Full Text Journal Articles by
Author Vinay Sakhuja

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Cytomegalovirus Infection in Postrenal Transplant Recipients: 18 Years' Experience From a Tertiary Referral Center.

Ranjana W Minz, Mahendra Kumar, Deepesh B Kanwar, Ashish Sharma, Prabhsimran Singh, Jagdeep Singh, Sarbpreet Singh, Shashi Anand, Vinay Sakhuja, Mukut Minz,

BACKGROUND:Cytomegalovirus (CMV) reactivation or infection is one of the most important infectious complications in transplant recipient leading to significant morbidity and mortality. Its early detection and prompt treatment is imperative to improve transplant outcome. The present study estimated the frequency of CMV in renal transplant recipients (RTR). Various aspects of ... Read more >>

Transplant. Proc. (Transplantation proceedings)
[2020, :]

Cited: 0 times

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Pretransplant HbA1c and Glucose Metabolism Parameters in Predicting Posttransplant Diabetes Mellitus and Their Course in the First 6 Months After Living-Donor Renal Transplant.

Namrata Rao, Manish Rathi, Ashish Sharma, Raja Ramachandran, Vivek Kumar, Harbir Singh Kohli, Krishan Lal Gupta, Vinay Sakhuja,

OBJECTIVES:Posttransplant diabetes mellitus is a common and serious metabolic complication after renal transplant. Patients with uremia are known to have abnormal glucose metabolism characterized by insulin resistance and defects in insulin secretion, which are ameliorated to some extent with renal replacement therapy and more so with renal transplant. However, the ... Read more >>

Exp Clin Transplant (Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation)
[2018, 16(4):446-454]

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Two-Year Follow-up Study of Membranous Nephropathy Treated With Tacrolimus and Corticosteroids Versus Cyclical Corticosteroids and Cyclophosphamide.

Raja Ramachandran, Ashok Kumar Yadav, Vinod Kumar, Venkata Siva Tez Pinnamaneni, Ritambhra Nada, Ratan Ghosh, Vivek Kumar, Manish Rathi, Harbir Singh Kohli, Krishan Lal Gupta, Vinay Sakhuja, Vivekanand Jha,

Both cCTX/GCs and CNIs are recommended as first-line agents in the management of PMN. The present study is an extended report of patients randomized to receive TAC/GCs or cCTX/GCs at 2 years post randomization.Seventy patients enrolled in the clinical trial Tacrolimus Combined With Corticosteroids Versus Modified Ponticelli Regimen in Treatment ... Read more >>

Kidney Int Rep (Kidney international reports)
[2017, 2(4):610-616]

Cited: 5 times

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Management of Hypertension in Chronic Kidney Disease: Consensus Statement by an Expert Panel of Indian Nephrologists.

Georgi Abraham, K N Arun, N Gopalakrishnan, S Renuka, Dilip Kumar Pahari, Pradeep Deshpande, Rajan Isaacs, Deodatta Shripad Chafekar, Vijay Kher, Alan Fernandes Almeida, Vinay Sakhuja, Sankaran Sundar, Sanjeev Gulati, Abi Abraham, R Padmanaban,

J Assoc Physicians India (The Journal of the Association of Physicians of India)
[2017, 65(2 Suppl):6-22]

Cited: 0 times

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Non-imaging assisted insertion of un-cuffed, non-tunneled internal jugular venous catheters for hemodialysis: Safety and utility in modern day world.

Manish Rathi, Venkata Siva Tez Pinnamaneni, Vinay Sakhuja,

<label>BACKGROUND</label>Absolute necessity in acute kidney injury (AKI) and ignorance in chronic kidney disease (CKD) make the use of un-cuffed, non-tunneled catheters an indispensable vascular access for hemodialysis. Although these catheters should be inserted under radiological guidance, it may not be feasible in certain circumstances. The aim of the present study ... Read more >>

Biomed J (Biomedical Journal)
[2016, 39(4):283-288]

Cited: 1 time

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A prospective study of collapsing focal segmental glomerulosclerosis.

Ramachandran Raja, Ritambhra Nada, Ashok K Yadav, Ashwani Kumar, Ajay Goyal, Vivek Kumar, Manish Rathi, H S Kohli, K L Gupta, Vinay Sakhuja, Vivekanand Jha,

Collapsing focal segmental glomerulosclerosis (cFSGS) is characterized by rapid progression to end-stage renal disease (ESRD). We evaluated the clinicopathological spectrum of cFSGS and compared its clinical behavior to steroid and tacrolimus (TAC)-resistant noncollapsing focal segmental glomerulosclerosis (FSGS). All patients (>14 years) diagnosed with cFSGS were enrolled in the study. Staining ... Read more >>

Ren Fail (Renal failure)
[2016, 38(6):894-898]

Cited: 1 time

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Correlates of hematuria on glomerular histology and electron microscopy in IgA nephropathy.

