Full Text Journal Articles by
Author Vijay Kumar Prajapati

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Asymptomatic malaria infection prevailing risks for human health and malaria elimination.

Dhaneswar Prusty, Nidhi Gupta, Arun Upadhyay, Ashraf Dar, Biswajit Naik, Navin Kumar, Vijay Kumar Prajapati,

There has been a consistent rise in malaria cases in the last few years. The existing malaria control measures are challenged by insecticide resistance in the mosquito vector, drug résistance in parasite populations, and asymptomatic malaria (ASM) in healthy individuals. The absence of apparent malaria symptoms and the presence of ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2021, 93:104987]

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Critical evaluation of the utility of pre- and post-therapy immunophenotypes in assessment of measurable residual disease in B-ALL.

Nupur Das, Ritu Gupta, Sanjeev Kumar Gupta, Sameer Bakhshi, Rachna Seth, Chandan Kumar, Sandeep Rai, Saroj Singh, Vijay Kumar Prajapati, Ajay Gogia, Ranjit Kumar Sahoo, Atul Sharma, Lalit Kumar,

Measurable residual disease (MRD) is an important parameter to predict outcome in B-cell acute lymphoblastic leukemia (B-ALL). Two different approaches have been used for the assessment of MRD by multiparametric flow cytometry that include the "Leukemia Associated Aberrant Immunophenotype (LAIP)" and "Difference from Normal (DFN)" approach. In this retrospective study, ... Read more >>

Ann Hematol (Annals of hematology)
[2021, :]

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Cognizance of posttranslational modifications in vaccines: A way to enhanced immunogenicity.

Rupal Ojha, Vijay Kumar Prajapati,

Vaccination is a significant advancement or preventative strategy for controlling the spread of various severe infectious and noninfectious diseases. The purpose of vaccination is to stimulate or activate the immune system by injecting antigens, i.e., either whole microorganisms or using the pathogen's antigenic part or macromolecules. Over time, researchers have ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2021, :]

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Interleukin-17-A multifaceted cytokine in viral infections.

Utkarsha Sahu, Debasis Biswas, Vijay Kumar Prajapati, Anirudh K Singh, Mukesh Samant, Prashant Khare,

Viral infections are a major threat to the human population due to the lack of selective therapeutic measures. The morbidity and mortality reported worldwide are very alarming against viral pathogens. The proinflammatory environment is required for viral inhibition by initiating the host immune response. The host immune response fights these ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2021, :]

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Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases.

Arun Upadhyay, Ayeman Amanullah, Vibhuti Joshi, Rohan Dhiman, Vijay Kumar Prajapati, Krishna Mohan Poluri, Amit Mishra,

Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout. Ibuprofen acts as a potential inhibitor for cyclooxygenase enzymes (COX-1 and COX-2). In the past few decades, research on this small molecule ... Read more >>

Drug Metab Rev (Drug metabolism reviews)
[2021, 53(1):100-121]

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Complex Inclusion Bodies and Defective Proteome Hubs in Neurodegenerative Disease: New Clues, New Challenges.

Arun Upadhyay, Naveen Sundaria, Rohan Dhiman, Vijay Kumar Prajapati, Amit Prasad, Amit Mishra,

A healthy physiological environment of cells represents the dynamic homeostasis of crowded molecules. A subset of cellular proteome forms protein quality control (PQC) machinery to maintain an uninterrupted synthesis of new polypeptides and targeted elimination of old or defective proteins. The process of PQC may get overwhelmed under specific genetic ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421989582]

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High throughput and comprehensive approach to develop multiepitope vaccine against minacious COVID-19.

Rupal Ojha, Nidhi Gupta, Biswajit Naik, Satyendra Singh, Vijay Kumar Verma, Dhaneswar Prusty, Vijay Kumar Prajapati,

The ongoing enigmatic COVID-19 outbreak, first reported from Wuhan, China, on last day of the year 2019, which has spread to 213 countries, territories/areas till 28th April 2020, threatens hundreds of thousands human souls. This devastating viral infection has stimulated the urgent development of viable vaccine against COVID-19 across the ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2020, 151:105375]

Cited: 14 times

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Immunoglobulin interface redesigning to enhance lebrikizumab mediated immunomodulation of IL-13 hyper-response.

