Full Text Journal Articles by
Author Veit Krenn

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The histopathological synovitis score is influenced by biopsy location in patients with knee osteoarthritis.

Haider Mussawy, Jozef Zustin, Andreas M Luebke, André Strahl, Veit Krenn, Wolfgang Rüther, Tim Rolvien,

<h4>Introduction</h4>Osteoarthritis (OA) and rheumatoid arthritis (RA) represent the most common forms of arthritis, which are mainly caused by mechanical and inflammatory components, respectively. Determination of synovial inflammation in synovial biopsies via the histopathological Krenn score may be crucial for correct diagnosis and treatment. Specifically, it remains unclear whether synovitis scores ... Read more >>

Arch Orthop Trauma Surg (Archives of orthopaedic and trauma surgery)
[2021, :]

Cited: 0 times

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Degeneration of the articular disc in the human triangular fibrocartilage complex.

Susanne Rein, Veit Krenn, Elisabet Hagert, Marc Garcia-Elias, Alex Lluch, Thomas Kremer, Manuel Semisch,

<h4>Introduction</h4>Traumatic injuries of the triangular fibrocartilage complex (TFCC) are frequent reasons for ulnar wrist pain. The assessment of the extent of articular disc (AD) degeneration is important for the differentiation of acute injuries versus chronic lesions.<h4>Materials and methods</h4>The AD of the TFCC of eleven human cadaver wrists was dissected. Degeneration ... Read more >>

Arch Orthop Trauma Surg (Archives of orthopaedic and trauma surgery)
[2021, 141(4):699-708]

Cited: 1 time

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Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation.

Aparna Mahajan, Lenka Hasíková, Ulrike Hampel, Anika Grüneboom, Xiaomei Shan, Irmgard Herrmann, Fabian Garreis, Felix Bock, Jasmin Knopf, Jeeshan Singh, Christine Schauer, Siddharth Mahajan, Moritz Leppkes, Friedrich Paulsen, Ursula Schlötzer-Schrehardt, Veit Krenn, Anselm Jünemann, Bettina Hohberger, Georg Schett, Martin Herrmann, Luis E Muñoz,

<h4>Purpose</h4>Obstructive Meibomian gland dysfunction (MGD) is one of the leading causes of evaporative dry eye disease. Meibomian glands at the eyelid secrete lipids that prevent evaporation of the aqueous tear film. The pathogenesis of obstructive MGD is incompletely understood to date. Herein, we aim to investigate the pathogenesis of obstructive ... Read more >>

Ocul Surf (The ocular surface)
[2021, 20:1-12]

Cited: 4 times

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[Very rare cases of periprosthetic malignant neoplasms : Data from 4000 cases of endoprosthetic joint replacements from the histopathologic implant register].

Kevin Keidel, Marc Thomsen, Christian Dierkes, Holger Haas, Ingo Arnold, Karl-Dieter Heller, Vincent Krenn, Martin Liebisch, Mike Otto, Thorsten Gehrke, Veit Krenn,

BACKGROUND:In 2016, the AG 11 (work group for implant-material-intolerance) of the German society for Orthopaedics and Orthopaedic Surgery (DGOOC) created a histopathologic implant register (HIR). The goal was to conduct a retrospective data analysis based on the revised SLIM-consensus-classification, which defines eight different failure mechanisms. QUESTIONS:The analysis of 4000 cases of endoprosthetic joint replacements ... Read more >>

Orthopade (Der Orthopade)
[2020, 49(3):248-254]

Cited: 1 time

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Lipoma arborescens - Uncommon Diagnosis for Joint Swelling: Case Report and Review of the Literature.

Ralf Theermann, Malte Ohlmeier, Carl Heinz Hartwig, Matthias Wolff, Veit Krenn, Caroline Liewen, Mustafa Citak, Thorsten Gehrke,

<h4>Introduction</h4>Soft tissue swelling of the knee joint can be caused by many diseases. Lipomas are one of the most reasonable differential diagnoses we have to consider. Therefore, we now present the uncommon case of a Lipoma arborescens (LA) and differentiate it from a quite similar manifesting spindle cell lipoma as ... Read more >>

Z Orthop Unfall (Zeitschrift fur Orthopadie und Unfallchirurgie)
[2020, 158(6):618-624]

Cited: 0 times

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Neutrophil Extracellular Traps Initiate Gallstone Formation.

