Full Text Journal Articles by
Author Veronique V Schulz


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Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer.

Eric A Nollet, Marina Cardo-Vila, Sourik S Ganguly, Jack D Tran, Veronique V Schulz, Anne Cress, Eva Corey, Cindy K Miranti,

The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration-resistant disease (CRPC) when treated with anti-androgen therapy. In CRPC, AR is often aberrantly activated independent of androgen. Targeting survival pathways downstream of AR could be a viable strategy to ... Read more >>

Oncogene (Oncogene)
[2020, 39(31):5390-5404]

Cited: 0 times

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Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC.

Rachel K Toth, Jack D Tran, Michelle T Muldong, Eric A Nollet, Veronique V Schulz, Corbin C Jensen, Lori A Hazlehurst, Eva Corey, Donald Durden, Christina Jamieson, Cindy K Miranti, Noel A Warfel,

Bone-metastatic castration-resistant prostate cancer (CRPC) is lethal due to inherent resistance to androgen deprivation therapy, chemotherapy, and targeted therapies. Despite the fact that a majority of CRPC patients (approximately 70%) harbor a constitutively active PI3K survival pathway, targeting the PI3K/mTOR pathway has failed to increase overall survival in clinical trials. ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(4):297-312]

Cited: 1 time

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Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1.

Lia Tesfay, Veronique V Schulz, Sander B Frank, Laura E Lamb, Cindy K Miranti,

Matrix adhesion via integrins is required for cell survival. Adhesion of epithelial cells to laminin via integrin α3β1 was previously shown to activate at least two independent survival pathways. First, integrin α3β1 is required for autophagy-induced cell survival after growth factor deprivation. Second, integrin α3β1 independently activates two receptor tyrosine ... Read more >>

Mol Biol Cell (Molecular biology of the cell)
[2016, 27(15):2493-2504]

Cited: 7 times

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Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase.

Jelani C Zarif, Laura E Lamb, Veronique V Schulz, Eric A Nollet, Cindy K Miranti,

Castration-resistant prostate cancers still depend on nuclear androgen receptor (AR) function despite their lack of dependence on exogenous androgen. Second generation anti-androgen therapies are more efficient at blocking nuclear AR; however resistant tumors still develop. Recent studies indicate Src is highly active in these resistant tumors. By manipulating AR activity ... Read more >>

Oncotarget (Oncotarget)
[2015, 6(9):6862-6876]

Cited: 20 times

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Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.

Penny L Berger, Sander B Frank, Veronique V Schulz, Eric A Nollet, Mathew J Edick, Brittany Holly, Ting-Tung A Chang, Galen Hostetter, Suwon Kim, Cindy K Miranti,

The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer development are poorly understood. We identified the chromatin remodeling protein, ING4, as a crucial switch downstream of Myc and Pten that is required for human prostate epithelial differentiation. Myc-induced transient expression of ING4 is required for the differentiation ... Read more >>

Cancer Res (Cancer research)
[2014, 74(12):3357-3368]

Cited: 18 times

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Src, PKCalpha, and PKCdelta are required for alphavbeta3 integrin-mediated metastatic melanoma invasion.

Andrew J Putnam, Veronique V Schulz, Eric M Freiter, Heather M Bill, Cindy K Miranti,

<h4>Background</h4>Integrins, cell-surface receptors that mediate adhesive interactions between cells and the extracellular matrix (ECM), play an important role in cancer progression. Expression of the vitronectin receptor alphavbeta3 integrin correlates with increased invasive and metastatic capacity of malignant melanomas, yet it remains unclear how expression of this integrin triggers melanoma invasion ... Read more >>

Cell Commun Signal (Cell communication and signaling : CCS)
[2009, 7:10]

Cited: 21 times

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