Rohit Tewari, Ritambhra Nada, Maninder Kaur, Puja Dudeja, Charan Singh Rayat, Vinay Sakhuja, Kusum Joshi,

Hematuria is the most important clinical manifestation of IgA nephropathy. This study was undertaken with the objective to describe the spectrum of histological changes with reference to the Oxford classification and the ultrastructural changes in the glomerular basement membrane and to correlate them with hematuria.66 patients who underwent renal biopsy ... Read more >>

Med J Armed Forces India (Medical journal, Armed Forces India)
[2016, 72(2):120-124]

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Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft.

Rohit Tewari, Kusum Joshi, Ashwani Kumar, C S Rayat, Rajaram Iyer, Vinay Sakhuja, Mukut Minz,

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described. A 55-year-old male presented with rapid deterioration of renal function. Light microscopy showed membranoproliferative glomerulonephritis with kappa light chain restriction and only one sub-class of IgG. ... Read more >>

Saudi J Kidney Dis Transpl (Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia)
[2016, 27(2):381-385]

Cited: 3 times

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Tacrolimus combined with corticosteroids versus Modified Ponticelli regimen in treatment of idiopathic membranous nephropathy: Randomized control trial.

Raja Ramachandran, Harsha Kumar Hn, Vinod Kumar, Ritambhra Nada, Ashok Kumar Yadav, Ajay Goyal, Vivek Kumar, Manish Rathi, Vivekanand Jha, Krishan Lal Gupta, Vinay Sakhuja, Harbir Singh Kohli,

There have been very few studies comparing cyclophosphamide (CTX) and calcineurin inhibitor based regimens in the management of non-immunosuppressive symptomatic therapy (NIST) resistant idiopathic membranous nephropathy (IMN). The present study was aimed at comparing the efficacy and safety of tacrolimus (TAC)/steroids with cyclical CTX/steroids (Modified Ponticelli regimen (MPR)) in patients ... Read more >>

Nephrology (Carlton) (Nephrology (Carlton, Vic.))
[2016, 21(2):139-146]

Cited: 30 times

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Comparison of low-dose intravenous cyclophosphamide with oral mycophenolate mofetil in the treatment of lupus nephritis.

Manish Rathi, Ajay Goyal, Ajay Jaryal, Aman Sharma, Pramod K Gupta, Raja Ramachandran, Vivek Kumar, Harbir S Kohli, Vinay Sakhuja, Vivekanand Jha, Krishan L Gupta,

No previous study has compared mycophenolate mofetil (MMF) with low-dose cyclophosphamide (CYC) in the treatment of lupus nephritis (LN). To do so, we recruited patients with LN (class III, IV, or V) and randomized them to receive either low-dose CYC or oral MMF. Those with crescentic LN, a serum creatinine ... Read more >>

Kidney Int. (Kidney international)
[2016, 89(1):235-242]

Cited: 26 times

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PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians.

Raja Ramachandran, Vinod Kumar, Ashwani Kumar, Ashok Kumar Yadav, Ritambhra Nada, Harsha Kumar, Vivek Kumar, Manish Rathi, Harbir Singh Kohli, Krishan Lal Gupta, Vinay Sakhuja, Vivekanand Jha,

Antibodies to M-type phospholipase A2 receptor (PLA2R) correlate with clinical activity of primary membranous nephropathy (PMN). Risk alleles in PLA2R1 and HLA-DQA1 genes are associated with PMN. Whether these alleles are associated with the development of anti-PLA2R is unknown. In this prospective study we evaluated anti-PLA2R, enhanced glomerular staining for ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2016, 31(9):1486-1493]

Cited: 24 times

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Non-invasive screening tool for chronic kidney disease.

Anita Saxena, Amit Gupta, Georgi Abraham, Vinay Sakhuja, V Jha,

Saudi J Kidney Dis Transpl (Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia)
[2015, 26(6):1311-1313]

Cited: 0 times

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Pauci-immune glomerulonephritis: does negativity of anti-neutrophilic cytoplasmic antibodies matters?

