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Kidney Health for Everyone Everywhere-From Prevention to Detection and Equitable Access to Care.

Philip Kam-Tao Li, Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston Wing-Shing Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh, ,

The global burden of chronic kidney disease (CKD) is increasing with a projection of becoming the fifth leading cause of years of life lost globally by 2040. CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the entire annual ... Read more >>

J Ren Care (Journal of renal care)
[2020, 46(1):4-12]

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Kidney health for everyone everywhere - from prevention to detection and equitable access to care.

Philip Kam-Tao Li, Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston Wing-Shing Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh,

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of ... Read more >>

Clin. Nephrol. (Clinical nephrology)
[2020, 93(3):111-122]

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Kidney health for everyone everywhere-From prevention to detection and equitable access to care.

Philip K-T Li, Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston W-S Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh, ,

Nephrology (Carlton) (Nephrology (Carlton, Vic.))
[2020, 25(3):195-201]

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Kidney health for everyone everywhere-from prevention to detection and equitable access to care.

Philip Kam-Tao Li, Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston Wing-Shing Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh, ,

Kidney Int. (Kidney international)
[2020, 97(2):226-232]

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Kidney health for everyone, everywhere: from prevention to detection and equitable access to care.

Philip K-T Li, Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston W-S Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh, ,

Intern Med J (Internal medicine journal)
[2020, 50(2):145-150]

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Hypertension in Chronic Kidney Disease: Novel Insights.

Anila Duni, Evangelia Dounousi, Paraskevi Pavlakou, Theodoros Eleftheriadis, Vassilios Liakopoulos,

Management of arterial hypertension in patients with chronic kidney disease (CKD) remains a major challenge due to its high prevalence and associations with cardiovascular disease (CVD) and CKD progression. Several clinical trials and meta-analyses have demonstrated that aggressive treatment of hypertension in patients with and without CKD lowers the risk ... Read more >>

Curr Hypertens Rev (Current hypertension reviews)
[2020, 16(1):45-54]

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Urate crystals trigger B-cell receptor signal transduction and induce B-cell proliferation.

Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis,

Background Urate in its crystal form is a known danger-associated molecular pattern, which after its internalization activates cells of the innate immune system. However, by inducing lipid raft sequestration and clustering of membrane-bound proteins with immunoreceptor tyrosine-based activation motifs, urate crystals can also activate cells of the innate immune system ... Read more >>

J Basic Clin Physiol Pharmacol (Journal of basic and clinical physiology and pharmacology)
[2020, :]

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Activation of General Control Nonderepressible-2 Kinase Ameliorates Glucotoxicity in Human Peritoneal Mesothelial Cells, Preserves Their Integrity, and Prevents Mesothelial to Mesenchymal Transition.

Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Evdokia Nikolaou, Spyridon Golfinopoulos, Vassilios Liakopoulos, Ioannis Stefanidis,

Along with infections, ultrafiltration failure due to the toxicity of glucose-containing peritoneal dialysis (PD) solutions is the Achilles' heel of PD method. Triggered by the protective effect of general control nonderepressible-2 (GCN-2) kinase activation against high-glucose conditions in other cell types, we evaluated whether the same occurs in human peritoneal ... Read more >>

Biomolecules (Biomolecules)
[2019, 9(12):]

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Weak within-individual association of blood pressure and pulse wave velocity in hemodialysis is related to adverse outcomes.

Pantelis A Sarafidis, Charalampos Loutradis, Christopher C Mayer, Antonios Karpetas, Eleni Pagkopoulou, Athanasios Bikos, Danai Faitatzidou, Siegfried Wassertheurer, Christoph Schmaderer, Vassilios Liakopoulos, Aikaterini Papagianni, Gerard London,

OBJECTIVES:Hemodialysis patients have premature arterial stiffness, and the relationship between pulse wave velocity (PWV) and blood pressure (BP) may be different than in other hypertensives. Previous studies in such patients showed that when BP decrease is accompanied by PWV decrease the survival is improved. This study examines the prognostic role ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(11):2200-2208]

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A cohort of fat enough but malnourished hemodialysis patients.

Theodoros Eleftheriadis, Vassilios Liakopoulos, Ioannis Stefanidis,

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2020, 39(1):320-321]

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The H2S-Nrf2-Antioxidant Proteins Axis Protects Renal Tubular Epithelial Cells of the Native Hibernator Syrian Hamster from Reoxygenation-Induced Cell Death.