Luis E Muñoz, Sebastian Boeltz, Rostyslav Bilyy, Christine Schauer, Aparna Mahajan, Navena Widulin, Anika Grüneboom, Irmgard Herrmann, Edgyda Boada, Manfred Rauh, Veit Krenn, Mona H C Biermann, Malgorzata J Podolska, Jonas Hahn, Jasmin Knopf, Christian Maueröder, Solomiya Paryzhak, Tetiana Dumych, Yi Zhao, Markus F Neurath, Markus H Hoffmann, Tobias A Fuchs, Moritz Leppkes, Georg Schett, Martin Herrmann,

The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth of gallstones. We show that gallstone assembly essentially requires neutrophil ... Read more >>

Immunity (Immunity)
[2019, 51(3):443-450.e4]

Cited: 23 times

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[Histopathological Charcot score on intraoperative tissue samples from the foot : A prospective investigation].

Ulrich Illgner, Alexander T Mehlhorn, Nani Osada, Veit Krenn,

<h4>Background</h4>Charcot neuropathy is a severe complication in patients with neuropathy. Without treatment, CN can lead to a destruction and collapse of the foot, with subsequent ulceration and infection. Finding an early diagnosis is essential and is based on clinical and radiological parameters (X-ray and MRI) because there is still no specific and ... Read more >>

Orthopade (Der Orthopade)
[2019, 48(8):693-703]

Cited: 1 time

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General synovitis score and immunologic synovitis score reflect clinical disease activity in patients with advanced stage rheumatoid arthritis.

Tobias Schmidt, Aurélie Najm, Haider Mussawy, Rolf Burghardt, Nicola Oehler, Veit Krenn, Wolfgang Rüther, Andreas Niemeier,

The purpose of this study was to investigate the relationship between clinical disease activity in patients with advanced stage rheumatoid arthritis (RA) on treatment with Disease Modifying Antirheumatic Drugs (DMARDs) and histopathological scores of synovial inflammation. To this end, synovial biopsies of 62 RA patients who underwent surgery for either ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):8448]

Cited: 2 times

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Correction to: Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.

Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Søren Andreas Just, Vasco C Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W Tas, Maria Stoenoiu, Laurent Meric de Bellefon, Patrick Durez, Vibeke Strand, Mihir D Wechalekar, Joao E Fonseca, Bernard Lauwerys, Ursula Fearon, Douglas J Veale, ,

Following publication of the original article [1], the authors reported an error in the spelling of the ninth author's name. ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2018, 20(1):282]

Cited: 1 time

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Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.

Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Søren Andreas Just, Vasco C Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W Tas, Maria Stoenoiu, Laurent Meric de Bellefon, Patrick Durez, Vibeke Strand, Mihir D Wechalekar, Joao E Fonseca, Bernard Lauwerys, Ursula Fearon, Douglas J Veale, ,

<h4>Background</h4>The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.<h4>Methods</h4>Participants were consulted through a modified Delphi method. Three sequential rounds occurred ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2018, 20(1):265]

Cited: 12 times

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Hip and Knee Section, Diagnosis, Reimplantation: Proceedings of International Consensus on Orthopedic Infections.

Arash Aalirezaie, Thomas W Bauer, Hangama Fayaz, William Griffin, Carlos A Higuera, Veit Krenn, Vincent Krenn, Miguel Molano, Dirk-Jan Moojen, Camilo Restrepo, AliSina Shahi, Igor Shubnyakov, Scott Sporer, Aree Tanavalee, Marco Teloken, Job Diego Velázquez Moreno,

J Arthroplasty (The Journal of arthroplasty)
[2019, 34(2S):S369-S379]

Cited: 10 times

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Hip and Knee Section, Diagnosis, Laboratory Tests: Proceedings of International Consensus on Orthopedic Infections.

Thomas W Bauer, Hany Bedair, Jonathan D Creech, Carl Deirmengian, Hannah Eriksson, Yale Fillingham, Grigor Grigoryan, Noreen Hickok, Veit Krenn, Vincent Krenn, Stergios Lazarinis, Lars Lidgren, Jess Lonner, Susan Odum, Jay Shah, AliSina Shahi, Noam Shohat, Majd Tarabichi, Annette W-Dahl, Montri D Wongworawat,

J Arthroplasty (The Journal of arthroplasty)
[2019, 34(2S):S351-S359]

Cited: 5 times

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Gastrointestinal schwannomas: a rare but important differential diagnosis of mesenchymal tumors of gastrointestinal tract.

