Eric A Nollet, Marina Cardo-Vila, Sourik S Ganguly, Jack D Tran, Veronique V Schulz, Anne Cress, Eva Corey, Cindy K Miranti,
The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration-resistant disease (CRPC) when treated with anti-androgen therapy. In CRPC, AR is often aberrantly activated independent of androgen. Targeting survival pathways downstream of AR could be a viable strategy to ... Read more >>
Oncogene (Oncogene)
[2020, 39(31):5390-5404]
Cited: 0 times
Rachel K Toth, Jack D Tran, Michelle T Muldong, Eric A Nollet, Veronique V Schulz, Corbin C Jensen, Lori A Hazlehurst, Eva Corey, Donald Durden, Christina Jamieson, Cindy K Miranti, Noel A Warfel,
Bone-metastatic castration-resistant prostate cancer (CRPC) is lethal due to inherent resistance to androgen deprivation therapy, chemotherapy, and targeted therapies. Despite the fact that a majority of CRPC patients (approximately 70%) harbor a constitutively active PI3K survival pathway, targeting the PI3K/mTOR pathway has failed to increase overall survival in clinical trials. ... Read more >>
Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(4):297-312]
Cited: 0 times
Lia Tesfay, Veronique V Schulz, Sander B Frank, Laura E Lamb, Cindy K Miranti,
Matrix adhesion via integrins is required for cell survival. Adhesion of epithelial cells to laminin via integrin α3β1 was previously shown to activate at least two independent survival pathways. First, integrin α3β1 is required for autophagy-induced cell survival after growth factor deprivation. Second, integrin α3β1 independently activates two receptor tyrosine ... Read more >>
Mol. Biol. Cell (Molecular biology of the cell)
[2016, 27(15):2493-2504]
Cited: 6 times
Jelani C Zarif, Laura E Lamb, Veronique V Schulz, Eric A Nollet, Cindy K Miranti,
Castration-resistant prostate cancers still depend on nuclear androgen receptor (AR) function despite their lack of dependence on exogenous androgen. Second generation anti-androgen therapies are more efficient at blocking nuclear AR; however resistant tumors still develop. Recent studies indicate Src is highly active in these resistant tumors. By manipulating AR activity ... Read more >>
Oncotarget (Oncotarget)
[2015, 6(9):6862-6876]
Cited: 19 times
Penny L Berger, Sander B Frank, Veronique V Schulz, Eric A Nollet, Mathew J Edick, Brittany Holly, Ting-Tung A Chang, Galen Hostetter, Suwon Kim, Cindy K Miranti,
The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer development are poorly understood. We identified the chromatin remodeling protein, ING4, as a crucial switch downstream of Myc and Pten that is required for human prostate epithelial differentiation. Myc-induced transient expression of ING4 is required for the differentiation ... Read more >>
Cancer Res. (Cancer research)
[2014, 74(12):3357-3368]
Cited: 16 times
Andrew J Putnam, Veronique V Schulz, Eric M Freiter, Heather M Bill, Cindy K Miranti,
BACKGROUND: Integrins, cell-surface receptors that mediate adhesive interactions between cells and the extracellular matrix (ECM), play an important role in cancer progression. Expression of the vitronectin receptor alphavbeta3 integrin correlates with increased invasive and metastatic capacity of malignant melanomas, yet it remains unclear how expression of this integrin triggers melanoma ... Read more >>
Cell Commun. Signal (Cell communication and signaling : CCS)
[2009, 7:10]
Cited: 21 times