Theodoros Eleftheriadis, Georgios Pissas, Evdokia Nikolaou, Vassilios Liakopoulos, Ioannis Stefanidis,

During hibernation, repeated cycles of ischemia-reperfusion (I-R) leave vital organs without injury. Studying this phenomenon may reveal pathways applicable to improving outcomes in I-R injury-induced human diseases. We evaluated whether the H2S-nuclear factor erythroid 2-like 2 (Nrf2)-antioxidant proteins axis protects renal proximal tubular epithelial cells (RPTECs) of the native hibernator, ... Read more >>

Biology (Basel) (Biology)
[2019, 8(4):]

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Clinic and Home Blood Pressure Monitoring for the Detection of Ambulatory Hypertension Among Patients on Peritoneal Dialysis.

Vasilios Vaios, Panagiotis I Georgianos, Georgia Vareta, Evangelia Dounousi, Chrysostomos Dimitriadis, Theodoros Eleftheriadis, Aikaterini Papagianni, Pantelis E Zebekakis, Vassilios Liakopoulos,

The International Society of Peritoneal Dialysis recommends that adequate blood pressure (BP) assessment among patients on peritoneal dialysis should at least include measurements performed once-weekly at home and at each visit at clinic. However, the quality of evidence to support this guidance is suboptimal. Using ambulatory daytime BP as reference ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2019, 74(4):998-1004]

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In-Depth Bioinformatic Study of the CLDN16 Gene and Protein: Prediction of Subcellular Localization to Mitochondria.

Erasmia Rouka, Vassilios Liakopoulos, Konstantinos I Gourgoulianis, Chrissi Hatzoglou, Sotirios G Zarogiannis,

Background and Objectives: The defects in the CLDN16 gene are a cause of primary hypomagnesemia (FHHNC), which is characterized by massive renal magnesium wasting, resulting in nephrocalcinosis and renal failure. The mutations occur throughout the gene's coding region and can impact on intracellular trafficking of the protein or its paracellular ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(8):]

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Wave reflections and systemic vascular resistance are stronger determinants of pulse pressure amplification than aortic stiffness in drug-naïve hypertensives.

Eleftherios Papakonstantinou, Maria Pikilidou, Panagiotis Georgianos, Maria Yavropoulou, Georgios Tsivgoulis, Lina Hadjistavri, Sideris Nanoudis, Vassilios Liakopoulos, Anastasios Lasaridis, Pantelis Zebekakis,

Background: Aortic-to-brachial pulse pressure (PP) amplification is a novel biomarker that prognosticates the cardiovascular risk above and beyond central aortic and brachial blood pressure. This phenomenon is modulated by left ventricular contractility and chronotrophy, large-artery stiffness and reflecting properties of microcirculation. However, the relative importance of these parameters as hemodynamic ... Read more >>

Clin. Exp. Hypertens. (Clinical and experimental hypertension (New York, N.Y. : 1993))
[2020, 42(3):287-293]

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Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review.

Stefanos Roumeliotis, Athanasios Roumeliotis, Evangelia Dounousi, Theodoros Eleftheriadis, Vassilios Liakopoulos,

Increased serum levels of uric acid have been associated with the onset and development of chronic kidney disease (CKD), cardiovascular disease, and mortality, through several molecular pathogenetic mechanisms, such as inflammation and oxidative stress. Oxidative stress is present even in the early stages of CKD, progresses parallelly with the deterioration ... Read more >>

Nutrients (Nutrients)
[2019, 11(8):]

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Optimal diastolic blood pressure range in intensive systolic targets: Resolving the controversy between observational and intention-to-treat analyses.

Panagiotis I Georgianos, Pantelis E Zebekakis, Vassilios Liakopoulos,

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2019, 21(7):919-921]

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Attitudes of hemodialysis patients, medical and nursing staff towards patients' physical activity.

Vassiliki Michou, Evangelia Kouidi, Vassilios Liakopoulos, Evangelia Dounousi, Asterios Deligiannis,

PURPOSE:Patients with end-stage renal disease (ESRD) seem to have a negative attitude towards physical activity, which is mainly favored by the lack of counseling provided by the medical and nursing staff. The aim of this study was to investigate the attitudes of both ESRD patients and medical staff on the ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2019, 51(7):1249-1260]

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Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and induces T-cell and B-cell proliferation.

Theodoros Eleftheriadis, Georgios Pissas, Sotirios Zarogiannis, Vassilios Liakopoulos, Ioannis Stefanidis,

Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen presenting cells. However, the direct effect of silica on T-cells and B-cells has not been evaluated ... Read more >>

Autoimmunity (Autoimmunity)
[2019, 52(3):136-143]

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Indoleamine 2,3-dioxygenase suppresses humoral alloimmunity via pathways that different to those associated with its effects on T cells.