Alexandros Mekras, Veit Krenn, Aristotelis Perrakis, Roland S Croner, Vasileios Kalles, Cem Atamer, Robert Grützmann, Nikolaos Vassos,

<h4>Background</h4>Schwannomas of gastrointestinal tract are rare, mostly benign and notably different neoplasms from conventional schwannomas that arise in soft tissue or the central nervous system. These tumors are of clinical importance since they should always be considered in the differential diagnosis of submucosal lesions of gastrointestinal tract.<h4>Methods</h4>Seven patients with a ... Read more >>

BMC Surg (BMC surgery)
[2018, 18(1):47]

Cited: 11 times

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IMSYC immunologic synovitis score: A new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis.

Aurélie Najm, Benoît le Goff, Guillaume Venet, Thomas Garraud, Jérôme Amiaud, Noura Biha, Céline Charrier, Sophie Touchais, Vincent Crenn, Frédéric Blanchard, Veit Krenn,

OBJECTIVES:Krenn synovitis Score has been developed by Krenn et al. in order to assess synovitis severity and is used in synovial research. Cell signature of synovial tissue can be studied using immunohistochemistry and is of interest as a biomarker for both prognosis and prediction of response to treatment. However, no ... Read more >>

Joint Bone Spine (Joint bone spine)
[2019, 86(1):77-81]

Cited: 7 times

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Host DNases prevent vascular occlusion by neutrophil extracellular traps.

Miguel Jiménez-Alcázar, Chandini Rangaswamy, Rachita Panda, Josephine Bitterling, Yashin J Simsek, Andy T Long, Rostyslav Bilyy, Veit Krenn, Christoph Renné, Thomas Renné, Stefan Kluge, Ulf Panzer, Ryushin Mizuta, Hans Georg Mannherz, Daisuke Kitamura, Martin Herrmann, Markus Napirei, Tobias A Fuchs,

Platelet and fibrin clots occlude blood vessels in hemostasis and thrombosis. Here we report a noncanonical mechanism for vascular occlusion based on neutrophil extracellular traps (NETs), DNA fibers released by neutrophils during inflammation. We investigated which host factors control NETs in vivo and found that two deoxyribonucleases (DNases), DNase1 and ... Read more >>

Science (Science (New York, N.Y.))
[2017, 358(6367):1202-1206]

Cited: 170 times

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Varus knee osteoarthritis: Elevated synovial CD15 counts correlate with inferior biomechanical properties of lateral-compartment cartilage.

Ulrich Koller, Wenzel Waldstein, Veit Krenn, Reinhard Windhager, Friedrich Boettner,

The study analyzed the influence of synovitis on the histological and biomechanical properties of lateral-compartment cartilage. In a prospective cohort study, 84 patients (100 knees) with varus deformity of the knee were included. Osteochondral samples from the distal lateral femur underwent biomechanical and histologic analysis. Synovial tissue was sampled for ... Read more >>

J Orthop Res (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2018, 36(3):841-846]

Cited: 4 times

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Cellular analyses in the monitoring of autoimmune diseases.

Ulrich Sack, Andreas Boldt, Nora Mallouk, Rudolf Gruber, Veit Krenn, Anne-Emmanuelle Berger-Depincé, Karsten Conrad, Attila Tarnok, Claude Lambert, Dirk Reinhold, Stephan Fricke,

Autoimmun Rev (Autoimmunity reviews)
[2016, 15(9):883-889]

Cited: 4 times

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[Histopathophysiology of Gout].

Thomas Hügle, Veit Krenn,

Despite being a frequent cause of arthritis and bone erosions, the underlying cellular and subcellular reaction in gout is insufficiently understood. The inflammasome as intracellular sensor for crystals plays an important role, notably resulting in interleukin (IL)-1 production. Morphologically, hyperplasia of the synovial membrane with joint effusion, along with fibrinogen ... Read more >>

Ther Umsch (Therapeutische Umschau. Revue therapeutique)
[2016, 73(3):137-140]

Cited: 1 time

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Preanalytical variables and performance of diagnostic RNA-based gene expression analysis in breast cancer.

Christopher Poremba, Jennifer Uhlendorff, Berit M Pfitzner, Guido Hennig, Kerstin Bohmann, Hans Bojar, Veit Krenn, Jan C Brase, Franziska Haufe, Manuela Averdick, Manfred Dietel, Ralf Kronenwett, Carsten Denkert,

Prognostic multigene expression assays have become widely available to provide additional information to standard clinical parameters and to support clinicians in treatment decisions. In this study, we analyzed the impact of variations in tissue handling on the diagnostic EndoPredict test results. EndoPredict is a quantitative reverse transcription PCR assay conducted ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2014, 465(4):409-417]

Cited: 8 times

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Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines.

