Full Text Journal Articles by
Author Ville Holmberg

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Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements.

Juha Rannikko, Ville Holmberg, Matti Karppelin, Pertti Arvola, Reetta Huttunen, Eero Mattila, Niina Kerttula, Teija Puhto, Ülle Tamm, Irma Koivula, Risto Vuento, Jaana Syrjänen, Ulla Hohenthal,

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):]

Cited: 0 times

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Male predominance in disease severity and mortality in a low Covid-19 epidemic and low case-fatality area - a population-based registry study.

Erik Forsblom, Suvi Silén, Elisa Kortela, Maarit Ahava, Hanna-Riikka Kreivi, Ville Holmberg, Asko Järvinen, Johanna Hästbacka, Sanna-Maria Kivivuori, Atte Meretoja,

<h4>Background</h4>Men reportedly suffer from a more severe disease and higher mortality during the global SARS-CoV-2 (Covid-19) pandemic. We analysed sex differences in a low epidemic area with low overall mortality in Covid-19 in a population based setting with patients treated in specialized healthcare.<h4>Methods</h4>We entered all hospitalized laboratory-confirmed Covid-19 cases of ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2021, :1-11]

Cited: 0 times

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Maternal health care utilization and the obstetric outcomes of undocumented women in Finland – a retrospective register-based study

Janita Tasa, Ville Holmberg, Susanna Sainio, Päivi Kankkunen, Katri Vehviläinen-Julkunen,

<h4>Background: </h4> Undocumented pregnant women constitute a vulnerable group of people who lack equal access to pregnancy care. Previous research has shown that undocumented migrants encounter difficulties in accessing health services, the onset of prenatal care is delayed, and women have an increased risk for infectious diseases. The aim of ... Read more >>

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Epidemiology and outcome of HIV patients in Finland co-infected with tuberculosis 1998-2015.

Ville Holmberg, Hanna Soini, Pia Kivelä, Jukka Ollgren, Matti Ristola,

<h4>Background</h4>Tuberculosis (TB) is a major cause of death in HIV patients worldwide. Here we describe the epidemiology and outcome of HIV-TB co-infections in a high-income country with low TB incidence and integrated HIV and TB therapy according to European guidelines.<h4>Methods</h4>This study was based on the HIV cohort of the Helsinki ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2019, 19(1):264]

Cited: 1 time

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Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia.

A Inkeri Lokki, Tea Kaartokallio, Ville Holmberg, Päivi Onkamo, Lotta L E Koskinen, Päivi Saavalainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Pia M Villa, Leena Hiltunen, Hannele Laivuori, Seppo Meri,

Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood. In this study, we determined the potential linkage of severe PE to the most central complement gene, <i>C3</i>. Three cohorts of Finnish patients and ... Read more >>

Front Immunol (Frontiers in immunology)
[2017, 8:589]

Cited: 15 times

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Automated segmentation of blood cells in Giemsa stained digitized thin blood films

Margarita Walliander, Riku Turkki, Nina Linder, Mikael Lundin, Juho Konsti, Ville Ojansivu, Taru Meri, Ville Holmberg, Johan Lundin,

Diagn Pathol (Diagnostic pathology)
[2013, 8(Suppl 1):S37-S37]

Cited: 4 times

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Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria.

Ville Holmberg, Päivi Onkamo, Elisa Lahtela, Päivi Lahermo, George Bedu-Addo, Frank P Mockenhaupt, Seppo Meri,

<h4>Background</h4>Innate immunity plays a crucial role in the host defense against malaria including Plasmodium falciparum malaria in pregnancy, but the roles of the various underlying genes and mechanisms predisposing to the disease are poorly understood.<h4>Methods</h4>98 single-nucletoide polymorphisms were genotyped in a set of 17 functionally related genes of the complement ... Read more >>

Malar J (Malaria journal)
[2012, 11:61]

Cited: 17 times

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Lactase persistence genotypes and malaria susceptibility in Fulani of Mali.