Vinita Sharma, Priya Chouhan, Rajan Kumar Pandey, Rupal Ojha, Veeranarayanan Surya Aathmanathan, Muthukalingan Krishnan, Vijay Kumar Prajapati,

The overexpression of interleukin-13 (IL-13) leads to autoimmune and inflammatory diseases. These adverse responses can be neutralized by using lebrikizumab as a therapeutic monoclonal antibody (mAb). Herein, we have attempted to modulate the lebrikizumab mAb to enhance its binding affinity towards IL-13. The interface residues of the lebrikizumab-IL-13 complex were ... Read more >>

J Biomol Struct Dyn (Journal of biomolecular structure & dynamics)
[2021, 39(11):4051-4065]

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Vaccinomics strategy to concoct a promising subunit vaccine for visceral leishmaniasis targeting sandfly and leishmania antigens.

Rupal Ojha, Rajan Kumar Pandey, Vijay Kumar Prajapati,

Visceral leishmaniasis (VL) has been declared as one of the most severely neglected tropical diseases by the World Health Organization report 2017. Cumulative incidences of treatment failure and drug resistance, demanding a potential treatment and preventive strategy for VL. In this study, we have devised a multi-epitope vaccine by targeting ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2020, 156:548-557]

Cited: 1 time

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A Real-world Perspective of CD123 Expression in Acute Leukemia as Promising Biomarker to Predict Treatment Outcome in B-ALL and AML.

Nupur Das, Ritu Gupta, Sanjeev Kumar Gupta, Sameer Bakhshi, Ankit Malhotra, Sandeep Rai, Saroj Singh, Vijay Kumar Prajapati, Ranjeet Kumar Sahoo, Ajay Gogia, Atul Sharma, Lalit Kumar,

<h4>Introduction</h4>CD123 is overexpressed in many hematologic malignancies and found to be useful in characterizing leukemic blasts of both acute myeloid leukemia (AML) and B-acute lymphoblastic leukemia (B-ALL). CD123 has been recently found to be a marker of leukemic stem cells, and its utility to measure residual disease and potential role ... Read more >>

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2020, 20(10):e673-e684]

Cited: 1 time

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Immunoselective algorithm to devise multi-epitope subunit vaccine fighting against human cytomegalovirus infection.

Rajan Kumar Pandey, Rupal Ojha, Kumari Dipti, Rajiv Kumar, Vijay Kumar Prajapati,

<h4>Background</h4>Human cytomegalovirus (HCMV) generally causes asymptomatic infection, but sometimes it may cause severe complications among immunocompromised individuals. It may also promote various malignancies like prostate cancer and breast cancer. However, even after having this severe illness, there is no effective cure yet. This situation urges the need for effective chemotherapeutics ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2020, 82:104282]

Cited: 1 time

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Receptor-ligand based molecular interaction to discover adjuvant for immune cell TLRs to develop next-generation vaccine.

Nidhi Gupta, Hansa Regar, Vijay Kumar Verma, Dhaneswar Prusty, Amit Mishra, Vijay Kumar Prajapati,

Human immune cell toll-like receptors (TLRs) provide a novel chance for the development of the vaccine adjuvant engaging TLR signaling. A library of peptides was developed and peptides structure was generated through homology modeling and refinement. Further, these peptides were subjected to receptor-ligand interaction study against human immune cell TLRs ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2020, 152:535-545]

Cited: 5 times

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Structural vaccinology approach to investigate the virulent and secretory proteins of Bacillus anthracis for devising anthrax next-generation vaccine.

Nidhi Gupta, Nazia Khatoon, Amit Mishra, Vijay Kumar Verma, Vijay Kumar Prajapati,

Communicated by Ramaswamy H. Sarma. ... Read more >>

J Biomol Struct Dyn (Journal of biomolecular structure & dynamics)
[2020, 38(16):4895-4905]

Cited: 0 times

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Development a multi-epitope driven subunit vaccine for immune response reinforcement against Serogroup B of Neisseria meningitidis using comprehensive immunoinformatics approaches.

