Full Text Journal Articles by
Author Victoria Navarro

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Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease.

Maria V Sanchez-Mico, Sebastian Jimenez, Angela Gomez-Arboledas, Clara Muñoz-Castro, Carmen Romero-Molina, Victoria Navarro, Elisabeth Sanchez-Mejias, Cristina Nuñez-Diaz, Raquel Sanchez-Varo, Elena Galea, José C Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques in Alzheimer's disease (AD). We have previously shown that reactive astrocytes enwrap, phagocytose, and degrade dystrophic synapses in the hippocampus of APP mice and AD patients, but affecting less than 7% of dystrophic neurites, suggesting reduced ... Read more >>

Glia (Glia)
[2021, 69(4):997-1011]

Cited: 2 times

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Classical McIndoe Technique Versus the McIndoe Technique with a Neovaginal PACIENA Prosthesis® and No Skin Graft.

Victoria Navarro, Maria Isabel Acién, Pedro Acién,

An observational, retrospective study was completed to compare the results of the PACIENA clinical trial (using the modified McIndoe technique) with a historical control group of nine patients who were operated on at San Juan University Hospital (1992-2015) using the classic technique. The PACIENA clinical trial included seven patients with ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

Cited: 1 time

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Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.

Juan Jose Fernandez-Valenzuela, Raquel Sanchez-Varo, Clara Muñoz-Castro, Vanessa De Castro, Elisabeth Sanchez-Mejias, Victoria Navarro, Sebastian Jimenez, Cristina Nuñez-Diaz, Angela Gomez-Arboledas, Ines Moreno-Gonzalez, Marisa Vizuete, Jose Carlos Davila, Javier Vitorica, Antonia Gutierrez,

In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation of hyperphosphorylated tau leading to neurofibrillary pathology. AD brains also accumulate amyloid-beta (Aβ) deposits. However, the effect of microtubule stabilizing agents on Aβ pathology has ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14776]

Cited: 2 times

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Expert Consensus on a Set of Outcomes to Assess the Effectiveness of Biologic Treatment in Psoriatic Arthritis: The MERECES Study.

Juan D Cañete, Joan M Nolla, Ruben Queiro, Miguel J Rodríguez, Miguel Ruiz, Luis Lizán, ,

<h4>Objective</h4>To reach a consensus on the instruments to be used in clinical practice to evaluate the effectiveness of biological disease-modifying antirheumatic drug (bDMARD) treatment in patients with psoriatic arthritis (PsA) in the short to medium term (3-6 mos), and to establish the minimum health outcomes for treatment continuation.<h4>Methods</h4>A 2-round Delphi ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, 47(11):1637-1643]

Cited: 1 time

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Development and validation of SCAISS, a tool for semi-automated quantification of sacroilitis by magnetic resonance in spondyloarthritis.

Pedro Zarco, Raquel Almodóvar, Ángel Bueno, Luis Miguel Molinero, ,

To develop a semi-automated method to quantify inflammation in sacroiliac (SI) joints by measuring bone marrow edema (BME) on MRI. The SCAISS was designed as an image-processing software. Validation followed: (1) three readers evaluated SI images of 23 patients with axial SpA and various levels of BME severity with the ... Read more >>

Rheumatol Int (Rheumatology international)
[2018, 38(10):1919-1926]

Cited: 0 times

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Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.

Carmen Romero-Molina, Victoria Navarro, Raquel Sanchez-Varo, Sebastian Jimenez, Juan J Fernandez-Valenzuela, Maria V Sanchez-Mico, Clara Muñoz-Castro, Antonia Gutierrez, Javier Vitorica, Marisa Vizuete,

Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology but, comparatively, little is known about inflammatory processes associated to tau pathology. In the hippocampus of AD patients, where tau ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2018, 12:421]

Cited: 5 times

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Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.

