Full Text Journal Articles by
Author Veronique Fremeaux Bacchi

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Malignant hypertension and thrombotic microangiopathy: complement as a usual suspect.

Fadi Fakhouri, Salima Sadallah, Véronique Frémeaux-Bacchi,

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2020, :]

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Management of thrombotic microangiopathy in pregnancy and postpartum: report from an international working group.

Fadi Fakhouri, Marie Scully, François Provôt, Miquel Blasco, Paul Coppo, Marina Noris, Kathy Paizis, David Kavanagh, Frédéric Pène, Sol Quezada, Alexandre Hertig, Sébastien Kissling, Patrick O'Brien, Yahsou Delmas, Lorenzo Alberio, Norbert Winer, Agnès Veyradier, Spero Cataland, Véronique Frémeaux-Bacchi, Chantal Loirat, Giuseppe Remuzzi, Vassilis Tsatsaris,

Pregnancy and postpartum are high-risk periods for different forms of thrombotic microangiopathy (TMA). However, the management of pregnancy-associated TMA remains ill defined. This report, by an international multidisciplinary working group of obstetricians, nephrologists, hematologists, intensivists, neonatologists, and complement biologists, summarizes the current knowledge of these potentially severe disorders and proposes ... Read more >>

Blood (Blood)
[2020, 136(19):2103-2117]

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Anti-C5 antibody treatment for delayed hemolytic transfusion reactions in sickle cell disease.

Aline Floch, Alexandre Morel, Fabian Zanchetta-Balint, Catherine Cordonnier-Jourdin, Slimane Allali, Maximilien Grall, Ghislaine Ithier, Benjamin Carpentier, Sadaf Pakdaman, Jean-Claude Merle, Radjiv Goulabchand, Tackwa Khalifeh, Ana Berceanu, Cécile Helmer, Christelle Chantalat-Auger, Véronique Frémeaux-Bacchi, Marc Michel, Mariane de Montalembert, Armand Mekontso-Dessap, France Pirenne, Anoosha Habibi, Pablo Bartolucci,

Haematologica (Haematologica)
[2020, 105(11):2694-2697]

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Eculizumab as an emergency treatment for adult patients with severe COVID-19 in the intensive care unit: A proof-of-concept study.

Djillali Annane, Nicholas Heming, Lamiae Grimaldi-Bensouda, Véronique Frémeaux-Bacchi, Marie Vigan, Anne-Laure Roux, Armance Marchal, Hugues Michelon, Martin Rottman, Pierre Moine, ,

<h4>Background</h4>Complement pathway inhibition may provide benefit for severe acute respiratory illnesses caused by viral infections such as COVID-19. We present results from a nonrandomized proof-of-concept study of complement C5 inhibitor eculizumab for treatment of severe COVID-19.<h4>Methods</h4>All patients (<i>N</i> = 80) with confirmed SARS-CoV-2 infection and severe COVID-19 admitted to our intensive care ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2020, 28:100590]

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Post-partum acute kidney injury: sorting placental and non-placental thrombotic microangiopathies using the trajectory of biomarkers.

Fleuria Meibody, Matthieu Jamme, Vassilis Tsatsaris, François Provot, Jérôme Lambert, Véronique Frémeaux-Bacchi, Anne-Sophie Ducloy-Bouthors, Mercédès Jourdain, Yahsou Delmas, Pierre Perez, Julien Darmian, Alain Wynckel, Jean-Michel Rebibou, Paul Coppo, Cédric Rafat, Eric Rondeau, Luc Frimat, Alexandre Hertig,

<h4>Background</h4>Among the severe complications of preeclampsia (PE), acute kidney injury (AKI) is problematic if features of thrombotic microangiopathy (TMA) are present. Although a haemolysis enzyme liver low-platelets syndrome is considerably more frequent, it is vital to rule out a flare of atypical haemolytic and uraemic syndrome (aHUS). Our objective was ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2020, 35(9):1538-1546]

Cited: 2 times

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Atypical hemolytic and uremic syndrome due to C3 mutation in pancreatic islet transplantation: a case report.