Maryam Rostamtabar, Abolfazl Rahmani, Masoud Baee, Ahmad Karkhah, Vijay Kumar Prajapati, Soheil Ebrahimpour, Hamid Reza Nouri,

Serogroup B of Neisseria meningitidis is the main cause of mortality due to meningococcal meningitis. Despite of many investigations, there is still no effective vaccine to prevent this serious infection. Therefore, this study was conducted to design a multi-epitope based vaccine through immunoinformatics approaches. The T CD4<sup>+</sup> and TCD8<sup>+</sup> cells ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2019, 75:103992]

Cited: 0 times

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Iron superoxide dismutase contributes to miltefosine resistance in Leishmania donovani.

Jalaja Veronica, Sambamurthy Chandrasekaran, Alti Dayakar, Moodu Devender, Vijay Kumar Prajapati, Shyam Sundar, Radheshyam Maurya,

The emergence of drug-resistant Leishmania is the major challenge to management of visceral leishmaniasis (VL) in areas in which this parasite is endemic. Miltefosine has been widely used against VL, but the emergence of resistant strains could impose a significant threat in the near future. The present study used high-throughput ... Read more >>

FEBS J (The FEBS journal)
[2019, 286(17):3488-3503]

Cited: 7 times

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LRSAM1 E3 ubiquitin ligase: molecular neurobiological perspectives linked with brain diseases.

Ribhav Mishra, Arun Upadhyay, Vijay Kumar Prajapati, Rohan Dhiman, Krishna Mohan Poluri, Nihar Ranjan Jana, Amit Mishra,

Cellular protein quality control (PQC) plays a significant role in the maintenance of cellular homeostasis. Failure of PQC mechanism may lead to various neurodegenerative diseases due to accumulation of aberrant proteins. To avoid such fatal neuronal conditions PQC employs autophagy and ubiquitin proteasome system (UPS) to degrade misfolded proteins. Few ... Read more >>

Cell Mol Life Sci (Cellular and molecular life sciences : CMLS)
[2019, 76(11):2093-2110]

Cited: 2 times

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Exploratory algorithm to devise multi-epitope subunit vaccine by investigating Leishmania donovani membrane proteins.

Nazia Khatoon, Rajan Kumar Pandey, Rupal Ojha, Veeranarayanan Surya Aathmanathan, Muthukalingan Krishnan, Vijay Kumar Prajapati,

Visceral leishmaniasis (VL) is a deadly parasitic infection which affects poorest to poor population living in the endemic countries. Increasing resistant to existing drugs, disease burden and a significant number of deaths, necessitates the need for an effective vaccine to prevent the VL infection. This study employed a combinatorial approach ... Read more >>

J Biomol Struct Dyn (Journal of biomolecular structure & dynamics)
[2019, 37(9):2381-2393]

Cited: 3 times

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Anti-infective activities of 11 plants species used in traditional medicine in Malaysia.

Nadiah Syafiqah Nor Azman, Md Shahadat Hossan, Veeranoot Nissapatorn, Chairat Uthaipibull, Parichat Prommana, Khoo Teng Jin, Mohammed Rahmatullah, Tooba Mahboob, Chandramathi Samudi Raju, Hassan Mahmood Jindal, Banasri Hazra, Mohd Ridzuan Mohd Abd Razak, Vijay Kumar Prajapati, Rajan Kumar Pandey, Norhaniza Aminudin, Khozirah Shaari, Nor Hadiani Ismail, Mark S Butler, Vladimir V Zarubaev, Christophe Wiart,

Treatment of drug resistant protozoa, bacteria, and viruses requires new drugs with alternative chemotypes. Such compounds could be found from Southeast Asian medicinal plants. The present study examines the cytotoxic, antileishmanial, and antiplasmodial effects of 11 ethnopharmacologically important plant species in Malaysia. Chloroform extracts were tested for their toxicity against ... Read more >>

Exp Parasitol (Experimental parasitology)
[2018, 194:67-78]

Cited: 2 times

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Immuno-informatics based approaches to design a novel multi epitope-based vaccine for immune response reinforcement against Leptospirosis.