Aman Sharma, Ritambra Nada, Godasi S R S N K Naidu, Ranjana W Minz, Harbir Singh Kohli, Vinay Sakhuja, Krishan Lal Gupta, Manish Rathi,

A significant proportion of pauci-immune glomerulonephritis (PIGN) patients are reported to have absence of anti-neutrophilic cytoplasmic antibodies (ANCA). However, studies are controversial regarding their significance and there is limited data after the new prognostic classification of PIGN.Renal biopsy-proven cases of PIGN were included and their clinical details, ANCA status by ... Read more >>

Int J Rheum Dis (International journal of rheumatic diseases)
[2016, 19(1):74-81]

Cited: 8 times

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Sequential changes in bone biochemical parameters and bone mineral density after renal transplant.

Manish Rathi, Deepak Kumar, Sanjay Kumar Bhadada, Niranjan Khandelwal, Harbir S Kohli, Vivekanand Jha, Vinay Sakhuja,

To evaluate sequential changes in biochemical bone parameters, parathyroid hormone (iPTH), vitamin D levels and bone mineral density (BMD) over a period of 24 weeks after renal transplantation, we studied 75 patients (58 males, with a mean age of 35.4 years) who underwent their first renal transplantation without a past ... Read more >>

Saudi J Kidney Dis Transpl (Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia)
[2015, 26(4):671-677]

Cited: 0 times

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Clinico-pathologic spectrum of C3 glomerulopathy-an Indian experience.

Ganesh Kumar Viswanathan, Ritambhra Nada, Ashwani Kumar, Raja Ramachandran, Charan Singh Rayat, Vivekanand Jha, Vinay Sakhuja, Kusum Joshi,

C3 glomerulopathy (C3GP) is characterized by deposition of complement C3 with absence/traces of immunoglobulins in the glomeruli and categorized into dense deposit disease (DDD), C3 glomerulonephritis (C3GN), complement factor H related protein 5(CFHR5) nephropathy etc. Collaborative efforts of pathologists, complement biologists and nephrologists worldwide are expanding the histomorphological pattern and ... Read more >>

Diagn Pathol (Diagnostic pathology)
[2015, 10:6]

Cited: 4 times

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Histopathological indicators of disease outcome in class IV lupus nephritis: a revisit of various indices.

Manish Rathi, Krishan Lal Gupta, Kusum Joshi, Pramod K Gupta, Aman Sharma, Harbir Singh Kohli, Vivekanand Jha, Vinay Sakhuja,

Current management guidelines for lupus nephritis (LN) do not attach importance to histological indices of disease activity or chronicity. The present study was performed to evaluate the clinical relevance of these indices in determining outcomes in patients with class IV LN. We analyzed the data of all patients with biopsy-proven ... Read more >>

Rheumatol. Int. (Rheumatology international)
[2015, 35(9):1511-1517]

Cited: 3 times

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Safety and efficacy of autologous mesenchymal stromal cells transplantation in patients undergoing living donor kidney transplantation: a pilot study.

Chetan Mudrabettu, Vinod Kumar, Aruna Rakha, Ashok K Yadav, Raja Ramachandran, Deepesh B Kanwar, Ritambhra Nada, Mukut Minz, Vinay Sakhuja, Neelam Marwaha, Vivekanand Jha,

AIM: This pilot study assesses the safety and feasibility of autologous mesenchymal stromal cell (MSC) transplantation in four patients that underwent living donor renal transplantation, and the effect on the immunophenotype and functionality of peripheral T lymphocytes following transplantation. METHODS: All patients received low dose ATG induction followed by calcineurin ... Read more >>

Nephrology (Carlton) (Nephrology (Carlton, Vic.))
[2015, 20(1):25-33]

Cited: 26 times

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Correlation of proteinuria with podocyte foot process effacement in IgA nephropathy: an ultrastructural study.

Rohit Tewari, Ritambhra Nada, Charan Singh Rayat, Dibyajyoti Boruah, Puja Dudeja, Kusum Joshi, Vinay Sakhuja,

Proteinuria is an uncommon clinical manifestation of IgA nephropathy and is usually seen in cases with severe lesions like endocapillary proliferation. However, it is occasionally seen even with cases with mild glomerular manifestations and may even be of nephrotic range.Podocyte foot process effacement.Severity of proteinuria.Podocyte foot process effacement was measured. ... Read more >>

Ultrastruct Pathol (Ultrastructural pathology)
[2015, 39(2):147-151]

Cited: 2 times

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Serum proteomic profiling in granumomatosis with polyangiitis using two-dimensional gel electrophoresis along with matrix assisted laser desorption ionization time of flight mass spectrometry.

