Full Text Journal Articles by
Author Victoria Kutilek

Advertisement

Find full text journal articles








Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(10):1149]

Cited: 0 times

View full text PDF listing >>



A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

Mass spectrometry-based discovery proteomics is an essential tool for the proximal readout of cellular drug action. Here, we apply a robust proteomic workflow to rapidly profile the proteomes of five lung cancer cell lines in response to more than 50 drugs. Integration of millions of quantitative protein-drug associations substantially improved ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1111-1119]

Cited: 0 times

View full text PDF listing >>



Advertisement

Identification of G-Quadruplex-Binding Inhibitors of Myc Expression through Affinity Selection-Mass Spectrometry.

Deborah A Flusberg, Noreen F Rizvi, Victoria Kutilek, Christine Andrews, Peter Saradjian, Chad Chamberlin, Patrick Curran, Brooke Swalm, Sam Kattar, Graham F Smith, Peter Dandliker, Elliott B Nickbarg, Jennifer O'Neil,

The Myc oncogene is overexpressed in many cancers, yet targeting it for cancer therapy has remained elusive. One strategy for inhibition of Myc expression is through stabilization of the G-quadruplex (G4), a G-rich DNA secondary structure found within the Myc promoter; stabilization of G4s has been shown to halt transcription ... Read more >>

SLAS Discov (SLAS discovery : advancing life sciences R & D)
[2019, 24(2):142-157]

Cited: 1 time

View full text PDF listing >>



Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.

Victoria D Kutilek, Christine L Andrews, Matthew P Richards, Zangwei Xu, Tianxiao Sun, Yiping Chen, Andrew Hashke, Nadya Smotrov, Rafael Fernandez, Elliott B Nickbarg, Chad Chamberlin, Berengere Sauvagnat, Patrick J Curran, Ryan Boinay, Peter Saradjian, Samantha J Allen, Noel Byrne, Nathaniel L Elsen, Rachael E Ford, Dawn L Hall, Maria Kornienko, Keith W Rickert, Sujata Sharma, Jennifer M Shipman, Kevin J Lumb, Kevin Coleman, Peter J Dandliker, Ilona Kariv, Bruce Beutel,

The primary objective of early drug discovery is to associate druggable target space with a desired phenotype. The inability to efficiently associate these often leads to failure early in the drug discovery process. In this proof-of-concept study, the most tractable starting points for drug discovery within the NF-κB pathway model ... Read more >>

J Biomol Screen (Journal of biomolecular screening)
[2016, 21(6):608-619]

Cited: 6 times

View full text PDF listing >>



Identification of an allosteric binding site for RORγt inhibition.

Marcel Scheepstra, Seppe Leysen, Geert C van Almen, J Richard Miller, Jennifer Piesvaux, Victoria Kutilek, Hans van Eenennaam, Hongjun Zhang, Kenneth Barr, Sunil Nagpal, Stephen M Soisson, Maria Kornienko, Kristen Wiley, Nathaniel Elsen, Sujata Sharma, Craig C Correll, B Wesley Trotter, Mario van der Stelt, Arthur Oubrie, Christian Ottmann, Gopal Parthasarathy, Luc Brunsveld,

RORγt is critical for the differentiation and proliferation of Th17 cells associated with several chronic autoimmune diseases. We report the discovery of a novel allosteric binding site on the nuclear receptor RORγt. Co-crystallization of the ligand binding domain (LBD) of RORγt with a series of small-molecule antagonists demonstrates occupancy of ... Read more >>

Nat Commun (Nature communications)
[2015, 6:8833]

Cited: 19 times

View full text PDF listing >>



Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3.

Holly Heaslet, Victoria Kutilek, Garrett M Morris, Ying-Chuan Lin, John H Elder, Bruce E Torbett, C David Stout,

The development of resistance to anti-retroviral drugs targeted against HIV is an increasing clinical problem in the treatment of HIV-1-infected individuals. Many patients develop drug-resistant strains of the virus after treatment with inhibitor cocktails (HAART therapy), which include multiple protease inhibitors. Therefore, it is imperative that we understand the mechanisms ... Read more >>

J. Mol. Biol. (Journal of molecular biology)
[2006, 356(4):967-981]

Cited: 14 times

View full text PDF listing >>





Advertisement

Disclaimer
0.7005 s