transmitted (TT) hepatitis E. Since the first described case in 2006, several TT hepatitis E have been reported to the French hemovigilance network. We performed a retrospective analysis of all cases of TT hepatitis E reported between 2006 and 2016. Transfusion-transmitted ... Read more >>

Transfus Med Rev (Transfusion Medicine Reviews)
[2019, 33(3):146-153]

Cited: 1 time

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Can we differentiate HIV-associated obliterative portopathy from liver cirrhosis using MRI?

Esther Chouraqui, Laura Leguilloux, Anthony Dohan, Hervé Gouya, Matthias Barral, Anais Vallet-Pichard, Philippe Sogni, Stanislas Pol, Vincent Mallet, Philippe Soyer,

AIM:To describe the magnetic resonance imaging (MRI) features of HIV-associated obliterative portopathy (HIV-OP) and determine the most indicative appearance of this condition on MRI by using a retrospective case-control study. METHODS:MRI examinations of 24 patients with HIV-OP (16 men, 8 women; mean age = 48 ± 6.6 [SD] years; age range, 35-71 years) were analyzed ... Read more >>

Eur Radiol (European radiology)
[2020, 30(1):213-223]

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Augmented base pairing networks encode RNA-small molecule binding preferences

Carlos Oliver, Vincent Mallet, Roman Sarrazin Gendron, Vladimir Reinharz, William Hamilton, Nicolas Moitessier, Jérôme Waldispühl,

A bstract Motivation The binding of small molecules to RNAs is an important mechanism which can stabilize 3D structures or activate key molecular functions. To date, computational and experimental efforts toward small molecule binding prediction have primarily focused on protein targets. Considering that a very large portion of the genome ... Read more >>

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Contributing factors and outcomes of burn-associated cholestasis.

Christian de Tymowski, François Dépret, Sabri Soussi, Moreno Nabila, Thomas Vauchel, Maité Chaussard, Mourad Benyamina, Axelle Ferry, Alexandru Cupaciu, Marion Jully, Haikel Oueslati, Alexandre Fratani, Maxime Coutrot, Philippe Sogni, Maurice Mimoun, Marc Chaouat, Anne-Marie Zagdanski, Eric De Kerviler, Alexandre Mebazaa, Richard Moreau, Vincent Mallet, Matthieu Legrand, ,

BACKGROUND & AIMS:Cholestasis often occurs after burn injuries. However, the prevalence of cholestasis and its effect on outcomes in patients with severe burn injuries are unknown. The aim of this study was to describe the course and the burden of cholestasis in a cohort of severely burned adult patients. METHODS:We ... Read more >>

J. Hepatol. (Journal of hepatology)
[2019, 71(3):563-572]

Cited: 1 time

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Hepatitis E and Allogeneic Hematopoietic Stem Cell Transplantation: A French Nationwide SFGM-TC Retrospective Study.

Aliénor Xhaard, Anne-Marie Roque-Afonso, Vincent Mallet, Patricia Ribaud, Stéphanie Nguyen-Quoc, Pierre-Simon Rohrlich, Reza Tabrizi, Johanna Konopacki, Séverine Lissandre, Florence Abravanel, Régis Peffault de Latour, Anne Huynh,

Usually self-limited, hepatitis E virus (HEV) infection may evolve to chronicity and cirrhosis in immunosuppressed patients. HEV infection has been described in solid-organ transplantation and hematology patients, but for allogeneic hematopoietic stem cell transplant (alloHSCT) recipients, only small cohorts are available. This retrospective nationwide multi-center series aimed to describe HEV ... Read more >>

Viruses (Viruses)
[2019, 11(7):]

Cited: 1 time

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The burden of hepatitis E among patients with haematological malignancies: A retrospective European cohort study.

Johann von Felden, Laurent Alric, Sven Pischke, Celia Aitken, Stefan Schlabe, Ulrich Spengler, Maria Teresa Giordani, Paul Schnitzler, Dominik Bettinger, Robert Thimme, Alienor Xhaard, Mascha Binder, Francis Ayuk, Ansgar W Lohse, Jan J Cornelissen, Robert A de Man, Vincent Mallet,

BACKGROUND & AIMS:The burden of hepatitis E virus (HEV) infection among patients with haematological malignancy has only been scarcely reported. Therefore, we aimed to describe this burden in patients with haematological malignancies, including those receiving allogeneic haematopoietic stem cell transplantation. METHODS:We conducted a retrospective, multicentre cohort study across 11 European ... Read more >>

J. Hepatol. (Journal of hepatology)
[2019, 71(3):465-472]

Cited: 6 times

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Chronic Hepatitis E in Rheumatology and Internal Medicine Patients: A Retrospective Multicenter European Cohort Study.