Lekha Rani, Ranjana W Minz, Amit Arora, Monica Kannan, Aman Sharma, Shashi Anand, Dheeraj Gupta, Naresh K Panda, Vinay K Sakhuja,

AIM: The present study is a proteomic approach to find differentially expressed proteins in sera of limited and systemic subsets of active disease versus their remitting state in patients with granulomatosis with polyangiitis (GPA) and their correlation with disease activity. METHODS: Eighteen patients with GPA in active as well as ... Read more >>

Int J Rheum Dis (International journal of rheumatic diseases)
[2014, 17(8):910-919]

Cited: 4 times

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Is there need of an extension channel/new double-cuffed channel in surgical management for channel perforation and aneurysm of Tenckhoff catheter?: modified partial replantation.

Dig Vijay Singh, Shrawan Kumar Singh, Vivekanand Jha, Vinay Sakhuja,

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2014, 34(5):549-552]

Cited: 0 times

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Potential of organ donation from deceased donors: study from a public sector hospital in India.

Vivek Kumar, Ravinder Ahlawat, Anil K Gupta, Rakesh K Sharma, Mukut Minz, Vinay Sakhuja, Vivekanand Jha,

Deceased donor organ programme is still in infancy in India. Assessing deceased donation potential and identifying barriers to its utilization are required to meet needs of patients with organ failure. Over a 6-month period, we identified and followed all presumed brainstem dead patients secondary to brain damage. All patients requiring ... Read more >>

Transpl. Int. (Transplant international : official journal of the European Society for Organ Transplantation)
[2014, 27(10):1007-1014]

Cited: 4 times

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An analysis of transplant glomerulopathy and thrombotic microangiopathy in kidney transplant biopsies.

Sreejesh Sreedharanunni, Kusum Joshi, Rajan Duggal, Ritambhra Nada, Mukut Minz, Vinay Sakhuja,

Glomerular diseases of the transplanted kidney are the most important cause of poor long- term outcome. The estimation of the magnitude of this problem and an elucidation of pathogenic mechanism is essential for improvement of graft survival. This study from the Indian subcontinent aims (i) to determine the incidence of ... Read more >>

Transpl. Int. (Transplant international : official journal of the European Society for Organ Transplantation)
[2014, 27(8):784-792]

Cited: 5 times

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A rare case of Cytomegalovirus, Scedosporium apiospermum and Mycobacterium tuberculosis in a renal transplant recipient.

Manish Rathi, Srikant Gundlapalli, Raja Ramachandran, Sandeep Mohindra, Harsimran Kaur, Vivek Kumar, Harbir Singh Kohli, Krishan Lal Gupta, Vinay Sakhuja,

BACKGROUND: Renal transplant recipients are at high risk of developing multiple infections, often concomitantly because of their immunocompromised status. Post renal transplant infections are often elusive and require extensive evaluation for proper diagnosis and treatment. A high index of suspicion is required and an attempt should be made to confirm ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2014, 14:259]

Cited: 4 times

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Tacrolimus therapy in adult-onset steroid-resistant nephrotic syndrome due to a focal segmental glomerulosclerosis single-center experience.

Raja Ramachandran, Vivek Kumar, Manish Rathi, Ritambhra Nada, Vivekanand Jha, Krishan Lal Gupta, Vinay Sakhuja, Harbir Singh Kohli,

INTRODUCTION: Management of adults with steroid-resistant (SR) nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS) is a challenging task. Is tacrolimus (TAC) effective in this situation without serious adverse effects? This prospective study was done to answer this question. MATERIALS AND METHODS: In patients with SR nephrotic syndrome due to ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2014, 29(10):1918-1924]

Cited: 18 times

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Podocin and beta dystroglycan expression to study podocyte-podocyte and basement membrane matrix connections in adult protienuric states.

Praveen B Shankar, Ritambhra Nada, Kusum Joshi, Ashwani Kumar, Charan Singh Rayat, Vinay Sakhuja,

BACKGROUND: Podocytes can be the primary site of injury or secondarily involved in various protienuric states. Cross talk between adjacent foot processes and with basement membrane is important for slit diaphragm function. Does expression of podocyte associated proteins in kidney biopsies alter with site/type of primary injury? Genetic mutations of ... Read more >>

Diagn Pathol (Diagnostic Pathology)
[2014, 9:40]

Cited: 0 times

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