Maria Sounidaki, Georgios Pissas, Theodoros Eleftheriadis, Georgia Antoniadi, Spyridon Golfinopoulos, Vassilios Liakopoulos, Ioannis Stefanidis,

Chronic antibody-mediated rejection remains a major cause of late graft loss. Regarding cellular alloimmunity, the immunosuppressive properties of indoleamine 2,3-dioxygenase (IDO) have been well investigated; however, little is known of its effects on humoral alloimmunity. Therefore, the present study aimed to evaluate the effects of IDO on humoral alloimmunity. We ... Read more >>

Biomed Rep (Biomedical reports)
[2019, 1(1):1-5]

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Is oxidative stress an issue in peritoneal dialysis?

Stefanos Roumeliotis, Theodoros Eleftheriadis, Vassilios Liakopoulos,

During the last two decades, oxidative stress (OS) has emerged as a novel risk factor for a variety of adverse events, including atherosclerosis and mortality in chronic kidney disease (CKD) patients. Increased OS occurs even in early stages of the disease, progresses with deterioration of renal function and is further ... Read more >>

Semin Dial (Seminars in dialysis)
[2019, 32(5):463-466]

Cited: 2 times

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Remission of nephrotic syndrome after resolution of renal artery stenosis in a patient with a single functional kidney.

Jan Schiefer, Christos Chatzikyrkou, Peter R Mertens, Vassilios Liakopoulos,

Clin. Nephrol. (Clinical nephrology)
[2019, 91(4):265-267]

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Factors that May Protect the Native Hibernator Syrian Hamster Renal Tubular Epithelial Cells from Ferroptosis Due to Warm Anoxia-Reoxygenation.

Theodoros Eleftheriadis, Georgios Pissas, Vassilios Liakopoulos, Ioannis Stefanidis,

Warm anoxia-reoxygenation induces ferroptotic cell death in mouse proximal renal tubular epithelial cells (RPTECs), whereas RPTECs of the native hibernator Syrian hamster resist cell death. Clarifying how hamster cells escape ferroptosis may reveal new molecular targets for preventing or ameliorating ischemia-reperfusion-induced human diseases or expanding the survival of organ transplants. ... Read more >>

Biology (Basel) (Biology)
[2019, 8(2):]

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The association of interdialytic blood pressure variability with cardiovascular events and all-cause mortality in haemodialysis patients.

Pantelis A Sarafidis, Charalampos Loutradis, Antonios Karpetas, Georgios Tzanis, Athanasios Bikos, Vassilios Raptis, Christos Syrgkanis, Vassilios Liakopoulos, Aikaterini Papagianni, George Bakris, Gianfranco Parati,

BACKGROUND:Long-term pre-dialysis blood pressure variability (BPV) in haemodialysis patients is associated with increased cardiovascular risk. The association of the main haemodynamic culprit in dialysis, that is, short-term BPV, with outcomes has not been investigated. We examine the prognostic role of short-term BPV for mortality and cardiovascular events in this population. ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, 34(3):515-523]

Cited: 1 time

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The effects of nebivolol and irbesartan on postdialysis and ambulatory blood pressure in patients with intradialytic hypertension: a randomized cross-over study.

Athanasios Bikos, Charalampos Loutradis, Elena Angeloudi, Antonios Karpetas, Vasilios Raptis, Rigas Kalaitzidis, Stylianos Panagoutsos, Ploumis Pasadakis, Ilias Balaskas, Vassilios Liakopoulos, Aikaterini Papagianni, Pantelis A Sarafidis,

OBJECTIVES:Intradialytic hypertension is estimated at 5-15% of hemodialysis patients and is associated with poor prognosis. Studies on therapeutic interventions for this entity are extremely few. We aimed to evaluate the effects of nebivolol and irbesartan on peridialytic, intradialytic, and ambulatory BP in patients with intradialytic hypertension. METHODS:This is a pilot ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(2):432-442]

Cited: 1 time

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Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review.

Stefanos Roumeliotis, Evangelia Dounousi, Theodoros Eleftheriadis, Vassilios Liakopoulos,

Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful natural occurring inhibitor of calcification in the human body. To become biologically active, MGP must undergo vitamin K-dependent carboxylation and phosphorylation. Vitamin K deficiency leads to the inactive uncarboxylated, dephosphorylated form of MGP (dpucMGP). We aimed ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(3):]

Cited: 4 times

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