Victoria Navarro, Elisabeth Sanchez-Mejias, Sebastian Jimenez, Clara Muñoz-Castro, Raquel Sanchez-Varo, Jose C Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, the immune system and microglial cells (as part of the cerebral immunity) play a central role. In other degenerative processes, ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2018, 10:140]

Cited: 40 times

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Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.

David Baglietto-Vargas, Elisabeth Sánchez-Mejias, Victoria Navarro, Sebastián Jimenez, Laura Trujillo-Estrada, Angela Gómez-Arboledas, Maria Sánchez-Mico, Raquel Sánchez-Varo, Marisa Vizuete, José Carlos Dávila, José Manuel García-Verdugo, Javier Vitorica, Antonia Gutierrez,

Alzheimer's disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors underlying memory defects in Alzheimer's patients. In this regard, new evidence linking Alzheimer's disease-related pathology and neuronal stem cells ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):10085]

Cited: 11 times

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Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease.

Angela Gomez-Arboledas, Jose C Davila, Elisabeth Sanchez-Mejias, Victoria Navarro, Cristina Nuñez-Diaz, Raquel Sanchez-Varo, Maria Virtudes Sanchez-Mico, Laura Trujillo-Estrada, Juan Jose Fernandez-Valenzuela, Marisa Vizuete, Joan X Comella, Elena Galea, Javier Vitorica, Antonia Gutierrez,

Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in close association with neuritic plaques; however, the precise role of these glial cells in disease pathogenesis is unknown. In this ... Read more >>

Glia (Glia)
[2018, 66(3):637-653]

Cited: 49 times

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Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo.

Alberto Serrano-Pozo, Manuel A Sánchez-García, Antonio Heras-Garvín, Rosana March-Díaz, Victoria Navarro, Marisa Vizuete, José López-Barneo, Javier Vitorica, Alberto Pascual,

<h4>Background</h4>Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number of in vitro and in vivo studies have reported that hypoxia can induce amyloid-β peptide accumulation through various molecular mechanisms including the up-regulation of the amyloid-β precursor protein, the β-secretase Bace1, or the γγ-secretase complex ... Read more >>

PLoS One (PloS one)
[2017, 12(1):e0170345]

Cited: 1 time

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Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.

Elisabeth Sanchez-Mejias, Victoria Navarro, Sebastian Jimenez, Maria Sanchez-Mico, Raquel Sanchez-Varo, Cristina Nuñez-Diaz, Laura Trujillo-Estrada, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

The role of microglial cells in the development and progression of Alzheimer's disease (AD) has not been elucidated. Here, we demonstrated the existence of a weak microglial response in human AD hippocampus which is in contrast to the massive microglial activation observed in APP-based models. Most importantly, microglial cells displayed ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2016, 132(6):897-916]

Cited: 51 times

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Disruption of amyloid plaques integrity affects the soluble oligomers content from Alzheimer disease brains.

Sebastian Jimenez, Victoria Navarro, Javier Moyano, María Sanchez-Mico, Manuel Torres, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of soluble extracellular Abeta species, such as monomeric and/or oligomeric Abeta, seems to correlate with the clinico-pathological dysfunction observed in AD patients. However, the nature (monomeric, dimeric or other oligomers), the relative ... Read more >>

PLoS One (PloS one)
[2014, 9(12):e114041]

Cited: 12 times

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In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.

Laura Trujillo-Estrada, Sebastian Jimenez, Vanessa De Castro, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Victoria Navarro, Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

<h4>Background</h4>Alzheimer's disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, neuronal loss and the deterioration of cognitive capabilities of patients. However, no effective disease-modifying treatment has been yet developed. In this work we have evaluated whether chronic lithium ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2013, 1:73]

Cited: 12 times

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Effectiveness of a new health care organization model in primary care for chronic cardiovascular disease patients based on a multifactorial intervention: the PROPRESE randomized controlled trial.