Christine Schauer, Christina Janko, Luis E Munoz, Yi Zhao, Deborah Kienhöfer, Benjamin Frey, Michael Lell, Bernhard Manger, Jürgen Rech, Elisabeth Naschberger, Rikard Holmdahl, Veit Krenn, Thomas Harrer, Ivica Jeremic, Rostyslav Bilyy, Georg Schett, Markus Hoffmann, Martin Herrmann,

Gout is characterized by an acute inflammatory reaction and the accumulation of neutrophils in response to monosodium urate (MSU) crystals. Inflammation resolves spontaneously within a few days, although MSU crystals can still be detected in the synovial fluid and affected tissues. Here we report that neutrophils recruited to sites of ... Read more >>

Nat Med (Nature medicine)
[2014, 20(5):511-517]

Cited: 344 times

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Diagnosis of periprosthetic joint infection.

Benjamin Zmistowski, Craig Della Valle, Thomas W Bauer, Konstantinos N Malizos, Abbas Alavi, Hani Bedair, Robert E Booth, Peter Choong, Peter Choong, Carl Deirmengian, Garth D Ehrlich, Anil Gambir, Ronald Huang, Yair Kissin, Hideo Kobayashi, Naomi Kobayashi, Veit Krenn, Drago Lorenzo, S B Marston, Geert Meermans, Javier Perez, J J Ploegmakers, Aaron Rosenberg, C Simpfendorfer, Peter Thomas, Stephan Tohtz, Jorge A Villafuerte, Peter Wahl, Frank-Christiaan Wagenaar, Eivind Witzo,

J Orthop Res (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2014, 32 Suppl 1:S98-107]

Cited: 39 times

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Diagnosis of periprosthetic joint infection.

Benjamin Zmistowski, Craig Della Valle, Thomas W Bauer, Konstantinos N Malizos, Abbas Alavi, Hani Bedair, Robert E Booth, Peter Choong, Peter Choong, Carl Deirmengian, Garth D Ehrlich, Anil Gambir, Ronald Huang, Yair Kissin, Hideo Kobayashi, Naomi Kobayashi, Veit Krenn, Lorenzo Drago, S B Marston, Geert Meermans, Javier Perez, J J Ploegmakers, Aaron Rosenberg, C Simpendorfer, Peter Thomas, Stephan Tohtz, Jorge A Villafuerte, Peter Wahl, Frank-Christiaan Wagenaar, Eivind Witzo,

J Arthroplasty (The Journal of arthroplasty)
[2014, 29(2 Suppl):77-83]

Cited: 61 times

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Amyloid arthropathy associated with multiple myeloma: polyarthritis without synovial infiltration of CD20+ or CD38+ cells.

Frank Pessler, Alexis R Ogdie, Christian T Mayer, Warren W Kretzschmar, Lie Dai, Ahmed M Elsaman, Eugene Einhorn, Veit Krenn, H Ralph Schumacher,

<h4>Objectives</h4>To describe histological, immunohistochemical and ultrastructural features of synovial biopsies of amyloid arthropathy associated with multiple myeloma (MM).<h4>Methods</h4>Synovial biopsies from affected joints of two patients with MM and amyloid arthropathy were examined with light and electron microscopy, and immunohistochemically for expression of CD3, CD8, CD20, CD38, CD68, Ki-67 and vWF. ... Read more >>

Amyloid (Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis)
[2014, 21(1):28-34]

Cited: 4 times

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Multicentric giant cell tumor of bone: synchronous and metachronous presentation.

Reiner Wirbel, Frank Blümler, Dirk Lommel, Guido Syré, Veit Krenn,

A 27-year-old man treated 2.5 years ago for synchronous multicentric giant cell tumor of bone located at the right proximal humerus and the right 5th finger presented now with complaints of pain in his right hip and wrist of two-month duration. Radiology and magnetic resonance revealed multicentric giant cell tumor ... Read more >>

Case Rep Orthop (Case reports in orthopedics)
[2013, 2013:756723]

Cited: 7 times

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BMP-2 Dependent Increase of Soft Tissue Density in Arthrofibrotic TKA.

Tilman Pfitzner, Eric Röhner, Veit Krenn, Carsten Perka, Georg Matziolis,

Arthrofibrosis after total knee arthroplasty (TKA) is difficult to treat, as its aetiology remains unclear. In a previous study, we established a connection between the BMP-2 concentration in the synovial fluid and arthrofibrosis after TKA. The hypothesis of the present study was, therefore, that the limited range of motion in ... Read more >>

Open Orthop J (The open orthopaedics journal)
[2012, 6:199-203]

Cited: 3 times

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