Sven Pischke, Jean-Marie Peron, Moritz von Wulffen, Johann von Felden, Christoph Höner Zu Siederdissen, Sophie Fournier, Marc Lütgehetmann, Christoph Iking-Konert, Dominik Bettinger, Gabriella Par, Robert Thimme, Alain Cantagrel, Ansgar W Lohse, Heiner Wedemeyer, Robert de Man, Vincent Mallet,

Objectives: Hepatitis E virus (HEV) infection is a pandemic with regional outbreaks, including in industrialized countries. HEV infection is usually self-limiting but can progress to chronic hepatitis E in transplant recipients and HIV-infected patients. Whether other immunocompromised hosts, including rheumatology and internal medicine patients, are at risk of developing chronic ... Read more >>

Viruses (Viruses)
[2019, 11(2):]

Cited: 3 times

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Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth.

Clémence Hollande, Jeremy Boussier, James Ziai, Tamaki Nozawa, Vincent Bondet, Wilson Phung, Binfeng Lu, Darragh Duffy, Valerie Paradis, Vincent Mallet, Gérard Eberl, Wendy Sandoval, Jill M Schartner, Stanislas Pol, Rosa Barreira da Silva, Matthew L Albert,

Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell migration and tumor immunity by preserving functional chemokine CXCL10. By extending those initial findings to pre-clinical models of hepatocellular carcinoma and breast cancer, we discovered ... Read more >>

Nat. Immunol. (Nature immunology)
[2019, 20(3):257-264]

Cited: 18 times

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Hepatitis C Virus Infection in Patients With Cancer: Impact on Clinical Trial Enrollment, Selection of Therapy, and Prognosis.

Harrys A Torres, Pooja Pundhir, Vincent Mallet,

Gastroenterology (Gastroenterology)
[2019, 157(4):909-916]

Cited: 0 times

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European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia.

Johan A Maertens, Corrado Girmenia, Roger J Brüggemann, Rafael F Duarte, Christopher C Kibbler, Per Ljungman, Zdenek Racil, Patricia Ribaud, Monica A Slavin, Oliver A Cornely, J Peter Donnelly, Catherine Cordonnier, , ,

The European Conference on Infections in Leukaemia (ECIL) updated its guidelines on antifungal prophylaxis for adults using the grading system of IDSA. The guidelines were extended to provide recommendations for other haematological diseases besides AML and recipients of an allogeneic haematopoietic stem cell transplantation (HSCT). Posaconazole remains the drug of ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2018, 73(12):3221-3230]

Cited: 14 times

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Incidence of grade 3-4 liver injury under immune checkpoints inhibitors: A retrospective study.

Lucia Parlati, Anais Vallet-Pichard, Rui Batista, Alain Hernvann, Philippe Sogni, Stanislas Pol, Vincent Mallet, ,

J. Hepatol. (Journal of hepatology)
[2018, 69(6):1396-1397]

Cited: 1 time

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Transmission of Hepatitis E Virus With Plasma Exchange in Kidney Transplant Recipients: A Retrospective Cohort Study.

Vincent Mallet, Rebecca Sberro-Soussan, Anne-Marie Roque-Afonso, Anaïs Vallet-Pichard, Bénédicte Deau, Alix Portal, Marie-Laure Chaix, Lisette Hauser, Alexandre Beylouné, Anne Mercadier, Jacques Izopet, Christophe Legendre, Stanislas Pol,

BACKGROUND:After observing a case of plasma exchange-mediated hepatitis E virus (HEV) infection in a kidney transplant recipient, we investigated the relationship between plasma exchange and HEV infection after kidney transplantation. METHODS:A cohort of 263 patients who underwent kidney transplantation from January 1, 2011, through December 31, 2012, was screened for ... Read more >>

Transplantation (Transplantation)
[2018, 102(8):1351-1357]

Cited: 2 times

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Chronic hepatitis E in patients with indolent lymphoma after treatment with rituximab and bendamustine.

Khaled Alnuaimi, Julie Lavolé, Caroline Lascoux-Combes, Anne-Marie Roque Afonso, Philippe Sogni, Stanislas Pol, Vincent Mallet,

Hepatology (Hepatology (Baltimore, Md.))
[2018, 67(6):2468-2470]

Cited: 1 time

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"Who killed JR": Chronic hepatitis C or alcohol use disorders?

Michaël Schwarzinger, Jürgen Rehm, Vincent Mallet,

J. Hepatol. (Journal of hepatology)
[2018, 68(5):1098-1099]

Cited: 2 times

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