Domingo Orozco-Beltran, Esther Ruescas-Escolano, Ana Isabel Navarro-Palazón, Alberto Cordero, María Gaubert-Tortosa, Jorge Navarro-Perez, Concepción Carratalá-Munuera, Salvador Pertusa-Martínez, Enrique Soler-Bahilo, Francisco Brotons-Muntó, Jose Bort-Cubero, Miguel Angel Nuñez-Martinez, Vicente Bertomeu-Martinez, Vicente Francisco Gil-Guillen, ,

<h4>Background</h4>To evaluate the effectiveness of a new multifactorial intervention to improve health care for chronic ischemic heart disease patients in primary care. The strategy has two components: a) organizational for the patient/professional relationship and b) training for professionals.<h4>Methods/design</h4>Experimental study. Randomized clinical trial. Follow-up period: one year.<h4>Study setting</h4>primary care, multicenter (15 ... Read more >>

BMC Health Serv Res (BMC health services research)
[2013, 13:293]

Cited: 0 times

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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.

Manuel Torres, Sebastian Jimenez, Raquel Sanchez-Varo, Victoria Navarro, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Irene Carmona, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

<h4>Background</h4>Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer's patients and transgenic models at early ages. These axonal dystrophies could reflect the disruption of axonal transport and the accumulation of multiple vesicles at local points. It has been also proposed that ... Read more >>

Mol Neurodegener (Molecular neurodegeneration)
[2012, 7:59]

Cited: 53 times

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Measuring the "fifth vital sign" in cataract surgery patients--is it necessary?

Cynthia Henry, Victoria Navarro, Albert Jun, Shohrat Annaberdyev,

As an ophthalmic nurse, you may wonder why it is so important to assess and manage the pain, or "fifth vital sign" of cataract surgery patients. How much pain could a patient experience as a result of a relatively short procedure? In January 2004, while reviewing the pain levels of ... Read more >>

Insight (Insight (American Society of Ophthalmic Registered Nurses))
[2006, 31(2):7-9]

Cited: 2 times

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Sequencing EVC and EVC2 identifies mutations in two-thirds of Ellis-van Creveld syndrome patients.

Stuart W J Tompson, Victor L Ruiz-Perez, Helen J Blair, Stephanie Barton, Victoria Navarro, Joanne L Robson, Michael J Wright, Judith A Goodship,

Ellis-van Creveld syndrome (EvC) is caused by mutations in EVC and EVC2, genes in a divergent orientation separated by only 2.6 kb. We systematically sought mutations in both genes in a panel of 65 affected individuals to assess the proportion of cases resulting from mutations in each gene. We PCR ... Read more >>

Hum Genet (Human genetics)
[2007, 120(5):663-670]

Cited: 51 times

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Patients with prion disease: planning for eye surgery.

Maureen A O'Brien, Victoria Navarro, Cora Hancock, Terrence P O'Brien,

Human prion diseases are characterized by rapidly progressive fatal neurodegenerative symptoms. In prion diseases, neural tissues have the greatest potential for infectivity, and ocular tissues are included in the category of high infection risk. The Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) have published ... Read more >>

Insight (Insight (American Society of Ophthalmic Registered Nurses))
[2005, 30(3):13-16]

Cited: 0 times

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EMTALA: the ophthalmic nurse as qualified medical personnel (QMP).

Martha A Conlon, Victoria B Navarro, James C Lai, Andrew P Schachat,

Insight (Insight (American Society of Ophthalmic Registered Nurses))
[2004, 29(3):7-9]

Cited: 0 times

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Recommended practices for the LASIK procedure: sterile versus surgically clean technique.

Jane Katzen, Rene Magrogan, Victoria B Navarro, Terrence P O'Brien, Debbie Rich, Sharon Sjulstad, ,

Insight (Insight (American Society of Ophthalmic Registered Nurses))
[2002, 27(2):33-36]

Cited: 0 times

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An evidence-based practice study: critical events following eye surgery in one ophthalmic PACU.

Dee A Channel, Victoria B Navarro, Marie T Nolan,

Insight (Insight (American Society of Ophthalmic Registered Nurses))
[2002, 27(4):92-94]

Cited: 0 times

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