Full Text Journal Articles by
Author Venkatakrishna Rao Jala

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Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme.

Rajbir Singh, Sandeep Chandrashekharappa, Praveen Kumar Vemula, Bodduluri Haribabu, Venkatakrishna Rao Jala,

Urolithins are gut microbial metabolites derived from ellagitannins (ET) and ellagic acid (EA), and shown to exhibit anticancer, anti-inflammatory, anti-microbial, anti-glycative and anti-oxidant activities. Similarly, the parent molecules, ET and EA are reported for their neuroprotection and antidepressant activities. Due to the poor bioavailability of ET and EA, the in ... Read more >>

Metabolites (Metabolites)
[2020, 10(6):]

Cited: 0 times

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Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells.

Praveen Kumar Vemula, Venkatakrishna Rao Jala,

Transl Cancer Res (Translational cancer research)
[2016, 5(Suppl 3):S536-S539]

Cited: 0 times

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The upper respiratory tract microbiome of hospitalised patients with community-acquired pneumonia of unknown aetiology: a pilot study.

Timothy L Wiemken, Venkatakrishna Rao Jala, Robert R Kelley, Paula Peyrani, William A Mattingly, Forest W Arnold, Patricio W Cabral, Rodrigo Cavallazzi, Bodduluri Haribabu, Julio A Ramirez,

The composition of the upper respiratory tract microbiome may play an important role in the development of lower respiratory tract infections. Here, we characterised the microbiome of the nasopharynx and oropharynx of hospitalised patients with community-acquired pneumonia (CAP) with unknown aetiology in an attempt to obtain insight into the aetiology ... Read more >>

Pneumonia (Nathan) (Pneumonia (Nathan Qld.))
[2015, 6:83-89]

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Expression of leukotriene B₄ receptor-1 on CD8⁺ T cells is required for their migration into tumors to elicit effective antitumor immunity.

Rajesh Kumar Sharma, Zinal Chheda, Venkatakrishna Rao Jala, Bodduluri Haribabu,

Leukotriene B₄ (LTB₄) receptor (BLT)1 is expressed on variety of immune cells and has been implicated as a mediator of diverse inflammatory diseases. However, whether biological responses initiated via this receptor generate tumor-promoting inflammation or antitumor immunity remains unexplored. In this study, we investigated the role of BLT1 in antitumor ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2013, 191(6):3462-3470]

Cited: 16 times

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Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer.

Venkatakrishna Rao Jala, Brandie N Radde, Bodduluri Haribabu, Carolyn M Klinge,

BACKGROUND:G-protein-coupled estrogen receptor (GPER/GPR30) was reported to bind 17β-estradiol (E2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signaling in breast, endometrial and thyroid cancer cells. Although lung adenocarcinomas express estrogen receptors α and β (ERα and ERβ), the expression of GPER in lung ... Read more >>

BMC Cancer (BMC Cancer)
[2012, 12:624]

Cited: 29 times

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Disruption of distal interactions of Arg 262 and of substrate binding to Ser 52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase.

Venkatakrishna Rao Jala, M Ambili, V Prakash, N Appaji Rao, H S Savithri,

The crystal structure of human liver cytosolic recombinant serine hydroxymethyltransferase (hcSHMT) suggested that Ser53 and Arg 263 could participate in the reaction catalyzed by SHMT. The mutation of Arg262 (corresponding to Arg263 in hcSHMT) to "A" in sheep liver cytosolic SHMT (scSHMT) resulted in a 5-fold increase in Km for ... Read more >>

Indian J. Biochem. Biophys. (Indian journal of biochemistry & biophysics)
[2003, 40(4):226-237]

Cited: 2 times

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Identification of amino acid residues, essential for maintaining the tetrameric structure of sheep liver cytosolic serine hydroxymethyltransferase, by targeted mutagenesis.

Venkatakrishna Rao Jala, Naropantul Appaji Rao, Handanahal Subbarao Savithri,

Serine hydroxymethyltransferase (SHMT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, catalyses the transfer of the hydroxymethyl group from serine to tetrahydrofolate to yield glycine and N (5), N (10)-methylenetetrahydrofolate. An analysis of the known SHMT sequences indicated that several amino acid residues were conserved. In this paper, we report the identification of ... Read more >>

Biochem. J. (The Biochemical journal)
[2003, 369(Pt 3):469-476]

Cited: 7 times

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