Thibault Bahougne, Jérome Olagne, Marion Munch, Laura Braun-Parvez, Marie-Pierrette Chenard, Véronique Frémeaux-Bacchi, Sophie Caillard, Philippe Baltzinger, Michel Greget, Laurence Kessler, Bruno Moulin,

<h4>Background</h4>We here report on the first observation of a C3 mutation that is related to atypical hemolytic and uremic syndrome (aHUS), which occurred in a pancreatic islet transplant patient. Immunosuppressive treatments, such as calcineurin inhibitors, have been linked to undesirable effects like nephrotoxicity.<h4>Case presentation</h4>A 40-year-old man with brittle diabetes, who ... Read more >>

BMC Nephrol (BMC nephrology)
[2020, 21(1):405]

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Practical management of C3 glomerulopathy and Ig-mediated MPGN: facts and uncertainties.

Fadi Fakhouri, Moglie Le Quintrec, Véronique Frémeaux-Bacchi,

In recent years, a substantial body of experimental and clinical work has been devoted to C3 glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the rapid accumulation of data, several uncertainties about these 2 rare forms of nephropathies persist. They concern their pathophysiology, classification, clinical course, relevance of biomarkers and of pathology ... Read more >>

Kidney Int (Kidney international)
[2020, 98(5):1135-1148]

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Identification of Distinct Immunophenotypes in Critically Ill Coronavirus Disease 2019 Patients.

Thibault Dupont, Sophie Caillat-Zucman, Véronique Fremeaux-Bacchi, Florence Morin, Etienne Lengliné, Michael Darmon, Régis Peffault de Latour, Lara Zafrani, Elie Azoulay, Guillaume Dumas,

<h4>Background</h4>Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection causes direct lung damage, overwhelming endothelial activation, and inflammatory reaction, leading to acute respiratory failure and multi-organ dysfunction. Ongoing clinical trials are evaluating targeted therapies to hinder this exaggerated inflammatory response. Critically ill coronavirus disease 2019 (COVID-19) patients have shown heterogeneous severity trajectories, suggesting ... Read more >>

Chest (Chest)
[2020, :]

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Complement C5 inhibition in patients with COVID-19 - a promising target?

Regis Peffault de Latour, Anne Bergeron, Etienne Lengline, Thibault Dupont, Armance Marchal, Lionel Galicier, Nathalie de Castro, Louise Bondeelle, Michael Darmon, Clairelyne Dupin, Guillaume Dumas, Pierre Leguen, Isabelle Madelaine, Sylvie Chevret, Jean-Michel Molina, Elie Azoulay, Veronique Fremeaux-Bacchi, Core Group,

Haematologica (Haematologica)
[2020, 105(12):2847-2850]

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Eculizumab discontinuation in children and adults with atypical haemolytic uremic syndrome: a prospective multicentric study.

Fadi Fakhouri, Marc Fila, Aurelie Hummel, David Ribes, Anne-Laure Sellier-Leclerc, Simon Ville, Claire Pouteil-Noble, Jean-Philippe Coindre, Moglie Le Quintrec, Eric Rondeau, Olivia Boyer, François Provôt, Djamal Djeddi, W Hanf, Yahsou Delmas, Ferielle Louillet, Annie Lahoche, Guillaume Favre, Valérie Chatelet, Emma Allain-Launay, Claire Presne, Ariane Zaloszyc, Sophie Caillard, Stéphane Bally, Quentin Raimbourg, Leila Tricot, Christiane Mousson, Aurélie Le Thuaut, Chantal Loirat, Veronique Fremeaux-Bacchi,

The optimal duration of eculizumab treatment in patients with atypical haemolytic uremic syndrome (aHUS) remains poorly defined. We conducted a prospective national multicentric open-label study in order to assess eculizumab discontinuation in children and adults with aHUS. Fifty-five patients (including 19 children) discontinued eculizumab (mean duration of treatment, 16.5 months). ... Read more >>

Blood (Blood)
[2020, :]

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Anti-Factor B Antibodies and Acute Postinfectious GN in Children.