A Inkeri Lokki, Irma Järvelä, Elisabeth Israelsson, Bakary Maiga, Marita Troye-Blomberg, Amagana Dolo, Ogobara K Doumbo, Seppo Meri, Ville Holmberg,

<h4>Background</h4>Fulani are a widely spread African ethnic group characterized by lower susceptibility to Plasmodium falciparum, clinical malaria morbidity and higher rate of lactase persistence compared to sympatric tribes. Lactase non-persistence, often called lactose intolerance, is the normal condition where lactase activity in the intestinal wall declines after weaning. Lactase persistence, ... Read more >>

Malar J (Malaria journal)
[2011, 10:9]

Cited: 23 times

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Screening of variants for lactase persistence/non-persistence in populations from South Africa and Ghana.

Suvi Torniainen, M Iqbal Parker, Ville Holmberg, Elisa Lahtela, Collet Dandara, Irma Jarvela,

<h4>Background</h4>Lactase non-persistence is a condition where lactase activity is decreased in the intestinal wall after weaning. In European derived populations a single nucleotide polymorphism (SNP) C/T-13910 residing 13.9 kb upstream from the lactase gene has been shown to define lactase activity, and several other single nucleotide polymorphisms (G/C-14010 T/G-13915, C/G-13907 ... Read more >>

BMC Genet (BMC genetics)
[2009, 10:31]

Cited: 23 times

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Rapid increase in the prevalence of sulfadoxine-pyrimethamine resistance among Plasmodium falciparum isolated from pregnant women in Ghana.

Frank P Mockenhaupt, George Bedu-Addo, Teunis A Eggelte, Lena Hommerich, Ville Holmberg, Christa von Oertzen, Ulrich Bienzle,

Use of intermittent preventive treatment with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) has become policy in much of sub-Saharan Africa but crucially depends on the efficacy of SP. We assessed the frequency of the dhfr triple mutation among Plasmodium falciparum isolates obtained from pregnant Ghanaian women in 1998, 2000, and 2006. ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2008, 198(10):1545-1549]

Cited: 46 times

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Decline of placental malaria in southern Ghana after the implementation of intermittent preventive treatment in pregnancy.

Lena Hommerich, Christa von Oertzen, George Bedu-Addo, Ville Holmberg, Patrick A Acquah, Teunis A Eggelte, Ulrich Bienzle, Frank P Mockenhaupt,

<h4>Background</h4>Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) has been adopted as policy by many countries in sub-Saharan Africa. However, data on the post-implementation effectiveness of this measure are scarce.<h4>Methods</h4>Clinical and parasitological parameters were assessed among women delivering at a district hospital in rural southern Ghana in the year 2000 ... Read more >>

Malar J (Malaria journal)
[2007, 6:144]

Cited: 49 times

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Mannose-binding lectin variant associated with severe malaria in young African children.

Ville Holmberg, Friederike Schuster, Ekkehart Dietz, J Chantale Sagarriga Visconti, Sylvester D Anemana, Ulrich Bienzle, Frank P Mockenhaupt,

Mannose-binding lectin (MBL) is a serum protein which initiates innate immune responses to microbial pathogens by binding to non-self surface oligosaccharides. MBL deficiency is the most common congenital immunodeficiency of human and has been shown to predispose to infections, particularly in children and immune compromised. In a matched case-control study ... Read more >>

Microbes Infect (Microbes and infection)
[2008, 10(4):342-348]

Cited: 20 times

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The mouse ortholog of the neuronal ceroid lipofuscinosis CLN5 gene encodes a soluble lysosomal glycoprotein expressed in the developing brain.

Ville Holmberg, Anu Jalanko, Juha Isosomppi, Anna-Liisa Fabritius, Leena Peltonen, Outi Kopra,

Neuronal ceroid lipofuscinoses (NCLs) are recessively inherited neurodegenerative lysosomal storage disorders characterized by progressive motor and mental retardation, visual failure, and epileptic seizures. Finnish variant late infantile NCL (vLINCL(Fin)) is caused by mutations in the CLN5 gene. We have isolated the mouse Cln5 gene and analyzed its spatiotemporal expression in ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2004, 16(1):29-40]

Cited: 36 times

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