Majid Validi, Ahmad Karkhah, Vijay Kumar Prajapati, Hamid Reza Nouri,

Leptospirosis is known as a zoonotic disease of global importance originated from infection with the spirochete bacterium Leptospira. Although several leptospirosis vaccines have been tested, the vaccination is relatively unsuccessful in clinical application despite decades of research. Therefore, this study was conducted to construct a novel multi-epitope based vaccine against ... Read more >>

Mol Immunol (Molecular immunology)
[2018, 104:128-138]

Cited: 4 times

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Vaccination and immunization strategies to design Aedes aegypti salivary protein based subunit vaccine tackling Flavivirus infection.

Rajan Kumar Pandey, Surbhi Dahiya, Jarjapu Mahita, Ramanathan Sowdhamini, Vijay Kumar Prajapati,

Flavivirus causes arthropod-borne severe diseases that sometimes lead to the death. The Flavivirus species including Dengue virus, Zika virus and yellow fever virus are transmitted by the bite of Aedes mosquitoes. All these viral species target the people living in their respective endemic zone causing a high mortality rate. Recent ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2019, 122:1203-1211]

Cited: 4 times

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Contriving multiepitope subunit vaccine by exploiting structural and nonstructural viral proteins to prevent Epstein-Barr virus-associated malignancy.

Rupal Ojha, Raj Nandani, Vijay Kumar Prajapati,

Cancer is one of the common lifestyle diseases and is considered to be the leading cause of death worldwide. Epstein-Barr virus (EBV)-infected individuals remain asymptomatic; but under certain stress conditions, EBV may lead to the development of cancers such as Burkitt's and Hodgkin's lymphoma and nasopharyngeal carcinoma. EBV-associated cancers result ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2019, 234(5):6437-6448]

Cited: 6 times

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Emerging role of circulating microRNA in the diagnosis of human infectious diseases.

Rupal Ojha, Raj Nandani, Rajan Kumar Pandey, Amit Mishra, Vijay Kumar Prajapati,

The endogenic microRNAs (miRNA) are evolutionary, conserved, and belong to a group of small noncoding RNAs with a stretch of 19-24 nucleotides. The miRNAs play an indispensable role in gene modulation at the posttranscriptional level, inclusive of stem-cell differentiation, embryogenesis, hematopoiesis, metabolism, immune responses, or infections. The miRNAs secreted from ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2019, 234(2):1030-1043]

Cited: 12 times

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Examination of antigenic proteins of Trypanosoma cruzi to fabricate an epitope-based subunit vaccine by exploiting epitope mapping mechanism.

Nazia Khatoon, Rupal Ojha, Amit Mishra, Vijay Kumar Prajapati,

Chagas disease is a protozoan parasitic disease caused by Trypanosoma cruzi. This injurious disease spread by the circulation of the blood sucking triatomine insects and transmitted to humans. Chagas disease is endemic in Latin America and also known as American trypanosomasis. Currently, 7 million people are infected by T. cruzi ... Read more >>

Vaccine (Vaccine)
[2018, 36(42):6290-6300]

Cited: 4 times

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Development of multi-epitope driven subunit vaccine in secretory and membrane protein of Plasmodium falciparum to convey protection against malaria infection.

Rajan Kumar Pandey, Mudassar Ali, Rupal Ojha, Tarun Kumar Bhatt, Vijay Kumar Prajapati,

Malaria infection is the severe health concern for a long time. As per the WHO reports, the malarial infection causes huge mortality all around the world and is incomparable with any other infectious diseases. The absence of effective treatment options and increasing drug resistance to the available therapeutics like artemisinin ... Read more >>

Vaccine (Vaccine)
[2018, 36(30):4555-4565]

Cited: 7 times

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Scrutinizing Mycobacterium tuberculosis membrane and secretory proteins to formulate multiepitope subunit vaccine against pulmonary tuberculosis by utilizing immunoinformatic approaches.

Nina Chatterjee, Rupal Ojha, Nazia Khatoon, Vijay Kumar Prajapati,

Tuberculosis is a menacing disease caused eminently to the people inhabiting the tropical and sub-tropical nations. A holistic approach is required to generate T and B memory cells to effectuate a long-term exemption from the pulmonary tuberculosis. In this study, immunoinformatic approaches were used to design a multi-epitope-based subunit vaccine ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2018, 118(Pt A):180-188]

Cited: 7 times

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