Sophie Chauvet, Romain Berthaud, Magali Devriese, Morgane Mignotet, Paula Vieira Martins, Tania Robe-Rybkine, Maria A Miteva, Aram Gyulkhandanyan, Amélie Ryckewaert, Ferielle Louillet, Elodie Merieau, Guillaume Mestrallet, Caroline Rousset-Rouvière, Eric Thervet, Julien Hogan, Tim Ulinski, Bruno O Villoutreix, Lubka Roumenina, Olivia Boyer, Véronique Frémeaux-Bacchi,

BACKGROUND:The pathophysiology of the leading cause of pediatric acute nephritis, acute postinfectious GN, including mechanisms of the pathognomonic transient complement activation, remains uncertain. It shares clinicopathologic features with C3 glomerulopathy, a complement-mediated glomerulopathy that, unlike acute postinfectious GN, has a poor prognosis. METHODS:This retrospective study investigated mechanisms of complement activation ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2020, 31(4):829-840]

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Complement activation in sickle cell disease: Dependence on cell density, hemolysis and modulation by hydroxyurea therapy.

Lubka T Roumenina, Philippe Chadebech, Gwellaouen Bodivit, Paula Vieira-Martins, Anne Grunenwald, Idris Boudhabhay, Victoria Poillerat, Sadaf Pakdaman, Laurent Kiger, Alicia Jouard, Etienne Audureau, France Pirenne, Frédéric Galactéros, Véronique Frémeaux-Bacchi, Pablo Bartolucci,

The complement system is an innate immune defense cascade that can cause tissue damage when inappropriately activated. Evidence for complement over activation has been reported in small cohorts of patients with sickle cell disease (SCD). However, the mechanism governing complement activation in SCD has not been elucidated. Here, we observe ... Read more >>

Am J Hematol (American journal of hematology)
[2020, 95(5):456-464]

Cited: 2 times

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Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis.

Idris Boudhabhay, Victoria Poillerat, Anne Grunenwald, Carine Torset, Juliette Leon, Marie V Daugan, Francesca Lucibello, Khalil El Karoui, Amandine Ydee, Sophie Chauvet, Patrick Girardie, Steven Sacks, Conrad A Farrar, Peter Garred, Romain Berthaud, Moglie Le Quintrec, Marion Rabant, Pascale de Lonlay, Caroline Rambaud, Viviane Gnemmi, Veronique Fremeaux-Bacchi, Marie Frimat, Lubka T Roumenina,

Rhabdomyolysis is a life-threatening condition caused by skeletal muscle damage with acute kidney injury being the main complication dramatically worsening the prognosis. Specific treatment for rhabdomyolysis-induced acute kidney injury is lacking and the mechanisms of the injury are unclear. To clarify this, we studied intra-kidney complement activation (C3d and C5b-9 ... Read more >>

Kidney Int (Kidney international)
[2020, :]

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Atypical HUS relapse triggered by COVID-19.

Simon Ville, Sabine Le Bot, Agnès Chapelet-Debout, Gilles Blancho, Véronique Fremeaux-Bacchi, Clément Deltombe, Fadi Fakhouri,

Kidney Int (Kidney international)
[2021, 99(1):267-268]

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C3 glomerulonephritis in a patient treated with anti-PD-1 antibody.

Simon Ville, Christine Kandel-Aznar, Véronique Frémeaux-Bacchi, Fadi Fakhouri,

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 125:46-48]

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Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome in solid organ transplant recipients.

Simon Ville, Amandine Ydee, Claire Garandeau, Emmanuel Canet, Adrien Tissot, Diego Cantarovich, Véronique Frémeaux-Bacchi, Patricia Mariani-Kurkdjian, François Provôt, Fadi Fakhouri,

Kidney Int (Kidney international)
[2019, 96(6):1423-1424]

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Monitoring Complement Activation: The New Conundrum in Thrombotic Microangiopathies.

Fadi Fakhouri, Véronique Frémeaux-Bacchi,

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2019, 14(12):1682-1683]

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Use of Highly Individualized Complement Blockade Has Revolutionized Clinical Outcomes after Kidney Transplantation and Renal Epidemiology of Atypical Hemolytic Uremic Syndrome.

Julien Zuber, Marie Frimat, Sophie Caillard, Nassim Kamar, Philippe Gatault, Florent Petitprez, Lionel Couzi, Noemie Jourde-Chiche, Valérie Chatelet, Raphael Gaisne, Dominique Bertrand, Jamal Bamoulid, Magali Louis, Rebecca Sberro Soussan, David Navarro, Pierre-Francois Westeel, Luc Frimat, Charlotte Colosio, Antoine Thierry, Joseph Rivalan, Laetitia Albano, Nadia Arzouk, Emilie Cornec-Le Gall, Guillaume Claisse, Michelle Elias, Khalil El Karoui, Sophie Chauvet, Jean-Philippe Coindre, Jean-Philippe Rerolle, Leila Tricot, Johnny Sayegh, Cyril Garrouste, Christophe Charasse, Yahsou Delmas, Ziad Massy, Maryvonne Hourmant, Aude Servais, Chantal Loirat, Fadi Fakhouri, Claire Pouteil-Noble, Marie-Noelle Peraldi, Christophe Legendre, Eric Rondeau, Moglie Le Quintrec, Véronique Frémeaux-Bacchi,

<h4>Background</h4>Atypical hemolytic uremic syndrome (HUS) is associated with high recurrence rates after kidney transplant, with devastating outcomes. In late 2011, experts in France recommended the use of highly individualized complement blockade-based prophylaxis with eculizumab to prevent post-transplant atypical HUS recurrence throughout the country.<h4>Methods</h4>To evaluate this strategy's effect on kidney transplant ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2019, 30(12):2449-2463]

Cited: 4 times

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Atypical hemolytic uremic syndrome and hypertensive crisis.

Khalil El Karoui, Idris Boudhabhay, Véronique Frémeaux-Bacchi,

Kidney Int (Kidney international)
[2019, 96(5):1239]

Cited: 0 times

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Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.

Nicolas S Merle, Juliette Leon, Victoria Poillerat, Anne Grunenwald, Idris Boudhabhay, Samantha Knockaert, Tania Robe-Rybkine, Carine Torset, Matthew C Pickering, Sophie Chauvet, Veronique Fremeaux-Bacchi, Lubka T Roumenina,

Intravascular hemolysis of any cause can induce acute kidney injury (AKI). Hemolysis-derived product heme activates the innate immune complement system and contributes to renal damage. Therefore, we explored the role of the master complement regulator Factor H (FH) in the kidney's resistance to hemolysis-mediated AKI. Acute systemic hemolysis was induced ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:1772]

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Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies.

Carine El Sissy, Jérémie Rosain, Paula Vieira-Martins, Pauline Bordereau, Aurélia Gruber, Magali Devriese, Loïc de Pontual, Muhamed-Kheir Taha, Claire Fieschi, Capucine Picard, Véronique Frémeaux-Bacchi,

The complement system is crucial for defense against pathogens and the removal of dying cells or immune complexes. Thus, clinical indications for possible complete complement deficiencies include, among others, recurrent mild or serious bacterial infections as well as autoimmune diseases (AID). The diagnostic approach includes functional activity measurements of the ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:1936]

Cited: 2 times

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Neisseria meningitidis inside neutrophils, revealing properdin deficiency.

Benjamin Gillet, Nicolas Joram, Véronique Frémeaux Bacchi, Caroline Thomas, Marie C Béné, Soraya Wuillème,

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 99:117-118]

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The authors reply.

Alice Le Clech, Véronique Frémeaux-Bacchi, Fadi Fakhouri,

Kidney Int (Kidney international)
[2019, 96(2):517-518]

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Glomerulonephritis With Isolated C3 Deposits as a Manifestation of Subtotal Factor I Deficiency.

Idris Boudhabhay, Véronique Frémeaux-Bacchi, Lubka T Roumenina, Anissa Moktefi, Jean-Michel Goujon, Marie Matignon, Valérie Caudwell, Vincent Audard, Khalil El Karoui,

Kidney Int Rep (Kidney international reports)
[2019, 4(9):1354-1358]

Cited: 0 times

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Haemolytic uraemic syndrome associated with non shiga toxin-producing Escherichia coli bacteraemia: a case report.

Stéphane Bally, Jacques Fourcade, Véronique Frémeaux-Bacchi,

<h4>Background</h4>Haemolytic uraemic syndrome (HUS) is a thrombotic microangiopathy (TMA) characterized by predominant renal involvement. Several types of HUS can be distinguished: the most frequent « typical » HUS, due to shiga toxin producing Escherichia coli (STEC), "atypical" HUS due to complement alternative pathway dysregulation and "secondary" HUS associated with various ... Read more >>

BMC Nephrol (BMC nephrology)
[2019, 20(1):157]

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